SI1567493T1 - Phenyl substituted piperidine compounds for use as ppar activators - Google Patents

Phenyl substituted piperidine compounds for use as ppar activators

Info

Publication number
SI1567493T1
SI1567493T1 SI200331552T SI200331552T SI1567493T1 SI 1567493 T1 SI1567493 T1 SI 1567493T1 SI 200331552 T SI200331552 T SI 200331552T SI 200331552 T SI200331552 T SI 200331552T SI 1567493 T1 SI1567493 T1 SI 1567493T1
Authority
SI
Slovenia
Prior art keywords
phenyl substituted
piperidine compounds
substituted piperidine
ppar activators
ppar
Prior art date
Application number
SI200331552T
Other languages
Slovenian (sl)
Inventor
Scott William Bagley
Thomas Andrew Brandt
Robert Wayne Dugger
William Andrew Hada
Cheryl Myers Hayward
Zhengyu Liu
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SI1567493T1 publication Critical patent/SI1567493T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200331552T 2002-11-26 2003-11-14 Phenyl substituted piperidine compounds for use as ppar activators SI1567493T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42950602P 2002-11-26 2002-11-26
PCT/IB2003/005235 WO2004048334A1 (en) 2002-11-26 2003-11-14 Phenyl substituted piperidine compounds for use as ppar activators
EP03811832A EP1567493B1 (en) 2002-11-26 2003-11-14 Phenyl substituted piperidine compounds for use as ppar activators

Publications (1)

Publication Number Publication Date
SI1567493T1 true SI1567493T1 (en) 2009-06-30

Family

ID=32393563

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200331552T SI1567493T1 (en) 2002-11-26 2003-11-14 Phenyl substituted piperidine compounds for use as ppar activators

Country Status (34)

Country Link
US (2) US7199243B2 (en)
EP (1) EP1567493B1 (en)
JP (1) JP4029091B2 (en)
KR (2) KR100760055B1 (en)
CN (1) CN100439337C (en)
AR (1) AR042131A1 (en)
AT (1) ATE425966T1 (en)
AU (1) AU2003276596B8 (en)
BR (1) BR0316521A (en)
CA (1) CA2507465C (en)
CO (1) CO5570701A2 (en)
DE (1) DE60326752D1 (en)
DK (1) DK1567493T3 (en)
EA (1) EA008928B1 (en)
ES (1) ES2321509T3 (en)
GT (1) GT200300258A (en)
HK (1) HK1083502A1 (en)
HR (1) HRP20050437A2 (en)
IS (1) IS7816A (en)
MA (1) MA27532A1 (en)
MX (1) MXPA05005583A (en)
NL (1) NL1024881C2 (en)
NO (1) NO20052921L (en)
NZ (1) NZ539546A (en)
PE (1) PE20040699A1 (en)
PL (1) PL378268A1 (en)
PT (1) PT1567493E (en)
SI (1) SI1567493T1 (en)
TN (1) TNSN05146A1 (en)
TW (1) TW200424172A (en)
UA (1) UA83202C2 (en)
UY (1) UY28097A1 (en)
WO (1) WO2004048334A1 (en)
ZA (1) ZA200503104B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1567493B1 (en) * 2002-11-26 2009-03-18 Pfizer Products Inc. Phenyl substituted piperidine compounds for use as ppar activators
WO2005115389A2 (en) * 2004-05-25 2005-12-08 Pfizer Products Inc. Specific ppar agonists for treating negative energy balance
JP2008500328A (en) * 2004-05-25 2008-01-10 ファイザー・プロダクツ・インク New use
RU2391340C2 (en) 2004-08-11 2010-06-10 Киорин Фармасьютикал Ко., Лтд. Novel cyclic derivative of aminobenzoic acid
KR20070084455A (en) * 2004-11-23 2007-08-24 워너-램버트 캄파니 엘엘씨 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
US20090036489A1 (en) * 2005-03-22 2009-02-05 Masahiro Nomura Novel Cyclic Aminophenylalkanoic Acid Derivative
GB0510141D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
CN101296914B (en) * 2005-08-26 2012-07-18 盐野义制药株式会社 Derivative having PPAR agonistic activity
US9173875B2 (en) * 2006-04-11 2015-11-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Treatment for nicotine-induced lung disease using peroxisome proliferator-activated receptor gamma agonists
ATE496043T1 (en) * 2006-12-01 2011-02-15 Actelion Pharmaceuticals Ltd 3-HETEROARYL (AMINO OR AMIDO)-1- (BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERDINE DERIVATIVES AS OREXIN RECEPTOR INHIBITORS
US8455520B2 (en) 2007-07-17 2013-06-04 Merck Sharp & Dohme Corp. Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
SI2178865T1 (en) 2007-07-19 2015-11-30 Lundbeck, H., A/S 5-membered heterocyclic amides and related compounds
TW201006816A (en) 2008-05-15 2010-02-16 Organon Nv Hexafluoroisopropanol derivatives
FR2935510B1 (en) 2008-08-28 2010-12-10 Oberthur Technologies METHOD OF EXCHANGING DATA BETWEEN TWO ELECTRONIC ENTITIES
FR2935511B1 (en) 2008-08-28 2010-12-10 Oberthur Technologies METHOD OF EXCHANGING DATA BETWEEN TWO ELECTRONIC ENTITIES
UA107938C2 (en) * 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
WO2011037793A1 (en) * 2009-09-25 2011-03-31 Merck Sharp & Dohme Corp. Substituted aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
TWI513695B (en) * 2009-10-27 2015-12-21 Merck Sharp & Dohme (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives
EP2363825B1 (en) 2010-03-04 2016-04-27 Inside Secure Method for conducting a transaction by means of an NFC device
WO2012120414A2 (en) 2011-03-04 2012-09-13 Pfizer Inc. Edn3-like peptides and uses thereof
GB201314286D0 (en) 2013-08-08 2013-09-25 Takeda Pharmaceutical Therapeutic Compounds
RU2615769C2 (en) * 2015-07-29 2017-04-11 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Уфимский Государственный Университет Экономики И Сервиса" Agent for inhibiting alpha-amylase enzyme
WO2021055936A1 (en) * 2019-09-20 2021-03-25 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small-molecule inhibitors for the β-catenin/b-cell lymphoma 9 protein−protein interaction
WO2024022521A1 (en) * 2022-07-28 2024-02-01 南通环聚泰生物科技有限公司 SMALL MOLECULE COMPOUND TARGETING BCL9/β-CATENIN INTERACTION

