SG11202012869SA - Heteroaryl compounds for treating huntington's disease - Google Patents
Heteroaryl compounds for treating huntington's diseaseInfo
- Publication number
- SG11202012869SA SG11202012869SA SG11202012869SA SG11202012869SA SG11202012869SA SG 11202012869S A SG11202012869S A SG 11202012869SA SG 11202012869S A SG11202012869S A SG 11202012869SA SG 11202012869S A SG11202012869S A SG 11202012869SA SG 11202012869S A SG11202012869S A SG 11202012869SA
- Authority
- SG
- Singapore
- Prior art keywords
- disease
- heteroaryl compounds
- treating huntington
- huntington
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690540P | 2018-06-27 | 2018-06-27 | |
| PCT/US2019/038895 WO2020005877A1 (en) | 2018-06-27 | 2019-06-25 | Heteroaryl compounds for treating huntington's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012869SA true SG11202012869SA (en) | 2021-01-28 |
Family
ID=67185796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012869SA SG11202012869SA (en) | 2018-06-27 | 2019-06-25 | Heteroaryl compounds for treating huntington's disease |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210284660A1 (en) |
| EP (1) | EP3814345A1 (en) |
| JP (1) | JP2021528466A (en) |
| KR (1) | KR20210038845A (en) |
| CN (1) | CN112805280A (en) |
| AU (2) | AU2019294482B2 (en) |
| BR (1) | BR112020026534A2 (en) |
| CA (1) | CA3104516A1 (en) |
| EA (1) | EA202092899A1 (en) |
| IL (1) | IL279714A (en) |
| MX (1) | MX2020014315A (en) |
| SG (1) | SG11202012869SA (en) |
| WO (1) | WO2020005877A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2879995T3 (en) | 2015-12-10 | 2021-11-23 | Ptc Therapeutics Inc | Methods for treating Huntington's disease |
| EA201992878A1 (en) | 2017-06-05 | 2020-05-08 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | COMPOUNDS FOR TREATMENT OF HUNTINGTON'S DISEASE |
| MX2019015580A (en) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Methods for treating huntington's disease. |
| BR112019027717A2 (en) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | methods to treat huntington's disease |
| SG10202002990XA (en) | 2017-08-04 | 2020-05-28 | Skyhawk Therapeutics Inc | Methods and compositions for modulating splicing |
| CN112135815A (en) | 2018-03-27 | 2020-12-25 | Ptc医疗公司 | Compounds for the treatment of huntington's disease |
| AU2019294478B2 (en) | 2018-06-27 | 2023-03-23 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating Huntington's disease |
| EP3814360A1 (en) | 2018-06-27 | 2021-05-05 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CN114007613A (en) | 2019-02-05 | 2022-02-01 | 斯基霍克疗法公司 | Methods and compositions for modulating splicing |
| EP3920928A4 (en) | 2019-02-06 | 2022-09-28 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
| AU2020377204A1 (en) | 2019-11-01 | 2022-06-02 | Novartis Ag | The use of a splicing modulator for a treatment slowing progression of huntington's disease |
| CN116997548A (en) | 2020-05-13 | 2023-11-03 | Chdi基金会股份有限公司 | HTT modulators for the treatment of huntington's disease |
| BR112022027107A2 (en) | 2020-07-02 | 2023-03-14 | Remix Therapeutics Inc | 2-(INDAZOL-5-IL)-6-(PIPERIDIN-4-IL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR NUCLEIC ACID SPLICING AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
| JP2023532331A (en) | 2020-07-02 | 2023-07-27 | リミックス セラピューティクス インコーポレイテッド | 5-[5-(piperidin-4-yl)thieno[3,2-c]pyrazol-2-yl]indazole derivatives and related compounds as modifiers for splicing nucleic acids and for treating proliferative diseases and compounds and methods for modulating splicing |
| CN116981673A (en) * | 2021-03-17 | 2023-10-31 | 豪夫迈·罗氏有限公司 | Novel thiadiazolopyrimidinone derivatives |
| WO2022194800A1 (en) * | 2021-03-17 | 2022-09-22 | F. Hoffmann-La Roche Ag | New thienopyrimidinone derivatives |
| WO2022194801A1 (en) * | 2021-03-17 | 2022-09-22 | F. Hoffmann-La Roche Ag | New thiazolopyrimidinone derivatives |
