SG11202009992VA - 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors - Google Patents
2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitorsInfo
- Publication number
- SG11202009992VA SG11202009992VA SG11202009992VA SG11202009992VA SG11202009992VA SG 11202009992V A SG11202009992V A SG 11202009992VA SG 11202009992V A SG11202009992V A SG 11202009992VA SG 11202009992V A SG11202009992V A SG 11202009992VA SG 11202009992V A SG11202009992V A SG 11202009992VA
- Authority
- SG
- Singapore
- Prior art keywords
- amino
- pyridine
- kinase inhibitors
- dependent kinase
- pyrimidine derivatives
- Prior art date
Links
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 title 2
- 150000005006 2-aminopyrimidines Chemical class 0.000 title 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663096P | 2018-04-26 | 2018-04-26 | |
| US201862750454P | 2018-10-25 | 2018-10-25 | |
| US201962826609P | 2019-03-29 | 2019-03-29 | |
| PCT/IB2019/053314 WO2019207463A1 (en) | 2018-04-26 | 2019-04-22 | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202009992VA true SG11202009992VA (en) | 2020-11-27 |
Family
ID=66676856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202009992VA SG11202009992VA (en) | 2018-04-26 | 2019-04-22 | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10766884B2 (en) |
| EP (1) | EP3784664A1 (en) |
| JP (2) | JP7089061B2 (en) |
| KR (2) | KR102596598B1 (en) |
| CN (1) | CN112313219B (en) |
| AU (1) | AU2019259653B2 (en) |
| BR (1) | BR112020021689B1 (en) |
| CA (1) | CA3098283C (en) |
| CL (1) | CL2020002748A1 (en) |
| CO (1) | CO2020013149A2 (en) |
| CR (1) | CR20200503A (en) |
| CU (1) | CU20200070A7 (en) |
| DO (1) | DOP2020000191A (en) |
| EC (1) | ECSP20067394A (en) |
| GE (1) | GEP20227433B (en) |
| IL (1) | IL278075B2 (en) |
| MA (1) | MA52360A (en) |
| MX (1) | MX2020011294A (en) |
| NI (1) | NI202000072A (en) |
| PE (1) | PE20201202A1 (en) |
| PH (1) | PH12020551692A1 (en) |
| RU (1) | RU2762557C1 (en) |
| SG (1) | SG11202009992VA (en) |
| TW (1) | TWI740135B (en) |
| UA (1) | UA126177C2 (en) |
| UY (1) | UY38196A (en) |
| WO (1) | WO2019207463A1 (en) |
| ZA (1) | ZA202006944B (en) |
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| AR109595A1 (en) | 2016-09-09 | 2018-12-26 | Incyte Corp | PIRAZOLOPIRIMIDINE COMPOUNDS AND USES OF THESE AS HPK1 INHIBITORS |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| ES2922237T3 (en) | 2018-02-20 | 2022-09-12 | Incyte Corp | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as HPK1 inhibitors to treat cancer |
| CN112313219B (en) | 2018-04-26 | 2024-04-26 | 辉瑞公司 | 2-Amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (en) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2021026180A1 (en) | 2019-08-06 | 2021-02-11 | Incyte Corporation | Solid forms of an hpk1 inhibitor |
| EP4013750A1 (en) | 2019-08-14 | 2022-06-22 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
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| JOP20220087A1 (en) | 2019-10-11 | 2023-01-30 | Incyte Corp | Bicyclic amines as cdk2 inhibitors |
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| WO2022166799A1 (en) | 2021-02-03 | 2022-08-11 | 上海拓界生物医药科技有限公司 | Fused tricyclic cyclin-dependent kinase inhibitor, and preparation method therefor and pharmaceutical use thereof |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
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| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| WO2023116862A1 (en) * | 2021-12-24 | 2023-06-29 | 江苏恒瑞医药股份有限公司 | Hydrogenated indole compound, and preparation method and medical use therefor |
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2019
- 2019-04-22 CN CN201980042382.5A patent/CN112313219B/en active Active
- 2019-04-22 SG SG11202009992VA patent/SG11202009992VA/en unknown
- 2019-04-22 PE PE2020001635A patent/PE20201202A1/en unknown
- 2019-04-22 CR CR20200503A patent/CR20200503A/en unknown
- 2019-04-22 BR BR112020021689-5A patent/BR112020021689B1/en active IP Right Grant
- 2019-04-22 RU RU2020134811A patent/RU2762557C1/en active
- 2019-04-22 GE GEAP201915475A patent/GEP20227433B/en unknown
- 2019-04-22 KR KR1020207033931A patent/KR102596598B1/en active Application Filing
- 2019-04-22 MA MA052360A patent/MA52360A/en unknown
- 2019-04-22 UA UAA202006733A patent/UA126177C2/en unknown
- 2019-04-22 EP EP19727502.7A patent/EP3784664A1/en active Pending
- 2019-04-22 CA CA3098283A patent/CA3098283C/en active Active
- 2019-04-22 WO PCT/IB2019/053314 patent/WO2019207463A1/en active Application Filing
- 2019-04-22 KR KR1020237036862A patent/KR102661053B1/en active IP Right Grant
- 2019-04-22 MX MX2020011294A patent/MX2020011294A/en unknown
- 2019-04-22 AU AU2019259653A patent/AU2019259653B2/en active Active
- 2019-04-22 JP JP2020560277A patent/JP7089061B2/en active Active
- 2019-04-22 CU CU2020000070A patent/CU20200070A7/en unknown
- 2019-04-23 TW TW108114112A patent/TWI740135B/en active
- 2019-04-23 US US16/391,836 patent/US10766884B2/en active Active
- 2019-04-24 UY UY0001038196A patent/UY38196A/en unknown
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2020
- 2020-07-29 US US16/942,209 patent/US11220494B2/en active Active
- 2020-10-13 PH PH12020551692A patent/PH12020551692A1/en unknown
- 2020-10-15 IL IL278075A patent/IL278075B2/en unknown
- 2020-10-21 EC ECSENADI202067394A patent/ECSP20067394A/en unknown
- 2020-10-21 CO CONC2020/0013149A patent/CO2020013149A2/en unknown
- 2020-10-22 NI NI202000072A patent/NI202000072A/en unknown
- 2020-10-23 DO DO2020000191A patent/DOP2020000191A/en unknown
- 2020-10-23 CL CL2020002748A patent/CL2020002748A1/en unknown
- 2020-11-06 ZA ZA2020/06944A patent/ZA202006944B/en unknown
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2021
- 2021-12-07 US US17/544,303 patent/US20220089580A1/en active Pending
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2022
- 2022-06-09 JP JP2022093962A patent/JP2022120096A/en active Pending
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