SI1173440T1 - Tetraciklične azepinoindolne spojine kot 5-HT receptorski ligandi - Google Patents

Tetraciklične azepinoindolne spojine kot 5-HT receptorski ligandi

Info

Publication number: SI1173440T1
Authority: SI; Slovenia
Prior art keywords: azepinoindole; tetracyclic; compounds; receptor ligands; ligands
Prior art date: 1999-04-23

Application number

SI200030516T

Other languages

English (en)

Inventor

Jackson B. Hester Jr.

Bruce N. Rogers

E. Jon Jacobsen

Michael Dalton Ennis

Brad A. Acker

Velde Susan L. Vander

Kristine E. Frank

Original Assignee

Pharmacia & Upjohn Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-23

Filing date

2000-04-20

Publication date

2005-02-28

2000-04-20 Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company

2005-02-28 Publication of SI1173440T1 publication Critical patent/SI1173440T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/16—Peri-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Immunology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SI200030516T 1999-04-23 2000-04-20 Tetraciklične azepinoindolne spojine kot 5-HT receptorski ligandi SI1173440T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13081199P	1999-04-23	1999-04-23
PCT/US2000/010600 WO2000064899A1 (en)	1999-04-23	2000-04-20	Tetracyclic azepinoindole compounds as 5-ht receptor ligands
EP00923532A EP1173440B1 (en)	1999-04-23	2000-04-20	Tetracyclic azepinoindole compounds as 5-ht receptor ligands

Publications (1)

Publication Number	Publication Date
SI1173440T1 true SI1173440T1 (sl)	2005-02-28

Family

ID=22446459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200030516T SI1173440T1 (sl)	1999-04-23	2000-04-20	Tetraciklične azepinoindolne spojine kot 5-HT receptorski ligandi

Country Status (20)

