SG11201903187WA - Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors - Google Patents

Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors

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Publication number
SG11201903187WA
SG11201903187WA SG11201903187WA SG11201903187WA SG11201903187WA SG 11201903187W A SG11201903187W A SG 11201903187WA SG 11201903187W A SG11201903187W A SG 11201903187WA SG 11201903187W A SG11201903187W A SG 11201903187WA SG 11201903187W A SG11201903187W A SG 11201903187WA
Authority
SG
Singapore
Prior art keywords
boulder
colorado
walnut
array
street
Prior art date
Application number
SG11201903187WA
Inventor
Steven W Andrews
Sean Aronow
James F Blake
Barbara J Brandhuber
James Collier
Adam Cook
Julia Haas
Yutong Jiang
Gabrielle R Kolakowski
Elizabeth A Mcfaddin
Megan L Mckenney
Oren T Mcnulty
Andrew T Metcalf
David A Moreno
Ginelle A Ramann
Tony P Tang
Li Ren
Shane M Walls
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of SG11201903187WA publication Critical patent/SG11201903187WA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 0 11101 HOE HI 1 0 101110 Ell 010 HE 100 MO MIS Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/071454 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: nut Street, Boulder, Colorado 80301 (US). MORENO, CO7D 471/04 (2006.01) A61P 35/00 (2006.01) David A. [US/US]; c/o Array BioPharma Inc., 3200 Walnut A61K 31/437 (2006.01) Street, Boulder, Colorado 80301 (US). RAMANN, Ginelle (21) International Application Number: A. [US/US]; c/o Array BioPharma, Inc., 3200 Walnut St., PCT/US2017/055993 Boulder, Colorado 80301 (US). TANG, Tony P. [US/US]; c/o Array BioPharma Inc., 3200 Walnut Street, Boulder, (22) International Filing Date: Colorado 80301 (US). REN, Li [US/US]; c/o Array Bio- 10 October 2017 (10.10.2017) Pharma Inc., 3200 Walnut Street, Boulder, Colorado 80301 (US). WALLS, Shane M. [US/US]; c/o Array BioPharma, (25) Filing Language: English Inc., 3200 Walnut St., Boulder, Colorado 80301 (US). (26) Publication Language: English (74) Agent: FOLLETT, Angela D. et al.; Fish & Richardson (30) Priority Data: P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 62/406,275 10 October 2016 (10.10.2016) US (US). 62/447,849 18 January 2017 (18.01.2017) US (81) Designated States (unless otherwise indicated, for every 62/491,180 27 April 2017 (27.04.2017) US kind of national protection available): AE, AG, AL, AM, 62/531,690 12 July 2017 (12.07.2017) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/566,030 29 September 2017 (29.09.2017) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (72) Inventors; and DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicants: ANDREWS, Steven W. [US/US]; c/o Array HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, BioPharma Inc., 3200 Walnut Street, Boulder, Colorado KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 80301 (US). ARONOW, Sean [US/US]; c/o Array Bio- MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, Pharma, Inc., 3200 Walnut St., Boulder, Colorado 80301 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (US). BLAKE, James F. [US/US]; c/o Array BioPhar- SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, ma Inc., 3200 Walnut Street, Boulder, Colorado 80301 TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (US). BRANDHUBER, Barbara J. [US/US]; c/o Array (84) Designated States (unless otherwise indicated, for every BioPharma Inc., 3200 Walnut Street, Boulder, Colorado kind of regional protection available): ARIPO (BW, GH, 80301 (US). COLLIER, James [US/US]; c/o Array Bio GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Pharma, Inc., 3200 Walnut St., Boulder, Colorado 80301 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (US). COOK, Adam [US/US]; c/o Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301 (US). HAAS, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Julia [[JS/US]; c/o Array BioPharma Inc., 3200 Wal- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, nut Street, Boulder, Colorado 80301 (US). JIANG, Yu- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, tong [US/US]; c/o Array BioPharma Inc., 3200 Walnut KM, ML, MR, NE, SN, TD, TG). Street, Boulder, Colorado 80301 (US). KOLAKOWSKI, Gabrielle R. [US/US]; c/o Array BioPharma Inc., 3200 Published: Walnut Street, Boulder, Colorado 80301 (US). MCFAD- — DIN, Elizabeth A. [US/US]; c/o Array BioPharma, Inc., with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) 3200 Walnut St., Boulder, Colorado 80301 (US). MCKEN- NEY, Megan L. [US/US]; c/o Array BioPharma, Inc., 3200 Walnut St., Boulder, Colorado 80301 (US). MCNULTY, Oren T. [US/US]; c/o Array BioPharma, Inc., 3200 Wal- nut St., Boulder, Colorado 80301 (US). METCALF, An- drew T. [US/US]; c/o Array BioPharma Inc., 3200 Wal- (54) Title: SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS (57) : Provided herein are compounds of the Formula I: (I) or pharmaceu- lin N i (Ra)„ tically acceptable salt or solvate thereof, wherein A, B, X 1 , X, X, X 2 3 4 , Ring D, E, 11' Il 1 X3=X2 R a , R b , n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which IN 0 p --.... / D ~X 4 _X~ d ca is rd n o b e e e tr rs . ated with a RET kinase inhibitor, including RET-associated diseases and X4-x1 B - O Il (Rb),„ © N I C