| TW202304446A (en) | 2021-03-29 | 2023-02-01 | 瑞士商諾華公司 | The use of a splicing modulator for a treatment slowing progression of huntington’s disease |
| CN116262758A (en) * | 2021-12-15 | 2023-06-16 | 上海博悦生物科技有限公司 | 7-methylthiazolo [5,4-d ] pyrimidine compound, preparation method and application thereof |
| WO2023225244A1 (en) * | 2022-05-20 | 2023-11-23 | Biogen Ma Inc. | Heterocyclic compounds for treating huntington's disease |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003262833A1 (en) * | 2002-08-23 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent glycosides and methods for their use |
| US7473784B2 (en) * | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| KR101280333B1 (en) * | 2006-03-28 | 2013-07-02 | 하이 포인트 파마슈티칼스, 엘엘씨 | Benzothiazoles having histamine ｈ３ receptor activity |
| US8153813B2 (en) * | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| WO2009114874A2 (en) * | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
| WO2009126635A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Laboratories | 2-amino-benzothiazole derivates useful as inhibitors of rock kinases |
| WO2010024903A1 (en) * | 2008-08-29 | 2010-03-04 | Yangbo Feng | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS |
| EP2379564A1 (en) * | 2008-12-19 | 2011-10-26 | Schering Corporation | Bicyclic heterocyclic derivatives and methods of use thereof |
| MX2012012902A (en) * | 2010-05-06 | 2012-12-17 | Bristol Myers Squibb Co | Bicyclic heteroaryl compounds as gpr119 modulators. |
| EP2560008B1 (en) * | 2011-08-18 | 2016-11-30 | Korea Institute of Science and Technology | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same |
| WO2016087417A1 (en) * | 2014-12-02 | 2016-06-09 | Bayer Cropscience Aktiengesellschaft | Bicyclic compounds as pest control agents |
| CN107635984B (en) * | 2015-03-11 | 2021-04-13 | Fmc公司 | Heterocyclic substituted bicyclic azoles as pesticidal agents |
| ES2879995T3 (en) * | 2015-12-10 | 2021-11-23 | Ptc Therapeutics Inc | Methods for treating Huntington's disease |
| SG10202006688RA (en) * | 2016-03-11 | 2020-08-28 | Ac Immune Sa | Bicyclic compounds for diagnosis and therapy |
| US10526345B2 (en) * | 2016-04-08 | 2020-01-07 | Mankind Pharma Ltd. | Compounds as GPR119 agonists |
| CN109689649B (en) * | 2016-07-14 | 2022-07-19 | 百时美施贵宝公司 | Bicyclic heteroaryl substituted compounds |
-
2019
- 2019-06-25 CN CN201980050967.1A patent/CN112805280A/en active Pending
- 2019-06-25 AU AU2019294482A patent/AU2019294482B2/en active Active
- 2019-06-25 CA CA3104516A patent/CA3104516A1/en active Pending
- 2019-06-25 WO PCT/US2019/038895 patent/WO2020005877A1/en unknown
- 2019-06-25 EA EA202092899A patent/EA202092899A1/en unknown
- 2019-06-25 MX MX2020014315A patent/MX2020014315A/en unknown
- 2019-06-25 JP JP2020572894A patent/JP2021528466A/en active Pending
- 2019-06-25 SG SG11202012869SA patent/SG11202012869SA/en unknown
- 2019-06-25 BR BR112020026534-9A patent/BR112020026534A2/en unknown
- 2019-06-25 US US17/254,828 patent/US20210284660A1/en active Pending
- 2019-06-25 KR KR1020207036998A patent/KR20210038845A/en unknown
- 2019-06-25 EP EP19736947.3A patent/EP3814345A1/en active Pending
-
2020
- 2020-12-23 IL IL279714A patent/IL279714A/en unknown
-
2022
- 2022-07-28 AU AU2022209304A patent/AU2022209304A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019294482A1 (en) | 2021-01-21 |
| JP2021528466A (en) | 2021-10-21 |
| BR112020026534A2 (en) | 2021-03-23 |
| KR20210038845A (en) | 2021-04-08 |
| CN112805280A (en) | 2021-05-14 |
| IL279714A (en) | 2021-03-01 |
| EA202092899A1 (en) | 2021-05-14 |
| AU2019294482B2 (en) | 2022-09-01 |
| MX2020014315A (en) | 2021-05-27 |
| WO2020005877A1 (en) | 2020-01-02 |
| CA3104516A1 (en) | 2020-01-02 |
| AU2022209304A1 (en) | 2022-08-25 |
| EP3814345A1 (en) | 2021-05-05 |
| US20210284660A1 (en) | 2021-09-16 |
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