SI1658848T1 - Formulacije vsebujoäśe ekteinascidin in disaharid - Google Patents

Formulacije vsebujoäśe ekteinascidin in disaharid

Info

Publication number
SI1658848T1
SI1658848T1 SI200530052T SI200530052T SI1658848T1 SI 1658848 T1 SI1658848 T1 SI 1658848T1 SI 200530052 T SI200530052 T SI 200530052T SI 200530052 T SI200530052 T SI 200530052T SI 1658848 T1 SI1658848 T1 SI 1658848T1
Authority
SI
Slovenia
Prior art keywords
ecteinascidin
disaccharide
formulations
Prior art date
Application number
SI200530052T
Other languages
English (en)
Inventor
Salve Pilar Calvo
Barreira Maria Tobio
Bastiaan Nuijen
Jacob Hendrik Beijnen
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35432682&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1658848(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of SI1658848T1 publication Critical patent/SI1658848T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
SI200530052T 2004-10-29 2005-10-12 Formulacije vsebujoäśe ekteinascidin in disaharid SI1658848T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62381304P 2004-10-29 2004-10-29
EP05077333A EP1658848B1 (en) 2004-10-29 2005-10-12 Formulations comprising ecteinascidin and a disaccharide

Publications (1)

Publication Number Publication Date
SI1658848T1 true SI1658848T1 (sl) 2007-12-31

Family

ID=35432682

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200530052T SI1658848T1 (sl) 2004-10-29 2005-10-12 Formulacije vsebujoäśe ekteinascidin in disaharid

Country Status (37)

