SG158919A1 - Constructs binding to phosphatidylserine and their use in disease treatment - Google Patents

Constructs binding to phosphatidylserine and their use in disease treatment

Info

Publication number
SG158919A1
SG158919A1 SG201000541-1A SG2010005411A SG158919A1 SG 158919 A1 SG158919 A1 SG 158919A1 SG 2010005411 A SG2010005411 A SG 2010005411A SG 158919 A1 SG158919 A1 SG 158919A1
Authority
SG
Singapore
Prior art keywords
phosphatidylserine
new
disclosed
constructs
disease treatment
Prior art date
Application number
SG201000541-1A
Other languages
English (en)
Inventor
Philip E Thorpe
Troy A Luster
Steven W King
Original Assignee
Univ Texas
Peregrine Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Peregrine Pharmaceuticals Inc filed Critical Univ Texas
Publication of SG158919A1 publication Critical patent/SG158919A1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6897Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
    • A61K47/6898Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies using avidin- or biotin-conjugated antibodies
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    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
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    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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SG201000541-1A 2005-01-24 2006-01-24 Constructs binding to phosphatidylserine and their use in disease treatment SG158919A1 (en)

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Application Number Priority Date Filing Date Title
US64633305P 2005-01-24 2005-01-24

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SG158919A1 true SG158919A1 (en) 2010-02-26

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SG201000541-1A SG158919A1 (en) 2005-01-24 2006-01-24 Constructs binding to phosphatidylserine and their use in disease treatment

