SG159390A1 - Use of n-desmethyclozapine to treat human neuropsychiatric disease - Google Patents
Use of n-desmethyclozapine to treat human neuropsychiatric diseaseInfo
- Publication number
- SG159390A1 SG159390A1 SG200705214-5A SG2007052145A SG159390A1 SG 159390 A1 SG159390 A1 SG 159390A1 SG 2007052145 A SG2007052145 A SG 2007052145A SG 159390 A1 SG159390 A1 SG 159390A1
- Authority
- SG
- Singapore
- Prior art keywords
- desmethyclozapine
- neuropsychiatric disease
- treat human
- human neuropsychiatric
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44269003P | 2003-01-23 | 2003-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG159390A1 true SG159390A1 (en) | 2010-03-30 |
Family
ID=32772052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200705214-5A SG159390A1 (en) | 2003-01-23 | 2004-01-21 | Use of n-desmethyclozapine to treat human neuropsychiatric disease |
Country Status (14)
Country | Link |
---|---|
US (2) | US20040224942A1 (ru) |
EP (2) | EP1589974A2 (ru) |
JP (1) | JP2006515628A (ru) |
KR (1) | KR20050092123A (ru) |
CN (1) | CN1741803A (ru) |
AU (1) | AU2004206931A1 (ru) |
BR (1) | BRPI0406592A (ru) |
CA (1) | CA2512043A1 (ru) |
MX (1) | MXPA05007784A (ru) |
NZ (1) | NZ541014A (ru) |
RU (2) | RU2336879C2 (ru) |
SG (1) | SG159390A1 (ru) |
WO (1) | WO2004064753A2 (ru) |
ZA (1) | ZA200505878B (ru) |
Families Citing this family (50)
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US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
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WO2006017614A1 (en) * | 2004-08-05 | 2006-02-16 | Acadia Pharmaceuticals Inc. | Use of n-desmethylclozapine to treat human neuropsychiatric disease |
US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
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US20090093461A1 (en) * | 2003-07-02 | 2009-04-09 | Astrazeneca Ab | Methods of Treating Anxiety and Mood Disorders |
US20090093460A1 (en) * | 2003-07-02 | 2009-04-09 | Astrazeneca Ab | Compositions |
US20060252743A1 (en) * | 2005-01-07 | 2006-11-09 | Astrazeneca Ab | Method of treating sleep disorders |
US20070117789A1 (en) * | 2005-11-18 | 2007-05-24 | Astrazeneca Ab | Method of treatment |
US20060217367A1 (en) * | 2004-07-01 | 2006-09-28 | Astrazeneca Ab | Method of treating anxiety disorders |
US20060229292A1 (en) * | 2005-01-07 | 2006-10-12 | Astrazeneca Ab | Method of treating childhood disorders |
US20060217366A1 (en) * | 2003-07-02 | 2006-09-28 | Astrazeneca Ab | Method of treating schizophrenia and other disorders |
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US20060217365A1 (en) * | 2003-07-02 | 2006-09-28 | Astrazeneca Ab | Method of treating mood disorders |
US20090239840A1 (en) * | 2003-12-22 | 2009-09-24 | Acadia Pharmaceuticals, Inc. | AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS |
DE602004020263D1 (de) * | 2003-12-22 | 2009-05-07 | Acadia Pharm Inc | Amino-substituierte diaryläa,dücyclohepten- analoga als muscarinische agonisten und verfahren zur behandlung von neuropsychiatrischen erkrankungen |
US20050171088A1 (en) * | 2004-01-30 | 2005-08-04 | Astrazeneca Ab | Treatment of psychoses with dibenzothiazepine antipsychotic |
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US20050261278A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
US7790899B2 (en) | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
CN101035759B (zh) | 2004-09-27 | 2011-06-15 | 阿卡蒂亚药品公司 | N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形 |
CA2599922A1 (en) * | 2005-04-04 | 2006-10-12 | Acadia Pharmaceuticals Inc. | Use of n-desmethylclozapine and related compounds as dopamine stabilizing agents |
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US9278947B2 (en) | 2006-06-22 | 2016-03-08 | Ramot At Tel-Aviv University Ltd. | Serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity |
ES2423485T3 (es) | 2007-03-19 | 2013-09-20 | Acadia Pharmaceuticals Inc. | Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos |
CA2728675A1 (en) | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Dibenzothiazepine derivatives and use thereof |
