SI2442651T1 - Zdravljenje multiple skleroze z lakvinimodom - Google Patents

Zdravljenje multiple skleroze z lakvinimodom

Info

Publication number
SI2442651T1
SI2442651T1 SI201031018T SI201031018T SI2442651T1 SI 2442651 T1 SI2442651 T1 SI 2442651T1 SI 201031018 T SI201031018 T SI 201031018T SI 201031018 T SI201031018 T SI 201031018T SI 2442651 T1 SI2442651 T1 SI 2442651T1
Authority
SI
Slovenia
Prior art keywords
laquinimod
treatment
multiple sclerosis
sclerosis
Prior art date
Application number
SI201031018T
Other languages
English (en)
Inventor
Nora Tarcic
Dan Bar-Zohar
Dina Kofler
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of SI2442651T1 publication Critical patent/SI2442651T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/215IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201031018T 2009-06-19 2010-06-18 Zdravljenje multiple skleroze z lakvinimodom SI2442651T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26907009P 2009-06-19 2009-06-19
EP10789873.6A EP2442651B1 (en) 2009-06-19 2010-06-18 Treatment of multiple sclerosis with laquinimod
PCT/US2010/001759 WO2010147665A1 (en) 2009-06-19 2010-06-18 Treatment of multiple sclerosis with laquinimod

Publications (1)

Publication Number Publication Date
SI2442651T1 true SI2442651T1 (sl) 2015-10-30

Family

ID=43354572

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031018T SI2442651T1 (sl) 2009-06-19 2010-06-18 Zdravljenje multiple skleroze z lakvinimodom

Country Status (26)

Country Link
US (7) US20100322900A1 (sl)
EP (2) EP3028572A1 (sl)
JP (4) JP2012530701A (sl)
KR (2) KR20120037477A (sl)
CN (2) CN107308162A (sl)
AU (2) AU2010260455A1 (sl)
BR (1) BR112012000568A2 (sl)
CY (1) CY1116727T1 (sl)
DK (1) DK2442651T3 (sl)
EA (1) EA201270041A1 (sl)
ES (1) ES2548999T3 (sl)
HK (1) HK1169563A1 (sl)
HR (1) HRP20150988T1 (sl)
HU (1) HUE026406T2 (sl)
IL (2) IL216780A0 (sl)
ME (1) ME02282B (sl)
MX (1) MX2011013902A (sl)
NZ (1) NZ597378A (sl)
PL (1) PL2442651T3 (sl)
PT (1) PT2442651E (sl)
RS (1) RS54328B1 (sl)
SG (2) SG10201403397TA (sl)
SI (1) SI2442651T1 (sl)
SM (1) SMT201500262B (sl)
WO (1) WO2010147665A1 (sl)
ZA (1) ZA201200029B (sl)

