SI1602660T1 - Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P - Google Patents

Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P

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Publication number
SI1602660T1
SI1602660T1 SI200431656T SI200431656T SI1602660T1 SI 1602660 T1 SI1602660 T1 SI 1602660T1 SI 200431656 T SI200431656 T SI 200431656T SI 200431656 T SI200431656 T SI 200431656T SI 1602660 T1 SI1602660 T1 SI 1602660T1
Authority
SI
Slovenia
Prior art keywords
acid derivatives
receptor modulators
aminophosphonic acid
addition salts
aminophosphonic
Prior art date
Application number
SI200431656T
Other languages
English (en)
Inventor
Yasushi Kohno
Kiyoaki Tanaka
Kazuhiko Kuriyama
Wataru Hori
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of SI1602660T1 publication Critical patent/SI1602660T1/sl

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
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    • C07C47/00—Compounds having —CHO groups
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
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    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
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    • C07F9/02—Phosphorus compounds
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
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  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
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SI200431656T 2003-02-18 2004-02-18 Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P SI1602660T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003039269 2003-02-18
PCT/JP2004/001783 WO2004074297A1 (ja) 2003-02-18 2004-02-18 アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤
EP04712184A EP1602660B1 (en) 2003-02-18 2004-02-18 Aminophosphonic acid derivatives, addition salts thereof and s1p receptor modulators

Publications (1)

Publication Number Publication Date
SI1602660T1 true SI1602660T1 (sl) 2011-06-30

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SI200431656T SI1602660T1 (sl) 2003-02-18 2004-02-18 Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P

Country Status (17)

Country Link
US (2) US7456157B2 (sl)
EP (2) EP1602660B1 (sl)
JP (1) JP4564918B2 (sl)
KR (1) KR101005171B1 (sl)
CN (1) CN100344638C (sl)
AT (1) ATE504590T1 (sl)
AU (1) AU2004213297B2 (sl)
BR (1) BRPI0407658A (sl)
CA (1) CA2515574C (sl)
CY (1) CY1111529T1 (sl)
DE (1) DE602004032118D1 (sl)
DK (1) DK1602660T3 (sl)
ES (1) ES2360394T3 (sl)
MX (1) MXPA05008760A (sl)
PT (1) PT1602660E (sl)
SI (1) SI1602660T1 (sl)
WO (1) WO2004074297A1 (sl)

Families Citing this family (48)

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Publication number Priority date Publication date Assignee Title
EP2617711A1 (en) 2002-09-19 2013-07-24 Kyorin Pharmaceutical Co., Ltd. Amino alcohol derivatives, salts thereof and immunosuppressive agents
ATE504590T1 (de) 2003-02-18 2011-04-15 Kyorin Seiyaku Kk Aminophosphonsäurederivate, deren additionssalze und s1p-rezeptormodulatoren
US7638637B2 (en) 2003-11-03 2009-12-29 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
WO2006009092A1 (ja) 2004-07-16 2006-01-26 Kyorin Pharmaceutical Co., Ltd. 効果的な医薬の使用法及び副作用発現の防御に関する方法
US20060223866A1 (en) * 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
JP2008509931A (ja) 2004-08-13 2008-04-03 プレーシス ファーマスーティカルズ インコーポレイテッド スフィンゴシン−１−ホスフェート（ｓ１ｐ）レセプター活性を調節するための方法および組成物
WO2006041019A1 (ja) * 2004-10-12 2006-04-20 Kyorin Pharmaceutical Co., Ltd. 2-アミノ-2-[2-[4-(3-ベンジルオキシフェニルチオ)-2-クロロフェニル]エチル]-1,3-プロパンジオール塩酸塩又はその水和物の製造方法及びその製造中間体
JP2008522977A (ja) 2004-12-06 2008-07-03 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン＝１−リン酸のアリールアミドアナログ
BRPI0615906A2 (pt) * 2005-09-09 2011-05-31 Novartis Ag tratamento de doenças autoimunes
KR101297302B1 (ko) * 2005-10-07 2013-08-19 교린 세이야꾸 가부시키 가이샤 2-아미노-1,3-프로판디올 유도체를 유효성분으로 하는간장질환 치료제 및 간장질환 치료방법
CA2640366A1 (en) 2006-01-27 2007-08-09 University Of Virginia Patent Foundation Method for treatment of neuropathic pain
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
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CA2515574A1 (en) 2004-09-02
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