PE20051089A1 - PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS - Google Patents

PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Info

Publication number
PE20051089A1
PE20051089A1 PE2005000080A PE2005000080A PE20051089A1 PE 20051089 A1 PE20051089 A1 PE 20051089A1 PE 2005000080 A PE2005000080 A PE 2005000080A PE 2005000080 A PE2005000080 A PE 2005000080A PE 20051089 A1 PE20051089 A1 PE 20051089A1
Authority
PE
Peru
Prior art keywords
phenyl
pyrimidin
piperazin
methyl
pyrazole
Prior art date
Application number
PE2005000080A
Other languages
Spanish (es)
Inventor
Guido Bold
Andreas Floersheimer
Pascal Furet
Patricia Imbach
Keiichi Masuya
Joseph Schoepfer
Georg Martiny-Baron
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34807167&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20051089(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20051089A1 publication Critical patent/PE20051089A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOLO [1,5-a] PIRIMIDIN-7-IL-AMINA DE FORMULA (I), EN DONDE R1 ES H, HALOGENO O ALQUILO INFERIOR; R2 ES H, ARILO, HETEROARILO, ALQUILO INFERIOR, CICLOALQUILO, BENCILO, BENZOTIENILO, INDOLILO ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO INFERIOR, OPCIONALMENTE SUSTITUIDOS; A ES H, HALOGENO, BENZOTIENILO, PIRIDILO, FENILO, PIPERAZINILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: 3-{7-AMINO-3-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO-[1,5-A]-PIPRIMIDIN-6-IL}-FENOL, 6-(3-BENCILOXI-FENIL)-3-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO[1,5-A]PIRIMIDIN-7-IL)-FENOL, 6-(3-METOXI-FENIL)-4-[4-(4-METIL-PIPERAZIN-1-IL)-FENIL]-PIRAZOLO[1,5-A]PIRIMIDIN-7-IL-AMINA, ENTRE OTROS. SE REFIERE A UNA COMPOSICION Y UN PROCESO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA DE DIFERENTES GRADOS DE ESPECIFICIDAD, POR LO QUE SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS TALES COMO TUMOR BENIGNO O MALIGNOREFERS TO COMPOUNDS DERIVED FROM PYRAZOLO [1,5-a] PYRIMIDIN-7-IL-AMINE OF FORMULA (I), WHERE R1 IS H, HALOGEN OR LOWER ALKYL; R2 IS H, ARYL, HETEROARYL, LOWER ALKYL, CYCLOALKYL, BENZYL, BENZOTHENYL, INDOLYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED; R3 IS H, LOWER RENT, OPTIONALLY REPLACED; A IS H, HALOGEN, BENZOTHENYL, PYRIDYL, PHENYL, PIPERAZINYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED. PREFERRED COMPOUNDS ARE: 3- {7-AMINO-3- [4- (4-METHYL-PIPERAZIN-1-IL) -PHENYL] -PIRAZOLO- [1,5-A] -PIPRIMIDIN-6-IL} -PHENOL, 6- (3-BENZYLOXY-PHENYL) -3- [4- (4-METHYL-PIPERAZIN-1-IL) -PHENYL] -PYRAZOLO [1,5-A] PYRIMIDIN-7-IL) -PHENOL, 6- ( 3-METHOXY-PHENYL) -4- [4- (4-METHYL-PIPERAZIN-1-IL) -PHENYL] -PIRAZOLO [1,5-A] PYRIMIDIN-7-IL-AMINE, AMONG OTHERS. IT REFERS TO A COMPOSITION AND A PREPARATION PROCESS. THESE COMPOUNDS ARE INHIBITORS OF KINASE OF DIFFERENT DEGREES OF SPECIFICITY, SO THEY ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS BENIGN OR MALIGNANT TUMOR

PE2005000080A 2004-01-22 2005-01-20 PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS PE20051089A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53822004P 2004-01-22 2004-01-22

Publications (1)

Publication Number Publication Date
PE20051089A1 true PE20051089A1 (en) 2006-01-25

Family

ID=34807167

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000080A PE20051089A1 (en) 2004-01-22 2005-01-20 PYRAZOLE [1,5-A] PYRIMIDIN-7-IL-AMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Country Status (17)

