SG11201910118RA - Multiwell plate with variable compression seal - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT ~~~~~~~~~~~~~ 011101010VIIIOH olo oi oloiloimo Ho lio iflo ow (10) International Publication Number WO 2018/209020 Al (51) International Patent Classification: BOLD 29/00 (2006.01) (21) International Application Number: PCT/US2018/031958 (22) International Filing Date: 10 May 2018 (10.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,128 10 May 2017 (10.05.2017) US 62/551,268 29 August 2017 (29.08.2017) US 62/668,908 09 May 2018 (09.05.2018) US (71) Applicant: EMD MILLIPORE CORPORATION [US/US]; 400 Summit Drive, Burlington, Massachusetts 01803 (US). (72) Inventors: CLARK, Phillip; c/o EMD Millipore Corpora- tion, 400 Summit Drive, Burlington, Massachusetts 01803 (US). GREENIZEN, Kurt E.; c/o EMD Millipore Corpo- ration, 400 Summit Drive, Burlington, Massachusetts 01803 (US). DOYLE, John; c/o EMD Millipore Corporation, 400 Summit Drive, Burlington, Massachusetts 01803 (US). (74) Agent: LEMACK, Kevin S. et al.; NIELDS, LEMACK & FRAME, LLC, 176 E. Main Street, Suite 5, Westboro, Massachusetts 01581 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: MULTIWELL PLATE WITH VARIABLE COMPRESSION SEAL (57) : Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate. [Continued on next page] WO 2018/209020 Al IMEDIMOM0101011M0H10 010 1101MOIMMODEVOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))