SG10202006688RA - Bicyclic compounds for diagnosis and therapy - Google Patents

Bicyclic compounds for diagnosis and therapy

Info

Publication number
SG10202006688RA
SG10202006688RA SG10202006688RA SG10202006688RA SG10202006688RA SG 10202006688R A SG10202006688R A SG 10202006688RA SG 10202006688R A SG10202006688R A SG 10202006688RA SG 10202006688R A SG10202006688R A SG 10202006688RA SG 10202006688R A SG10202006688R A SG 10202006688RA
Authority
SG
Singapore
Prior art keywords
diagnosis
therapy
bicyclic compounds
bicyclic
compounds
Prior art date
Application number
SG10202006688RA
Inventor
Jérôme Molette
Emanuele Gabellieri
Vincent Darmency
Original Assignee
Ac Immune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ac Immune Sa filed Critical Ac Immune Sa
Publication of SG10202006688RA publication Critical patent/SG10202006688RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0429—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K51/0431—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nuclear Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG10202006688RA 2016-03-11 2017-03-10 Bicyclic compounds for diagnosis and therapy SG10202006688RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16159878 2016-03-11
EP16199577 2016-11-18

Publications (1)

Publication Number Publication Date
SG10202006688RA true SG10202006688RA (en) 2020-08-28

Family

ID=58488956

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202006688RA SG10202006688RA (en) 2016-03-11 2017-03-10 Bicyclic compounds for diagnosis and therapy
SG11201807778YA SG11201807778YA (en) 2016-03-11 2017-03-10 Bicyclic compounds for diagnosis and therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201807778YA SG11201807778YA (en) 2016-03-11 2017-03-10 Bicyclic compounds for diagnosis and therapy

Country Status (14)

Country Link
US (3) US20190071450A1 (en)
EP (2) EP4001277A3 (en)
JP (4) JP2019512491A (en)
KR (3) KR102646115B1 (en)
CN (2) CN109071528B (en)
AU (1) AU2017231781C1 (en)
BR (1) BR112018068066B1 (en)
CA (2) CA3015947A1 (en)
ES (1) ES2905539T3 (en)
MX (1) MX2018010693A (en)
NZ (1) NZ746901A (en)
RU (2) RU2766139C2 (en)
SG (2) SG10202006688RA (en)
WO (1) WO2017153601A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3102038A1 (en) 2018-06-08 2019-12-12 Ac Immune Sa Novel compounds for diagnosis
BR112020026534A2 (en) * 2018-06-27 2021-03-23 Ptc Therapeutics, Inc. HETEROARYL COMPOUNDS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
WO2020041331A1 (en) * 2018-08-20 2020-02-27 Arvinas Operations, Inc. Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases
KR20210106506A (en) 2018-12-21 2021-08-30 셀진 코포레이션 Thienopyridine inhibitor of RIPK2
US20210002712A1 (en) * 2019-07-05 2021-01-07 National University Corporation Chiba University Phosphatidic acid sensor
GB201914989D0 (en) * 2019-10-16 2019-11-27 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU Aggregates
JP2023502794A (en) * 2019-11-19 2023-01-25 モダグ ゲーエムベーハー Novel compounds for the diagnosis, treatment and prevention of diseases associated with α-synuclein aggregation
AU2021251341A1 (en) 2020-04-07 2022-11-03 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
CN115515961A (en) 2020-05-07 2022-12-23 Ac免疫有限公司 Novel compounds for use in diagnostics
AR123730A1 (en) * 2020-10-15 2023-01-04 Ac Immune Sa NOVEL COMPOUNDS
CN117940435A (en) * 2021-07-16 2024-04-26 Ac免疫有限公司 Novel compounds for diagnosing TDP-43 proteinopathies
TW202328151A (en) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 Substituted 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines, salts thereof and their use as herbicidally active substances
TW202328150A (en) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
WO2023083998A1 (en) 2021-11-10 2023-05-19 Ac Immune Sa Dihydropyrrolo[3,4c]-pyrazole derivatives and their use in diagnosis
WO2023083961A1 (en) 2021-11-10 2023-05-19 Ac Immune Sa Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis
IL312593A (en) 2021-11-10 2024-07-01 Ac Immune Sa 4h-imidazo[1,5-b]pyrazole derivatives for diagnosis
CN116262744A (en) * 2021-12-13 2023-06-16 复旦大学 Small molecule probes for alpha-synuclein aggregate imaging
JP2023101156A (en) 2022-01-07 2023-07-20 三菱重工マリンマシナリ株式会社 Vibration monitoring device, supercharger, and vibration monitoring method
WO2023163033A1 (en) * 2022-02-24 2023-08-31 国立研究開発法人量子科学技術研究開発機構 NOVEL COMPOUND, α-SYNUCLEIN AGGREGATE BINDER, AND USE THEREOF
US20240201205A1 (en) * 2022-09-15 2024-06-20 The Regents Of The University Of California Method for detecting neurological diseases using supramolecule polymer therapeutics
WO2024068948A1 (en) * 2022-09-30 2024-04-04 Ac Immune Sa Novel compounds for the diagnosis of tdp-43 proteinopathies
WO2024126842A1 (en) 2022-12-16 2024-06-20 Ac Immune Sa Novel compounds for diagnosis
WO2024126840A1 (en) 2022-12-16 2024-06-20 Ac Immune Sa Novel compounds for diagnosis

