SG11202010504QA - Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide by racemate separation by means of diastereomeric tartaric acid esters - Google Patents
Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide by racemate separation by means of diastereomeric tartaric acid estersInfo
- Publication number
- SG11202010504QA SG11202010504QA SG11202010504QA SG11202010504QA SG11202010504QA SG 11202010504Q A SG11202010504Q A SG 11202010504QA SG 11202010504Q A SG11202010504Q A SG 11202010504QA SG 11202010504Q A SG11202010504Q A SG 11202010504QA SG 11202010504Q A SG11202010504Q A SG 11202010504QA
- Authority
- SG
- Singapore
- Prior art keywords
- naphthyridine
- carboxamide
- methoxyphenyl
- dihydro
- ethoxy
- Prior art date
Links
- BTBHLEZXCOBLCY-QGZVFWFLSA-N (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide Chemical compound C1([C@@H]2C(=C(C)NC=3C(C)=CN=C(C2=3)OCC)C(N)=O)=CC=C(C#N)C=C1OC BTBHLEZXCOBLCY-QGZVFWFLSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 150000003899 tartaric acid esters Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18169052.0A EP3560922A1 (en) | 2018-04-24 | 2018-04-24 | Process for preparation of (4s) - 4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide by racemate resoution through diastereomeric tartaric acid |
| PCT/EP2019/060368 WO2019206909A1 (en) | 2018-04-24 | 2019-04-23 | Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide by racemate separation by means of diastereomeric tartaric acid esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202010504QA true SG11202010504QA (en) | 2020-11-27 |
Family
ID=62062935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202010504QA SG11202010504QA (en) | 2018-04-24 | 2019-04-23 | Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide by racemate separation by means of diastereomeric tartaric acid esters |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20210163474A1 (en) |
| EP (2) | EP3560922A1 (en) |
| JP (1) | JP7394785B2 (en) |
| KR (1) | KR20210005000A (en) |
| CN (1) | CN112041318A (en) |
| AR (1) | AR114833A1 (en) |
| AU (1) | AU2019258116A1 (en) |
| BR (1) | BR112020018738A2 (en) |
| CA (1) | CA3097924A1 (en) |
| CL (1) | CL2020002742A1 (en) |
| CO (1) | CO2020013150A2 (en) |
| IL (1) | IL278078B2 (en) |
| JO (1) | JOP20200267A1 (en) |
| MX (1) | MX2020011198A (en) |
| PE (1) | PE20211903A1 (en) |
| SG (1) | SG11202010504QA (en) |
| TW (1) | TW202003514A (en) |
| UY (1) | UY38197A (en) |
| WO (1) | WO2019206909A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114667284A (en) * | 2019-10-17 | 2022-06-24 | 拜耳公司 | Method for producing 2-cyanoethyl (4S) -4- (4-cyano-2-methoxyphenyl) -5-hydroxy-2, 8-dimethyl-1, 4-dihydro-1, 6-naphthyridine-3-carboxylic acid esters from the diastereomer tartrate by optical resolution |
| WO2021254896A1 (en) | 2020-06-16 | 2021-12-23 | Bayer Aktiengesellschaft | Process for preparing (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide enabled by a catalytic asymmetric hantzsch ester reduction |
| CN115340539B (en) * | 2022-01-19 | 2024-02-27 | 奥锐特药业股份有限公司 | Process for preparing non-nereirenone and intermediates thereof |
| CN115340540A (en) * | 2022-01-20 | 2022-11-15 | 奥锐特药业股份有限公司 | Process for preparing non-neferone and intermediates thereof |
| CN114605410B (en) * | 2022-04-06 | 2023-12-29 | 浙江科聚生物医药有限公司 | Preparation method of non-neridrone bulk drug |
| WO2023205164A1 (en) | 2022-04-18 | 2023-10-26 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of finerenone |
| WO2023223188A1 (en) * | 2022-05-16 | 2023-11-23 | Glenmark Life Sciences Limited | Process for the preparation of finerenone and intermediates thereof |
| WO2024075139A1 (en) * | 2022-10-06 | 2024-04-11 | Maithri Drugs Private Limited | A process for preparation of finerenone and intermediates thereof |