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US (3) US8956616B2 (fr)
EP (1) EP1853631B1 (fr)
JP (2) JP5127043B2 (fr)
CN (3) CN104277117A (fr)
AU (1) AU2006206187B2 (fr)
CA (1) CA2591914C (fr)
DK (1) DK1853631T3 (fr)
ES (1) ES2565543T3 (fr)
HK (2) HK1198255A1 (fr)
IL (1) IL184406A (fr)
NZ (1) NZ556065A (fr)
SG (1) SG158919A1 (fr)
SI (1) SI1853631T1 (fr)
WO (1) WO2006079120A2 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
GB0707034D0 (en) 2007-04-12 2007-05-23 St Andrews The Compounds
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
US20110064744A1 (en) * 2007-05-30 2011-03-17 Sabbadini Roger A Prevention and treatment of pain using antibodies to lysophosphatidic acid
DK2164992T3 (en) * 2007-05-30 2016-08-15 Lpath Inc COMPOSITIONS AND METHODS FOR BONDING OF LYTHOPHOSPHATIC ACID
WO2009049083A1 (fr) 2007-10-09 2009-04-16 Washington University In St. Louis Particules d'imagerie
WO2009049089A1 (fr) 2007-10-09 2009-04-16 Washington University In St. Louis Nanoparticules toroïdales dirigées ligand pour thérapie et imagerie de diagnostic
US20110160642A1 (en) * 2007-11-15 2011-06-30 Wolfgang Neuberger Pegylated liposomal formulations for photodynamic treatment of inflammatory diseases
GB0723797D0 (en) 2007-12-05 2008-01-16 Immunosolv Ltd Method
WO2009089098A1 (fr) * 2008-01-03 2009-07-16 Musc Foundation For Research Development Traitements anticancéreux
CN102046151A (zh) * 2008-03-26 2011-05-04 牛津大学 靶向内质网的脂质体
GB0819287D0 (en) 2008-10-22 2008-11-26 Univ Bradford Compounds
AU2009322145A1 (en) * 2008-12-05 2011-06-23 Abraxis Bioscience, Llc SPARC Binding ScFvs
WO2011036467A1 (fr) * 2009-09-24 2011-03-31 Russell David Keenan Produits utiles dans le traitement de l'hémophilie
WO2011069090A1 (fr) * 2009-12-04 2011-06-09 Alavita Pharmaceuticals, Inc. Inhibition de l'activation du facteur xii de la coagulation par des ligands de phosphatidylsérine
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
US9764043B2 (en) 2009-12-17 2017-09-19 Washington University Antithrombotic nanoparticle
EP2369551B1 (fr) * 2010-03-25 2019-10-30 Emory University Système et procédé d'imagerie
AU2011239414A1 (en) 2010-04-15 2012-11-08 The Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
CN103124788B (zh) 2010-05-21 2016-01-13 梅里麦克制药股份有限公司 双特异性融合蛋白
CN105524176B (zh) * 2010-05-21 2021-03-19 银溪制药股份有限公司 双特异性融合蛋白
WO2012030949A2 (fr) * 2010-09-01 2012-03-08 Kansas State University Research Foundation Inhibiteurs peptidiques de la β2-glycoprotéine i
EP2750662A4 (fr) 2011-08-31 2015-06-24 Univ Georgia Nanoparticules ciblant l'apoptose
US9463217B1 (en) * 2012-02-10 2016-10-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and pharmaceutical compositions for treatment of retinal occlusion
US10416167B2 (en) 2012-02-17 2019-09-17 University Of Georgia Research Foundation, Inc. Nanoparticles for mitochondrial trafficking of agents
EP3184121A3 (fr) * 2012-07-25 2017-09-27 Salk Institute For Biological Studies Régulation de l'interaction entre les ligands de tam et les membranes lipidiques contenant de la phosphatidylsérine
US20140287024A1 (en) * 2013-03-08 2014-09-25 Shu Wang Nanoparticle-based delivery system with oxidized phospholipids as targeting ligands for the prevention, diagnosis and treatment of atherosclerosis
DK3524617T3 (da) * 2013-03-15 2023-05-15 Gladiator Biosciences Inc Gla-domæner som terapeutiske midler
GB2516882A (en) 2013-08-02 2015-02-11 Univ Bradford Tumour-targeted theranostic
EP3083946B1 (fr) 2013-12-16 2024-08-07 The University of North Carolina at Chapel Hill Déplétion de cellules dendritiques plasmacytoïdes
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
JP6779866B2 (ja) 2014-06-13 2020-11-04 チルドレンズ メディカル センター コーポレイション ミトコンドリアを単離するための製品および方法
US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