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05125076A (en) * 1991-11-06 1993-05-21 Canon Inc Liquid-crystalline compound, liquid crystal composition containing the same, liquid crystal element having the same, display method and display device using the same
PL340589A1 (en) * 1997-11-11 2001-02-12 Pfizer Prod Inc Derivatives of thienepyrimidine and thienepyridine useful as anticarcinogenic agents
PT2264018E (en) * 2000-08-24 2015-06-03 Univ Pittsburgh Thioflavin derivatives for use in the diagnosis of alzheimer's disease
US6700722B2 (en) * 2001-05-25 2004-03-02 Infineon Technologies Ag High-speed zero phase restart of a multiphase clock
AU2002349477A1 (en) * 2001-11-26 2003-06-10 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
US20040214856A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2006066174A1 (en) * 2004-12-17 2006-06-22 Eli Lilly And Company Thiazolopyridinone derivates as mch receptor antagonists
PE20070619A1 (en) * 2005-09-27 2007-07-02 Wyeth Corp I HAVE (2,3-b) PYRIDIN-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS
AU2007229492B2 (en) * 2006-03-28 2011-11-03 High Point Pharmaceuticals, Llc Benzothiazoles having histamine H3 receptor activity
EP2023919A4 (en) 2006-05-08 2010-12-22 Molecular Neuroimaging Llc Compounds and amyloid probes thereof for therapeutic and imaging uses
JP5225269B2 (en) * 2006-06-08 2013-07-03 イーライ リリー アンド カンパニー Novel MCH receptor antagonist
US20100183513A1 (en) * 2006-11-24 2010-07-22 Wolfgang Froestl N-(methyl) -1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's
CN101675045B (en) * 2007-05-11 2012-11-28 弗·哈夫曼-拉罗切有限公司 Hetarylanilines as modulators for amyloid beta
US8153813B2 (en) 2007-12-20 2012-04-10 Abbott Laboratories Benzothiazole and benzooxazole derivatives and methods of use
JP2011511005A (en) * 2008-02-04 2011-04-07 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 2-aminopyridine kinase inhibitor
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
US20090258907A1 (en) * 2008-04-09 2009-10-15 Abbott Laboratories Compounds useful as inhibitors of rock kinases
WO2009155017A2 (en) 2008-05-30 2009-12-23 Merck & Co., Inc. Novel substituted azabenzoxazoles
CA2731738A1 (en) * 2008-07-24 2010-01-28 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying ad pathology
WO2010021381A1 (en) * 2008-08-22 2010-02-25 武田薬品工業株式会社 Fused heterocyclic derivative and use thereof
GB0821994D0 (en) 2008-12-02 2009-01-07 Ge Healthcare Ltd In viva imaging method
WO2010071819A1 (en) 2008-12-19 2010-06-24 Schering Corporation Bicyclic heterocyclic derivatives and methods of use thereof
US20130137728A1 (en) * 2010-03-24 2013-05-30 MUSC Foundation for Research and Development Compositions and Methods for the Treatment of Degenerative Diseases
DK2558446T5 (en) 2010-04-16 2019-12-09 Ac Immune Sa New compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
US20110256064A1 (en) * 2010-04-16 2011-10-20 Ac Immune, S.A. Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins
GB201012889D0 (en) * 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
WO2012007510A1 (en) * 2010-07-14 2012-01-19 Bayer Pharma Aktiengesellschaft Compounds for binding and imaging amyloid plaques and their use
DE102010045797A1 (en) 2010-09-20 2012-03-22 Klinikum Darmstadt Gmbh Compounds for the diagnosis of neurodegenerative diseases of the olfactory epithelium
JP5720253B2 (en) * 2011-01-06 2015-05-20 コニカミノルタ株式会社 ORGANIC ELECTRONIC ELECTRONIC DEVICE, DISPLAY DEVICE AND LIGHTING DEVICE HAVING THE SAME
US20130046093A1 (en) * 2011-08-18 2013-02-21 Korea Institute Of Science And Technology Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
US9464064B2 (en) * 2011-09-07 2016-10-11 University Of Kansas HCV helicase inhibitors and methods of use thereof
US20140349308A1 (en) * 2011-09-19 2014-11-27 C2N Diagnostics Methods for the Diagnosis and Treatment of Neurological and Neurodegenerative Diseases, Disorders and Associated Processes
US9169255B2 (en) * 2011-10-27 2015-10-27 Proteo Tech Inc. Caffeinated compounds and compositions for treatment of amyloid diseases and synucleinopathies
WO2013156431A1 (en) * 2012-04-17 2013-10-24 Syngenta Participations Ag Pesticidally active pyridyl- and pyrimidyl- substituted thiazole and thiadiazole derivatives
KR20150022876A (en) * 2012-06-22 2015-03-04 이 아이 듀폰 디 네모아 앤드 캄파니 Fungicidal heterocyclic compounds
US9695178B2 (en) * 2013-01-15 2017-07-04 Suzhou Kintor Pharmaceuticals, Inc. 6-(2-pyridyl)-7,8-dihydro-5H-pyrido[4,3-D]pyrimidine analogs as hedgehog pathway signaling inhibitors and therapeutic applications thereof
TWI652014B (en) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 Heterocyclic substituted bicycloazole insecticide
WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors
HRP20211778T1 (en) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Probes for imaging huntingtin protein
JP2017537909A (en) 2014-12-02 2017-12-21 バイエル・クロップサイエンス・アクチェンゲゼルシャフト Bicyclic compounds as pest control agents The present application relates to novel bicyclic compounds, compositions containing these compounds, their use to control pests, and to prepare them And to intermediates.
EP3372601B1 (en) 2015-10-22 2022-09-21 Mitsubishi Tanabe Pharma Corporation Novel bicyclic heterocyclic compound

