SG11202104229WA - Compounds, compositions, and methods for modulating cdk9 activity - Google Patents

Compounds, compositions, and methods for modulating cdk9 activity

Info

Publication number
SG11202104229WA
SG11202104229WA SG11202104229WA SG11202104229WA SG11202104229WA SG 11202104229W A SG11202104229W A SG 11202104229WA SG 11202104229W A SG11202104229W A SG 11202104229WA SG 11202104229W A SG11202104229W A SG 11202104229WA SG 11202104229W A SG11202104229W A SG 11202104229WA
Authority
SG
Singapore
Prior art keywords
modulating
compositions
compounds
methods
cdk9 activity
Prior art date
Application number
SG11202104229WA
Other languages
English (en)
Inventor
Peter Mikochik
Joseph VACCA
David Freeman
Andrew Tasker
Original Assignee
Kronos Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kronos Bio Inc filed Critical Kronos Bio Inc
Publication of SG11202104229WA publication Critical patent/SG11202104229WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11202104229WA 2018-10-30 2019-10-29 Compounds, compositions, and methods for modulating cdk9 activity SG11202104229WA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862752635P 2018-10-30 2018-10-30
US201962884993P 2019-08-09 2019-08-09
US201962910058P 2019-10-03 2019-10-03
PCT/US2019/058482 WO2020092314A1 (en) 2018-10-30 2019-10-29 Compounds, compositions, and methods for modulating cdk9 activity

Publications (1)

Publication Number Publication Date
SG11202104229WA true SG11202104229WA (en) 2021-05-28

Family

ID=70328627

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104229WA SG11202104229WA (en) 2018-10-30 2019-10-29 Compounds, compositions, and methods for modulating cdk9 activity

Country Status (20)

Country Link
US (3) US11155560B2 (ja)
EP (1) EP3873911A4 (ja)
JP (1) JP7385658B2 (ja)
KR (1) KR20210068597A (ja)
CN (1) CN112996790B (ja)
AU (1) AU2019370200A1 (ja)
BR (1) BR112021008176A2 (ja)
CA (1) CA3118472A1 (ja)
CO (1) CO2021005502A2 (ja)
CR (1) CR20210202A (ja)
DO (1) DOP2021000066A (ja)
IL (1) IL282254A (ja)
MA (1) MA54092A (ja)
MD (1) MD20210033A2 (ja)
MX (1) MX2021004769A (ja)
PE (1) PE20212196A1 (ja)
PH (1) PH12021550857A1 (ja)
SG (1) SG11202104229WA (ja)
WO (1) WO2020092314A1 (ja)
ZA (1) ZA202102609B (ja)

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* Cited by examiner, † Cited by third party
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PE20212196A1 (es) * 2018-10-30 2021-11-16 Kronos Bio Inc Compuestos, composiciones, y metodos para modular la actividad cdk9
US20230158159A1 (en) * 2020-04-24 2023-05-25 Massachusetts Institute Of Technology Chimeric degraders of cyclin-dependent kinase 9 and uses thereof
EP4240422A1 (en) * 2020-11-05 2023-09-13 Kronos Bio, Inc. Compounds and methods for modulating cdk9 activity
WO2023096922A1 (en) * 2021-11-24 2023-06-01 Kronos Bio, Inc. Polymorphic and salt forms of (ls,3s)-n1-(5-(pentan-3- yl)pyrazolo[l,5-a]pyrimidin-7-yl)cyclopentane-l,3-diamine
WO2024017365A1 (zh) * 2022-07-22 2024-01-25 上海海雁医药科技有限公司 取代的吡唑并[1,5-a]嘧啶-7-胺衍生物的药学上可接受的盐和多晶型物及其应用

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Also Published As

Publication number Publication date
PE20212196A1 (es) 2021-11-16
MD20210033A2 (ro) 2021-10-31
MX2021004769A (es) 2021-08-24
JP2022505268A (ja) 2022-01-14
US11155560B2 (en) 2021-10-26
IL282254A (en) 2021-05-31
US20200131189A1 (en) 2020-04-30
US20220002305A1 (en) 2022-01-06
CR20210202A (es) 2022-02-08
US11845754B2 (en) 2023-12-19
CN112996790B (zh) 2023-11-03
EP3873911A1 (en) 2021-09-08
US20240132506A1 (en) 2024-04-25
CA3118472A1 (en) 2020-05-07
MA54092A (fr) 2021-09-08
WO2020092314A1 (en) 2020-05-07
AU2019370200A1 (en) 2021-06-10
JP7385658B2 (ja) 2023-11-22
BR112021008176A2 (pt) 2021-08-03
CO2021005502A2 (es) 2021-09-20
KR20210068597A (ko) 2021-06-09
DOP2021000066A (es) 2021-10-31
PH12021550857A1 (en) 2021-12-06
CN112996790A (zh) 2021-06-18
EP3873911A4 (en) 2022-06-22
ZA202102609B (en) 2023-02-22

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