SG11201809649WA - Macromolecule analysis employing nucleic acid encoding - Google Patents
Macromolecule analysis employing nucleic acid encodingInfo
- Publication number
- SG11201809649WA SG11201809649WA SG11201809649WA SG11201809649WA SG11201809649WA SG 11201809649W A SG11201809649W A SG 11201809649WA SG 11201809649W A SG11201809649W A SG 11201809649WA SG 11201809649W A SG11201809649W A SG 11201809649WA SG 11201809649W A SG11201809649W A SG 11201809649WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- rule
- suite
- nucleic acid
- flintkote
- Prior art date
Links
- 229920002521 macromolecule Polymers 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6818—Sequencing of polypeptides
- G01N33/6824—Sequencing of polypeptides involving N-terminal degradation, e.g. Edman degradation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/6416—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/619—Detection means characterised by use of a special device being a video camera
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0111010101111101011111 0 1110111110101111011 Inn Oil lil Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/192633 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) Agent: SUN, Eileen, S. et al.; Seed Intellectual Property C12N 15/10 (2006.01) C4OB 40/04 (2006.01) Law Group LLP, Suite 5400, 701 Fifth Avenue, Seattle, C40B 20/04 (2006.01) C40B 70/00 (2006.01) Washington 98104-7064 (US). International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/030702 kind of national protection available): AE, AG, AL, AM, International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 02 May 2017 (02.05.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/330,841 02 May 2016 (02.05.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 62/339,071 19 May 2016 (19.05.2016) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/376,886 18 August 2016 (18.08.2016) US (84) Designated States (unless otherwise indicated, for every Applicant: PROCURE LIFE SCIENCES INC. [US/US]; kind of regional protection available): ARIPO (BW, GH, 11125 Flintkote Ave. Suite B, San Diego, California 92121 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Inventors: CHEF, Mark; 11125 Flintkote Ave. Suite B, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, San Diego, California 92121 (US). GUNDERSON, Kevin; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 11125 Flintkote Ave. Suite B, San Diego, California 92121 ego, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (US). WEINER, Michael, Phillip; 52 Leighton Trail, Guil-KM, ML, MR, NE, SN, TD, TG). ford, Connecticut 06437 (US). — = Title: MACROMOLECULE ANALYSIS EMPLOYING NUCLEIC ACID ENCODING din,\"1124—. imiRwwwsmiazgawa.m. 1111101( . . 7-7, Ng _ Kt (54) Protein or polypeptide Peptides DNA Encoded Library (DEL) of Extended Recording Tags polypeptides, and proteins, employing nucleic acid cu- .6:::..1111111 = = = = = = _ = = = = = .4 en en CN ,-, IN ,-, 0 (57) r l coding ow - - A . :AS, ' '1 'Mi• A — 1 N iiiiiagicafttattla\XsalIWZA-• Fig. 1B : A method for analyzing macromolecules, including peptides, is disclosed. C [Continued on next page] WO 2017/192633 Al IMEDIMOM0101011MMEMOMOICEEHIONOMOVOIMIE Declarations under Rule 4.17: — as to the applicant's entitlement to claim the priority of he earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) — with information concerning incorporation by reference of missing parts and/or elements (Rule 20.6)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662330841P | 2016-05-02 | 2016-05-02 | |
US201662339071P | 2016-05-19 | 2016-05-19 | |
US201662376886P | 2016-08-18 | 2016-08-18 | |
PCT/US2017/030702 WO2017192633A1 (en) | 2016-05-02 | 2017-05-02 | Macromolecule analysis employing nucleic acid encoding |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201809649WA true SG11201809649WA (en) | 2018-11-29 |
Family
ID=60203299
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809649WA SG11201809649WA (en) | 2016-05-02 | 2017-05-02 | Macromolecule analysis employing nucleic acid encoding |
SG10201911917WA SG10201911917WA (en) | 2016-05-02 | 2017-05-02 | Macromolecule analysis employing nucleic acid encoding |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201911917WA SG10201911917WA (en) | 2016-05-02 | 2017-05-02 | Macromolecule analysis employing nucleic acid encoding |
Country Status (12)