WO2016179430A1 (fr) * 2015-05-05 2016-11-10 Rubicon Biotechnology Llc Immunothérapie du cancer
CA2988771A1 (fr) * 2015-06-09 2016-12-15 The Board Of Regents Of The University Of Texas System Test de diagnostic pour le cancer a un stade precoce
CN108367048B (zh) 2015-10-02 2022-08-12 银溪制药股份有限公司 用于组织修复的双特异性治疗性蛋白质
IL310404A (en) * 2015-12-15 2024-03-01 Oncoc4 Inc Chimeric and humanized monoclonal antibodies against CTLA-4 and uses thereof
CN109152795A (zh) * 2016-01-15 2019-01-04 儿童医学中心公司 线粒体和组合的线粒体试剂的治疗用途
WO2017133018A1 (fr) * 2016-02-06 2017-08-10 法玛科技顾问股份有限公司 Peptide de bêta 2-glycoprotéine de recombinaison et application antitumorale associée
CN109195992A (zh) * 2016-04-29 2019-01-11 本康生物制药(深圳)有限公司 多特异性结合偶联物、相关的药物组合物及应用
US11525009B2 (en) 2016-06-22 2022-12-13 Benhealth Biopharmaceutic (Shenzhen) Co. Ltd. Bispecific antibody and antibody conjugate for tumor therapy and use thereof
EA038617B1 (ru) * 2016-07-06 2021-09-23 Онкоиммьюн, Инк. Химерные и гуманизированные античеловеческие ctla-4 моноклональные антитела и их использование
MX2019003569A (es) * 2016-09-27 2020-07-22 Oncologie Inc Metodos para tratar el cancer con bavituximab en funcion de niveles de b2 glucoproteina 1 y ensayos de estos.
CN110036033B (zh) 2016-09-27 2023-12-08 森罗治疗公司 嵌合吞噬受体分子
WO2018187227A1 (fr) 2017-04-03 2018-10-11 Concologie, Inc. Procédés de traitement du cancer à l'aide d'anticorps ciblant ps avec des agents immuno-oncologiques
CN108727489B (zh) * 2017-04-19 2021-02-09 广州市第八人民医院 一种单克隆抗体zk2c2及应用
JP7221545B2 (ja) * 2017-07-24 2023-02-14 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー ホスファチジルセリン標的化融合分子およびそれらの使用方法
WO2019028336A1 (fr) * 2017-08-03 2019-02-07 The Cleveland Clinic Foundation Expression peptidique améliorée et détection d'anticorps de sujet spécifique d'apo-h
PE20201462A1 (es) * 2017-09-05 2020-12-17 Gladiator Biosciences Inc Metodo de direccionamiento de exosomas
KR20200100598A (ko) 2017-09-26 2020-08-26 세로 테라퓨틱스, 인코포레이티드 키메라 포식작용 수용체 분자 및 사용 방법
CN108021784B (zh) * 2017-12-01 2021-05-11 大连理工大学 纳米金属氧化物光致产生活性氧物种的预测方法
ES2727261B2 (es) * 2018-04-12 2020-05-06 Fundacion Para La Investig Biomedica Del Hospital 12 De Octubre INMUNOCOMPLEJOS ARTIFICIALES Y SU USO COMO CALIBRES EN SISTEMAS DE DETECCION DE INMUNOCOMPLEJOS CIRCULANTES B2GP1-aB2GP1
WO2020097165A1 (fr) * 2018-11-08 2020-05-14 Nasr Mahmoud Nanodisques pour la prévention et le traitement d'infections pathogènes et leurs procédés d'utilisation
TW202039583A (zh) 2018-12-07 2020-11-01 瑞士商巴克斯歐塔有限公司 結合因子IXa及因子X的蛋白分子
WO2020114614A1 (fr) 2018-12-07 2020-06-11 Baxalta GmbH Molécules protéiques se liant au facteur ixa et au facteur x
EP3711772A1 (fr) * 2019-03-20 2020-09-23 Oslo Universitetssykehus HF Protéines recombinantes et protéines de fusion
WO2020264181A1 (fr) * 2019-06-28 2020-12-30 The Board Of Regents Of The University Of Oklahoma Conjugués d'annexine-médicament thérapeutiques et procédés d'utilisation
US20220033426A1 (en) * 2020-07-28 2022-02-03 Yale University Transition Metal Macrocyclics as MRI Contrast Agents for Molecular Imaging
WO2022040635A1 (fr) * 2020-08-21 2022-02-24 The University Of Chicago Nanoparticules contenant de multiples promédicaments clivables pour la thérapie du cancer
WO2022170145A1 (fr) * 2021-02-05 2022-08-11 Viqi, Inc. Apprentissage machine pour la détection précoce de changements morphologiques cellulaires
CN114002133B (zh) * 2021-10-25 2023-01-24 南京大学 血清中ps阳性外泌体作为乳腺癌化疗敏感性标志物的应用
AU2023209872A1 (en) * 2022-01-19 2024-08-01 Lyndra Therapeutics, Inc. Dosage forms for gastric retention
CN114288399B (zh) * 2022-01-20 2023-10-27 武汉科技大学 一种嵌合抗原受体联合抗肿瘤药物组合物及其应用
US20230324382A1 (en) * 2022-02-01 2023-10-12 Trustees Of Tufts College Antiphospholipid antibodies for the diagnosis of lyme disease
WO2023150672A1 (fr) * 2022-02-04 2023-08-10 Duke University Compositions et méthodes de traitement de cancers hématologiques