Country	Link
EP (1)	EP1173440B1 (sl)
JP (1)	JP2002543080A (sl)
KR (1)	KR20020005708A (sl)
CN (1)	CN1183132C (sl)
AR (1)	AR023574A1 (sl)
AT (1)	ATE276255T1 (sl)
AU (1)	AU760943C (sl)
BR (1)	BR0009983A (sl)
CA (1)	CA2367682A1 (sl)
DE (1)	DE60013803T2 (sl)
DK (1)	DK1173440T3 (sl)
EC (1)	ECSP003426A (sl)
ES (1)	ES2226822T3 (sl)
HK (1)	HK1045512B (sl)
NZ (1)	NZ514553A (sl)
PE (1)	PE20010052A1 (sl)
PT (1)	PT1173440E (sl)
SI (1)	SI1173440T1 (sl)
WO (1)	WO2000064899A1 (sl)
ZA (1)	ZA200108636B (sl)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7071186B2 (en)	1999-06-15	2006-07-04	Bristol-Myers Squibb Pharma Co.	Substituted heterocycle fused gamma-carbolines
DE60014370T2 (de)	1999-06-15	2006-02-09	Bristol-Myers Squibb Pharma Co., Wilmington	Substituierte heterocyclylkondensierte gamma carboline
US6713471B1 (en)	1999-06-15	2004-03-30	Bristol-Myers Squibb Pharma Company	Substituted heterocycle fused gamma-carbolines
AU2001269781A1 (en)	2000-07-06	2002-01-21	Pharmacia And Upjohn Company	Substituted 2,3,7,8,9,10,11,12-octahydroazepino(4,5-b)pyrano(3,2-e) indoles
WO2002024700A2 (en)	2000-09-20	2002-03-28	Pharmacia & Upjohn Company	SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
AR031200A1 (es)	2000-11-03	2003-09-10	Wyeth Corp	Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
AR031202A1 (es)	2000-11-03	2003-09-10	Wyeth Corp	Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados
AR031199A1 (es)	2000-11-03	2003-09-10	Wyeth Corp	Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados
EP1343791A2 (en)	2000-12-20	2003-09-17	Bristol-Myers Squibb Company	Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
US6849619B2 (en)	2000-12-20	2005-02-01	Bristol-Myers Squibb Company	Substituted pyridoindoles as serotonin agonists and antagonists
US20020160999A1 (en) *	2001-01-08	2002-10-31	Jacobsen Susan Fox	Substituted indolines
JP2005501092A (ja) *	2001-08-06	2005-01-13	ファルマシア・アンド・アップジョン・カンパニー	治療上有用な四環リガンド
US20030060462A1 (en) *	2001-08-06	2003-03-27	Hoffman Robert L.	Therapeutic compounds
BR0212676A (pt) *	2001-09-21	2006-05-23	Upjohn Co	compostos terapêuticos ligantes de 5-ht, composições farmacêuticas compreendendo tais compostos e seus usos
WO2003033497A1 (en) *	2001-10-18	2003-04-24	Pharmacia & Upjohn Company	Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity
TWI312781B (en)	2002-04-25	2009-08-01		[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en)	2002-04-25	2003-12-16	Wyeth Corp	[1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TW200307682A (en)	2002-04-25	2003-12-16	Wyeth Corp	1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
EP2400300A1 (en)	2004-08-25	2011-12-28	Takeda Pharmaceutical Company Limited	Method of screening preventives/remedies for stress urinary incontinence
GT200500317A (es)	2004-11-05	2006-10-27		Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es)	2005-07-26	2007-07-18	Wyeth Corp	Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
US7893051B2 (en) *	2006-01-19	2011-02-22	Athersys, Inc.	Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof
US8158617B2 (en)	2006-05-16	2012-04-17	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound and use thereof
KR102107954B1 (ko)	2007-03-12	2020-05-07	인트라-셀룰라 써래피스, 인코퍼레이티드.	치환된 헤테로환 융합 감마-카르볼린 합성
WO2009063992A1 (ja)	2007-11-15	2009-05-22	Takeda Pharmaceutical Company Limited	縮合ピリジン誘導体およびその用途
EP2240481A1 (en)	2008-01-11	2010-10-20	Albany Molecular Research, Inc.	(1-azinone) -substituted pyridoindoles as mch antagonists
EP2421870B1 (en) *	2009-04-23	2016-03-09	AbbVie Inc.	Modulators of 5-ht receptors and methods of use thereof
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003005A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en)	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
JPWO2011071136A1 (ja)	2009-12-11	2013-04-22	アステラス製薬株式会社	線維筋痛症治療剤
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
EP2836213B1 (en)	2012-04-14	2018-07-04	Intra-Cellular Therapies, Inc.	Fused gamma carbolines
PL2968320T3 (pl)	2013-03-15	2021-05-17	Intra-Cellular Therapies, Inc.	Związki organiczne
KR20230023817A (ko)	2013-12-03	2023-02-17	인트라-셀룰라 써래피스, 인코퍼레이티드.	신규한 방법
CN106456638A (zh)	2014-04-04	2017-02-22	细胞内治疗公司	有机化合物
RU2020123764A (ru)	2014-04-04	2020-08-05	Интра-Селлулар Терапиз, Инк.	Органические соединения
PL3407888T3 (pl)	2016-01-26	2021-08-30	Intra-Cellular Therapies, Inc.	Związki pirydopirolochinoksaliny, ich kompozycje i zastosowania
WO2017172811A1 (en)	2016-03-28	2017-10-05	Intra-Cellular Therapies, Inc.	Novel co-crystals
JP2019513143A (ja)	2016-03-28	2019-05-23	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	新規塩類および結晶
EP3436083A4 (en)	2016-03-28	2019-11-27	Intra-Cellular Therapies, Inc.	NEW COMPOSITIONS AND METHODS
CN105837571A (zh) *	2016-04-23	2016-08-10	何华琼	盐酸倍他司汀的药物组合物及其在生物医药中的应用
US11331316B2 (en)	2016-10-12	2022-05-17	Intra-Cellular Therapies, Inc.	Amorphous solid dispersions
JP6987868B2 (ja)	2016-12-29	2022-01-05	イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc.	有機化合物
WO2018126140A1 (en)	2016-12-29	2018-07-05	Intra-Cellular Therapies, Inc.	Organic compounds
MX2021013640A (es)	2017-03-24	2022-08-31	Intra Cellular Therapies Inc	Composiciones novedosas y metodos.
IL272249B2 (en)	2017-07-26	2023-11-01	Intra Cellular Therapies Inc	organic compounds
CA3071137A1 (en)	2017-07-26	2019-01-31	Intra-Cellular Therapies, Inc.	Prodrugs of substituted heterocycle fused gamma-carbolines
EP3733204A4 (en)	2017-12-27	2021-09-15	Takeda Pharmaceutical Company Limited	THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE
MX2020013335A (es)	2018-06-08	2021-05-27	Intra Cellular Therapies Inc	Metodos novedosos.
CN110831941A (zh)	2018-06-11	2020-02-21	细胞内治疗公司	取代的杂环稠合的γ-咔啉类化合物合成
JP7457000B2 (ja)	2018-08-31	2024-03-27	イントラ－セルラー・セラピーズ・インコーポレイテッド	新規方法
CA3108553A1 (en)	2018-08-31	2020-03-05	Intra-Cellular Therapies, Inc.	Novel methods
BR112021016620A2 (pt)	2019-02-27	2021-11-03	Univ California	Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3839357A (en) *	1966-05-10	1974-10-01	Upjohn Co	1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles
US3676558A (en) *	1970-08-28	1972-07-11	Upjohn Co	Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment
EP0377238A1 (en) *	1988-12-22	1990-07-11	Duphar International Research B.V	New annelated indolo (3,2-c)-lactams

