SI3129400T1 - Živali, ki niso človek in imajo humanizirane receptorje FC-gama - Google Patents

Živali, ki niso človek in imajo humanizirane receptorje FC-gama

Info

Publication number
SI3129400T1
SI3129400T1 SI201531233T SI201531233T SI3129400T1 SI 3129400 T1 SI3129400 T1 SI 3129400T1 SI 201531233 T SI201531233 T SI 201531233T SI 201531233 T SI201531233 T SI 201531233T SI 3129400 T1 SI3129400 T1 SI 3129400T1
Authority
SI
Slovenia
Prior art keywords
humanized
human animals
gamma receptors
receptors
gamma
Prior art date
Application number
SI201531233T
Other languages
English (en)
Inventor
Andrew J. Murphy
Lynn Macdonald
Cagan Gurer
Karolina A. Meagher
Naxin Tu
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of SI3129400T1 publication Critical patent/SI3129400T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI201531233T 2014-04-08 2015-04-08 Živali, ki niso človek in imajo humanizirane receptorje FC-gama SI3129400T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461977037P 2014-04-08 2014-04-08
PCT/US2015/024920 WO2015157415A1 (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors
EP15718060.5A EP3129400B1 (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Publications (1)

Publication Number Publication Date
SI3129400T1 true SI3129400T1 (sl) 2020-07-31

Family

ID=52997579

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531233T SI3129400T1 (sl) 2014-04-08 2015-04-08 Živali, ki niso človek in imajo humanizirane receptorje FC-gama

Country Status (23)

Country Link
US (4) US9474255B2 (sl)
EP (2) EP3129400B1 (sl)
JP (2) JP6652931B2 (sl)
KR (2) KR102439412B1 (sl)
CN (2) CN111690052B (sl)
AU (2) AU2015243865C1 (sl)
CA (1) CA2935472C (sl)
CY (1) CY1123046T1 (sl)
DK (1) DK3129400T3 (sl)
ES (1) ES2794942T3 (sl)
HR (1) HRP20200899T1 (sl)
HU (1) HUE051088T2 (sl)
IL (2) IL246497B (sl)
LT (1) LT3129400T (sl)
MX (1) MX2016013241A (sl)
PH (1) PH12016501341A1 (sl)
PL (1) PL3129400T3 (sl)
PT (1) PT3129400T (sl)
RS (1) RS60398B1 (sl)
RU (2) RU2700484C2 (sl)
SG (2) SG11201604886WA (sl)
SI (1) SI3129400T1 (sl)
WO (1) WO2015157415A1 (sl)

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KR102439412B1 (ko) 2014-04-08 2022-09-02 리제너론 파아마슈티컬스, 인크. 인간화된 Fc-감마 수용체를 갖는 비-인간 동물
NO2785538T3 (sl) 2014-05-07 2018-08-04
RS60097B1 (sr) 2014-06-19 2020-05-29 Regeneron Pharma Ne-humane životinje koje imaju humanizovani gen za programiranu ćelijsku smrt 1
LT3223605T (lt) 2014-11-24 2021-01-11 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, ekspresuojantys humanizuotą cd3 kompleksą
KR102617691B1 (ko) 2014-12-05 2023-12-27 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 47 유전자를 가진 비인간 동물
SI3376857T1 (sl) 2015-11-20 2021-09-30 Regeneron Pharmaceuticals, Inc. Nehumane živali, ki imajo humaniziran gen 3 za aktivacijo limfocitov
KR102493894B1 (ko) 2016-02-29 2023-01-31 리제너론 파마슈티칼스 인코포레이티드 인간화 tmprss 유전자를 갖는 설치류
EP4299732A3 (en) 2017-11-30 2024-03-27 Regeneron Pharmaceuticals, Inc. Rats comprising a humanized trkb locus
SG11202008620VA (en) * 2018-03-26 2020-10-29 Regeneron Pharma Humanized rodents for testing therapeutic agents
JP2021530970A (ja) 2018-07-16 2021-11-18 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Ｄｉｔｒａの非ヒト動物モデルおよびその使用
JP2024500399A (ja) 2020-12-16 2024-01-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化Ｆｃアルファ受容体を発現するマウス