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2025518A1 (en) * 1969-06-05 1970-12-10
US4476311A (en) * 1980-03-12 1984-10-09 The Purdue Frederick Company Analgesic 4-carboxy-pyrrolidin-2-one compound
EP0077607A1 (en) * 1981-09-17 1983-04-27 Beecham Group Plc N-substituted 3-aryl piperidines and derivatives thereof
EP0115607A1 (en) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazol derivatives
GB9027023D0 (en) * 1990-12-12 1991-01-30 Wellcome Found Anti-atherosclerotic aryl compounds
PT100441A (en) 1991-05-02 1993-09-30 Smithkline Beecham Corp PIRROLIDINONES, ITS PREPARATION PROCESS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE
US5274143A (en) * 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
AU2869092A (en) 1991-10-11 1993-05-03 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production
WO1993012086A1 (en) * 1991-12-11 1993-06-24 Ss Pharmaceutical Co., Ltd. Arylamide derivative
JPH05255089A (en) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd Antiviral agent
JP3233991B2 (en) * 1992-06-26 2001-12-04 株式会社ソフィア Gaming machine
DE69329894T2 (en) * 1992-12-08 2001-05-03 Ss Pharmaceutical Co Arylamide derivatives
WO1996002250A1 (en) 1994-07-20 1996-02-01 Acea Pharmaceuticals Inc. Haloperidol analogs and the use thereof
GB9606805D0 (en) 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
DE19614204A1 (en) * 1996-04-10 1997-10-16 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds, their use and processes for their preparation
JPH09312086A (en) * 1996-05-22 1997-12-02 Matsushita Electric Ind Co Ltd Optical disk reproducing system, optical disk reproducing method and optical disk
WO1998005331A2 (en) 1996-08-02 1998-02-12 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
IT1286497B1 (en) * 1996-11-20 1998-07-15 Italfarmaco Sud Spa DIPHOSPHINES OF MIXED ETHEROARYL-ARYL TYPE AS CHIRAL BINDERS, RELATIVE COMPLEXES WITH TRANSITION METALS AND USE OF THESE
TR200001753T2 (en) * 1997-12-19 2000-11-21 Merck & Co., Inc. Arylthiazolidinedione derivatives.
ATE273970T1 (en) * 1998-04-16 2004-09-15 Pfizer Prod Inc N-ACYL AND N-AROYL ARALKYLAMIDE
US6376494B1 (en) * 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
HN1999000149A (en) 1998-09-09 2000-01-12 Pfizer Prod Inc DERIVATIVES OF 4,4-BIARILPIPERIDINA
GB9822473D0 (en) 1998-10-16 1998-12-09 Glaxo Group Ltd Chemical compounds
US6303637B1 (en) * 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
CA2324330A1 (en) * 1999-11-08 2001-05-08 Ssp Co., Ltd. 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same
US20020045613A1 (en) 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
WO2001085716A1 (en) 2000-05-11 2001-11-15 Kyowa Hakko Kogyo Co., Ltd 2-piperidone compounds for the treatment of cancer
CN1230431C (en) 2000-05-22 2005-12-07 阿温蒂斯药物公司 Arylmethy lamine derivatives for use as tryptase inhibitors
AU2001211337A1 (en) 2000-10-06 2002-04-15 Smithkline Beecham Plc Process for the preparation of aryl-piperidine carbinols and intermediates thereof
TW579375B (en) 2000-10-12 2004-03-11 Ssp Co Ltd 2,2-Diphenylbutanamide derivatives and medicines containing the same
JP2002173426A (en) 2000-12-05 2002-06-21 Ss Pharmaceut Co Ltd Hypoglycemic agent
CA2438551A1 (en) * 2001-02-15 2002-08-22 Pfizer Products Inc. Ppar agonists
JP2004523543A (en) * 2001-02-15 2004-08-05 ニューロサーチ、アクティーゼルスカブ A method for treating Parkinson's disease by the combined action of a compound having neurotrophic activity and a compound increasing dopamine activity
EP1567493B1 (en) * 2002-11-26 2009-03-18 Pfizer Products Inc. Phenyl substituted piperidine compounds for use as ppar activators