2000
- 2000-04-19 AR ARP000101881A patent/AR023574A1/es unknown
- 2000-04-19 PE PE2000000368A patent/PE20010052A1/es not_active Application Discontinuation
- 2000-04-20 AU AU43637/00A patent/AU760943C/en not_active Ceased
- 2000-04-20 PT PT00923532T patent/PT1173440E/pt unknown
- 2000-04-20 WO PCT/US2000/010600 patent/WO2000064899A1/en not_active Application Discontinuation
- 2000-04-20 KR KR1020017013458A patent/KR20020005708A/ko not_active Application Discontinuation
- 2000-04-20 EP EP00923532A patent/EP1173440B1/en not_active Expired - Lifetime
- 2000-04-20 AT AT00923532T patent/ATE276255T1/de not_active IP Right Cessation
- 2000-04-20 DK DK00923532T patent/DK1173440T3/da active
- 2000-04-20 CA CA002367682A patent/CA2367682A1/en not_active Abandoned
- 2000-04-20 ES ES00923532T patent/ES2226822T3/es not_active Expired - Lifetime
- 2000-04-20 NZ NZ514553A patent/NZ514553A/en unknown
- 2000-04-20 CN CNB008066639A patent/CN1183132C/zh not_active Expired - Fee Related
- 2000-04-20 JP JP2000614251A patent/JP2002543080A/ja active Pending
- 2000-04-20 SI SI200030516T patent/SI1173440T1/sl unknown
- 2000-04-20 DE DE60013803T patent/DE60013803T2/de not_active Expired - Fee Related
- 2000-04-20 BR BR0009983-0A patent/BR0009983A/pt not_active IP Right Cessation
- 2000-04-27 EC EC2000003426A patent/ECSP003426A/es unknown
2001
- 2001-10-19 ZA ZA200108636A patent/ZA200108636B/en unknown
2002
- 2002-09-26 HK HK02107016.3A patent/HK1045512B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1173440E (pt)	2004-12-31
CN1183132C (zh)	2005-01-05
AR023574A1 (es)	2002-09-04
PE20010052A1 (es)	2001-01-27
AU760943C (en)	2003-12-04
BR0009983A (pt)	2002-04-16
DE60013803T2 (de)	2005-11-17
HK1045512B (zh)	2005-09-02
NZ514553A (en)	2003-10-31
HK1045512A1 (en)	2004-10-15
ZA200108636B (en)	2003-02-19
ES2226822T3 (es)	2005-04-01
WO2000064899A1 (en)	2000-11-02
EP1173440B1 (en)	2004-09-15
EP1173440A1 (en)	2002-01-23
DK1173440T3 (da)	2004-12-20
AU4363700A (en)	2000-11-10
AU760943B2 (en)	2003-05-22
JP2002543080A (ja)	2002-12-17
KR20020005708A (ko)	2002-01-17
CA2367682A1 (en)	2000-11-02
ECSP003426A (es)	2000-10-24
CN1348454A (zh)	2002-05-08
DE60013803D1 (de)	2004-10-21
ATE276255T1 (de)	2004-10-15

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