SI1910348T1 - Spojine benzotiazola in azabenzotiazola, uporabne kot kinazni inhibitorji - Google Patents
Spojine benzotiazola in azabenzotiazola, uporabne kot kinazni inhibitorjiInfo
- Publication number
- SI1910348T1 SI1910348T1 SI200632054A SI200632054A SI1910348T1 SI 1910348 T1 SI1910348 T1 SI 1910348T1 SI 200632054 A SI200632054 A SI 200632054A SI 200632054 A SI200632054 A SI 200632054A SI 1910348 T1 SI1910348 T1 SI 1910348T1
- Authority
- SI
- Slovenia
- Prior art keywords
- benzothiazole
- kinase inhibitors
- compounds useful
- azabenzothiazole
- azabenzothiazole compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70435105P | 2005-08-01 | 2005-08-01 | |
| US11/494,234 US7473784B2 (en) | 2005-08-01 | 2006-07-27 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| PCT/US2006/029520 WO2007016392A2 (en) | 2005-08-01 | 2006-07-28 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| EP06788851.1A EP1910348B1 (en) | 2005-08-01 | 2006-07-28 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1910348T1 true SI1910348T1 (sl) | 2016-06-30 |
Family
ID=37569657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200632054A SI1910348T1 (sl) | 2005-08-01 | 2006-07-28 | Spojine benzotiazola in azabenzotiazola, uporabne kot kinazni inhibitorji |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7473784B2 (sl) |
| EP (2) | EP2266981B1 (sl) |
| CY (1) | CY1118723T1 (sl) |
| DK (1) | DK1910348T3 (sl) |
| ES (1) | ES2578278T3 (sl) |
| HU (1) | HUE029733T2 (sl) |
| PL (1) | PL1910348T3 (sl) |
| PT (1) | PT1910348T (sl) |
| SI (1) | SI1910348T1 (sl) |
| WO (1) | WO2007016392A2 (sl) |
Families Citing this family (49)
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| ES2594874T3 (es) | 2004-11-18 | 2016-12-23 | Synta Pharmaceuticals Corp. | Compuestos de triazol que modulan la actividad de HSP90 |
| WO2007021966A1 (en) | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
| JP5118039B2 (ja) | 2005-08-18 | 2013-01-16 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０活性を調節するトリアゾール化合物 |
| AU2007267852A1 (en) * | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Compounds that modulate Hsp90 activity and methods for identifying same |
| EP2617397B1 (en) | 2007-03-13 | 2016-12-14 | Optimedica Corporation | Intraocular lens providing improved placement |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| US7928140B2 (en) | 2007-08-02 | 2011-04-19 | Amgen Inc. | Benzothiazole PI3 kinase modulators for cancer treatment |
| CA2710194C (en) | 2007-12-19 | 2014-04-22 | Amgen Inc. | Inhibitors of p13 kinase |
| WO2009126635A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Laboratories | 2-amino-benzothiazole derivates useful as inhibitors of rock kinases |
| CN104163816A (zh) * | 2008-12-03 | 2014-11-26 | 普雷西迪奥制药公司 | Hcv ns5a的抑制剂 |
| WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
| SG10201402969QA (en) * | 2009-03-27 | 2014-09-26 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
| US9139569B2 (en) | 2009-05-12 | 2015-09-22 | Merck Sharp & Dohme Corp. | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
| WO2010133534A1 (en) * | 2009-05-19 | 2010-11-25 | Cellzome Limited | Bicyclic amino substituted compounds as pi3k inhibitors |
| WO2010138791A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| AU2010253790A1 (en) | 2009-05-29 | 2011-12-15 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as Hepatitis C |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
| ES2558554T3 (es) * | 2010-03-09 | 2016-02-05 | Merck Sharp & Dohme Corp. | Compuestos de sililo tricíclicos condensados y métodos de uso de los mismos para el tratamiento de enfermedades víricas |
| WO2011133520A1 (en) | 2010-04-19 | 2011-10-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| US8877707B2 (en) * | 2010-05-24 | 2014-11-04 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
| AP2013006706A0 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| CN103209963A (zh) | 2010-07-02 | 2013-07-17 | 吉里德科学公司 | 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物 |
| WO2012040389A2 (en) | 2010-09-22 | 2012-03-29 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic hcv inhibitors |
| EP2621279B1 (en) | 2010-09-29 | 2018-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| EP2730564B1 (en) * | 2010-11-19 | 2018-04-18 | Ligand Pharmaceuticals Inc. | Heterocycle amines and uses thereof |
| AR083868A1 (es) | 2010-12-03 | 2013-03-27 | Lilly Co Eli | Compuestos de oxazol[5,4-b]piridin-5-ilo |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| ES2707997T3 (es) * | 2011-04-21 | 2019-04-08 | Gilead Sciences Inc | Compuestos de benzotiazol y su uso farmacéutico |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| JP6042896B2 (ja) | 2011-10-06 | 2016-12-14 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺菌剤としての複素環ピリ（ミ）ジニルピラゾール |
