SG11202009559RA - Human kynureninase enzymes and uses thereof - Google Patents
Human kynureninase enzymes and uses thereofInfo
- Publication number
- SG11202009559RA SG11202009559RA SG11202009559RA SG11202009559RA SG11202009559RA SG 11202009559R A SG11202009559R A SG 11202009559RA SG 11202009559R A SG11202009559R A SG 11202009559RA SG 11202009559R A SG11202009559R A SG 11202009559RA SG 11202009559R A SG11202009559R A SG 11202009559RA
- Authority
- SG
- Singapore
- Prior art keywords
- human kynureninase
- enzymes
- kynureninase enzymes
- human
- kynureninase
- Prior art date
Links
- 101001021858 Homo sapiens Kynureninase Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y307/00—Hydrolases acting on carbon-carbon bonds (3.7)
- C12Y307/01—Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)
- C12Y307/01003—Kynureninase (3.7.1.3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862658261P | 2018-04-16 | 2018-04-16 | |
PCT/US2019/027623 WO2019204269A1 (en) | 2018-04-16 | 2019-04-16 | Human kynureninase enzymes and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009559RA true SG11202009559RA (en) | 2020-10-29 |
Family
ID=68240288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009559RA SG11202009559RA (en) | 2018-04-16 | 2019-04-16 | Human kynureninase enzymes and uses thereof |
Country Status (17)
Country | Link |
---|---|
US (2) | US11648272B2 (en) |
EP (1) | EP3781179A4 (en) |
JP (1) | JP7432851B2 (en) |
KR (1) | KR20200143455A (en) |
CN (1) | CN112218644A (en) |
AR (1) | AR115051A1 (en) |
AU (1) | AU2019257340A1 (en) |
BR (1) | BR112020020772A2 (en) |
CA (1) | CA3096549A1 (en) |
CL (1) | CL2020002650A1 (en) |
CO (1) | CO2020013050A2 (en) |
EA (1) | EA202092487A1 (en) |
IL (1) | IL277765A (en) |
MX (1) | MX2020010932A (en) |
SG (1) | SG11202009559RA (en) |
TW (1) | TWI827593B (en) |
WO (1) | WO2019204269A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105722522B (en) | 2013-08-30 | 2021-10-19 | 得克萨斯大学体系董事会 | Administration of kynurenine depleting enzymes for tumor therapy |
WO2017151860A1 (en) | 2016-03-02 | 2017-09-08 | Broard Of Regents, The University Of Texas System | Human kynureninase enzyme variants having improved pharmacological properties |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030194721A1 (en) | 2001-09-19 | 2003-10-16 | Incyte Genomics, Inc. | Genes expressed in treated foam cells |
US20030215840A1 (en) | 2002-02-01 | 2003-11-20 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cardiovascular disease using 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 26156, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2448, 2445, 64624, 84237, 8912, 2868, 283, 2554, 9464, 17799, 26686, 43848, 32135, 12208, 2914, 51130, 19489, 21833, 2917, 59590, 15992, 2094, 2252, 3474, 9792, 15400, 1452 or 6585 molecules |
CN1330774C (en) | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | Kynurenine hydrolase polymorphism and its diagnostic use |
JP4921965B2 (en) | 2003-03-27 | 2012-04-25 | ランケナー インスティテュート フォー メディカル リサーチ | New cancer treatment system |
US20070207158A1 (en) | 2003-06-17 | 2007-09-06 | Harrison Roger G | Conjugate for the specific targeting of anticancer agents to tumor cells or tumor vasculature and production thereof |
EP1648512A4 (en) | 2003-07-31 | 2009-01-21 | Immunomedics Inc | Anti-cd19 antibodies |
JP2008237022A (en) | 2005-06-30 | 2008-10-09 | Osaka Prefecture | Prophylactic/therapeutic agent and diagnostic agent for non-small cell lung cancer |