Country | Link |
---|---|
US (4) | US20190145982A1 (en) |
EP (2) | EP3452591B1 (en) |
JP (5) | JP7120630B2 (en) |
KR (3) | KR102379048B1 (en) |
CN (1) | CN110199019A (en) |
AU (1) | AU2017259794B2 (en) |
CA (1) | CA3022863A1 (en) |
DK (1) | DK3452591T3 (en) |
MX (1) | MX2018013341A (en) |
NZ (1) | NZ747941A (en) |
SG (2) | SG11201809649WA (en) |
WO (1) | WO2017192633A1 (en) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
DE112012002570B4 (en) | 2011-06-23 | 2023-11-23 | Board Of Regents, The University Of Texas System | Identifying peptides at the single molecule level |
US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
CA2961493C (en) | 2014-09-15 | 2023-10-03 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
SG11201705615UA (en) | 2015-01-12 | 2017-08-30 | 10X Genomics Inc | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
JP6828007B2 (en) | 2015-04-10 | 2021-02-10 | スペーシャル トランスクリプトミクス アクチボラグ | Spatial-identified multiplex nucleic acid analysis of biological samples |
WO2016210348A2 (en) | 2015-06-26 | 2016-12-29 | Ancera, Inc. | Background defocusing and clearing in ferrofluid-based capture assays |
SG11201809649WA (en) | 2016-05-02 | 2018-11-29 | Encodia Inc | Macromolecule analysis employing nucleic acid encoding |
WO2018017914A1 (en) | 2016-07-22 | 2018-01-25 | President And Fellows Of Harvard College | Methods and compositions for protein identification |
JP7091348B2 (en) * | 2016-09-26 | 2022-06-27 | ベクトン・ディキンソン・アンド・カンパニー | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
US10650312B2 (en) | 2016-11-16 | 2020-05-12 | Catalog Technologies, Inc. | Nucleic acid-based data storage |
CA3043887A1 (en) | 2016-11-16 | 2018-05-24 | Catalog Technologies, Inc. | Nucleic acid-based data storage |
CN110249082B (en) | 2016-12-01 | 2023-07-07 | 诺迪勒思附属公司 | Method for determining protein |
FI3929304T3 (en) * | 2016-12-16 | 2024-03-27 | Aratome Llc | Molecular detection using ligation amplification |
US10815525B2 (en) * | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
EP3545089B1 (en) | 2017-01-30 | 2022-03-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
GB201707140D0 (en) * | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
GB201715684D0 (en) * | 2017-09-28 | 2017-11-15 | Univ Gent | Means and methods for single molecule peptide sequencing |
WO2019084058A2 (en) * | 2017-10-23 | 2019-05-02 | Massachusetts Institute Of Technology | Functionalized solid support |
AU2018358057B2 (en) * | 2017-10-31 | 2023-03-02 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
CA3081451A1 (en) * | 2017-10-31 | 2019-05-09 | Encodia, Inc. | A method for assaying interactions between biological targets and binding agents |
US20200355673A1 (en) * | 2017-11-22 | 2020-11-12 | The University Of Chicago | Chemical probe-dependent evaluation of protein activity and uses thereof |
EP3752832A1 (en) | 2018-02-12 | 2020-12-23 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
CA3094077A1 (en) | 2018-03-16 | 2019-09-19 | Catalog Technologies, Inc. | Chemical methods for nucleic acid-based data storage |
JP7326778B2 (en) | 2018-03-19 | 2023-08-16 | 株式会社リコー | Nucleic Acid Sample Containing Container, Nucleic Acid Sample Containing Container Manufacturing Method, Nucleic Acid Sample Containing Container Manufacturing Device, Nucleic Acid Sample Containing Container Manufacturing Program, and Nucleic Acid Sample |
CN112513269A (en) * | 2018-07-12 | 2021-03-16 | 德克萨斯大学***董事会 | Molecular neighborhood detection by oligonucleotides |
CN108866046A (en) * | 2018-07-25 | 2018-11-23 | 辽宁润基生物科技有限公司 | A method of excretion body and/or free nucleic acid in separation, purification of samples |
US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
WO2020051162A1 (en) * | 2018-09-04 | 2020-03-12 | Encodia, Inc. | Proximity interaction analysis |
US11828684B2 (en) | 2018-09-17 | 2023-11-28 | California Institute Of Technology | Detection of molecular associations |
US11078480B2 (en) * | 2018-09-19 | 2021-08-03 | California Institute Of Technology | High-throughput identification of intermolecular interactions |
WO2020073008A1 (en) * | 2018-10-05 | 2020-04-09 | University Of Washington | Reporter constructs for nanopore-based detection of biological activity |
KR20210091243A (en) | 2018-11-15 | 2021-07-21 | 퀀텀-에스아이 인코포레이티드 | Methods and compositions for protein sequencing |