Also Published As

Publication number Publication date
HK1083502A1 (en) 2006-07-07
NL1024881C2 (en) 2009-09-16
IS7816A (en) 2005-04-20
NZ539546A (en) 2007-11-30
ZA200503104B (en) 2006-12-27
AU2003276596B8 (en) 2009-03-05
AR042131A1 (en) 2005-06-08
CN100439337C (en) 2008-12-03
US20040157885A1 (en) 2004-08-12
KR100760055B1 (en) 2007-09-18
UY28097A1 (en) 2004-06-30
AU2003276596A1 (en) 2004-06-18
ES2321509T3 (en) 2009-06-08
EA200500629A1 (en) 2005-12-29
BR0316521A (en) 2005-10-04
MA27532A1 (en) 2005-09-01
CN1717389A (en) 2006-01-04
AU2003276596B2 (en) 2009-02-12
HRP20050437A2 (en) 2005-10-31
CO5570701A2 (en) 2005-10-31
JP4029091B2 (en) 2008-01-09
KR20070063051A (en) 2007-06-18
US7199243B2 (en) 2007-04-03
PL378268A1 (en) 2006-03-20
NO20052921D0 (en) 2005-06-15
ATE425966T1 (en) 2009-04-15
PT1567493E (en) 2009-04-09
UA83202C2 (en) 2008-06-25
EP1567493B1 (en) 2009-03-18
CA2507465A1 (en) 2004-06-10
CA2507465C (en) 2009-04-28
DK1567493T3 (en) 2009-06-08
TW200424172A (en) 2004-11-16
PE20040699A1 (en) 2004-10-23
NO20052921L (en) 2005-08-18
MXPA05005583A (en) 2005-07-27
WO2004048334A1 (en) 2004-06-10
KR100875318B1 (en) 2008-12-22
EP1567493A1 (en) 2005-08-31
JP2006509001A (en) 2006-03-16
EA008928B1 (en) 2007-08-31
GT200300258A (en) 2004-11-30
DE60326752D1 (en) 2009-04-30
TNSN05146A1 (en) 2007-05-14
KR20050086794A (en) 2005-08-30
NL1024881A1 (en) 2004-05-27
US20070191429A1 (en) 2007-08-16

Similar Documents

Publication Publication Date Title
HK1083502A1 (en) Phenyl substituted piperidine compounds for use as ppar activators
TWI341314B (en) New compounds
IL177933A0 (en) New compounds
IL166650A0 (en) New compounds
AU2003264018A8 (en) New compounds
IL163894A0 (en) New compounds
GB0202216D0 (en) Novel compounds
AU2003287979A8 (en) Phenyl compounds
GB0205256D0 (en) Novel compounds
PL376754A1 (en) Heterocyclic compounds useful as nurr-1 activators
GB0202679D0 (en) Novel compounds
HU0203976D0 (en) New compounds
GB0207246D0 (en) Novel compounds
GB0200025D0 (en) Novel compounds
GB0204252D0 (en) Novel compounds
GB0207281D0 (en) Novel compounds
GB0202636D0 (en) Novel compounds
GB0207289D0 (en) Novel compounds
GB0201231D0 (en) Novel compounds
GB0207278D0 (en) Novel compounds
GB0201211D0 (en) Novel compounds
GB0206716D0 (en) Novel compounds
GB0206610D0 (en) Novel compounds
GB0206201D0 (en) Novel compounds
GB0202140D0 (en) Novel compounds