SI2145002T1 - Bakterijsko - pridobljene, intaktne minicelice, ki zaobjemajo funkcionalne nukleinske kisline brez plazmida za in vivo dostavo v celice sesalcev - Google Patents

Bakterijsko - pridobljene, intaktne minicelice, ki zaobjemajo funkcionalne nukleinske kisline brez plazmida za in vivo dostavo v celice sesalcev

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Publication number
SI2145002T1
SI2145002T1 SI200831411T SI200831411T SI2145002T1 SI 2145002 T1 SI2145002 T1 SI 2145002T1 SI 200831411 T SI200831411 T SI 200831411T SI 200831411 T SI200831411 T SI 200831411T SI 2145002 T1 SI2145002 T1 SI 2145002T1
Authority
SI
Slovenia
Prior art keywords
bacterially
derived
nucleic acid
mammalian cells
vivo delivery
Prior art date
Application number
SI200831411T
Other languages
English (en)
Inventor
Himanshu Brahmbhatt
Jennifer Macdiarmid
Toby Hulf
Original Assignee
Engeneic Molecular Delivery Pty Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engeneic Molecular Delivery Pty Ltd. filed Critical Engeneic Molecular Delivery Pty Ltd.
Publication of SI2145002T1 publication Critical patent/SI2145002T1/sl

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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    • C12Y207/11021—Polo kinase (2.7.11.21)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
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    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
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    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
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    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Polysaccharides And Polysaccharide Derivatives (AREA)
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SI200831411T 2007-03-30 2008-03-26 Bakterijsko - pridobljene, intaktne minicelice, ki zaobjemajo funkcionalne nukleinske kisline brez plazmida za in vivo dostavo v celice sesalcev SI2145002T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90907407P 2007-03-30 2007-03-30
EP08828079.7A EP2145002B1 (en) 2007-03-30 2008-03-26 Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
PCT/IB2008/002984 WO2009027830A2 (en) 2007-03-30 2008-03-26 Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells

Publications (1)

Publication Number Publication Date
SI2145002T1 true SI2145002T1 (sl) 2015-05-29

Family

ID=40386454

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200831798A SI2865755T1 (sl) 2007-03-30 2008-03-26 Intaktne minicelice, ki so izvedene iz bakterij in vključujejo regulatorno RNA
SI200831411T SI2145002T1 (sl) 2007-03-30 2008-03-26 Bakterijsko - pridobljene, intaktne minicelice, ki zaobjemajo funkcionalne nukleinske kisline brez plazmida za in vivo dostavo v celice sesalcev

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Application Number Title Priority Date Filing Date
SI200831798A SI2865755T1 (sl) 2007-03-30 2008-03-26 Intaktne minicelice, ki so izvedene iz bakterij in vključujejo regulatorno RNA

Country Status (18)

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EP (5) EP2865755B1 (sl)
JP (1) JP5167338B2 (sl)
CN (2) CN101715489B (sl)
AU (1) AU2008291833B2 (sl)
CA (3) CA2933978C (sl)
CY (1) CY1119031T1 (sl)
DK (2) DK2865755T3 (sl)
ES (2) ES2534435T3 (sl)
HK (2) HK1138326A1 (sl)
HR (2) HRP20150328T1 (sl)
LT (1) LT2865755T (sl)
MX (1) MX2009010411A (sl)
NZ (1) NZ580487A (sl)
PL (2) PL2865755T3 (sl)
PT (2) PT2865755T (sl)
SG (2) SG10201804257RA (sl)
SI (2) SI2865755T1 (sl)
WO (1) WO2009027830A2 (sl)

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US9006200B2 (en) * 2013-03-13 2015-04-14 Asbestos Diseases Research Foundation MicroRNA-based approach to treating malignant pleural mesothelioma
MX2016004285A (es) 2013-10-04 2016-07-08 Engeneic Molecular Delivery Pty Ltd Tratamiento de tumor por combinacion con minicelulas dirigidas a ligando, biespecificas, cargadas con farmacos e interferon-gamma.
SG11201702627UA (en) * 2014-10-03 2017-04-27 Engeneic Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
SG11201902940RA (en) * 2016-10-06 2019-05-30 Engeneic Molecular Delivery Pty Ltd Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same
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CA3073449A1 (en) 2017-09-25 2019-03-28 Agrospheres, Inc. Compositions and methods for scalable production and delivery of biologicals
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US20230044257A1 (en) * 2019-12-23 2023-02-09 Agrospheres, Inc. Compositions and methods for enhanced uptake of active ingredients for animal health and nutrition

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AU2005276145C1 (en) * 2004-08-26 2011-01-06 Engeneic Molecular Delivery Pty Ltd Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells
CN101715489B (zh) * 2007-03-30 2016-05-25 因詹尼克分子递送控股有限公司 用于体内递送至哺乳动物细胞的、包含无质粒的功能性核酸的、源自细菌的完整小细胞

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DK2145002T3 (en) 2015-04-20
EP2532746A3 (en) 2013-08-14
SI2865755T1 (sl) 2017-06-30
JP2010523487A (ja) 2010-07-15
ES2534435T3 (es) 2015-04-22
CN105854029A (zh) 2016-08-17
EP2865755B1 (en) 2017-02-01
CA2933978C (en) 2018-08-21
PL2865755T3 (pl) 2017-08-31
EP3205724B1 (en) 2019-05-08
EP3564372A1 (en) 2019-11-06
CY1119031T1 (el) 2018-01-10
AU2008291833A1 (en) 2009-03-05
HRP20170662T1 (hr) 2017-07-14
WO2009027830A2 (en) 2009-03-05
EP2532746A2 (en) 2012-12-12
NZ580487A (en) 2012-04-27
PT2865755T (pt) 2017-05-26
CA2844647C (en) 2016-07-26
CN101715489B (zh) 2016-05-25
CA2844647A1 (en) 2009-03-05
SG10201507969PA (en) 2015-10-29
CA2933978A1 (en) 2009-03-05
ES2626179T3 (es) 2017-07-24
AU2008291833B2 (en) 2012-11-08
EP2865755A2 (en) 2015-04-29
PL2145002T3 (pl) 2015-06-30
CA2682704A1 (en) 2009-03-05
DK2865755T3 (en) 2017-05-15
HK1138326A1 (en) 2010-08-20
EP3205724A1 (en) 2017-08-16
WO2009027830A3 (en) 2009-05-14
CN101715489A (zh) 2010-05-26
HRP20150328T1 (hr) 2015-05-22
LT2865755T (lt) 2017-07-25
EP2145002A2 (en) 2010-01-20
CA2682704C (en) 2014-07-08
MX2009010411A (es) 2009-11-23
HK1209786A1 (en) 2016-04-08
PT2145002E (pt) 2015-04-29
EP2865755A3 (en) 2015-05-06
EP2145002B1 (en) 2015-01-07
JP5167338B2 (ja) 2013-03-21
SG10201804257RA (en) 2018-06-28
CN105854029B (zh) 2019-10-18

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