EP3894586A2 (en) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Methods for determining a location of a biological analyte in a biological sample |
US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
CA3124957A1 (en) * | 2019-01-08 | 2020-07-16 | Massachusetts Institute Of Technology | Single-molecule protein and peptide sequencing |
US20220127754A1 (en) * | 2019-01-21 | 2022-04-28 | Encodia, Inc. | Methods and compositions of accelerating reactions for polypeptide analysis and related uses |
US11427814B2 (en) | 2019-03-26 | 2022-08-30 | Encodia, Inc. | Modified cleavases, uses thereof and related kits |
SG11202110373WA (en) * | 2019-03-26 | 2021-10-28 | Encodia Inc | Modified cleavases, uses thereof and related kits |
CA3137716A1 (en) * | 2019-04-23 | 2020-10-29 | Encodia, Inc. | Methods for spatial analysis of proteins and related kits |
CN114072499A (en) * | 2019-04-30 | 2022-02-18 | Encodia 公司 | Method for preparing an analyte and related kit |
EP3962930A4 (en) * | 2019-04-30 | 2024-03-27 | Encodia Inc | Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide |
WO2020227718A1 (en) | 2019-05-09 | 2020-11-12 | Catalog Technologies, Inc. | Data structures and operations for searching, computing, and indexing in dna-based data storage |
EP3973299A4 (en) * | 2019-05-20 | 2023-04-19 | Encodia, Inc. | Methods and related kits for spatial analysis |
EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
WO2020254672A1 (en) * | 2019-06-19 | 2020-12-24 | Therycell Gmbh | Spatial characterisation of target structures in a sample |
US11346842B2 (en) | 2019-06-20 | 2022-05-31 | Massachusetts Institute Of Technology | Single molecule peptide sequencing methods |
CN110689929B (en) * | 2019-08-29 | 2021-12-17 | 浙江工业大学 | Protein ATP docking method based on contact probability assistance |
EP4041920A1 (en) | 2019-10-11 | 2022-08-17 | Catalog Technologies, Inc. | Nucleic acid security and authentication |
BR112022008003A2 (en) * | 2019-10-28 | 2022-07-12 | Quantum Si Inc | SAMPLE PREPARATION METHODS, KITS AND DEVICES FOR MULTIPLEX POLYPEPTIDE SEQUENCING |
CN114981448A (en) * | 2019-10-28 | 2022-08-30 | 宽腾矽公司 | Method for sequencing single cell proteins and nucleic acids |
WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
EP3891300B1 (en) | 2019-12-23 | 2023-03-29 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
WO2021141924A1 (en) * | 2020-01-07 | 2021-07-15 | Encodia, Inc. | Methods for stable complex formation and related kits |
EP4073263A4 (en) * | 2020-01-07 | 2023-11-08 | Encodia, Inc. | Methods for stable complex formation and related kits |
US20230056532A1 (en) * | 2020-01-07 | 2023-02-23 | Encodia, Inc. | Methods for information transfer and related kits |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
CN116157533A (en) * | 2020-02-21 | 2023-05-23 | 10X基因组学有限公司 | Capturing genetic targets using hybridization methods |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
KR102376443B1 (en) | 2020-02-26 | 2022-03-17 | 포항공과대학교 산학협력단 | A nanostructure, a biosensor including the nanostructure, and a screening method |
KR102482668B1 (en) * | 2020-03-10 | 2022-12-29 | 사회복지법인 삼성생명공익재단 | A method for improving the labeling accuracy of Unique Molecular Identifiers |
US20240011009A1 (en) * | 2020-03-24 | 2024-01-11 | Encodia, Inc. | Modified dipeptide cleavases, uses thereof and related kits |
CN112280829B (en) * | 2020-04-07 | 2023-12-26 | 南方科技大学 | Kit, sample marking method and single-cell sequencing method |
EP4136255A1 (en) * | 2020-04-16 | 2023-02-22 | Singleron (Nanjing) Biotechnologies, Ltd. | Methods and compositions for high-throughput target sequencing in single cells |
EP4242325A3 (en) | 2020-04-22 | 2023-10-04 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
CA3183416A1 (en) | 2020-05-11 | 2021-11-18 | Catalog Technologies, Inc. | Programs and functions in dna-based data storage |
EP4153775A1 (en) | 2020-05-22 | 2023-03-29 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
WO2021247543A2 (en) * | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
WO2021252591A1 (en) | 2020-06-10 | 2021-12-16 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
US11935311B2 (en) | 2020-06-11 | 2024-03-19 | Nautilus Subsidiary, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
WO2021263111A1 (en) | 2020-06-25 | 2021-12-30 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
EP4182476A2 (en) * | 2020-07-14 | 2023-05-24 | Ancera, Inc. | Systems, devices and methods for analysis |
