SG163583A1 - Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment - Google Patents
Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatmentInfo
- Publication number
- SG163583A1 SG163583A1 SG201004913-8A SG2010049138A SG163583A1 SG 163583 A1 SG163583 A1 SG 163583A1 SG 2010049138 A SG2010049138 A SG 2010049138A SG 163583 A1 SG163583 A1 SG 163583A1
- Authority
- SG
- Singapore
- Prior art keywords
- ctla
- antibody
- cpg
- motif
- combination therapy
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 238000002648 combination therapy Methods 0.000 title 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 title 1
- 229940045513 CTLA4 antagonist Drugs 0.000 abstract 2
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 abstract 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000009098 adjuvant therapy Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009093 first-line therapy Methods 0.000 abstract 1
- 102000043321 human CTLA4 Human genes 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 229960005386 ipilimumab Drugs 0.000 abstract 1
- 238000009099 neoadjuvant therapy Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000009094 second-line therapy Methods 0.000 abstract 1
- 238000009095 third-line therapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69708205P | 2005-07-07 | 2005-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG163583A1 true SG163583A1 (en) | 2010-08-30 |
Family
ID=37492285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG201004913-8A SG163583A1 (en) | 2005-07-07 | 2006-06-30 | Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment |
Country Status (17)
Country | Link |
---|---|
US (2) | US20090117132A1 (fr) |
EP (1) | EP1904530A2 (fr) |
JP (1) | JP2009500412A (fr) |
KR (1) | KR20080030656A (fr) |
CN (1) | CN101268101A (fr) |
AR (1) | AR054536A1 (fr) |
AU (1) | AU2006269555A1 (fr) |
BR (1) | BRPI0612408A2 (fr) |
CA (1) | CA2614320A1 (fr) |
EA (1) | EA200800268A1 (fr) |
IL (1) | IL188588A0 (fr) |
MX (1) | MX2008000379A (fr) |
NZ (1) | NZ565311A (fr) |
SG (1) | SG163583A1 (fr) |
TW (1) | TW200801042A (fr) |
WO (1) | WO2007008463A2 (fr) |
ZA (1) | ZA200801190B (fr) |
Families Citing this family (59)
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US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
EP1674574A1 (fr) * | 1998-05-14 | 2006-06-28 | Coley Pharmaceutical GmbH | Méthodes pour réguler l'hématopoiese en utilisant des oligonucléotides CpG |
EP1499187B1 (fr) | 2002-04-04 | 2015-06-17 | Zoetis Belgium S.A. | Oligoribonucleotides immunostimulants contenant de la guanine et de l'uracile |
AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
WO2004087203A2 (fr) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Formulations de type huile-dans-l'eau a base d'acides nucleiques immunostimulateurs, et procedes d'utilisation associes |
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OA13278A (en) * | 2003-10-30 | 2007-01-31 | Coley Pharm Gmbh | C-Class oligonucleotide analogs with enhanced immunostimulatory potency. |
EA013468B1 (ru) * | 2005-09-16 | 2010-04-30 | Коли Фармасьютикал Гмбх | Иммуностимулирующая одноцепочечная рибонуклеиновая кислота с фосфодиэфирным остовом |
CA2647282A1 (fr) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Polytherapie a base d'un anticorps anti-ctla4 |
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WO2010014784A2 (fr) * | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combinaison d'anticorps anti-ctla4 avec divers régimes thérapeutiques pour un traitement synergétique de maladies prolifératives |
US8883174B2 (en) | 2009-03-25 | 2014-11-11 | The Board Of Regents, The University Of Texas System | Compositions for stimulation of mammalian innate immune resistance to pathogens |
AU2009350151B2 (en) * | 2009-07-20 | 2015-07-16 | Bristol-Myers Squibb Company | Combination of anti-CTLA4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases |
WO2011014438A1 (fr) | 2009-07-31 | 2011-02-03 | N.V. Organon | Anticorps totalement humains dirigés contre le btla |
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WO2013010749A1 (fr) * | 2011-07-19 | 2013-01-24 | Philogen S.P.A | Thérapie séquentielle il-2 anti-ctla4 et ciblée |
US20130210896A1 (en) * | 2011-11-09 | 2013-08-15 | City Of Hope | Immunotheraphy of Brain Tumors Using a Nanoparticle CpG Delivery System |
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US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
WO2016044839A2 (fr) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions et méthodes pour traiter des infections virales par le biais de l'immunité innée stimulée en combinaison avec des composés antiviraux |
KR20170063949A (ko) | 2014-10-06 | 2017-06-08 | 엑시큐어, 인크. | 항-tnf 화합물 |
EP3204040B1 (fr) * | 2014-10-10 | 2021-12-08 | Idera Pharmaceuticals, Inc. | Traitement du cancer par agoniste(s) du tlr9 avec des inhibiteurs du point de contrôle |
EP3220895B1 (fr) | 2014-11-21 | 2022-08-31 | Northwestern University | Absorption cellulaire spécifique à une séquence de conjugués nanoparticulaires d'acides nucléiques sphériques |