SG11201903187WA 2016-10-10 2017-10-10 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors SG11201903187WA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662406275P 2016-10-10 2016-10-10
US201762447849P 2017-01-18 2017-01-18
US201762491180P 2017-04-27 2017-04-27
US201762531690P 2017-07-12 2017-07-12
US201762566030P 2017-09-29 2017-09-29
PCT/US2017/055993 WO2018071454A1 (en) 2016-10-10 2017-10-10 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors

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SG11201903187WA true SG11201903187WA (en) 2019-05-30

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EP (2) EP4144735A1 (en)
JP (1) JP7075399B2 (en)
KR (1) KR102287752B1 (en)
CN (1) CN110177786B (en)
AU (1) AU2017342027B2 (en)
BR (1) BR112019007143A2 (en)
CA (1) CA3039912A1 (en)
CL (1) CL2019000942A1 (en)
CO (1) CO2019004649A2 (en)
CR (1) CR20190224A (en)
DK (1) DK3523302T3 (en)
DO (1) DOP2019000091A (en)
EC (1) ECSP19033052A (en)
ES (1) ES2926136T3 (en)
HR (1) HRP20221154T1 (en)
HU (1) HUE060089T2 (en)
IL (1) IL265918B (en)
JO (1) JOP20190077A1 (en)
LT (1) LT3523302T (en)
MD (1) MD3523302T2 (en)
MX (1) MX2019004204A (en)
PE (1) PE20191613A1 (en)
PH (1) PH12019500776A1 (en)
PL (1) PL3523302T3 (en)
PT (1) PT3523302T (en)
RS (1) RS63510B1 (en)
SA (1) SA519401544B1 (en)
SG (1) SG11201903187WA (en)
SI (1) SI3523302T1 (en)
TN (1) TN2019000107A1 (en)
TW (1) TWI752098B (en)
UA (1) UA125032C2 (en)
WO (1) WO2018071454A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3322706T3 (en) 2015-07-16 2021-07-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
PT3371171T (en) 2015-11-02 2024-01-24 Blueprint Medicines Corp Inhibitors of ret
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
WO2018091687A1 (en) * 2016-11-18 2018-05-24 Integrative Research Laboratories Sweden Ab Novel azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
WO2018136661A1 (en) 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
TWI802635B (en) 2018-01-18 2023-05-21 美商亞雷生物製藥股份有限公司 Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
TW201932464A (en) 2018-01-18 2019-08-16 美商亞雷生物製藥股份有限公司 Substituted pyrazolyl[4,3-C]pyridine compounds as RET kinase inhibitors
US11524963B2 (en) 2018-01-18 2022-12-13 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors
AU2019247766A1 (en) 2018-04-03 2020-10-15 Blueprint Medicines Corporation RET inhibitor for use in treating cancer having a RET alteration
ES2922314T3 (en) 2018-09-10 2022-09-13 Array Biopharma Inc Fused Heterocyclic Compounds as RET Kinase Inhibitors
US20220041588A1 (en) * 2018-09-27 2022-02-10 Fochon Pharmaceuticals, Ltd. Substituted imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine compounds as ret kinase inhibitors
KR102558308B1 (en) * 2018-09-27 2023-07-24 주식회사 엘지화학 3-azabicyclo[3,1,1]heptane derivatives and pharmaceutical composition comprising the same
JP2022508533A (en) * 2018-09-30 2022-01-19 北京志健金瑞生物医▲薬▼科技有限公司 Pyrazole-substituted condensed ring derivative and its production method and application
WO2020094084A1 (en) * 2018-11-07 2020-05-14 南京明德新药研发有限公司 Tricyclic derivative as ret inhibitor
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US20220135557A1 (en) * 2018-12-07 2022-05-05 Sunshine Lake Pharma Co., Ltd. Ret inhibitors, pharmaceutical compositions and uses thereof
AU2019394519A1 (en) * 2018-12-07 2021-05-20 Sunshine Lake Pharma Co., Ltd. RET inhibitors, pharmaceutical compositions and uses thereof
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN111808077B (en) 2019-04-12 2023-05-02 浙江海正药业股份有限公司 Piperazine amide derivatives, process for their preparation and their use in medicine
JP2022532758A (en) * 2019-05-14 2022-07-19 上▲海▼翰森生物医▲薬▼科技有限公司 Inhibitors containing bicyclic derivatives, their production methods and uses
US20220220128A1 (en) * 2019-06-10 2022-07-14 Js Innopharm (Shanghai) Ltd Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof
WO2021043209A1 (en) * 2019-09-04 2021-03-11 广东东阳光药业有限公司 Ret inhibitor, pharmaceutical composition and use thereof
CN112574235B (en) * 2019-09-29 2024-01-16 广东东阳光药业股份有限公司 RET inhibitor, pharmaceutical composition and application thereof
CN112574236A (en) * 2019-09-29 2021-03-30 广东东阳光药业有限公司 RET inhibitor, pharmaceutical composition and application thereof
CN112778337B (en) * 2019-11-08 2023-09-26 杭州邦顺制药有限公司 3, 6 diazabicyclo [3.1.1] heptane derivatives as RET kinase inhibitors
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
AU2020410900A1 (en) * 2019-12-27 2022-08-18 Tyk Medicines, Inc. Compound used as RET kinase inhibitor and application thereof
CN113121524B (en) * 2019-12-31 2023-04-25 南京创济生物医药有限公司 Heterocyclic sulfoxide imine compound, intermediate thereof, preparation method and application
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111285887B (en) * 2020-03-27 2020-11-17 苏州信诺维医药科技有限公司 Spiro compound
CN111269229B (en) * 2020-03-27 2021-02-12 苏州信诺维医药科技有限公司 Compound for treating cancer
CN111233899B (en) * 2020-03-27 2020-12-29 苏州信诺维医药科技有限公司 RET inhibitor
CN111410662B (en) * 2020-03-27 2020-12-29 苏州信诺维医药科技有限公司 Tyrosine kinase inhibitor