EP4121561A4 (en) | 2020-08-06 | 2024-04-17 | Singular Genomics Systems Inc | Methods for in situ transcriptomics and proteomics |
WO2022040098A1 (en) * | 2020-08-19 | 2022-02-24 | Encodia, Inc. | Sequential encoding methods and related kits |
US20230332202A1 (en) * | 2020-08-21 | 2023-10-19 | Ancera, Inc. | Systems, devices and methods for determing most probable number in biological sample analysis |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
WO2022094148A1 (en) * | 2020-10-30 | 2022-05-05 | Encodia, Inc. | Conjugation reagents and methods using 1,2-cyclohexanediones |
CA3196729A1 (en) | 2020-11-11 | 2022-05-19 | Tural AKSEL | Affinity reagents having enhanced binding and detection characteristics |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
EP4278004A1 (en) * | 2021-01-13 | 2023-11-22 | The Regents of the University of Colorado, a body corporate | Methods and compositions for molecular tracking in individual cells in vivo |
AU2022210423A1 (en) | 2021-01-20 | 2023-07-06 | Nautilus Subsidiary, Inc. | Methods for biomolecule quantitation |
EP4281775A1 (en) | 2021-01-21 | 2023-11-29 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
IL305336A (en) | 2021-03-11 | 2023-10-01 | Nautilus Subsidiary Inc | Systems and methods for biomolecule retention |
CA3222270A1 (en) | 2021-06-24 | 2022-12-29 | Vadim Lobanov | Methods and systems for assay refinement |
US11521947B1 (en) * | 2021-07-14 | 2022-12-06 | Nxp Usa, Inc. | Space efficient flip chip joint design |
EP4196605A1 (en) | 2021-09-01 | 2023-06-21 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
WO2023038859A1 (en) | 2021-09-09 | 2023-03-16 | Nautilus Biotechnology, Inc. | Characterization and localization of protein modifications |
CA3227592A1 (en) | 2021-09-22 | 2023-03-30 | Gregory KAPP | Methods and systems for determining polypeptide interactions |
US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
WO2023086847A1 (en) | 2021-11-10 | 2023-05-19 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
WO2023114732A2 (en) * | 2021-12-14 | 2023-06-22 | Glyphic Biotechnologies, Inc. | Single-molecule peptide sequencing through molecular barcoding and ex-situ analysis |
EP4206674A1 (en) | 2021-12-28 | 2023-07-05 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
WO2023212490A1 (en) | 2022-04-25 | 2023-11-02 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
WO2024058967A1 (en) | 2022-09-13 | 2024-03-21 | Nautilus Subsidiary, Inc. | Systems and methods of validating new affinity reagents |
US20240094215A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
CN115951051B (en) * | 2022-10-18 | 2024-01-12 | 北京卓诚惠生生物科技股份有限公司 | Novel high-sensitivity coronavirus antigen colloidal gold detection kit and preparation method thereof |
Family Cites Families (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863870A (en) | 1988-03-10 | 1989-09-05 | Bio-Affinity Systems, Inc. | Method of thioacylation peptide sequencing with alcoholysis of thiazolinones |
US5484735A (en) * | 1989-08-23 | 1996-01-16 | Northwestern University | Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids |
US5049507A (en) | 1989-12-21 | 1991-09-17 | Applied Biosystems, Inc. | Method of C-terminal peptide sequencing |
WO1993006121A1 (en) * | 1991-09-18 | 1993-04-01 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
SE9400088D0 (en) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
CA2176414A1 (en) | 1995-05-18 | 1996-11-19 | S. David Kimball | Acyl guanidine and amidine prodrugs |
EP0841945B1 (en) | 1995-08-03 | 2006-03-08 | Rijksuniversiteit te Leiden | Cell derived antigen presenting vesicles |
JP3124507B2 (en) | 1996-05-24 | 2001-01-15 | セイコーインスツルメンツ株式会社 | Method for determining amino acid sequence from carboxy terminus of protein or peptide |
US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
ATE529509T1 (en) * | 1997-01-21 | 2011-11-15 | Gen Hospital Corp | SELECTION OF PROTEINS USING RNA-PROTEIN FUSIONS |
US6306588B1 (en) | 1997-02-07 | 2001-10-23 | Invitrogen Corporation | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof |
US6465193B2 (en) | 1998-12-11 | 2002-10-15 | The Regents Of The University Of California | Targeted molecular bar codes and methods for using the same |
US6875851B1 (en) | 1999-03-05 | 2005-04-05 | University Of Georgia Research Foundation, Inc. | Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis |