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EP0663952A4 (en) 1992-09-11 1997-06-11 Univ California TRANSGENIC NON-HUMAN ANIMALS WITH TARGETED INTERRUPTED TRANSDUCTION GENES IN LYMPHOCYTES.
US5877396A (en) 1993-04-23 1999-03-02 Sloan Kettering Institute For Cancer Research Mice mutant for functional Fc receptors and method of treating autoimmune diseases
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FR2822161B1 (fr) 2001-03-15 2003-09-19 Genoway Cellule et animal transgenique modelisant les reponses humaines allergiques mediees par les ige, et leurs utilisations
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JP4653915B2 (ja) 2001-10-29 2011-03-16 独立行政法人科学技術振興機構 全身性エリテマトーデスモデル非ヒト動物
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JP2004147535A (ja) 2002-10-29 2004-05-27 Japan Science & Technology Agency ギラン・バレー症候群及び／又はフィッシャー症候群発症モデル非ヒト動物
EP1573314B1 (en) 2002-12-16 2008-07-23 Genentech, Inc. Transgenic mice expressing human cd20
FR2858235B1 (fr) 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
JP5070045B2 (ja) * 2004-05-27 2012-11-07 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 新規人工抗原提示細胞およびそれらの用途
JP2008516586A (ja) 2004-09-30 2008-05-22 メダレックス インコーポレーティッド Ｆｃγ受容体ＩＩ（ＣＤ３２）に対するヒトモノクローナル抗体
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JP6505689B2 (ja) 2013-11-19 2019-04-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｂ細胞活性化因子遺伝子を有する非ヒト動物
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KR102439412B1 (ko) * 2014-04-08 2022-09-02 리제너론 파아마슈티컬스, 인크. 인간화된 Fc-감마 수용체를 갖는 비-인간 동물

Also Published As

Publication number Publication date
JP6858283B2 (ja) 2021-04-14
EP3129400B1 (en) 2020-03-25
ES2794942T3 (es) 2020-11-19
AU2020217312A1 (en) 2020-08-27
LT3129400T (lt) 2020-06-25
AU2015243865A1 (en) 2016-08-18
US10555507B2 (en) 2020-02-11
WO2015157415A1 (en) 2015-10-15
PH12016501341A1 (en) 2016-08-15
HRP20200899T1 (hr) 2020-09-04
US20150282463A1 (en) 2015-10-08
US11503812B2 (en) 2022-11-22
RU2019128394A (ru) 2019-10-07
AU2020217312C1 (en) 2023-10-26
US20230232795A1 (en) 2023-07-27
JP6652931B2 (ja) 2020-02-26
EP3693383A1 (en) 2020-08-12
SG11201604886WA (en) 2016-07-28
PT3129400T (pt) 2020-05-27
MX2016013241A (es) 2017-05-03
CA2935472A1 (en) 2015-10-15
RS60398B1 (sr) 2020-07-31
SG10201908800YA (en) 2019-11-28
CN106163273A (zh) 2016-11-23
KR102223264B1 (ko) 2021-03-09
RU2700484C2 (ru) 2019-09-17
IL264364A (en) 2019-02-28
RU2016143036A3 (sl) 2018-10-24
CY1123046T1 (el) 2021-10-29
AU2015243865B2 (en) 2020-05-14
AU2020217312B2 (en) 2023-04-13
IL264364B (en) 2021-03-25
DK3129400T3 (da) 2020-06-08
IL246497B (en) 2019-06-30
US20170086432A1 (en) 2017-03-30
US9474255B2 (en) 2016-10-25
US20200288684A1 (en) 2020-09-17
PL3129400T3 (pl) 2020-09-07
RU2016143036A (ru) 2018-05-08
JP2020062051A (ja) 2020-04-23
CN111690052B (zh) 2024-06-04
JP2017510285A (ja) 2017-04-13
IL246497A0 (en) 2016-08-31
KR20210024249A (ko) 2021-03-04
HUE051088T2 (hu) 2021-03-01
CN106163273B (zh) 2020-07-24
KR102439412B1 (ko) 2022-09-02
CA2935472C (en) 2024-02-20
CN111690052A (zh) 2020-09-22
AU2015243865C1 (en) 2020-11-26
KR20160142309A (ko) 2016-12-12
EP3129400A1 (en) 2017-02-15

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