US20230234954A1 (en) * 2020-05-20 2023-07-27 Tyk Medicines, Inc. Compound used as ret kinase inhibitor and application thereof
KR20230107271A (en) * 2020-11-13 2023-07-14 상하이 한서 바이오메디컬 컴퍼니 리미티드 Crystal form of inhibitor free base including bicyclic derivatives, preparation method and use thereof
CA3234317A1 (en) 2021-10-22 2023-12-14 Wa Xian Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues
WO2024006841A2 (en) * 2022-06-29 2024-01-04 Knowledge Pharmaceuticals Inc. Compositions for weight loss and cancer treatment
WO2024027690A1 (en) * 2022-08-01 2024-02-08 江苏豪森药业集团有限公司 Intermediate of bicyclic inhibitor and preparation method therefor
WO2024030968A1 (en) * 2022-08-03 2024-02-08 Brystol-Myers Squibb Company Compounds for modulating ret protein

Family Cites Families (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US5844092A (en) 1994-03-18 1998-12-01 Genentech, Inc. Human TRK receptors and neurotrophic factor inhibitors
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
EA002544B1 (en) 1996-05-08 2002-06-27 Байоджен, Инк. Ret ligand (retl) for stimulating neutral and renal growth
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
US6682921B1 (en) 1996-08-21 2004-01-27 New York University Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
WO2001016169A2 (en) 1999-09-01 2001-03-08 Biogen, Inc. RET LIGAND 5 (Retl5) FROM HUMAN AND MOUSE
FI20000403A0 (en) 2000-02-22 2000-02-22 Hannu Sariola Use of GDNF family-related compounds for the preparation of testicular cancer treatment products
ATE446366T1 (en) 2000-06-22 2009-11-15 Genentech Inc AGONISTIC MONOCLONAL ANTIBODIES AGAINST TRKC
AU2002334355A1 (en) 2001-09-06 2003-03-18 Prochon Biotech Ltd. Protein tyrosine kinase inhibitors
PE20030762A1 (en) 2001-12-18 2003-09-05 Schering Corp HETEROCYCLIC COMPOUNDS AS NK1 ANTAGONISTS
US7466344B2 (en) 2002-06-07 2008-12-16 Scimeasure Analytical Systems, Inc. High-speed low noise CCD controller
ITMI20021620A1 (en) 2002-07-23 2004-01-23 Novuspharma Spa ANTI-TUMORAL ACTIVITY COMPOUND
BR0312873A (en) 2002-07-24 2005-06-28 Univ Cincinnati 4- (4-methylpiperazin-1-ylmethyl) -N- [4-methyl-3- (4-pyridin-3-yl) pyrimidin-2-ylamino) phenyl] benzamide for treating diseases associated with mutant retinase
ES2325440T3 (en) 2003-02-20 2009-09-04 Smithkline Beecham Corporation PIRIMIDINE COMPOUNDS.
US20090143399A1 (en) 2003-10-14 2009-06-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
US7169918B2 (en) 2003-10-27 2007-01-30 Genelabs Technologies, Inc. Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
CN1902200A (en) 2003-11-21 2007-01-24 诺瓦提斯公司 1h-imidazoquinoline derivatives as protein kinase inhibitors
US20080312192A1 (en) 2003-11-28 2008-12-18 Guido Bold Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases
EP1696920B8 (en) 2003-12-19 2015-05-06 Plexxikon Inc. Compounds and methods for development of ret modulators
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
WO2005068424A1 (en) 2004-01-20 2005-07-28 Cell Therapeutics Europe S.R.L. Indolinone derivatives as receptor tyrosine kinase ihibitors
US20050222171A1 (en) 2004-01-22 2005-10-06 Guido Bold Organic compounds
PE20051089A1 (en) 2004-01-22 2006-01-25 Novartis Ag PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
WO2005099363A2 (en) 2004-03-26 2005-10-27 Whitehead Institute For Biomedical Research Methods of diagnosing, preventing and treating cancer metastasis
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
US7465726B2 (en) 2004-08-02 2008-12-16 Osi Pharmaceuticals, Inc. Substituted pyrrolo[2.3-B]pyridines
PE20060664A1 (en) 2004-09-15 2006-08-04 Novartis Ag BICYCLE AMIDAS AS KINASE INHIBITORS
US7855205B2 (en) 2004-10-29 2010-12-21 Janssen Pharmaceutica Nv Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
EA012334B1 (en) 2004-12-17 2009-08-28 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Stilbene derivatives and their use for binding and imaging amyloid plaques
DE102005003687A1 (en) 2005-01-26 2006-07-27 Sphingo Tec Gmbh Immunodiagnostic determination of neurotensin in mammal blood, comprises injecting immune active N-terminal mammal proneurotensin in to the serum- or plasma- sample
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
WO2006089298A2 (en) 2005-02-18 2006-08-24 Attenuon, Llc Pyrimidine-fused diazepine derivatives and indole-fused pteridines
GB0507575D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
WO2006113509A2 (en) 2005-04-15 2006-10-26 Cylene Pharmaceuticals, Inc. Quinobenzoxazine analogs and methods of using thereof
EP1899323A2 (en) 2005-05-16 2008-03-19 AstraZeneca AB Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
US20100047777A1 (en) 2005-05-26 2010-02-25 The Johns Hopkins University Methods for identifying mutations in coding and non-coding dna
CA2650999A1 (en) 2005-05-31 2006-12-07 The Pfahl Family Trust (Dated 9 July 1996) Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases
WO2006130673A1 (en) 2005-05-31 2006-12-07 Janssen Pharmaceutica, N.V. 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
ITRM20050290A1 (en) 2005-06-07 2006-12-08 Lay Line Genomics Spa USE OF MOLECULES ABLE TO INHIBIT THE BOND BETWEEN NGF AND ITS TRKA RECEPTOR AS AN EXTENDED EFFECT ANALGESICS.