AU772069B2 (en) * | 1999-03-23 | 2004-04-08 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Protein isolation and analysis |
AU5723700A (en) | 1999-05-25 | 2000-12-12 | Praelux Incorporated | Method for sequency and characterizing polymeric biomolecules using aptamers anda method for producing aptamers |
DE60034566T2 (en) | 1999-07-27 | 2008-01-03 | Adnexus Therapeutics, Inc., Waltham | PEPTIDE RECEPTOR LIGATION PROCEDURE |
GB9927320D0 (en) | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
US7306904B2 (en) | 2000-02-18 | 2007-12-11 | Olink Ab | Methods and kits for proximity probing |
US6511809B2 (en) | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
CA2314398A1 (en) | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
JP4880188B2 (en) | 2001-01-23 | 2012-02-22 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | Nucleic acid programmed protein array |
US20030087232A1 (en) * | 2001-01-25 | 2003-05-08 | Fred Christians | Methods for screening polypeptides |
EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
CA2453176C (en) | 2001-07-06 | 2015-01-20 | Institut Pasteur | Eubacterial host cells devoid of n-terminal formylation and said host cells being useful for the production of proteins and peptides |
US7169894B2 (en) | 2001-11-14 | 2007-01-30 | Mirari Biosciences, Inc. | Methods and compositions for reverse translation |
EP1451356A1 (en) | 2001-11-23 | 2004-09-01 | Simon Fredriksson | Method and kit for proximity probing with multivalent proximity probes |
KR20050052666A (en) | 2002-10-10 | 2005-06-03 | 다이버사 코포레이션 | Proteases, nucleic acids encoding them and methods for making and using them |
US20090246879A1 (en) * | 2002-12-20 | 2009-10-01 | Callida Genomics | Materials and Methods Relating to Nano-Tags and Nano-Brands |
WO2005015239A2 (en) | 2003-08-07 | 2005-02-17 | Cornell Research Foundation, Inc. | Method for n-terminal labeling of proteins |
US7198900B2 (en) | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
WO2005026387A1 (en) * | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
EP1561755A2 (en) | 2003-10-16 | 2005-08-10 | Shimadzu Corporation | Method for derivatizing protein or peptide to sulfonic acid derivative |
EP1694693A2 (en) | 2003-12-17 | 2006-08-30 | Praecis Pharmaceuticals Inc. | Methods for synthesis of encoded libraries |
GB0404187D0 (en) | 2004-02-25 | 2004-03-31 | Biotransformations Ltd | Binding agents |
DK1730277T3 (en) | 2004-03-22 | 2010-03-01 | Nuevolution As | Coding by ligation using building block oligonucleotides |
WO2005108615A2 (en) | 2004-04-14 | 2005-11-17 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
US20060199279A1 (en) | 2005-03-07 | 2006-09-07 | Viorica Lopez-Avila | Methods for identifying post-translationally modified polypeptides |
US7229769B2 (en) | 2005-03-25 | 2007-06-12 | Illumina, Inc. | Compositions and methods for detecting protease activity |
US7883848B2 (en) | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
US7611834B2 (en) | 2005-09-30 | 2009-11-03 | Sandia Corporation | Methods and devices for protein assays |
DK1957644T3 (en) * | 2005-12-01 | 2011-03-28 | Nuevolution As | Enzymatic coding methods for efficient synthesis of large libraries |
US20070218503A1 (en) | 2006-02-13 | 2007-09-20 | Mitra Robi D | Methods of polypeptide identification, and compositions therefor |
DE102006015001A1 (en) | 2006-03-31 | 2007-10-11 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Method for detecting and / or enriching analyte proteins and / or analyte peptides from a complex protein mixture |
US8758991B2 (en) | 2006-04-26 | 2014-06-24 | University Of Louisville Research Foundation, Inc. | Isolation of membrane vesicles from biological fluids and methods of using same |
US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
WO2009019215A1 (en) | 2007-08-03 | 2009-02-12 | Dkfz Deutsches Krebsforschungszentrum | Method for prenatal diagnosis using exosomes and cd24 as a marker |
EP2210109A1 (en) * | 2007-10-19 | 2010-07-28 | Pronota NV | Preparation of samples for proteome analysis |
WO2010065531A1 (en) | 2008-12-01 | 2010-06-10 | Robi David Mitra | Single molecule protein screening |
WO2010065322A1 (en) | 2008-12-01 | 2010-06-10 | Research Triangle Institute | Concurrent identification of multitudes of polypeptides |
US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