| MX351460B (es) | 2011-10-06 | 2017-10-16 | Bayer Ip Gmbh | Heterociclilpiri(mi)dinilpirazol. |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| AU2012332421A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of Hsp90 inhibitors with topoisomerase I inhibitors |
| US9402831B2 (en) | 2011-11-14 | 2016-08-02 | Synta Pharmaceutical Corp. | Combination therapy of HSP90 inhibitors with BRAF inhibitors |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| JP5911638B2 (ja) | 2012-04-20 | 2016-04-27 | ギリアード サイエンシーズ， インコーポレイテッド | ベンゾチアゾール−６−イル酢酸誘導体およびｈｉｖ感染を処置するためのそれらの使用 |
| WO2014110687A1 (en) | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
| MY186133A (en) * | 2015-03-02 | 2021-06-24 | Rigel Pharmaceuticals Inc | Tgf-? inhibitors |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| US20200270240A1 (en) * | 2017-07-21 | 2020-08-27 | Icahn School Of Medicine At Mount Sinai | Benzothiazole and pyridothiazole compounds as sumo activators |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| SG10202110259QA (en) | 2017-10-05 | 2021-10-28 | Fulcrum Therapeutics Inc | Use of p38 inhibitors to reduce expression of dux4 |
| KR20210005559A (ko) | 2018-03-27 | 2021-01-14 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
| MX2020014315A (es) * | 2018-06-27 | 2021-05-27 | Ptc Therapeutics Inc | Compuestos de heteroarilo para tratar la enfermedad de huntington. |
| AU2019294478B2 (en) | 2018-06-27 | 2023-03-23 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating Huntington's disease |
| CN114437113B (zh) * | 2022-03-18 | 2023-05-02 | 西安交通大学 | 一种噻唑并吡啶环联三氮唑类化合物及其制备方法和应用 |
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| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| IL118544A (en) | 1995-06-07 | 2001-08-08 | Smithkline Beecham Corp | History of imidazole, the process for their preparation and the pharmaceutical preparations containing them |
| HUP9902460A3 (en) | 1996-01-11 | 2000-03-28 | Smithkline Beecham Corp | Novel substituted imidazole compounds, their use, method for their preparation and pharmaceutical compositions containing them |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6087496A (en) | 1998-05-22 | 2000-07-11 | G. D. Searle & Co. | Substituted pyrazoles suitable as p38 kinase inhibitors |
| US5932576A (en) | 1997-05-22 | 1999-08-03 | G. D. Searle & Company | 3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors |
| AU8381098A (en) | 1997-07-02 | 1999-01-25 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
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| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| US6916813B2 (en) | 2001-12-10 | 2005-07-12 | Bristol-Myers Squibb Co. | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase |
| DE60222804T2 (de) * | 2001-12-21 | 2008-07-03 | Vernalis (Cambridge) Ltd., Abington | 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung |
| ATE343572T1 (de) | 2002-08-09 | 2006-11-15 | Lilly Co Eli | Benzimidazole und benzothiazole als inhibitoren der map-kinase |
-
2006
- 2006-07-27 US US11/494,234 patent/US7473784B2/en active Active
- 2006-07-28 DK DK06788851.1T patent/DK1910348T3/en active
- 2006-07-28 EP EP10184708.5A patent/EP2266981B1/en not_active Not-in-force
- 2006-07-28 PT PT67888511T patent/PT1910348T/pt unknown
- 2006-07-28 ES ES06788851.1T patent/ES2578278T3/es active Active
- 2006-07-28 EP EP06788851.1A patent/EP1910348B1/en not_active Not-in-force
- 2006-07-28 PL PL06788851.1T patent/PL1910348T3/pl unknown
- 2006-07-28 WO PCT/US2006/029520 patent/WO2007016392A2/en active Application Filing
- 2006-07-28 SI SI200632054A patent/SI1910348T1/sl unknown
- 2006-07-28 HU HUE06788851A patent/HUE029733T2/en unknown
-
2008
- 2008-12-12 US US12/333,425 patent/US7994337B2/en active Active
-
2016
- 2016-07-07 CY CY20161100641T patent/CY1118723T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1910348T (pt) | 2016-07-11 |
| ES2578278T3 (es) | 2016-07-22 |
| PL1910348T3 (pl) | 2016-09-30 |
| EP1910348B1 (en) | 2016-04-13 |
| EP2266981A2 (en) | 2010-12-29 |
| DK1910348T3 (en) | 2016-08-01 |
| WO2007016392A2 (en) | 2007-02-08 |
| HUE029733T2 (en) | 2017-03-28 |
| US7994337B2 (en) | 2011-08-09 |
| US7473784B2 (en) | 2009-01-06 |
| EP1910348A2 (en) | 2008-04-16 |
| CY1118723T1 (el) | 2017-07-12 |
| EP2266981A3 (en) | 2011-05-04 |
| US20070185175A1 (en) | 2007-08-09 |
| EP2266981B1 (en) | 2016-07-06 |
| US20090118272A1 (en) | 2009-05-07 |
| WO2007016392A3 (en) | 2007-05-24 |
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