CN102603581B (en) 2005-06-22 2015-06-24 普莱希科公司 Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
GB0515026D0 (en) 2005-07-21 2005-08-31 Novartis Ag Organic compounds
EP1919979B2 (en) 2005-08-25 2017-03-29 Creabilis Therapeutics S.P.A. Polymer conjugates of k-252a and derivatives thereof
WO2007053776A1 (en) 2005-11-03 2007-05-10 Sgx Pharmaceuticals, Inc. Pyrimidinyl-thiophene kinase modulators
US20070149523A1 (en) 2005-11-14 2007-06-28 Jan Ehlert Thiazole Analogues and Uses Thereof
EP1785420A1 (en) 2005-11-14 2007-05-16 4Sc Ag Thiazole analogues and uses thereof
WO2007057399A2 (en) 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer with indole derivatives
WO2007057397A1 (en) 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer
GB0524436D0 (en) 2005-11-30 2006-01-11 Novartis Ag Organic compounds
RU2008127263A (en) 2005-12-08 2010-01-20 Новартис АГ (CH) Pyrazole [1,5-a] Pyridine-3-Carboxylic Acids As Inhibitors of EphB-and VEGFR2-Kinase
US8399442B2 (en) 2005-12-30 2013-03-19 Astex Therapeutics Limited Pharmaceutical compounds
EP1978958A4 (en) 2006-01-24 2009-12-02 Merck & Co Inc Ret tyrosine kinase inhibition
WO2007085188A1 (en) 2006-01-27 2007-08-02 Shanghai Hengrui Pharmaceutical Co. Ltd. Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors
US20090069360A1 (en) 2006-03-16 2009-03-12 David Bryant Batt Organic Compounds
KR101549364B1 (en) 2006-03-17 2015-09-01 암비트 바이오사이언시즈 코포레이션 Imidazolothiazole compounds for the treatment of disease
EA015126B1 (en) 2006-03-27 2011-06-30 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
MX2008014618A (en) 2006-05-15 2008-11-28 Irm Llc Compositions and methods for fgf receptor kinases inhibitors.
CA2652442C (en) 2006-05-18 2014-12-09 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
US8063225B2 (en) 2006-08-14 2011-11-22 Chembridge Corporation Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
US20110195072A1 (en) 2006-09-12 2011-08-11 Anne Boulay Non-neuroendocrine cancer therapy
AU2007294686B2 (en) 2006-09-15 2013-10-31 Equinox Sciences, Llc Kinase inhibitor compounds
US20120225057A1 (en) 2006-10-11 2012-09-06 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
EP1918291A1 (en) 2006-10-30 2008-05-07 Novartis AG 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
US8461161B2 (en) 2006-11-15 2013-06-11 Ym Biosciences Australia Pty Ltd Substituted pyrazines as inhibitors of kinase activity
CL2007003627A1 (en) * 2006-12-15 2008-07-25 Bayer Schering Pharma Ag COMPOUNDS DERIVED FROM 3-H-PIRAZOLOPIRIDINAS; PREPARATION METHOD; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT OF DECREGULATED VASCULAR GROWTH DISEASES SUCH AS ACUTE MYELOGEN LEUKEMIA, RETINOPATIA, REUMATOID ARTHRITIS, PSORIAS
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (en) 2006-12-21 2008-11-12 Plexxikon Inc PIRROLO [2,3-b] PYRIDINES COMPOUNDS AS KINASE MODULATORS
WO2008080001A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
US20080199426A1 (en) 2007-01-11 2008-08-21 Sukhatme Vikas P Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders
JP2010516692A (en) 2007-01-19 2010-05-20 バイエル・ヘルスケア・エルエルシー Treatment of cancer resistant to chemotherapeutic agents
US20080234267A1 (en) 2007-03-20 2008-09-25 Karen Elizabeth Lackey Compounds and Methods of Treatment
US20110189167A1 (en) * 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
EP2152688A1 (en) 2007-05-04 2010-02-17 Irm Llc Compounds and compositions as c-kit and pdgfr kinase inhibitors
WO2008138184A1 (en) 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Derivatives of pyrroloazacycles, the method of making them and the use thereof as inhibitors of protein kinases
WO2009003136A1 (en) 2007-06-26 2008-12-31 Rigel Pharmaceuticals, Inc. Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders
AR067478A1 (en) 2007-07-09 2009-10-14 Astrazeneca Ab COMPOUNDS DERIVED FROM MORPHOLINE PYRIMIDINE
US20100209488A1 (en) 2007-07-16 2010-08-19 The Regents Of The University Of California Protein kinase modulating compounds and methods for making and using them
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
JP5241834B2 (en) 2007-07-19 2013-07-17 メルク・シャープ・アンド・ドーム・コーポレーション Heterocyclic amide compounds as protein kinase inhibitors
CN103923072B (en) 2007-07-20 2017-05-31 内尔维阿诺医学科学有限公司 As the substituted indazole derivative with kinase inhibitory activity
WO2009017838A2 (en) 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
WO2009021137A2 (en) 2007-08-07 2009-02-12 Purdue Research Foundation Kinase inhibitors and uses thereof
EP2025678A1 (en) 2007-08-17 2009-02-18 Oncalis AG Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase
WO2009042646A1 (en) 2007-09-24 2009-04-02 Curis, Inc. Anti-proliferative agents
US20100297115A1 (en) 2007-10-23 2010-11-25 Novartis Ag Use of trkb antibodies for the treatment of respiratory disorders
EP2215091B1 (en) 2007-12-04 2016-03-30 Nerviano Medical Sciences S.r.l. Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
CN101459004B (en) 2007-12-14 2011-02-09 深圳富泰宏精密工业有限公司 Press-key panel construction for electronic device and method for manufacturing the press-key panel construction
CN102015769B (en) 2008-01-17 2014-12-10 Irm责任有限公司 Improved anti-TRKB antibodies