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245015A (en) * 1991-04-26 1993-09-14 Tanox Biosystems, Inc. Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro
CA2058769C (fr) 1990-04-06 1999-03-02 Steven Anthony Krilis Methodes pour le dosage des phospholipides et de leurs anticorps
ES2126644T3 (es) 1992-02-05 1999-04-01 Yamasa Corp Reactivo en fase solida y dosificado anticorporal que lo utiliza.
WO1994013323A1 (fr) 1992-12-04 1994-06-23 The Liposome Company, Inc. Methode d'inhibition de la clairance des liposomes contenus dans la circulation
FR2701319B1 (fr) 1993-02-09 1995-04-21 Elie Stefas Procédé de détection et/ou de dosage de composés viraux et support portant une glycoprotéine.
FR2701263B1 (fr) 1993-02-09 1995-04-21 Elie Stefas Procédé d'obtention d'une composition aqueuse protéinique, composition correspondante, glycoprotéine contenue et son utilisation pour la stabilisation de l'albumine et la détection ou le dosage d'anticorps.
AU7707294A (en) 1993-09-29 1995-04-18 Yamasa Corporation Method of assaying oxidized lipoprotein and application thereof
CA2176007A1 (fr) 1993-11-16 1995-05-26 Eiji Matsuura Procede pour le dosage d'anticorps antiphospholipides et kit associe
FR2722991B1 (fr) 1994-08-01 1996-10-11 Orstom Utilisation de la beta2-glycoproteine i sous au moins une de ses formes comme agent anti-infectueux et composition pharmaceutique corrrespondante
ES2179879T3 (es) 1994-08-01 2003-02-01 Inst Rech Developpement Ird Procedimiento de separacion y/o de deteccion y/o de cuantificacion de compuesto(s) infeccioso(s) y soporte para la realizacion de dicho procedimiento.
US5817789A (en) 1995-06-06 1998-10-06 Transkaryotic Therapies, Inc. Chimeric proteins for use in transport of a selected substance into cells
US5874409A (en) 1995-06-07 1999-02-23 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
US6203980B1 (en) 1998-02-02 2001-03-20 University Of Pittsburgh Identification of apolipoprotein H mutations and their diagnostic uses
US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
IL125262A0 (en) 1998-07-07 1999-03-12 Yeda Res & Dev Synthetic peptides and pharmaceutical compositions comprising them
JP2000028607A (ja) 1998-07-10 2000-01-28 Iatron Lab Inc 新規なモノクローナル抗体及びニックβ2グリコプロテインIの免疫学的分析方法
AU771224B2 (en) 1998-07-13 2004-03-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
ATE230614T1 (de) 1998-07-13 2003-01-15 Univ Texas Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US20050148499A1 (en) 1998-10-04 2005-07-07 Dror Harats Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of atherosclerosis
US20050197283A1 (en) 1998-10-04 2005-09-08 Vascular Biogenics Ltd. Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease
IL126447A (en) 1998-10-04 2004-09-27 Vascular Biogenics Ltd An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis
AUPQ272699A0 (en) 1999-09-09 1999-09-30 Unisearch Limited Use of beta2GPI in diagnostic tests for autoimmune diseases
US7600039B2 (en) * 2000-02-16 2009-10-06 Motorola, Inc. Label-based multiplexing
JP2004500099A (ja) 2000-03-08 2004-01-08 ナショナル ジューイッシュ メディカル アンド リサーチ センター ホスファチジルセリンレセプターおよびその使用
AU2001268228A1 (en) 2000-06-08 2001-12-17 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
EP2354149B1 (fr) * 2000-12-12 2017-08-30 MedImmune, LLC Molécules à demi-vies longues, compositions et utilisations de celles-ci
ES2296914T3 (es) * 2001-01-26 2008-05-01 The General Hospital Corporation Farmacos de serpina para el tratamiento de la infeccion por vih y metodo de uso de los mismos.
JP4351041B2 (ja) 2001-06-13 2009-10-28 ザ・ユニバーシティ・オブ・シドニー 傷治癒のための処置および組成物
FR2827047B1 (fr) 2001-07-03 2003-09-26 Apoh Technollgies Sa Procede de separation et/ou detection et/ou identification et/ou quantification de proteines prions
JP4681175B2 (ja) 2001-09-28 2011-05-11 三菱化学メディエンス株式会社 播種性血管内凝固症候群及びその発症前段階を検出する方法
JP4070443B2 (ja) 2001-10-11 2008-04-02 株式会社三菱化学ヤトロン 脳梗塞を検出する方法
US20030100036A1 (en) 2001-11-08 2003-05-29 Aristo Vojdani Saliva immunoassay for detection of antibodies for cardiovascular disease
WO2003044482A2 (fr) 2001-11-16 2003-05-30 The University Of Tennessee Research Corporation Proteines de fusion d'anticorps de recombinaison et procedes de detection de cellules apoptotiques
EP1515754B1 (fr) 2002-05-17 2011-05-25 Board Of Regents, The University Of Texas System La beta-2-glycoproteine 1 est un inhibiteur de l'angiogenese
US7678386B2 (en) 2002-07-15 2010-03-16 Board Of Regents The University Of Texas Liposomes coated with selected antibodies that bind to aminophospholipids
US7906115B2 (en) 2002-07-15 2011-03-15 Thorpe Philip E Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7247303B2 (en) 2002-07-15 2007-07-24 Board Of Regents, The University Of Texas System Selected antibody CDRs for binding to aminophospholipids
US7622118B2 (en) 2002-07-15 2009-11-24 Board Of Regents, The University Of Texas System Cancer treatment methods using selected antibodies to aminophospholipids
DK2269656T3 (da) 2002-07-15 2014-11-03 Univ Texas Udvalgte antistoffer, som binder til aminophospholipider og deres anvendelse i behandling, så som cancer
US7455833B2 (en) 2002-07-15 2008-11-25 Board Of Regents, The University Of Texas System Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7572448B2 (en) 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Combined cancer treatment methods using selected antibodies to aminophospholipids
US7625563B2 (en) 2002-07-15 2009-12-01 Board Of Regents, The University Of Texas System Cancer treatment methods using selected immunoconjugates for binding to aminophospholipids
US7611704B2 (en) 2002-07-15 2009-11-03 Board Of Regents, The University Of Texas System Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7790159B2 (en) 2002-07-15 2010-09-07 Board Of Regents, The University Of Texas System Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids
US7714109B2 (en) 2002-07-15 2010-05-11 Board Of Regents, The University Of Texas System Combinations and kits for cancer treatment using selected antibodies to aminophospholipids
US7615223B2 (en) 2002-07-15 2009-11-10 Board Of Regents, The University Of Texas System Selected immunoconjugates for binding to aminophospholipids
ATE512364T1 (de) 2002-08-07 2011-06-15 Ablynx Nv Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha
EP2298347B1 (fr) 2003-05-06 2015-09-30 Biogen Hemophilia Inc. Protéines chimériques du facteur de la coagulation pour le traitement d'un trouble de l'hémostase
US8198020B2 (en) 2003-08-22 2012-06-12 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
EP1874334A4 (fr) 2005-04-15 2011-03-30 Vascular Biogenics Ltd Compositions contenant des peptides derives de la glycoproteine i beta 2 pour la prevention et le traitement de maladie cardiovasculaire
CA2603814C (fr) 2005-04-18 2013-08-27 Bio-Rad Laboratories, Inc. Immobilisation en phase solide de phospholipides et de proteines cofacteur via liaison covalente

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IL184406A (en) 2014-11-30
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