| CN117986250A (en) * | 2022-11-04 | 2024-05-07 | 南京威凯尔生物医药科技有限公司 | Method for preparing non-nereirenone by resolution of racemate by diastereoisomeric tartrate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3906460C1 (en) * | 1989-03-01 | 1990-11-15 | Goedecke Ag, 1000 Berlin, De | |
| US7772400B2 (en) | 2004-12-02 | 2010-08-10 | Sk Chemicals Co., Ltd. | Optical resolution method of amlodipine |
| CA2634397A1 (en) * | 2005-12-22 | 2007-07-05 | Schering Corporation | Process for the preparation of 6,6-dimethyl-3-azabicyclo[3.1.0|-hexane compounds and enantiomeric salts thereof |
| DE102007009494A1 (en) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | New 1,6-naphthyridine or 8-azaquinazoline derivatives useful for treating aldosteronism, hypertension, cardiac insufficiency, myocardial infarct sequelae, liver cirrhosis, renal insufficiency and stroke |
| CN101648903A (en) | 2009-09-17 | 2010-02-17 | 南京大学 | Method for preparing optically active amlodipine tosilate |
| CN101798280B (en) * | 2010-03-22 | 2012-05-02 | 河北师范大学 | Method for preparing S-(-)-amlodipine and R-(+)-amlodipine by chirally resolving racemic amlodipine |
| CA3146285C (en) | 2014-08-01 | 2024-01-02 | Bayer Pharma Aktiengesellschaft | Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
| SG11201801110TA (en) * | 2015-08-21 | 2018-03-28 | Bayer Pharma AG | Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carboxamide and the purification thereof for use as an active pharmaceutical ingredient |
| PE20180555A1 (en) * | 2015-08-21 | 2018-04-02 | Bayer Pharma AG | PROCEDURE FOR THE PREPARATION OF (4S) -4- (4-CYANE-2-METOXYPHENYL) -5-ETOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE AND FOR THE RECOVERY OF (4S) -4- (4-CYANE-2-METOXYPHENYL) -5-ETOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE BY MEANS OF ELECTROCHEMICAL METHODS |
-
2018
- 2018-04-24 EP EP18169052.0A patent/EP3560922A1/en not_active Ceased
-
2019
- 2019-04-22 TW TW108113944A patent/TW202003514A/en unknown
- 2019-04-23 US US17/050,303 patent/US20210163474A1/en active Pending
- 2019-04-23 PE PE2020001634A patent/PE20211903A1/en unknown
- 2019-04-23 EP EP19720516.4A patent/EP3784668A1/en active Pending
- 2019-04-23 JO JOP/2020/0267A patent/JOP20200267A1/en unknown
- 2019-04-23 KR KR1020207030052A patent/KR20210005000A/en active Search and Examination
- 2019-04-23 JP JP2020558978A patent/JP7394785B2/en active Active
- 2019-04-23 MX MX2020011198A patent/MX2020011198A/en unknown
- 2019-04-23 AU AU2019258116A patent/AU2019258116A1/en active Pending
- 2019-04-23 SG SG11202010504QA patent/SG11202010504QA/en unknown
- 2019-04-23 CN CN201980028160.8A patent/CN112041318A/en active Pending
- 2019-04-23 CA CA3097924A patent/CA3097924A1/en active Pending
- 2019-04-23 BR BR112020018738-0A patent/BR112020018738A2/en unknown
- 2019-04-23 WO PCT/EP2019/060368 patent/WO2019206909A1/en unknown
- 2019-04-23 IL IL278078A patent/IL278078B2/en unknown
- 2019-04-24 UY UY0001038197A patent/UY38197A/en unknown
- 2019-04-24 AR ARP190101082A patent/AR114833A1/en unknown
-
2020
- 2020-10-21 CO CONC2020/0013150A patent/CO2020013150A2/en unknown
- 2020-10-22 CL CL2020002742A patent/CL2020002742A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3097924A1 (en) | 2019-10-31 |
| AR114833A1 (en) | 2020-10-21 |
| IL278078B1 (en) | 2023-06-01 |
| US20210163474A1 (en) | 2021-06-03 |
| PE20211903A1 (en) | 2021-09-27 |
| KR20210005000A (en) | 2021-01-13 |
| JP2021522236A (en) | 2021-08-30 |
| MX2020011198A (en) | 2020-11-13 |
| JOP20200267A1 (en) | 2020-10-25 |
| CL2020002742A1 (en) | 2021-01-15 |
| BR112020018738A2 (en) | 2021-01-05 |
| WO2019206909A1 (en) | 2019-10-31 |
| CN112041318A (en) | 2020-12-04 |
| CO2020013150A2 (en) | 2020-11-10 |
| EP3560922A1 (en) | 2019-10-30 |
| JP7394785B2 (en) | 2023-12-08 |
| IL278078B2 (en) | 2023-10-01 |
| IL278078A (en) | 2020-11-30 |
| UY38197A (en) | 2019-11-29 |
| TW202003514A (en) | 2020-01-16 |
| EP3784668A1 (en) | 2021-03-03 |
| AU2019258116A1 (en) | 2020-11-05 |
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