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DK2035001T3 (da) 2006-06-12 2012-02-27 Teva Pharma Stabile laquinimod-tilberedninger
SI2234485T1 (sl) 2007-12-20 2014-03-31 Teva Pharmaceutical Industries Ltd. Stabilni lakvinimodni pripravki
WO2010028015A2 (en) * 2008-09-03 2010-03-11 Auspex Pharmaceuticals, Inc 2-oxo-1,2-dihydro-quinoline modulators of immune function
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ES2601819T3 (es) * 2010-03-03 2017-02-16 Teva Pharmaceutical Industries Ltd. Tratamiento de la artritis lúpica usando laquinimod
MX337614B (es) * 2010-03-03 2016-03-10 Teva Pharma Tratamiento de lupus nefritis usando laquinimod.
SG183513A1 (en) * 2010-03-03 2012-09-27 Teva Pharma Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
CN102984939A (zh) 2010-07-09 2013-03-20 泰华制药工业有限公司 氘化的n-乙基-n-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺、其盐和用途
KR20130124518A (ko) * 2010-12-07 2013-11-14 테바 파마슈티컬 인더스트리즈 리미티드 다발경화증 환자의 피로를 감소시키고, 기능 상태를 개선시키고, 삶의 질을 개선시키기 위한 라퀴니모드의 용도
EP2736336A4 (en) * 2011-07-28 2015-03-04 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS WITH A COMBINATION OF LAQUINIMOD AND INTERFERON-BETA
EA201490377A1 (ru) * 2011-07-28 2014-11-28 Тева Фармасьютикал Индастриз Лтд. Лечение рассеянного склероза комбинацией лаквинимода и глатирамера ацетата
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SG11201404214QA (en) 2012-02-03 2014-08-28 Teva Pharma USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY
JP6215238B2 (ja) 2012-02-16 2017-10-18 テバ ファーマシューティカル インダストリーズ リミティド N−エチル−n−フェニル−1,2−ジヒドロ−4,5−ジ−ヒドロキシ−1−メチル−2−オキソ−3−キノリンカルボキサミド、その製剤、および使用
US20130259856A1 (en) * 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201347762A (zh) * 2012-05-02 2013-12-01 Teva Pharma 高劑量拉喹莫德(laquinimod)於治療多發性硬化症之用途
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
UY34896A (es) * 2012-07-12 2014-02-28 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療gaba媒介之疾病之拉喹莫德(laquinimod)
SG11201501874TA (en) * 2012-10-12 2015-05-28 Pharmaceutical Industries Ltd Teva Laquinimod for reducing thalamic damage in multiple sclerosis
CA2890194A1 (en) 2012-11-07 2014-05-15 Teva Pharmaceutical Industries Ltd. Amine salts of laquinimod
EA201591507A1 (ru) * 2013-02-15 2015-12-30 Тева Фармасьютикал Индастриз Лтд. Лечение рассеянного склероза лахинимодом
MX2015010967A (es) 2013-03-14 2015-10-26 Teva Pharma Formulaciones transdermicas de laquinimod.
US20160046582A1 (en) 2013-03-14 2016-02-18 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
CN105848653A (zh) * 2013-09-27 2016-08-10 梯瓦制药工业有限公司 用于治疗多发性硬化症的拉喹莫德联合治疗
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WO2016094516A1 (en) * 2014-12-10 2016-06-16 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and a statin
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MX337614B (es) * 2010-03-03 2016-03-10 Teva Pharma Tratamiento de lupus nefritis usando laquinimod.
SG183513A1 (en) * 2010-03-03 2012-09-27 Teva Pharma Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
ES2601819T3 (es) * 2010-03-03 2017-02-16 Teva Pharmaceutical Industries Ltd. Tratamiento de la artritis lúpica usando laquinimod
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CN102984939A (zh) * 2010-07-09 2013-03-20 泰华制药工业有限公司 氘化的n-乙基-n-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺、其盐和用途

Also Published As

Publication number Publication date
IL252699A0 (en) 2017-07-31
MX2011013902A (es) 2012-02-23
CN102802415A (zh) 2012-11-28
KR20120037477A (ko) 2012-04-19
SG176840A1 (en) 2012-02-28
ME02282B (me) 2016-02-20
JP2015107981A (ja) 2015-06-11
PT2442651E (pt) 2015-10-22
HK1169563A1 (en) 2013-02-01
EP2442651B1 (en) 2015-07-29
ES2548999T3 (es) 2015-10-22
PL2442651T3 (pl) 2015-12-31
US20130272996A1 (en) 2013-10-17
EP2442651A1 (en) 2012-04-25
HRP20150988T1 (hr) 2015-11-20
EP2442651A4 (en) 2012-10-31
EP3028572A1 (en) 2016-06-08
AU2010260455A1 (en) 2012-02-02
JP2016199555A (ja) 2016-12-01
CY1116727T1 (el) 2017-03-15
HUE026406T2 (en) 2016-06-28
US20140105850A1 (en) 2014-04-17
JP2018021045A (ja) 2018-02-08
NZ597378A (en) 2014-08-29
AU2016216586A1 (en) 2016-09-01
KR20170109091A (ko) 2017-09-27
US20160082001A1 (en) 2016-03-24
RS54328B1 (en) 2016-02-29
EA201270041A1 (ru) 2012-06-29
DK2442651T3 (en) 2015-09-21
SG10201403397TA (en) 2014-10-30
CN107308162A (zh) 2017-11-03
US20180042916A1 (en) 2018-02-15
US20100322900A1 (en) 2010-12-23
IL216780A0 (en) 2012-02-29
US20150164880A1 (en) 2015-06-18
ZA201200029B (en) 2013-03-27
JP2012530701A (ja) 2012-12-06
BR112012000568A2 (pt) 2015-10-06
WO2010147665A1 (en) 2010-12-23
US20170128435A1 (en) 2017-05-11
SMT201500262B (it) 2016-01-08

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