WO2008036642A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
ES2602743T3 (en) | 2010-09-08 | 2017-02-22 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
CN106220739A (en) | 2010-12-09 | 2016-12-14 | 宾夕法尼亚大学董事会 | The purposes of the T cell treatment cancer that Chimeric antigen receptor is modified |
KR20120085209A (en) | 2011-01-21 | 2012-07-31 | 인제대학교 산학협력단 | Composition for inhibiting immune response comprising stem cell expressing tryptophan metabolic enzyme gene |
WO2012099441A2 (en) | 2011-01-21 | 2012-07-26 | 인제대학교산학협력단 | Immune response inhibiting composition containing stem cells expressing tryptophan metabolizing enzyme genes |
JP6047160B2 (en) | 2011-09-07 | 2016-12-21 | ドイチェス クレブスフォルシュンクスツェントルム | Means and methods for treating and / or preventing a natural AHR ligand-dependent cancer |
EP2768863B1 (en) | 2011-10-20 | 2017-09-27 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd22 chimeric antigen receptors |
CN105722522B (en) | 2013-08-30 | 2021-10-19 | 得克萨斯大学体系董事会 | Administration of kynurenine depleting enzymes for tumor therapy |
JP7080053B2 (en) * | 2014-08-29 | 2022-06-03 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Administration of kynurenine-depleting enzymes for the treatment of tumors |
WO2017151860A1 (en) * | 2016-03-02 | 2017-09-08 | Broard Of Regents, The University Of Texas System | Human kynureninase enzyme variants having improved pharmacological properties |
-
2019
- 2019-04-16 EP EP19789290.4A patent/EP3781179A4/en active Pending
- 2019-04-16 EA EA202092487A patent/EA202092487A1/en unknown
- 2019-04-16 AR ARP190101000A patent/AR115051A1/en unknown
- 2019-04-16 CA CA3096549A patent/CA3096549A1/en active Pending
- 2019-04-16 JP JP2020556877A patent/JP7432851B2/en active Active
- 2019-04-16 BR BR112020020772-1A patent/BR112020020772A2/en unknown
- 2019-04-16 AU AU2019257340A patent/AU2019257340A1/en active Pending
- 2019-04-16 WO PCT/US2019/027623 patent/WO2019204269A1/en unknown
- 2019-04-16 TW TW108113281A patent/TWI827593B/en active
- 2019-04-16 CN CN201980025530.2A patent/CN112218644A/en active Pending
- 2019-04-16 KR KR1020207032702A patent/KR20200143455A/en unknown
- 2019-04-16 US US16/385,562 patent/US11648272B2/en active Active
- 2019-04-16 SG SG11202009559RA patent/SG11202009559RA/en unknown
- 2019-04-16 MX MX2020010932A patent/MX2020010932A/en unknown
-
2020
- 2020-10-03 IL IL277765A patent/IL277765A/en unknown
- 2020-10-14 CL CL2020002650A patent/CL2020002650A1/en unknown
- 2020-10-19 CO CONC2020/0013050A patent/CO2020013050A2/en unknown
-
2023
- 2023-04-06 US US18/296,687 patent/US20230405049A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EA202092487A1 (en) | 2021-02-05 |
EP3781179A1 (en) | 2021-02-24 |
AU2019257340A1 (en) | 2020-10-15 |
CN112218644A (en) | 2021-01-12 |
KR20200143455A (en) | 2020-12-23 |
JP2021521777A (en) | 2021-08-30 |
EP3781179A4 (en) | 2022-11-09 |
JP7432851B2 (en) | 2024-02-19 |
CO2020013050A2 (en) | 2020-10-30 |
MX2020010932A (en) | 2020-11-06 |
AR115051A1 (en) | 2020-11-25 |
CA3096549A1 (en) | 2019-10-24 |
TW202011973A (en) | 2020-04-01 |
TWI827593B (en) | 2024-01-01 |
BR112020020772A2 (en) | 2021-02-02 |
US20230405049A1 (en) | 2023-12-21 |
CL2020002650A1 (en) | 2021-06-18 |
IL277765A (en) | 2020-11-30 |
US20190350975A1 (en) | 2019-11-21 |
WO2019204269A1 (en) | 2019-10-24 |
US11648272B2 (en) | 2023-05-16 |
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