US20090227556A1 (en) 2008-01-31 2009-09-10 Eisai R&D Management Co., Ltd. Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives
TW200942537A (en) 2008-02-01 2009-10-16 Irm Llc Compounds and compositions as kinase inhibitors
US20090209496A1 (en) 2008-02-15 2009-08-20 David Chaplin Methods and compositions for enhancing the efficacy of rtk inhibitors
WO2009117097A1 (en) 2008-03-19 2009-09-24 Chembridge Corporation Novel tyrosine kinase inhibitors
US8207165B2 (en) 2008-03-28 2012-06-26 Nerviano Medical Sciences S.R.L. 3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2009143018A2 (en) 2008-05-19 2009-11-26 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20091846A1 (en) 2008-05-19 2009-12-16 Plexxikon Inc PIRROLO [2,3-d] -PYRIMIDINE DERIVATIVES AS KINE MODULATORS
CN102036963B (en) 2008-05-23 2013-08-21 诺瓦提斯公司 Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
WO2009152083A1 (en) 2008-06-10 2009-12-17 Plexxikon, Inc. 5h-pyrr0l0 [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor
WO2009155527A2 (en) 2008-06-19 2009-12-23 Progenics Pharmaceuticals, Inc. Phosphatidylinositol 3 kinase inhibitors
CA2730190A1 (en) 2008-07-14 2010-01-21 Queen's University At Kingston Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer
JO3041B1 (en) * 2008-07-25 2016-09-05 Galapagos Nv Novel compounds useful for the treatment of degenerative and inflammatory diseases
CN102105151B (en) 2008-07-29 2013-12-18 内尔维阿诺医学科学有限公司 Use of CDK inhibitor for treatment of glioma
KR101246656B1 (en) 2008-09-01 2013-03-25 샤프 가부시키가이샤 Organic electroluminescence panel, organic electroluminescence display, organic electroluminescence illumination and method for manufacturing such panel, display and illumination
WO2010028254A2 (en) 2008-09-05 2010-03-11 Auspek Pharmaceuticals, Inc. Substituted quinazoline inhibitors of growth factor receptor tyrosine kinases
EP2161271A1 (en) 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
ES2536730T3 (en) 2008-09-19 2015-05-28 Nerviano Medical Sciences S.R.L. 3,4-Dihydro-2H-pyrrolo [1,2-a] pyrazin-1-one derivatives
PT2350075E (en) 2008-09-22 2014-06-09 Array Biopharma Inc Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
CN102232071B (en) 2008-09-26 2016-03-23 财团法人卫生研究院 As the fused-polycyclic compounds of kinases inhibitor
SG10201914059WA (en) 2008-10-22 2020-03-30 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
WO2010054058A1 (en) 2008-11-06 2010-05-14 Ambit Bioscience Corporation Imidazolothiazole compounds as modulators of protein kinase
EP2376084B1 (en) 2008-11-24 2013-07-17 Nerviano Medical Sciences S.r.l. CDK inhibitor for the treatment of mesothelioma
KR101061599B1 (en) 2008-12-05 2011-09-02 한국과학기술연구원 Novel indazole derivatives that are protein kinase inhibitors for the treatment of abnormal cell growth diseases, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same as active ingredients
JO3265B1 (en) 2008-12-09 2018-09-16 Novartis Ag Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease
EP2408454A2 (en) * 2009-03-18 2012-01-25 Resverlogix Corp. Novel anti-inflammatory agents
WO2010111527A1 (en) 2009-03-26 2010-09-30 Plexxikon, Inc. Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
US8492374B2 (en) 2009-04-29 2013-07-23 Industrial Technology Research Institute Azaazulene compounds
PL2428508T3 (en) 2009-05-08 2016-05-31 Astellas Pharma Inc Diamino heterocyclic carboxamide compound
WO2010144909A1 (en) 2009-06-12 2010-12-16 Novartis Ag Fused heterocyclic compounds and their uses
EP3045457B1 (en) 2009-06-15 2018-05-09 Nerviano Medical Sciences S.r.l. Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
JP5819831B2 (en) 2009-08-17 2015-11-24 インテリカイン， エルエルシー Heterocyclic compounds and their use
KR101256018B1 (en) 2009-08-20 2013-04-18 한국과학기술연구원 1,3,6-Substituted indole derivatives having inhibitory activity for protein kinase
FR2951172B1 (en) 2009-10-13 2014-09-26 Pf Medicament PYRAZOLOPYRIDINE DERIVATIVES AS ANTI-CANCER AGENT
KR101147550B1 (en) 2009-10-22 2012-05-17 한국과학기술연구원 2,7-Substituted thieno[3,2-d]pyrimidine compounds as protein kinase inhibitors
KR101116756B1 (en) 2009-10-27 2012-03-13 한국과학기술연구원 Novel 1,6-disubstituted indole compounds as protein kinase inhibitors
CA2779105C (en) 2009-10-29 2016-08-16 Hong Woo Kim Kinase inhibitors
CA2780892C (en) 2009-11-13 2017-02-14 Genosco Kinase inhibitors
KR101094446B1 (en) 2009-11-19 2011-12-15 한국과학기술연구원 2,4,7-Substituted thieno[3,2-d]pyrimidine compounds as protein kinase inhibitors
CA2784807C (en) 2009-12-29 2021-12-14 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
CN102725296B (en) 2010-01-29 2015-04-01 韩美科学株式会社 Thieno[3,2-d]pyrimidine derivatives having inhibitory activity on protein kinases
US8772279B2 (en) 2010-01-29 2014-07-08 Nerviano Medical Sciences S.R.L. 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators
KR101483215B1 (en) 2010-01-29 2015-01-16 한미약품 주식회사 Bicyclic heteroaryl derivatives having inhibitory activity for protein kinases
JP2013519706A (en) 2010-02-18 2013-05-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Methods for preventing cancer metastasis
TWI619713B (en) 2010-04-21 2018-04-01 普雷辛肯公司 Compounds and methods for kinase modulation, and indications therefor
MX365251B (en) 2010-05-20 2019-05-28 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors.