US9566335B1 (en) | 2009-09-25 | 2017-02-14 | The Governing Council Of The University Of Toronto | Protein sequencing method and reagents |
US9175340B2 (en) | 2009-11-04 | 2015-11-03 | President And Fellows Of Harvard College | Reactivity-dependent and interaction-dependent PCR |
WO2011127006A1 (en) | 2010-04-05 | 2011-10-13 | Prognosys Biosciences, Inc. | Co-localization affinity assays |
ES2555106T3 (en) * | 2010-04-05 | 2015-12-29 | Prognosys Biosciences, Inc. | Spatially coded biological assays |
AU2011237669B2 (en) | 2010-04-06 | 2016-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for disease |
WO2011143583A1 (en) * | 2010-05-13 | 2011-11-17 | Illumina, Inc. | Binding assays for markers |
EP3399035B1 (en) | 2010-09-27 | 2021-02-17 | Vipergen | A method for making an enriched library |
US20130295574A1 (en) | 2010-11-10 | 2013-11-07 | Exosome Diagnostics, Inc. | Method for Isolation of Nucleic Acid Containing Particles and Extraction of Nucleic Acids Therefrom |
GB201101621D0 (en) | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
US20120258871A1 (en) | 2011-04-08 | 2012-10-11 | Prognosys Biosciences, Inc. | Peptide constructs and assay systems |
EP2697397B1 (en) | 2011-04-15 | 2017-04-05 | The Johns Hopkins University | Safe sequencing system |
CA3039234C (en) | 2011-05-11 | 2023-03-28 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
DE112012002570B4 (en) | 2011-06-23 | 2023-11-23 | Board Of Regents, The University Of Texas System | Identifying peptides at the single molecule level |
EP2748335B1 (en) | 2011-08-22 | 2018-10-03 | Exosome Diagnostics, Inc. | Urine biomarkers |
US20130052665A1 (en) * | 2011-08-25 | 2013-02-28 | Bruce Xuefeng Ling | Methods for diagnosis of systemic juvenile idiopathic arthritis |
US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
US10174361B2 (en) | 2011-11-10 | 2019-01-08 | Exosome Diagnostics, Inc. | Cerebrospinal fluid assay |
US20150087526A1 (en) | 2012-01-24 | 2015-03-26 | The Regents Of The University Of Colorado, A Body Corporate | Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation |
SI3363901T1 (en) | 2012-02-17 | 2021-04-30 | Fred Hutchinson Cancer Research Center | Compositions and methods for accurately identifying mutations |
CA2867293C (en) | 2012-03-13 | 2020-09-01 | Abhijit Ajit PATEL | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
PT2828218T (en) | 2012-03-20 | 2020-11-11 | Univ Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
US9005888B2 (en) | 2012-06-14 | 2015-04-14 | System Biosciences, Llc | Methods for microvesicle isolation and selective removal |
NL2009191C2 (en) | 2012-07-16 | 2014-01-20 | Univ Delft Tech | Single molecule protein sequencing. |
CN114891871A (en) | 2012-08-14 | 2022-08-12 | 10X基因组学有限公司 | Microcapsule compositions and methods |
US20140378322A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
US9557336B2 (en) * | 2012-09-07 | 2017-01-31 | University Of Rochester | Methods and compositions for site-specific labeling of peptides and proteins |
US20150252428A1 (en) | 2012-10-03 | 2015-09-10 | Exosome Diagnostics, Inc. | Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions |
AU2013340414B2 (en) | 2012-10-23 | 2019-05-02 | Caris Science, Inc. | Aptamers and uses thereof |
CN105189748B (en) | 2013-03-15 | 2021-06-08 | 血统生物科学公司 | Method for sequencing an immune repertoire |
WO2014145123A2 (en) * | 2013-03-15 | 2014-09-18 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity | Peptide array quality control |
US9435810B2 (en) | 2013-03-15 | 2016-09-06 | Washington University | Molecules and methods for iterative polypeptide analysis and processing |
EP2971071B1 (en) * | 2013-03-15 | 2018-02-28 | Illumina, Inc. | Enzyme-linked nucleotides |
EP2989214A4 (en) | 2013-04-23 | 2016-12-28 | Harvard College | In situ interaction determination |
US10011830B2 (en) * | 2013-05-19 | 2018-07-03 | The Board of Trustee of theLeland Stanford junior University | Devices and methods for display of encoded peptides, polypeptides, and proteins on DNA |
DK3013983T3 (en) * | 2013-06-25 | 2023-03-06 | Prognosys Biosciences Inc | SPATIALLY ENCODED BIOLOGICAL ASSAYS USING A MICROFLUIDIC DEVICE |
EP3019514A4 (en) * | 2013-07-10 | 2017-02-22 | President and Fellows of Harvard College | Compositions and methods relating to nucleic acid-protein complexes |
