SI1896422T1 - Tirosin kinazni inhibitorji - Google Patents

Tirosin kinazni inhibitorji

Info

Publication number
SI1896422T1
SI1896422T1 SI200631136T SI200631136T SI1896422T1 SI 1896422 T1 SI1896422 T1 SI 1896422T1 SI 200631136 T SI200631136 T SI 200631136T SI 200631136 T SI200631136 T SI 200631136T SI 1896422 T1 SI1896422 T1 SI 1896422T1
Authority
SI
Slovenia
Prior art keywords
tyrosine kinase
kinase inhibitors
inhibitors
tyrosine
kinase
Prior art date
Application number
SI200631136T
Other languages
English (en)
Inventor
Christopher J Dinsmore
James P Jewell
Jason D Katz
Michelle R Machacek
Ryan D Otte
Jonathan R Young
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SI1896422T1 publication Critical patent/SI1896422T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
SI200631136T 2005-06-23 2006-06-22 Tirosin kinazni inhibitorji SI1896422T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69322905P 2005-06-23 2005-06-23
US72906105P 2005-10-21 2005-10-21
US78947306P 2006-04-05 2006-04-05
EP06785319A EP1896422B1 (en) 2005-06-23 2006-06-22 Tyrosine kinase inhibitors
PCT/US2006/024256 WO2007002258A2 (en) 2005-06-23 2006-06-22 Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met

Publications (1)

Publication Number Publication Date
SI1896422T1 true SI1896422T1 (sl) 2011-11-30

Family

ID=37595817

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631136T SI1896422T1 (sl) 2005-06-23 2006-06-22 Tirosin kinazni inhibitorji

Country Status (21)

Country Link
EP (1) EP1896422B1 (sl)
KR (1) KR20080018907A (sl)
AR (1) AR057377A1 (sl)
AT (1) ATE520664T1 (sl)
BR (1) BRPI0612518A2 (sl)
CR (1) CR9579A (sl)
CY (1) CY1112038T1 (sl)
DO (1) DOP2006000143A (sl)
EC (1) ECSP078017A (sl)
IL (1) IL187895A0 (sl)
MA (1) MA29643B1 (sl)
MX (1) MX2007016533A (sl)
NI (1) NI200700318A (sl)
NO (1) NO20080417L (sl)
NZ (1) NZ563711A (sl)
PE (1) PE20070167A1 (sl)
PL (1) PL1896422T3 (sl)
PT (1) PT1896422E (sl)
SI (1) SI1896422T1 (sl)
TW (1) TW200738638A (sl)
WO (1) WO2007002258A2 (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
US7893081B2 (en) * 2007-12-20 2011-02-22 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2011039527A1 (en) 2009-09-30 2011-04-07 Merck Sharp & Dohme Ltd Formulations for c-met kinase inhibitors
EP2482821A4 (en) 2009-09-30 2013-03-06 Merck Sharp & Dohme CRYSTALLINE HYDROCHLORIDE SALTS FROM C-MET KINASE INHIBITORS
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2286275T3 (es) * 2001-09-19 2007-12-01 Pharmacia Corporation Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
WO2003084931A1 (en) * 2002-04-02 2003-10-16 Merck & Co., Inc. 5h-benzo[4,5]cyclohepta[1,2-b]pyridine nmda/nr2b antagonists

Also Published As

Publication number Publication date
WO2007002258A2 (en) 2007-01-04
EP1896422B1 (en) 2011-08-17
KR20080018907A (ko) 2008-02-28
PT1896422E (pt) 2011-11-08
AR057377A1 (es) 2007-11-28
PL1896422T3 (pl) 2012-01-31
ECSP078017A (es) 2008-01-23
TW200738638A (en) 2007-10-16
EP1896422A2 (en) 2008-03-12
DOP2006000143A (es) 2007-02-28
CR9579A (es) 2008-03-06
MX2007016533A (es) 2008-03-06
PE20070167A1 (es) 2007-04-16
NZ563711A (en) 2010-12-24
ATE520664T1 (de) 2011-09-15
BRPI0612518A2 (pt) 2010-11-23
NO20080417L (no) 2008-03-18
CY1112038T1 (el) 2015-11-04
IL187895A0 (en) 2008-03-20
MA29643B1 (fr) 2008-07-01
NI200700318A (es) 2008-05-23
WO2007002258A3 (en) 2007-06-07

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