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012037155A2 (en) 2010-09-13 2012-03-22 Gtx, Inc. Tyrosine kinase inhibitors
WO2012047017A2 (en) 2010-10-05 2012-04-12 크리스탈지노믹스(주) 2,3-dihydro-isoindol-1-one derivative and a composition comprising the same
JP2014005206A (en) 2010-10-22 2014-01-16 Astellas Pharma Inc Arylamino heterocyclic carboxamide compound
CN103339134B (en) 2011-01-26 2015-12-23 内尔维阿诺医学科学有限公司 Tricyclic azole derivative, their preparation method and they are as the application of kinase inhibitor
US8916577B2 (en) 2011-01-26 2014-12-23 Nerviano Medical Sciences S.R.L. Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
CN102093421B (en) 2011-01-28 2014-07-02 北京康辰药业有限公司 Phosphorus substituent group-containing quinoline compound and preparation method of quinoline compound as well as pharmaceutical composition containing quinoline compound and application of pharmaceutical composition
MA34948B1 (en) 2011-02-07 2014-03-01 Plexxikon Inc COMPOUNDS AND METHODS FOR MODULATING KINASE, AND INDICATIONS THEREOF
ES2580961T3 (en) 2011-02-24 2016-08-30 Nerviano Medical Sciences S.R.L. Thiazolylphenyl benzenesulfonamido derivatives as Kinase Inhibitors
BR112013021638A2 (en) 2011-02-25 2016-08-02 Irm Llc "trk inhibiting compounds, their use and compositions comprising them"
US8791112B2 (en) 2011-03-30 2014-07-29 Arrien Pharmaceuticals Llc Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
WO2012135800A1 (en) 2011-04-01 2012-10-04 University Of Utah Research Foundation Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
US9284298B2 (en) 2011-04-11 2016-03-15 Nerviano Medical Sciences S.R.L. Pyrazolyl-pyrimidine derivatives as kinase inhibitors
BR112013026137B1 (en) 2011-04-19 2020-12-01 Nerviano Medical Sciences S.R.L substituted pyrimidinyl-pyrroles as kinase inhibitors
AR086042A1 (en) * 2011-04-28 2013-11-13 Galapagos Nv USEFUL COMPOUND FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES AND PHARMACEUTICAL COMPOSITION
EP2707359B1 (en) 2011-05-12 2016-11-30 Nerviano Medical Sciences S.r.l. Substituted indazole derivatives active as kinase inhibitors
JP5933902B2 (en) 2011-05-13 2016-06-15 アレイ バイオファーマ、インコーポレイテッド Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors
RU2477723C2 (en) 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Protein kinase inhibitor (versions), use thereof for treating oncological diseases and based pharmaceutical composition
CN102827073A (en) * 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
EP2736514B1 (en) 2011-07-28 2017-10-18 Nerviano Medical Sciences S.r.l. Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors
WO2013016720A2 (en) 2011-07-28 2013-01-31 Gerinda Therapeutics, Inc. Novel substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases
CN103764676A (en) 2011-08-04 2014-04-30 日本国立癌症研究中心 Fusion gene of KIF5B gene and RET gene, and method for determining effectiveness of cancer treatment targeting fusion gene
DK2748192T3 (en) 2011-08-23 2019-02-25 Found Medicine Inc KIF5B-RET-FUSION MOLECULES AND APPLICATIONS THEREOF
JP6342805B2 (en) 2011-09-02 2018-06-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Substituted pyrazolo [3,4-D] pyrimidine and uses thereof
WO2013036232A2 (en) 2011-09-08 2013-03-14 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
CN102408411B (en) 2011-09-19 2014-10-22 北京康辰药业股份有限公司 Hydroximic acid compound containing quinolyl and preparation method thereof, and drug composition containing the compound and use thereof
JP5998223B2 (en) 2011-10-07 2016-09-28 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Substituted 3,4-dihydropyrrolo [1,2-a] pyrazin-1 (2H) -one derivatives as kinase inhibitors
JP6063945B2 (en) 2011-10-07 2017-01-18 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 4-alkyl-substituted 3,4-dihydropyrrolo [1,2-a] pyrazin-1 (2H) -one derivatives as kinase inhibitors
US20150306086A1 (en) 2011-11-14 2015-10-29 Tesaro, Inc. Modulating certain tyrosine kinases
US20140137274A1 (en) 2011-11-30 2014-05-15 Lsip, Llc Induced malignant stem cells
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
RS59420B1 (en) 2011-12-30 2019-11-29 Hanmi Pharmaceutical Co Ltd Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases
JP2015109806A (en) 2012-03-22 2015-06-18 アステラス製薬株式会社 Method for detecting new ret fused body
US9242977B2 (en) 2012-04-26 2016-01-26 Ono Pharmaceutical Co., Ltd. Trk-inhibiting compound
JP2015516439A (en) 2012-05-10 2015-06-11 シンタ ファーマシューティカルズ コーポレーション Treating cancer with Hsp90-inhibiting compounds
BR112014028841B1 (en) 2012-05-23 2021-01-12 Nerviano Medical Sciences S.R.L. CRYSTALLINE FORMS 1 AND 2, PHARMACEUTICAL COMPOSITION, USE OF CRYSTALLINE 1 FOR THE TREATMENT OF A DISEASE STATABLE BY ALK INHIBITION AND PROCESS FOR THE PREPARATION OF N- [5- (3,5-DIFLUORO-BENZIL) -1H- INDAZOL-3-IL] -4- (4-METHYLPIPERAZIN-1-IL) -2- (TETRA-HYDRO-PYRAN-4-ILAMINE) - BENZAMIDE
