SG11202002460QA - Selective p2x3 modulators - Google Patents

Selective p2x3 modulators

Info

Publication number
SG11202002460QA
SG11202002460QA SG11202002460QA SG11202002460QA SG11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA
Authority
SG
Singapore
Prior art keywords
modulators
selective
Prior art date
Application number
SG11202002460QA
Other languages
English (en)
Inventor
Denis Garceau
Antonios Matzouranis
Roberto Bellini
Kemal Payza
Nathalie Chauret
Susan Browne
Original Assignee
Bellus Health Cough Inc
Neomed Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bellus Health Cough Inc, Neomed Inst filed Critical Bellus Health Cough Inc
Publication of SG11202002460QA publication Critical patent/SG11202002460QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Amplifiers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
SG11202002460QA 2017-09-18 2018-09-14 Selective p2x3 modulators SG11202002460QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560077P 2017-09-18 2017-09-18
US15/936,316 US10111883B1 (en) 2017-09-18 2018-03-26 Selective P2X3 modulators
PCT/IB2018/001513 WO2019064079A2 (en) 2017-09-18 2018-09-14 SELECTIVE MODULATORS OF P2X3

Publications (1)

Publication Number Publication Date
SG11202002460QA true SG11202002460QA (en) 2020-04-29

Family

ID=63894683

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002460QA SG11202002460QA (en) 2017-09-18 2018-09-14 Selective p2x3 modulators

Country Status (12)

Country Link
US (6) US10111883B1 (he)
EP (2) EP3684368B8 (he)
JP (1) JP7242681B2 (he)
KR (1) KR20200092938A (he)
CN (1) CN111601601A (he)
AU (1) AU2018342751B2 (he)
CA (1) CA3076150C (he)
ES (1) ES2969868T3 (he)
IL (2) IL303257A (he)
MX (1) MX2020002968A (he)
SG (1) SG11202002460QA (he)
WO (1) WO2019064079A2 (he)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2963702T3 (es) * 2018-10-05 2024-04-01 Shionogi & Co Medicina para tratar la tos crónica
SG11202103671YA (en) * 2018-10-10 2021-05-28 Bellus Health Cough Inc Treatment of pruritus with p2x3 antagonists
CA3119711A1 (en) * 2018-11-13 2020-05-22 Bellus Health Cough Inc. Crystalline forms of a substituted imidazopyridine compound and use thereof as p2x3 modulator
CN113272301B (zh) * 2018-12-29 2024-04-26 武汉朗来科技发展有限公司 杂环类化合物、中间体、其制备方法及应用
JP2022521955A (ja) * 2019-02-25 2022-04-13 べルス・ヘルス・コフ・インコーポレーテッド P2x3修飾薬での治療
CN112409331B (zh) * 2019-08-21 2024-02-20 上海翰森生物医药科技有限公司 杂环类衍生物抑制剂、其制备方法和应用
MX2022009762A (es) * 2020-02-14 2022-09-09 Bellus Health Cough Inc Moduladores del purinorreceptor 3 p2x (p2x3).
IL297700A (he) 2020-04-27 2022-12-01 Twist Bioscience Corp ספריות משתנות של חומצות גרעין לנגיף הקורונה
CN114085220B (zh) * 2020-06-22 2023-06-16 上海海雁医药科技有限公司 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途
JP7478858B2 (ja) * 2020-06-29 2024-05-07 武漢朗来科技発展有限公司 複素環系化合物の結晶形及びその製造方法と使用
CN113912601B (zh) * 2020-07-10 2023-06-06 上海拓界生物医药科技有限公司 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途
WO2022033567A1 (zh) * 2020-08-13 2022-02-17 上海拓界生物医药科技有限公司 苯并咪唑类衍生物、其制备方法及医药用途
WO2022161462A1 (zh) * 2021-01-29 2022-08-04 上海海雁医药科技有限公司 吗啉衍生物及其药物组合物和用途
WO2022258059A1 (zh) * 2021-06-10 2022-12-15 武汉朗来科技发展有限公司 一种药物组合物、制剂及其制备方法和应用
CN115043836B (zh) * 2021-08-20 2023-07-18 苏州璞正医药有限公司 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途
US20230218661A1 (en) * 2022-01-10 2023-07-13 Sensory Cloud, Inc. Isotonic or hypertonic salt-based compositions, treatments, devices, and articles for delivery of same to larynx

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2542582C2 (ru) * 2009-11-18 2015-02-20 Астразенека Аб Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3
EP2951177B1 (en) * 2013-01-31 2018-04-04 Neomed Institute Imidazopyridine compounds and uses thereof
CR20160093A (es) * 2013-08-23 2016-08-26 Afferent Pharmaceuticals Inc Moduladores del receptor p2x3 y p2x2/3 de diaminopiridina para el tratamiento de la tos aguda, sub aguda o cronica
AU2016330466B2 (en) * 2015-09-29 2021-01-28 Afferent Pharmaceuticals, Inc. Diaminopyrimidine P2x3 and P2x2/3 receptor modulators for use in the treatment of cough
US9907795B2 (en) * 2016-01-08 2018-03-06 Nerre Therapeutics Limited Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents
WO2018064135A1 (en) * 2016-09-30 2018-04-05 Asana Biosciences, Llc P2x3 and/or p2x2/3 compounds and methods

Also Published As

Publication number Publication date
EP4331669A2 (en) 2024-03-06
US20200230148A1 (en) 2020-07-23
US20220160724A1 (en) 2022-05-26
CA3076150C (en) 2024-01-02
US20210322432A1 (en) 2021-10-21
IL273348B2 (he) 2023-11-01
MX2020002968A (es) 2020-08-17
IL273348B1 (he) 2023-07-01
JP2020534355A (ja) 2020-11-26
AU2018342751B2 (en) 2023-06-15
WO2019064079A3 (en) 2019-05-16
CN111601601A (zh) 2020-08-28
EP3684368A4 (en) 2021-05-26
CA3076150A1 (en) 2019-04-04
EP3684368B8 (en) 2024-02-14
US20230248736A1 (en) 2023-08-10
EP3684368A2 (en) 2020-07-29
ES2969868T3 (es) 2024-05-23
WO2019064079A2 (en) 2019-04-04
US10111883B1 (en) 2018-10-30
JP7242681B2 (ja) 2023-03-20
IL303257A (he) 2023-07-01
EP3684368B1 (en) 2024-01-03
KR20200092938A (ko) 2020-08-04
IL273348A (he) 2020-05-31
EP4331669A3 (en) 2024-05-01
AU2018342751A1 (en) 2020-04-23
US20210069201A1 (en) 2021-03-11

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