Country Link
US (2) US8895557B2 (sl)
EP (1) EP1658848B1 (sl)
JP (1) JP4268163B2 (sl)
KR (1) KR101188691B1 (sl)
CN (2) CN102018714B (sl)
AR (2) AR051653A1 (sl)
AT (1) ATE368461T1 (sl)
AU (1) AU2005227421B2 (sl)
BR (1) BRPI0517238B1 (sl)
CA (1) CA2520979C (sl)
CY (1) CY1107773T1 (sl)
DE (1) DE602005001833T2 (sl)
DK (1) DK1658848T3 (sl)
ES (1) ES2290844T3 (sl)
GT (1) GT200500314A (sl)
HK (1) HK1091724A1 (sl)
HN (1) HN2005029978A (sl)
HR (1) HRP20070374T3 (sl)
IL (1) IL182776A (sl)
JO (1) JO2464B1 (sl)
MX (1) MXPA05011650A (sl)
MY (1) MY139049A (sl)
NO (1) NO328035B1 (sl)
NZ (1) NZ554761A (sl)
PA (1) PA8650801A1 (sl)
PE (2) PE20100089A1 (sl)
PL (1) PL1658848T3 (sl)
PT (1) PT1658848E (sl)
RS (1) RS50510B (sl)
RU (1) RU2382647C2 (sl)
SI (1) SI1658848T1 (sl)
SV (1) SV2006002283A (sl)
TW (1) TWI296523B (sl)
UA (1) UA91032C2 (sl)
UY (1) UY29183A1 (sl)
WO (1) WO2006046079A1 (sl)
ZA (1) ZA200703450B (sl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CZ20031327A3 (cs) * 2000-11-06 2003-11-12 Pharma Mar, S. A. Užití ET-743 k výrobě léků pro účinnou protinádorovou léčbu
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
MXPA04003674A (es) * 2001-10-19 2004-07-23 Pharma Mar Sa Uso mejorado de compuesto antitumoral en terapia de cancer.
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
EP1691809A1 (en) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
NZ552607A (en) * 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
JP2008514688A (ja) * 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
PT1827500E (pt) * 2004-10-26 2009-08-05 Pharma Mar Sa Doxorrubicina pegilada lipossomal em combinação com ecteinescidina 743
ES2290844T3 (es) 2004-10-29 2008-02-16 Pharma Mar S.A., Sociedad Unipersonal Composiciones que comprenden ecteinascidinas y un disacarido.
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
US20100196272A1 (en) * 2009-01-30 2010-08-05 Neoprobe Corporation Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
CA2817420C (en) 2010-11-12 2019-09-24 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
KR102122416B1 (ko) * 2011-04-28 2020-06-12 온코펩타이드즈 아베 세포독성 디펩티드의 동결건조 제제
CN106853252B (zh) * 2015-12-09 2020-03-13 江苏恒瑞医药股份有限公司 曲贝替定药物组合物及其制备方法
CN106880592B (zh) * 2015-12-15 2021-04-06 江苏恒瑞医药股份有限公司 一种曲贝替定的纳米乳及其制备方法
WO2017133544A1 (zh) * 2016-02-04 2017-08-10 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
US20210169873A1 (en) * 2019-10-21 2021-06-10 RK Pharma Solutions LLC Storage-stable ready-to-use injectable formulations of Trabectedin
BR112022009283A2 (pt) * 2019-11-21 2022-08-02 Pharma Mar Sa Métodos de tratamento do câncer do pulmão de células pequenas com formulações de lurbinectedina
CA3176956A1 (en) 2020-04-15 2021-10-21 Ever Valinject Gmbh Composition comprising trabectedin and an amino acid
US20230226051A1 (en) 2022-01-20 2023-07-20 Extrovis Ag Trabectedin composition
WO2024131887A1 (zh) * 2022-12-22 2024-06-27 博瑞生物医药（苏州）股份有限公司 一种含卢比替定的药物组合物及其制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537883A (en) 1982-11-12 1985-08-27 Mead Johnson & Company Lyophilized cyclophosphamide
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
DE3774435D1 (de) * 1986-06-09 1991-12-12 Univ Pennsylvania Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
DE3635711A1 (de) 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5336669A (en) * 1991-12-10 1994-08-09 Erbamont, Inc. Cyclophosphamide monohydrate and lactose
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
DE4242863A1 (de) 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
GB9401447D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
GB9508195D0 (en) 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
AU7589898A (en) 1997-05-21 1998-12-11 Genentech Inc. Novel administration of thrombopoietin
PL196809B1 (pl) 1998-04-06 2008-02-29 Univ Illinois Półsyntetyczne ekteinascydyny, kompozycje farmaceutyczne oraz zastosowanie półsyntetycznych ekteinascydyn
CN100339375C (zh) 1998-05-11 2007-09-26 法马马有限公司 海鞘素743的代谢物
JP2000081438A (ja) 1998-06-25 2000-03-21 Sekisui Chem Co Ltd 被験者の癌化学療法による免疫機能低下の測定方法
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
GB9918178D0 (en) 2000-05-15 1999-10-06 Pharma Mar Sa Synthetic methods
CA2406080C (en) 2000-04-12 2011-11-29 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
US7247892B2 (en) 2000-04-24 2007-07-24 Taylor Geoff W Imaging array utilizing thyristor-based pixel elements
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
WO2002014554A2 (en) 2000-08-11 2002-02-21 City Of Hope The anti-neoplastic agent et-743 inhibits trans activation by sxr
SK286421B6 (sk) * 2000-10-31 2008-09-05 Pharma Mar, S. A. Prostriedok kahalalid F, súprava, rekonštituovanýa zriedený roztok s obsahom tohto prostriedku a použitie
CA2447553A1 (en) 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
CZ20031327A3 (cs) 2000-11-06 2003-11-12 Pharma Mar, S. A. Užití ET-743 k výrobě léků pro účinnou protinádorovou léčbu
CA2434566A1 (en) 2001-01-25 2002-08-15 Timothy M. Malloy Parenteral formulation containing epothilone analogs
EP1360337A1 (en) * 2001-02-09 2003-11-12 The Regents Of The University Of California Ecteinascidin family compounds: compositions and methods
JP2005506294A (ja) 2001-03-06 2005-03-03 ブリストル−マイヤーズ　スクイブ　カンパニー テガフル、ウラシル、フォリン酸、パクリタキセルおよびカルボプラチンの投与による腫瘍の治療方法および剤形
EP1372658A2 (en) 2001-03-30 2004-01-02 Shire Biochem Inc. Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
MXPA04003674A (es) * 2001-10-19 2004-07-23 Pharma Mar Sa Uso mejorado de compuesto antitumoral en terapia de cancer.
US20040019027A1 (en) * 2002-04-12 2004-01-29 Barry Forman Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
EP1691809A1 (en) 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2005118584A2 (en) 2004-05-26 2005-12-15 Axys Pharmaceuticals, Inc. Saframycin analogs as therapeutic agents in the treatment of cancer
NZ552607A (en) 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
JP2008514688A (ja) 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
PT1827500E (pt) 2004-10-26 2009-08-05 Pharma Mar Sa Doxorrubicina pegilada lipossomal em combinação com ecteinescidina 743
ES2290844T3 (es) 2004-10-29 2008-02-16 Pharma Mar S.A., Sociedad Unipersonal Composiciones que comprenden ecteinascidinas y un disacarido.
WO2006066183A2 (en) 2004-12-16 2006-06-22 Axys Pharmaceuticals, Inc. Novel saframycin analogs as therapeutic agents
DE602006020335D1 (de) 2005-11-25 2011-04-07 Pharma Mar Sa Verwendung von parp-1-hemmern
MX2008014404A (es) 2006-05-12 2008-11-27 Pharma Mar Sa Tratamientos anticancer con combinacion de docetaxel y ecteinascidin.