Also Published As

Publication number Publication date
NZ746901A (en) 2023-06-30
KR20180117707A (en) 2018-10-29
AU2017231781A1 (en) 2018-10-25
JP2021167310A (en) 2021-10-21
US11623931B2 (en) 2023-04-11
JP7297323B2 (en) 2023-06-26
JP7383304B2 (en) 2023-11-20
JP2023116823A (en) 2023-08-22
RU2766139C2 (en) 2022-02-08
EP4001277A2 (en) 2022-05-25
ES2905539T3 (en) 2022-04-11
EP4001277A3 (en) 2022-09-14
EP3426653A1 (en) 2019-01-16
KR20220151042A (en) 2022-11-11
MX2018010693A (en) 2019-03-28
KR102646115B1 (en) 2024-03-12
RU2022101103A (en) 2022-03-29
EP3426653B1 (en) 2021-12-15
JP2022001573A (en) 2022-01-06
CA3015947A1 (en) 2017-09-14
CN109071528B (en) 2023-02-17
KR20240036709A (en) 2024-03-20
US20190071450A1 (en) 2019-03-07
KR102464274B1 (en) 2022-11-07
BR112018068066B1 (en) 2023-11-28
WO2017153601A1 (en) 2017-09-14
CN109071528A (en) 2018-12-21
AU2017231781C1 (en) 2021-12-16
SG11201807778YA (en) 2018-10-30
RU2018135709A (en) 2020-04-13
US20240051967A1 (en) 2024-02-15
CN116199700A (en) 2023-06-02
AU2017231781B2 (en) 2021-07-15
BR112018068066A2 (en) 2019-01-08
US20200299305A1 (en) 2020-09-24
CA3224365A1 (en) 2017-09-14
RU2018135709A3 (en) 2020-06-30
JP2019512491A (en) 2019-05-16

Similar Documents

Publication Publication Date Title
SG10202006688RA (en) Bicyclic compounds for diagnosis and therapy
IL265759A (en) Therapeutic and diagnostic methods for cancer
HK1248773A1 (en) Therapeutic and diagnostic methods for cancer
HK1250376A1 (en) Therapeutic and diagnostic methods for cancer
IL261422A (en) Therapeutic and diagnostic methods for cancer
HK1244802A1 (en) Fused bicyclic compounds for the treatment of disease
HK1245795A1 (en) Fused bicyclic compounds for the treatment of disease
IL262208A (en) Diagnostic and therapeutic methods for cancer
HUE053551T2 (en) Apparatus for providing hyperthermia therapy
HK1258727A1 (en) Therapeutic compounds
HK1258128A1 (en) Selection of patients for combination therapy
GB201617064D0 (en) Compounds and their therapeutic use
GB201616839D0 (en) Therapeutic compounds
HK1249756A1 (en) Fused bicyclic compounds for the treatment of disease
PL3129483T3 (en) Combination therapy for the treatment of autoimmune diseases
GB201608797D0 (en) Therapeutic use
ZA201901578B (en) Combinations including abx196 for the treatment of cancer
GB201617339D0 (en) Therapeutic compounds
IL263821A (en) Therapeutic compounds
GB201401806D0 (en) Novel methods for diagnosis and therapy
ZA201704589B (en) Compounds for the treatment of cancer
GB201609737D0 (en) Therapeutic compounds
GB201609790D0 (en) Therapeutic compounds
GB201501202D0 (en) Novel methods for diagnosis and therapy