SG11201906933SA - Functionalized erythroid cells - Google Patents

Abstract

Substratereactive moiety \ Click handle 1 Click handle 2 /agen t\ Coupling reagent 1 Coupling reagent 2 Click handle 2 Click handle 1 Substrate-reactive moiety 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WI P0 I PC T limion omits onolomolu onolomiomom (10) International Publication Number WO 2018/151829 Al (51) International Patent Classification: C12N 5/078 (2010.01) (21) International Application Number: PCT/US2018/000042 (22) International Filing Date: 16 February 2018 (16.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/460,589 17 February 2017 (17.02.2017) US 62/542,142 07 August 2017 (07.08.2017) US (71) Applicant: RUBIUS THERAPEUTICS, INC. [US/US]; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). (72) Inventors: WICKHAM, Tom; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). CHEN, Tiffany, F.; 325 Vas- sar St Suite 1A, Cambridge, MA 02139 (US). ZHANG, Xuqing; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). HUDAK, Carolyn; 325 Vassar St Suite 1A, Cam- bridge, MA 02139 (US). MATA-FINK, Jordi; 325 Vas- sar St Suite 1A, Cambridge, MA 02139 (US). ELLOUL, Sivan; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). LAW, Billy; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). HOFFMAN, Lenka; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). TEICHERT, Kristian, Eric; 325 Vassar St Suite 1A, Cambridge, MA 02139 (US). DAS- TAGIR, Shamael, Rabia; 325 Vassar St Suite 1A, Cam- bridge, MA 02139 (US). (74) Agent: YANG, Peter et al.; Lando & Anastasi, LLP, River- front Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — (54) Title: FUNCTIONALIZED ERYTHROID CELLS 1111 A Click srt s ure FIG. 1 0 (57) : Described herein are novel preparations of functionalized erythroid cells and related compositions, reagents, and methods \" for use in human pharmaceutical and veterinary applications. C [Continued on next page] WO 2018/151829 Al MIDEDIMOMOIDEIREEM311011111010MODEVOIS UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))