Also Published As

Publication number Publication date
EP1658848A1 (en) 2006-05-24
UA91032C2 (en) 2010-06-25
WO2006046079A1 (en) 2006-05-04
CA2520979A1 (en) 2006-02-15
HRP20070374T3 (en) 2007-10-31
SV2006002283A (es) 2006-07-20
ZA200703450B (en) 2008-09-25
JP4268163B2 (ja) 2009-05-27
CN102018714A (zh) 2011-04-20
DE602005001833T2 (de) 2008-04-17
AU2005227421B2 (en) 2007-06-28
KR101188691B1 (ko) 2012-10-09
US20060094687A1 (en) 2006-05-04
AR110986A2 (es) 2019-05-22
PA8650801A1 (es) 2006-09-22
US10322183B2 (en) 2019-06-18
AU2005227421A1 (en) 2006-05-18
EP1658848B1 (en) 2007-08-01
CN1823794A (zh) 2006-08-30
JO2464B1 (en) 2009-01-20
KR20070091121A (ko) 2007-09-07
NO328035B1 (no) 2009-11-10
MY139049A (en) 2009-08-28
RU2007119724A (ru) 2008-12-10
NO20072713L (no) 2007-07-19
US20150094313A1 (en) 2015-04-02
JP2006124393A (ja) 2006-05-18
US8895557B2 (en) 2014-11-25
HK1091724A1 (en) 2007-01-26
RS50510B (sr) 2010-03-02
ES2290844T3 (es) 2008-02-16
IL182776A0 (en) 2007-08-19
RU2382647C2 (ru) 2010-02-27
BRPI0517238A (pt) 2008-10-07
ATE368461T1 (de) 2007-08-15
IL182776A (en) 2010-06-30
CY1107773T1 (el) 2013-06-19
TWI296523B (en) 2008-05-11
PL1658848T3 (pl) 2007-12-31
BRPI0517238B1 (pt) 2021-11-09
CN102018714B (zh) 2014-01-08
CA2520979C (en) 2009-03-24
PT1658848E (pt) 2007-11-05
PE20060925A1 (es) 2006-10-23
DK1658848T3 (da) 2007-11-26
GT200500314A (es) 2007-03-22
NZ554761A (en) 2010-01-29
AR051653A1 (es) 2007-01-31
HN2005029978A (es) 2009-10-27
MXPA05011650A (es) 2006-05-17
UY29183A1 (es) 2006-05-31
DE602005001833D1 (de) 2007-09-13
TW200621256A (en) 2006-07-01
PE20100089A1 (es) 2010-03-01

Similar Documents

Publication Publication Date Title
HK1091724A1 (en) Formulations comprising ecteinascidin and a disaccharide
IL180762A (en) Oligomer-insulin conjugates, formulations containing them and their use
EP1804831A4 (en) VACCINES BASED ON LLO AND LISTERIA
GB0413730D0 (en) A pharmaceutical composition and its use
IL179795A0 (en) A pharmaceutical composition and its use
HK1101911A1 (en) Tetrahydrocarbozoles and derivatives
IL177566A0 (en) Pharmaceutical formulations
AP2006003768A0 (en) TetraazabenzoÄeÜazulene derivatives and analogs tehereof
EP1731506A4 (en) 5-HYDROXYINDOL-3-CARBOXYLATE DERIVATIVES AND THEIR USE
GB0426301D0 (en) Pharmaceutical formulations
IL178888A0 (en) Arylphenylamino-, arylphenylamide-, and arylphenylether-sulfide derivatives
IL177826A0 (en) Oral matrix formulations comprising licarbazepine
ZA200610032B (en) Oculoselective drugs and prodrugs
IL181300A0 (en) Photosensitizer formulations and uses thereof
SI1812072T1 (sl) Formulacije benzotiazola in uporaba le-teh
GB0416397D0 (en) Pharmaceutical formulations
EP1810976A4 (en) BENZONAPHTHACENEGLYCOSIDE DERIVATIVE AND THE USE THEREOF
GB0406048D0 (en) Drug formulations
ZA200703998B (en) Benzothiazole formulations and use thereof
GB0406014D0 (en) Pharmaceutical composition and use
EP1841406A4 (en) METHOD AND FORMULATIONS
GB0414260D0 (en) Form and function fillings
EP1759703A4 (en) IMMUNOSTIMULATING AGENT AND INTERF ROGEN
GB0418932D0 (en) Helicopter-with tracked-launch and tunaround pad-vehicle design principles
IL165458A0 (en) And