BR112016004153A2 (en) | 2013-08-28 | 2019-09-17 | Caris Life Sciences Switzerland Holdings Gmbh | "method for characterizing a disease or disorder, kit, composition, method for generating an input library, oligonucleotide, plurality of oligonucleotides and method for identifying an aptamer |
WO2015042506A1 (en) | 2013-09-23 | 2015-03-26 | The Trustees Of Columbia University In The City Of New York | High-throughput single molecule protein identification |
WO2015070037A2 (en) | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
US9834814B2 (en) * | 2013-11-22 | 2017-12-05 | Agilent Technologies, Inc. | Spatial molecular barcoding of in situ nucleic acids |
EP3111212B1 (en) | 2014-02-27 | 2018-08-29 | Board of Regents, The University of Texas System | Methods and compositions for isolating exosomes |
US10858698B2 (en) * | 2014-03-25 | 2020-12-08 | President And Fellows Of Harvard College | Barcoded protein array for multiplex single-molecule interaction profiling |
JP6853667B2 (en) * | 2014-04-21 | 2021-03-31 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Systems and methods for barcoding nucleic acids |
US10590407B2 (en) | 2014-04-24 | 2020-03-17 | Nanyang Technological University | Asx-specific protein ligase |
WO2015166768A1 (en) * | 2014-05-02 | 2015-11-05 | 国立大学法人金沢大学 | Method for analyzing nucleic acid derived from single cell |
WO2015176034A1 (en) | 2014-05-15 | 2015-11-19 | Two Pore Guys, Inc. | Scaffold data storage and target detection in a sample using a nanopore |
AU2015279548B2 (en) | 2014-06-26 | 2020-02-27 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
AU2015279617A1 (en) * | 2014-06-26 | 2017-01-12 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
WO2016004068A1 (en) | 2014-06-30 | 2016-01-07 | Jae-Won Shin | Hydrogel compositions comprising encapsulated cells and methods of use thereof |
CN113699143A (en) | 2014-07-09 | 2021-11-26 | 外来体诊断公司 | Method for isolating microvesicles and extracting nucleic acids from biological samples |
EP3169812A4 (en) | 2014-07-18 | 2017-12-20 | CDI Laboratories Inc. | Methods and compositions to identify, quantify, and characterize target analytes and binding moieties |
EP4219710A3 (en) * | 2014-08-01 | 2023-08-16 | Dovetail Genomics, LLC | Tagging nucleic acids for sequence assembly |
CA2961493C (en) | 2014-09-15 | 2023-10-03 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
AU2015331739B2 (en) | 2014-10-17 | 2021-12-02 | Illumina Cambridge Limited | Contiguity preserving transposition |
US9771412B2 (en) | 2014-10-31 | 2017-09-26 | Wisconsin Alumni Research Foundation | Engineered intein for improved production of protein-intein fusions |
EP3256604B1 (en) | 2015-02-10 | 2020-03-25 | Illumina, Inc. | Methods and compositions for analyzing cellular components |
CN107208158B (en) * | 2015-02-27 | 2022-01-28 | 贝克顿迪金森公司 | Spatially addressable molecular barcode |
US20180284125A1 (en) | 2015-03-11 | 2018-10-04 | The Broad Institute, Inc. | Proteomic analysis with nucleic acid identifiers |
WO2016164530A1 (en) | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions and methods for high throughput protein sequencing |
AU2016276750A1 (en) | 2015-06-09 | 2018-01-18 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
EP3397764A4 (en) | 2015-12-30 | 2019-05-22 | Bio-Rad Laboratories, Inc. | Digital protein quantification |
CN108779486B (en) | 2016-02-17 | 2023-02-28 | 哈佛学院院长及董事 | Molecular programming tool |
SG11201809649WA (en) | 2016-05-02 | 2018-11-29 | Encodia Inc | Macromolecule analysis employing nucleic acid encoding |
EP3464636B1 (en) | 2016-05-27 | 2022-07-06 | President and Fellows of Harvard College | Conditional primer extension for single-molecule detection |
WO2018005720A1 (en) | 2016-06-30 | 2018-01-04 | President And Fellows Of Harvard College | Method of determining the molecular binding between libraries of molecules |
WO2018017914A1 (en) | 2016-07-22 | 2018-01-25 | President And Fellows Of Harvard College | Methods and compositions for protein identification |
EP3545089B1 (en) | 2017-01-30 | 2022-03-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
CN110475864B (en) | 2017-02-02 | 2024-01-12 | 纽约基因组研究中心公司 | Methods and compositions for identifying or quantifying targets in biological samples |
CA3081451A1 (en) | 2017-10-31 | 2019-05-09 | Encodia, Inc. | A method for assaying interactions between biological targets and binding agents |
CA3081446A1 (en) | 2017-10-31 | 2019-05-09 | Encodia, Inc. | Methods and compositions for polypeptide analysis |
