SI1626974T1 - Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta - Google Patents

Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta

Info

Publication number
SI1626974T1
SI1626974T1 SI200430916T SI200430916T SI1626974T1 SI 1626974 T1 SI1626974 T1 SI 1626974T1 SI 200430916 T SI200430916 T SI 200430916T SI 200430916 T SI200430916 T SI 200430916T SI 1626974 T1 SI1626974 T1 SI 1626974T1
Authority
SI
Slovenia
Prior art keywords
estrogen receptor
beta agonists
selective estrogen
substituted benzopyrans
substituted
Prior art date
Application number
SI200430916T
Other languages
English (en)
Inventor
Gregory Lee Durst
Bryan Hurst Norman
Lance Allen Pfeifer
Timothy Ivo Richardson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SI1626974T1 publication Critical patent/SI1626974T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI200430916T 2003-04-21 2004-04-08 Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta SI1626974T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46440403P 2003-04-21 2003-04-21
EP04759767A EP1626974B1 (en) 2003-04-21 2004-04-08 Substituted benzopyrans as selective estrogen receptor-beta agonists
PCT/US2004/009272 WO2004094400A2 (en) 2003-04-21 2004-04-08 Substituted benzopyrans as selective estrogen receptor-beta agonists

Publications (1)

Publication Number Publication Date
SI1626974T1 true SI1626974T1 (sl) 2009-02-28

Family

ID=33310882

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200430916T SI1626974T1 (sl) 2003-04-21 2004-04-08 Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta

Country Status (17)

Country Link
US (3) US7442812B2 (sl)
EP (1) EP1626974B1 (sl)
JP (1) JP4481300B2 (sl)
CN (1) CN100374444C (sl)
AT (1) ATE406373T1 (sl)
AU (1) AU2004232798B2 (sl)
BR (1) BRPI0409588A (sl)
CA (1) CA2518819A1 (sl)
CY (1) CY1110443T1 (sl)
DE (1) DE602004016150D1 (sl)
DK (1) DK1626974T3 (sl)
ES (1) ES2311838T3 (sl)
MX (1) MXPA05011243A (sl)
PL (1) PL1626974T3 (sl)
PT (1) PT1626974E (sl)
SI (1) SI1626974T1 (sl)
WO (1) WO2004094400A2 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1789421A1 (en) 2004-07-19 2007-05-30 Janssen Pharmaceutica N.V. Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors
EP1789420A2 (en) 2004-09-07 2007-05-30 Wyeth, A Corporation of the State of Delaware 6H-[1]BENZOPYRANO[4,3-b]QUINOLINES AND THEIR USE AS ESTROGENIC AGENTS
US7354951B2 (en) 2004-10-18 2008-04-08 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
EP1853578A1 (en) 2005-02-15 2007-11-14 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-beta agonists
JP2006232727A (ja) * 2005-02-24 2006-09-07 Chisso Corp クマリン誘導体、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9078888B2 (en) 2007-01-22 2015-07-14 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
WO2011014516A1 (en) 2009-07-28 2011-02-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Estrogen antagonists as treatments for sclerosing disorders
CN109134493A (zh) * 2018-09-19 2019-01-04 浙江师范大学 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN109400564B (zh) * 2018-09-25 2021-03-12 信阳师范学院 一种含三氟甲基的苯并二氢吡喃-4-酮类化合物及其制备方法
CN110128393B (zh) * 2019-06-21 2022-09-30 华侨大学 一种取代异香豆素衍生物的制备方法
CN112898263B (zh) * 2021-01-28 2022-03-08 江西中医药大学 一种从佛手中分离的香豆素骈木脂素化合物及其保肝用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU715528B2 (en) 1995-09-08 2000-02-03 Karo Bio Ab Orphan receptor
WO1999002512A1 (en) 1997-07-09 1999-01-21 Novo Nordisk A/S Dl-2,3-diaryl-2h-1-benzopyrans
US6436923B1 (en) * 1999-03-17 2002-08-20 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
US6593322B1 (en) * 1999-03-17 2003-07-15 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
MXPA01010423A (es) * 1999-04-16 2002-03-27 Astrazeneca Ab Ligandos del receptor beta de estrogeno.
DE60018215T2 (de) 1999-12-30 2006-02-09 Signal Pharmaceuticals Llc, San Diego Verbindungen und verfahren zur modulation von estrogen rezeptoren
PE20011077A1 (es) * 2000-03-01 2001-12-12 Akzo Nobel Nv Derivados de cromano que tiene afinidad por receptores de estrogenos
AU2001254710A1 (en) 2000-03-27 2001-10-08 Akzo Nobel N.V. Non-steroidal, tetracyclic compounds for estrogen-related treatments
GB2361642A (en) 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
EP1416948A1 (en) 2001-08-13 2004-05-12 Riley, Michael Hargreaves Compositions for removal of toxins
CN1312147C (zh) * 2001-11-19 2007-04-25 伊莱利利公司 作为选择性***受体－β激动剂的取代的苯并吡喃类化合物
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
TWI306450B (en) 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents
US6630508B1 (en) * 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists
DE602004025460D1 (de) * 2003-04-21 2010-03-25 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
US7354951B2 (en) * 2004-10-18 2008-04-08 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor-beta agonists
EP1853578A1 (en) 2005-02-15 2007-11-14 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-beta agonists

Also Published As

Publication number Publication date
DK1626974T3 (da) 2008-11-17
PL1626974T3 (pl) 2009-01-30
US7842822B2 (en) 2010-11-30
US20070106082A1 (en) 2007-05-10
WO2004094400A2 (en) 2004-11-04
AU2004232798A1 (en) 2004-11-04
JP4481300B2 (ja) 2010-06-16
EP1626974B1 (en) 2008-08-27
US20090298925A1 (en) 2009-12-03
JP2006524240A (ja) 2006-10-26
BRPI0409588A (pt) 2006-04-18
CN1777614A (zh) 2006-05-24
CA2518819A1 (en) 2004-11-04
AU2004232798B2 (en) 2010-04-22
WO2004094400A3 (en) 2005-02-24
MXPA05011243A (es) 2005-12-15
ES2311838T3 (es) 2009-02-16
PT1626974E (pt) 2008-11-14
CN100374444C (zh) 2008-03-12
ATE406373T1 (de) 2008-09-15
US7585985B2 (en) 2009-09-08
CY1110443T1 (el) 2015-04-29
US20080312312A1 (en) 2008-12-18
US7442812B2 (en) 2008-10-28
EP1626974A2 (en) 2006-02-22
DE602004016150D1 (de) 2008-10-09

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