SI2313371T1 - Postopek za pripravo soli 3-pirol substituirane 2-indolinonske jabolčne kisline - Google Patents

Postopek za pripravo soli 3-pirol substituirane 2-indolinonske jabolčne kisline

Info

Publication number
SI2313371T1
SI2313371T1 SI200930374T SI200930374T SI2313371T1 SI 2313371 T1 SI2313371 T1 SI 2313371T1 SI 200930374 T SI200930374 T SI 200930374T SI 200930374 T SI200930374 T SI 200930374T SI 2313371 T1 SI2313371 T1 SI 2313371T1
Authority
SI
Slovenia
Prior art keywords
indolinone
preparing
malate salt
pyrrole substituted
pyrrole
Prior art date
Application number
SI200930374T
Other languages
English (en)
Inventor
Bernardino Mangion
Stephen Benedict David Winter
Original Assignee
Medichem, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem, S.A. filed Critical Medichem, S.A.
Publication of SI2313371T1 publication Critical patent/SI2313371T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
SI200930374T 2008-06-13 2009-06-12 Postopek za pripravo soli 3-pirol substituirane 2-indolinonske jabolčne kisline SI2313371T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6143008P 2008-06-13 2008-06-13
EP09762051A EP2313371B1 (en) 2008-06-13 2009-06-12 Process for preparing a 3-pyrrole substituted 2-indolinone malate salt
PCT/IB2009/005914 WO2009150523A1 (en) 2008-06-13 2009-06-12 Process for preparing a 3-pyrrole substituted 2-indolinone malate salt

Publications (1)

Publication Number Publication Date
SI2313371T1 true SI2313371T1 (sl) 2013-02-28

Family

ID=41055390

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930374T SI2313371T1 (sl) 2008-06-13 2009-06-12 Postopek za pripravo soli 3-pirol substituirane 2-indolinonske jabolčne kisline

Country Status (7)

Country Link
US (1) US8153678B2 (sl)
EP (1) EP2313371B1 (sl)
AR (1) AR072117A1 (sl)
ES (1) ES2392762T3 (sl)
IL (1) IL209949A0 (sl)
SI (1) SI2313371T1 (sl)
WO (1) WO2009150523A1 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011004200A1 (en) * 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
WO2011095802A1 (en) * 2010-02-02 2011-08-11 Generics [Uk] Limited Hplc method for analyzing sunitinib
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
AU2011222470A1 (en) * 2010-03-04 2012-09-27 Ranbaxy Laboratories Limited Process for the direct preparation of malic acid salt of sunitinib
AU2011228765A1 (en) 2010-03-18 2012-10-11 Ranbaxy Laboratories Limited Process for the preparation of malic acid salt of sunitinib
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
EP2635568B1 (en) 2010-11-01 2017-08-16 Scinopharm (Kunshan) Biochemical Technology Co., Ltd. Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
EA006445B9 (ru) * 2001-08-15 2017-02-28 Фармация Энд Апджон Компани Кристаллы, содержащие соль яблочной кислоты n-[2-(диэтиламино)этил]-5-[(5-фторо-2-оксо-1,2-дигидро-3h-индол-3-илиден)метил]-2,4-диметил-1h-пиррол-3-карбоксамида, способы их получения и их композиции
EP2098521A1 (en) 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation

Also Published As

Publication number Publication date
WO2009150523A1 (en) 2009-12-17
ES2392762T3 (es) 2012-12-13
US8153678B2 (en) 2012-04-10
US20090318525A1 (en) 2009-12-24
EP2313371A1 (en) 2011-04-27
AR072117A1 (es) 2010-08-04
EP2313371B1 (en) 2012-08-15
IL209949A0 (en) 2011-02-28

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