TWI585088B (en) 2012-06-04 2017-06-01 第一三共股份有限公司 Imidazo[1,2-b]pyridazine analogues as kinase inhibitors
KR102163776B1 (en) 2012-07-11 2020-10-12 블루프린트 메디신즈 코포레이션 Inhibitors of the fibroblast growth factor receptor
CN109024018B (en) 2012-07-13 2021-10-08 奥的斯电梯公司 Belt comprising fibers
JPWO2014017491A1 (en) 2012-07-26 2016-07-11 国立研究開発法人国立がん研究センター Fusion gene of CEP55 gene and RET gene
JP6276762B2 (en) 2012-08-02 2018-02-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Substituted pyrroles active as kinase inhibitors
EP2892532B1 (en) 2012-09-07 2019-02-13 Exelixis, Inc. Inhibitors of met, vegfr and ret for use in the treatment of lung adenocarcinoma
CA3077553C (en) 2012-09-25 2022-08-02 Chugai Seiyaku Kabushiki Kaisha Ret inhibitor
CN108047219A (en) 2012-11-07 2018-05-18 内尔维阿诺医学科学有限公司 Substituted pyrimidine radicals and Pyridylpyrrole and pyridinone, its preparation method and its purposes as kinase inhibitor
TWI598341B (en) 2012-11-12 2017-09-11 伊格尼塔公司 Bendamustine derivatives and methods of using same
US9981959B2 (en) 2012-11-13 2018-05-29 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078378A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078372A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078325A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078328A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078417A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
UA117573C2 (en) 2012-11-13 2018-08-27 Ерей Біофарма Інк. Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
CN107857755B (en) 2012-11-13 2020-10-27 阵列生物制药公司 N-pyrrolidinyl, N' -pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TRKA kinase inhibitors
US20150290233A1 (en) 2012-11-29 2015-10-15 Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
CN103848785B (en) 2012-12-04 2016-07-13 上海医药集团股份有限公司 One class deuterated 3-cyano quinoline compound, its Pharmaceutical composition, preparation method and its usage
FR3000494B1 (en) 2012-12-28 2015-08-21 Oribase Pharma NOVEL AZAINDOLE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES
FR3000492B1 (en) 2012-12-28 2015-09-11 Oribase Pharma NOVEL AZAINDOLE DERIVATIVES AS MULTIKINASE INHIBITORS
FR3000493A1 (en) 2012-12-28 2014-07-04 Oribase Pharma NEW INHIBITORS OF PROTEIN KINASES
AU2013371146C1 (en) 2012-12-28 2019-01-17 Crystalgenomics, Inc. 2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
AU2014219855B2 (en) 2013-02-19 2017-09-28 Ono Pharmaceutical Co., Ltd. Trk-inhibiting compound
WO2014160524A1 (en) 2013-03-14 2014-10-02 The Trustees Of The University Of Pennsylvania Cardio- metabolic and cascular effects of glp-1 metabolites
AR095308A1 (en) 2013-03-15 2015-10-07 Glaxosmithkline Ip Dev Ltd COMPOSITE OF 2-PIRIDONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A MEDICINAL PRODUCT
WO2014160521A1 (en) 2013-03-15 2014-10-02 Blueprint Medicines Corporation Piperazine derivatives and their use as kit modulators
SI2970191T1 (en) 2013-03-15 2017-04-26 GlaxoSmithKline International Property Development Limited Pyridine derivatives as rearranged during transfection (ret) kinase inhibitors
US9682083B2 (en) 2013-05-14 2017-06-20 Nerviano Medical Sciences S.R.L. Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
CA2912568A1 (en) 2013-05-30 2014-12-04 Plexxikon Inc. Compounds for kinase modulation, and indications therefor
US10407509B2 (en) 2013-07-30 2019-09-10 Blueprint Medicines Corporation NTRK2 fusions
WO2015017528A1 (en) 2013-07-30 2015-02-05 Blueprint Medicines Corporation Pik3c2g fusions
WO2015025866A1 (en) 2013-08-20 2015-02-26 独立行政法人国立がん研究センター New fusion gene detected in lung cancer
CN105683182A (en) 2013-08-30 2016-06-15 埃姆比特生物科学公司 Biaryl acetamide compounds and methods of use thereof
EP3053923B1 (en) * 2013-09-30 2018-04-11 Korea Research Institute of Chemical Technology Triazolopyrazine derivatives as tyrosin kinase inhibitors
WO2015058129A1 (en) 2013-10-17 2015-04-23 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
CN105658652B (en) 2013-10-17 2019-04-12 蓝图药品公司 It can be used for treating the composition of illness relevant to KIT
PL3395814T3 (en) 2013-10-25 2022-08-22 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
GB201321146D0 (en) 2013-11-29 2014-01-15 Cancer Rec Tech Ltd Quinazoline compounds
US9801880B2 (en) 2013-12-02 2017-10-31 Bergenbio As Use of kinase inhibitors
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
US9714258B2 (en) 2014-01-24 2017-07-25 Tp Therapeutics, Inc. Diaryl macrocycles as modulators of protein kinases
AU2015218236B2 (en) 2014-02-14 2019-06-13 Exelixis, Inc. Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use
TWI672141B (en) 2014-02-20 2019-09-21 美商醫科泰生技 Molecules for administration to ros1 mutant cancer cells