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WO2018160536A1 (fr) * | 2017-02-28 | 2018-09-07 | Bristol-Myers Squibb Company | Utilisation d'anticorps anti-ctla-4 avec adcc améliorée pour renforcer la réponse immunitaire d'un vaccin |
EP3603668A4 (fr) | 2017-03-29 | 2021-01-06 | Terumo Kabushiki Kaisha | Composition d'adjuvant, et composition de vaccin et trousse de médicament la contenant |
US11690920B2 (en) | 2017-07-13 | 2023-07-04 | Northwestern University | General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles |
EP3752194A4 (fr) * | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | Compositions et méthodes d'immunothérapie anti-tumorale |
CN108486120B (zh) * | 2018-04-28 | 2019-12-06 | 新乡医学院 | 一种新型CpG ODN序列及其在抗黑色素瘤上的应用 |
CN111321159B (zh) * | 2018-12-14 | 2023-12-12 | 中天(上海)生物科技有限公司 | 用于免疫调节的嵌合核酸分子及其应用 |
EP3898677A1 (fr) | 2018-12-21 | 2021-10-27 | OSE Immunotherapeutics | Molécule bifonctionnelle anti-pd-1/il -7 |
WO2020165374A1 (fr) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Molécule bifonctionnelle comprenant il-15ra |
EP3983440A1 (fr) * | 2019-06-13 | 2022-04-20 | CytomX Therapeutics, Inc. | Utilisation d'un anticorps anti-pdl1 activable et d'un anticorps anti-ctla-4 dans une polythérapie néoadjuvante pour le traitement du cancer |
WO2021122866A1 (fr) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Molécules bifonctionnelles comprenant un variant de l'il-7 |
WO2022112198A1 (fr) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Procédé de sélection des thérapies optimales par points de contrôle immunitaire |
WO2022214653A1 (fr) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Nouvel échafaudage pour molécules bifonctionnelles présentant des propriétés améliorées |
WO2022214652A1 (fr) | 2021-04-09 | 2022-10-13 | Ose Immunotherapeutics | Échafaudage pour molécules bifonctionnelles comprenant des domaines de liaison pd-1 ou cd28 et sirp |
EP4326321A1 (fr) | 2021-04-20 | 2024-02-28 | Institut Curie | Compositions et procédés destinés à être utilisés en immunothérapie |
WO2024003360A1 (fr) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarqueurs et leurs utilisations pour le traitement du neuroblastome |
WO2024028386A1 (fr) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Molécule multifonctionnelle dirigée contre cd28 |
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CA2567789A1 (fr) * | 2004-06-08 | 2006-08-03 | Coley Pharmaceutical Gmbh | Oligonucleotide abasique utilise en tant que plate-forme support pour un antigene ainsi qu'un agoniste et un antagoniste immunostimulatoire |
EP1776105A2 (fr) * | 2004-07-18 | 2007-04-25 | Coley Pharmaceutical Group, Ltd | Methodes et compositions utiles pour induire des reponses immunitaires innees |
MY159370A (en) * | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
AU2005300315A1 (en) * | 2004-11-04 | 2006-05-11 | Pfizer Products Inc. | CTLA-4 antibody and aromatase inhibitor or combination treatment for breast cancer |
JP2008531018A (ja) * | 2005-02-24 | 2008-08-14 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫刺激性オリゴヌクレオチド |
ES2536103T3 (es) * | 2005-11-25 | 2015-05-20 | Zoetis Belgium S.A. | Oligorribonucleótidos inmunoestimuladores |
CA2642152C (fr) * | 2006-02-15 | 2016-11-01 | Coley Pharmaceutical Gmbh | Compositions et procedes pour formulations a base d'oligonucleotides |
-
2006
- 2006-06-30 AU AU2006269555A patent/AU2006269555A1/en not_active Abandoned
- 2006-06-30 MX MX2008000379A patent/MX2008000379A/es unknown
- 2006-06-30 CN CNA2006800325204A patent/CN101268101A/zh active Pending
- 2006-06-30 WO PCT/US2006/025711 patent/WO2007008463A2/fr active Application Filing
- 2006-06-30 CA CA002614320A patent/CA2614320A1/fr not_active Abandoned
- 2006-06-30 US US11/988,396 patent/US20090117132A1/en not_active Abandoned
- 2006-06-30 KR KR1020087003206A patent/KR20080030656A/ko not_active Application Discontinuation
- 2006-06-30 EA EA200800268A patent/EA200800268A1/ru unknown
- 2006-06-30 NZ NZ565311A patent/NZ565311A/en not_active IP Right Cessation
- 2006-06-30 SG SG201004913-8A patent/SG163583A1/en unknown
- 2006-06-30 JP JP2008520309A patent/JP2009500412A/ja active Pending
- 2006-06-30 BR BRPI0612408-9A patent/BRPI0612408A2/pt not_active Application Discontinuation
- 2006-06-30 EP EP06786046A patent/EP1904530A2/fr not_active Withdrawn
- 2006-07-03 TW TW095124152A patent/TW200801042A/zh unknown
- 2006-07-06 AR ARP060102913A patent/AR054536A1/es unknown
-
2008
- 2008-01-03 IL IL188588A patent/IL188588A0/en unknown
- 2008-02-04 ZA ZA200801190A patent/ZA200801190B/xx unknown
-
2011
- 2011-06-24 US US13/168,206 patent/US20120003179A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20080030656A (ko) | 2008-04-04 |
AU2006269555A1 (en) | 2007-01-18 |
JP2009500412A (ja) | 2009-01-08 |
ZA200801190B (en) | 2008-12-31 |
NZ565311A (en) | 2009-10-30 |
AR054536A1 (es) | 2007-06-27 |
BRPI0612408A2 (pt) | 2010-11-03 |
US20120003179A1 (en) | 2012-01-05 |
CA2614320A1 (fr) | 2007-01-18 |
EA200800268A1 (ru) | 2008-06-30 |
WO2007008463A3 (fr) | 2007-05-24 |
CN101268101A (zh) | 2008-09-17 |
TW200801042A (en) | 2008-01-01 |
US20090117132A1 (en) | 2009-05-07 |
EP1904530A2 (fr) | 2008-04-02 |
MX2008000379A (es) | 2008-03-18 |
WO2007008463A2 (fr) | 2007-01-18 |
IL188588A0 (en) | 2008-04-13 |
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