AU2018358057B2 (en) | 2017-10-31 | 2023-03-02 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
KR20200105497A (en) | 2017-12-29 | 2020-09-07 | 노틸러스 바이오테크놀로지, 인크. | Decoding Approaches for Protein Identification |
US20190219578A1 (en) | 2018-01-18 | 2019-07-18 | Nanosomix, Inc. | Dectection of exosomes and exosomal biomarkers for the diagnosis and prognosis of diseases and disorders |
US20190301985A1 (en) | 2018-04-03 | 2019-10-03 | Tymora Analytical Operations, Inc. | Methods for affinity-based non-antibody capture and purification of extracellular vesicles |
-
2017
- 2017-05-02 SG SG11201809649WA patent/SG11201809649WA/en unknown
- 2017-05-02 KR KR1020187034711A patent/KR102379048B1/en active IP Right Grant
- 2017-05-02 KR KR1020227009243A patent/KR102516168B1/en active IP Right Grant
- 2017-05-02 WO PCT/US2017/030702 patent/WO2017192633A1/en active Search and Examination
- 2017-05-02 US US16/098,436 patent/US20190145982A1/en active Pending
- 2017-05-02 EP EP17793198.7A patent/EP3452591B1/en active Active
- 2017-05-02 AU AU2017259794A patent/AU2017259794B2/en active Active
- 2017-05-02 SG SG10201911917WA patent/SG10201911917WA/en unknown
- 2017-05-02 NZ NZ747941A patent/NZ747941A/en unknown
- 2017-05-02 CA CA3022863A patent/CA3022863A1/en active Pending
- 2017-05-02 KR KR1020237010494A patent/KR20230047506A/en not_active Application Discontinuation
- 2017-05-02 JP JP2018558133A patent/JP7120630B2/en active Active
- 2017-05-02 DK DK17793198.7T patent/DK3452591T3/en active
- 2017-05-02 CN CN201780041157.0A patent/CN110199019A/en active Pending
- 2017-05-02 MX MX2018013341A patent/MX2018013341A/en unknown
- 2017-05-02 EP EP23184223.8A patent/EP4299803A3/en active Pending
-
2020
- 2020-05-01 JP JP2020081385A patent/JP7097627B2/en active Active
-
2021
- 2021-03-10 US US17/197,796 patent/US20210302431A1/en active Pending
- 2021-08-27 US US17/460,138 patent/US20210405058A1/en not_active Abandoned
-
2022
- 2022-02-22 JP JP2022025551A patent/JP7333975B2/en active Active
- 2022-06-30 JP JP2022106383A patent/JP2022126865A/en not_active Withdrawn
- 2022-08-09 US US17/818,616 patent/US11959922B2/en active Active
-
2024
- 2024-01-18 JP JP2024006005A patent/JP2024041969A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201809649WA (en) | Macromolecule analysis employing nucleic acid encoding | |
SG11201909160WA (en) | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same | |
SG11201909918XA (en) | Compositions and methods for improving sample identification in indexed nucleic acid libraries | |
SG11201908658TA (en) | Nucleobase editors comprising nucleic acid programmable dna binding proteins | |
SG11201908489XA (en) | De novo synthesized combinatorial nucleic acid libraries | |
SG11201907531XA (en) | Constraining motion vector information derived by decoder-side motion vector derivation | |
SG11202000105QA (en) | Anti-cd166 antibodies and uses thereof | |
SG11201906264YA (en) | Improved serum albumin binders | |
SG11201906468TA (en) | Chimeric antigen receptors against axl or ror2 and methods of use thereof | |
SG11201906341XA (en) | Improved serum albumin binders | |
SG11201803593QA (en) | Engineered nucleic-acid targeting nucleic acids | |
SG11201907814SA (en) | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof | |
SG11201810611YA (en) | Coumarin compounds and their uses as fluorescent labels | |
SG11201900746RA (en) | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions | |
SG11201803958WA (en) | Nucleic acids encoding repetitive amino acid sequences rich in proline and alanine residues that have low repetitive nucleotide sequences | |
SG11201901371XA (en) | Methods for the detection of genomic copy changes in dna samples | |
SG11201906301UA (en) | Methods of manufacture of nut flours and formulations for oral immunotherapy | |
SG11201809374VA (en) | Cd40l-fc fusion polypeptides and methods of use thereof | |
SG11201900573UA (en) | Methods of purifying fc-containing proteins | |
SG11201807596YA (en) | Gitr antibodies, methods, and uses | |
SG11201907764PA (en) | Methods for screening infections | |
SG11201909957TA (en) | Engineered ligase variants | |
SG11201810907UA (en) | Target reporter constructs and uses thereof | |
SG11201900744SA (en) | Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them | |
SG11201906961UA (en) | Polypeptide variants and uses thereof |