EP3132056B1 (en) 2014-04-18 2021-11-24 Blueprint Medicines Corporation Pik3ca fusions
WO2015161277A1 (en) 2014-04-18 2015-10-22 Blueprint Medicines Corporation Met fusions
RS59286B1 (en) 2014-05-15 2019-10-31 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
WO2015191666A2 (en) 2014-06-10 2015-12-17 Blueprint Medicines Corporation Raf1 fusions
WO2015191667A1 (en) 2014-06-10 2015-12-17 Blueprint Medicines Corporation Pkn1 fusions
EP3169809B1 (en) 2014-07-17 2020-04-29 Blueprint Medicines Corporation Prkc fusions
WO2016011144A1 (en) 2014-07-17 2016-01-21 Blueprint Medicines Corporation Tert fusions
US10370725B2 (en) 2014-07-17 2019-08-06 Blueprint Medicines Corporation FGR fusions
KR102485100B1 (en) 2014-07-17 2023-01-04 선샤인 레이크 파르마 컴퍼니 리미티드 Substituted urea derivatives and pharmaceutical uses thereof
US9688680B2 (en) 2014-08-04 2017-06-27 Blueprint Medicines Corporation Compositions useful for treating disorders related to kit
PL3184519T3 (en) 2014-08-18 2019-09-30 Ono Pharmaceutical Co., Ltd. Acid-addition salt of trk-inhibiting compound
WO2016038519A1 (en) 2014-09-08 2016-03-17 Glaxosmithkline Intellectual Property Development Limited Crystalline forms of 2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-n-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide
EP3191449B1 (en) 2014-09-10 2020-07-01 GlaxoSmithKline Intellectual Property Development Limited Compounds as rearranged during transfection (ret) inhibitors
MY181913A (en) 2014-09-10 2021-01-14 Glaxosmithkline Ip Dev Ltd Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors
TWI538914B (en) 2014-10-03 2016-06-21 國立交通大學 Selective inhibitors for protein kinases, a pharmaceutical composition and an use thereof
PL3218378T3 (en) 2014-11-14 2020-10-19 Nerviano Medical Sciences S.R.L. 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
CN113354649A (en) 2014-11-16 2021-09-07 阵列生物制药公司 Novel crystal form
EP3221700B1 (en) 2014-11-18 2022-06-22 Blueprint Medicines Corporation Prkacb fusions
US10336707B2 (en) 2014-12-16 2019-07-02 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
US10202365B2 (en) 2015-02-06 2019-02-12 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
KR101675984B1 (en) 2015-02-23 2016-11-14 한양대학교 에리카산학협력단 Thienodiazepine derivatives or pharmaceutically acceptable salt thereof, and pharmaceutical composition comprising the same as an active ingredient
EP3265079A4 (en) 2015-03-03 2019-01-02 Caris MPI, Inc. Molecular profiling for cancer
CN108137593B (en) 2015-04-21 2021-01-05 上海交通大学医学院附属瑞金医院 Preparation and use of protein kinase inhibitors
GB201512365D0 (en) 2015-07-15 2015-08-19 King S College London Novel therapy
PL3322706T3 (en) 2015-07-16 2021-07-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
EP3120851A1 (en) 2015-07-21 2017-01-25 Pangaea Biotech S.L. 4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8h)-one for treatment of solid cancers
KR101766194B1 (en) 2015-08-07 2017-08-10 한국과학기술연구원 Novel 3-(isoxazol-3-yl)-pyrazolo[3,4-d]pyrimidin-4-amine compounds as RET kinase inhibitor
US10550124B2 (en) 2015-08-13 2020-02-04 San Diego State University Foundation Atropisomerism for increased kinase inhibitor selectivity
MA41559A (en) 2015-09-08 2017-12-26 Taiho Pharmaceutical Co Ltd CONDENSED PYRIMIDINE COMPOUND OR A SALT THEREOF
WO2017049462A1 (en) 2015-09-22 2017-03-30 合肥中科普瑞昇生物医药科技有限公司 Novel flt3 kinase inhibitor and uses thereof
CN105255927B (en) 2015-09-30 2018-07-27 温州医科大学附属第一医院 A kind of KIAA1217-RET fusions
PT3371171T (en) 2015-11-02 2024-01-24 Blueprint Medicines Corp Inhibitors of ret
US20190002988A1 (en) 2015-12-08 2019-01-03 Boehringer Ingelheim International Gmbh Method of using a ret fusion gene as a biomarker to select non small cell lung cancer (nsclc) and thyroid cancer patients for a cancer treatment
JP6871869B2 (en) 2016-01-15 2021-05-19 公益財団法人がん研究会 New fusion and its detection method
TWI620748B (en) 2016-02-05 2018-04-11 National Health Research Institutes Aminothiazole compounds and use thereof
WO2017145050A1 (en) 2016-02-23 2017-08-31 Glaxosmithkline Intellectual Property Development Limited Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer
HUE049228T2 (en) 2016-02-23 2020-09-28 Taiho Pharmaceutical Co Ltd Novel condensed pyrimidine compound or salt thereof
WO2017161269A1 (en) 2016-03-17 2017-09-21 Blueprint Medicines Corporation Inhibitors of ret receptor tyrosine kinases
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
EP3442980B1 (en) 2016-04-15 2021-06-09 Cancer Research Technology Limited Heterocyclic compounds as ret kinase inhibitors
PL3442535T3 (en) 2016-04-15 2022-10-24 Cancer Research Technology Limited Heterocyclic compounds as ret kinase inhibitors
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors

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