US9018202B2 (en) * | 2010-12-03 | 2015-04-28 | Allergan, Inc. | Methods for treating diseases of the retina |
RU2506073C1 (ru) * | 2012-09-06 | 2014-02-10 | Алексей Николаевич Паршин | Способ лечения расстройства адаптации у пациентов с суицидальным риском |
US20160184290A1 (en) * | 2014-12-31 | 2016-06-30 | Paul J. Markovitz | Method of treating schizophrenia |
SI3325444T1 (sl) | 2015-07-20 | 2021-11-30 | Acadia Pharmaceuticals Inc. | Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C |
WO2017117347A1 (en) * | 2015-12-30 | 2017-07-06 | Markovitz M D Paul | Method of treating schizophrenia |
RU2667954C2 (ru) * | 2016-03-04 | 2018-09-25 | Общество С Ограниченной Ответственностью "Валентек" | Фармацевтическая композиция для лечения функциональных психических расстройств |
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US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
EP3558311A1 (en) | 2016-12-20 | 2019-10-30 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
US20210077479A1 (en) | 2017-08-30 | 2021-03-18 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
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CN107970243B (zh) * | 2017-10-30 | 2020-07-28 | 江苏理工学院 | 一种去甲氯氮平的新用途 |
CN109761826B (zh) * | 2019-01-17 | 2022-02-25 | 烟台大学 | 一种o-去甲基文拉法辛苯醚化合物及其制备方法和用途 |
CN114206349A (zh) | 2019-04-17 | 2022-03-18 | 指南针探路者有限公司 | 治疗神经认知障碍、慢性疼痛及减轻炎症的方法 |
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EP1596867A4 (en) * | 2003-02-19 | 2006-03-22 | Merck & Co Inc | TREATMENT OF PSYCHOSIS WITH ECTOPIC ACTIVATOR OF M1 MUSCARINIC RECEPTOR |
DE602004020263D1 (de) * | 2003-12-22 | 2009-05-07 | Acadia Pharm Inc | Amino-substituierte diaryläa,dücyclohepten- analoga als muscarinische agonisten und verfahren zur behandlung von neuropsychiatrischen erkrankungen |
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-
2004
- 2004-01-21 NZ NZ541014A patent/NZ541014A/en unknown
- 2004-01-21 BR BR0406592-1A patent/BRPI0406592A/pt not_active IP Right Cessation
- 2004-01-21 SG SG200705214-5A patent/SG159390A1/en unknown
- 2004-01-21 CA CA002512043A patent/CA2512043A1/en not_active Abandoned
- 2004-01-21 EP EP04704073A patent/EP1589974A2/en not_active Ceased
- 2004-01-21 WO PCT/US2004/001509 patent/WO2004064753A2/en active Application Filing
- 2004-01-21 JP JP2006501063A patent/JP2006515628A/ja not_active Withdrawn
- 2004-01-21 MX MXPA05007784A patent/MXPA05007784A/es not_active Application Discontinuation
- 2004-01-21 KR KR1020057013323A patent/KR20050092123A/ko not_active Application Discontinuation
- 2004-01-21 US US10/761,787 patent/US20040224942A1/en not_active Abandoned
- 2004-01-21 AU AU2004206931A patent/AU2004206931A1/en not_active Abandoned
- 2004-01-21 RU RU2005126614/15A patent/RU2336879C2/ru not_active IP Right Cessation
- 2004-01-21 CN CNA200480002642XA patent/CN1741803A/zh active Pending
- 2004-01-21 EP EP08016004A patent/EP1994932A1/en not_active Withdrawn
-
2005
- 2005-07-21 ZA ZA200505878A patent/ZA200505878B/en unknown
-
2008
- 2008-04-28 RU RU2008116931/14A patent/RU2008116931A/ru not_active Application Discontinuation
- 2008-09-22 US US12/235,526 patent/US20090018119A1/en not_active Abandoned
Non-Patent Citations (2)
Title |
---|
DOES THE PHARMACOLOGICALLY ACTIVE N- DEMETHYLATED METABOLITE OF CLOZAPINE PASS THE BLOOD-BRAIN BARRIER? * |
EFFECTS OF DESMETHYLCLOZAPINE ON FOS PROTEIN EXPRESSION IN THE FOREBRIAN: IN VIVO BIOLOGICAL ACTIVITY OF THE clozapine metabolite * |
Also Published As
Publication number | Publication date |
---|---|
EP1994932A1 (en) | 2008-11-26 |
CA2512043A1 (en) | 2004-08-05 |
MXPA05007784A (es) | 2005-09-30 |
US20090018119A1 (en) | 2009-01-15 |
RU2336879C2 (ru) | 2008-10-27 |
US20040224942A1 (en) | 2004-11-11 |
RU2005126614A (ru) | 2006-01-27 |
ZA200505878B (en) | 2006-04-26 |
WO2004064753A2 (en) | 2004-08-05 |
EP1589974A2 (en) | 2005-11-02 |
AU2004206931A1 (en) | 2004-08-05 |
WO2004064753A3 (en) | 2004-11-25 |
CN1741803A (zh) | 2006-03-01 |
KR20050092123A (ko) | 2005-09-20 |
BRPI0406592A (pt) | 2005-12-20 |
JP2006515628A (ja) | 2006-06-01 |
NZ541014A (en) | 2008-05-30 |
RU2008116931A (ru) | 2009-11-10 |
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