Country Link
EP (1) EP1708710A1 (en)
JP (1) JP2007519662A (en)
KR (1) KR20070009546A (en)
CN (1) CN1909908A (en)
AR (1) AR049769A1 (en)
AU (1) AU2005205915B2 (en)
BR (1) BRPI0507071A (en)
CA (1) CA2552885A1 (en)
EC (1) ECSP066718A (en)
IL (1) IL176737A0 (en)
MA (1) MA28400B1 (en)
NO (1) NO20063758L (en)
PE (1) PE20051089A1 (en)
RU (1) RU2006130003A (en)
TN (1) TNSN06226A1 (en)
TW (1) TW200528103A (en)
WO (1) WO2005070431A1 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7605155B2 (en) * 2002-09-04 2009-10-20 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7563798B2 (en) * 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7196078B2 (en) 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
GB0515026D0 (en) * 2005-07-21 2005-08-31 Novartis Ag Organic compounds
WO2007041712A1 (en) 2005-10-06 2007-04-12 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
JP5152922B2 (en) * 2005-10-06 2013-02-27 メルク・シャープ・アンド・ドーム・コーポレーション Use of pyrazolo [1,5-A] pyrimidine derivatives to inhibit protein kinases and methods for inhibiting protein kinases
DK1973545T3 (en) 2005-12-23 2013-02-25 Ariad Pharma Inc Bicyclic heteroaryl compounds
RU2008139560A (en) * 2006-03-08 2010-04-20 Новартис АГ (CH) APPLICATION OF PYRAZOLO [1,5a] PYRIMIDIN-7-ILAMINE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL DISORDERS
WO2007109183A2 (en) * 2006-03-20 2007-09-27 Novartis Ag Mutations and polymorphisms of fms-related tyrosine kinase 1
GB0606804D0 (en) * 2006-04-04 2006-05-17 Novartis Ag Organic Compounds
GB0606805D0 (en) * 2006-04-04 2006-05-17 Novartis Ag Organic compounds
US20100029636A1 (en) * 2006-09-28 2010-02-04 Peter Buehlmayer Lck inhibitors
US20090286779A1 (en) 2006-09-29 2009-11-19 Novartis Ag Pyrazolopyrimidines as lipid kinase inhibitors
EP1918291A1 (en) * 2006-10-30 2008-05-07 Novartis AG 3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators
CA2689667A1 (en) * 2007-06-07 2008-12-18 Schering Corporation Synthesis of substituted-3-aminopyrazoles
WO2010118207A1 (en) 2009-04-09 2010-10-14 Schering Corporation Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors
WO2011041152A1 (en) 2009-09-30 2011-04-07 Schering Corporation Novel compounds that are erk inhibitors
UY33227A (en) * 2010-02-19 2011-09-30 Novartis Ag PIRROLOPIRIMIDINE COMPOUNDS AS INHIBITORS OF THE CDK4 / 6
RU2594742C2 (en) 2010-05-20 2016-08-20 Эррэй Биофарма Инк. Macrocyclic compounds as trk kinase inhibitors
EP2604606B1 (en) * 2010-08-09 2014-10-08 Pharmadesign, Inc. Inhibitor of casein kinase 1delta and casein kinase 1epsilon
WO2012023143A1 (en) 2010-08-19 2012-02-23 E. I. Du Pont De Nemours And Company Fungicidal pyrazoles
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
KR101404151B1 (en) * 2011-11-25 2014-06-05 가톨릭대학교 산학협력단 Composition for preventing and treating ocular diseases
CN105906630B (en) * 2015-04-06 2018-10-23 四川百利药业有限责任公司 Two substitutional amine-group compounds of N- (1H- pyrazoles -5- bases) pyrimido pyrazoles -4,6- as FGFR inhibitor
MX2018000577A (en) 2015-07-16 2018-09-05 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors.
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
CN106588893A (en) * 2016-12-01 2017-04-26 北京万全德众医药生物技术有限公司 Preparation of vilazodone double oxide
JP6888101B2 (en) 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド Substituted pyrazolo [1,5-a] pyrazine compounds as RET kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
TWI791053B (en) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 Crystalline forms of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile and pharmaceutical composition thereof
TWI812649B (en) 2017-10-10 2023-08-21 美商絡速藥業公司 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CN111615514B (en) 2018-01-18 2022-10-11 奥瑞生物药品公司 Substituted pyrazolo [4,3-C ] pyridine compounds as RET kinase inhibitors
JP7060694B2 (en) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Substituted pyrolo [2,3-D] pyrimidine compounds as RET kinase inhibitors
CN111630054B (en) 2018-01-18 2023-05-09 奥瑞生物药品公司 Substituted pyrazolo [3,4-d ] pyrimidine compounds as RET kinase inhibitors
US10988477B2 (en) * 2018-01-29 2021-04-27 Merck Patent Gmbh GCN2 inhibitors and uses thereof
JP2022500383A (en) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Condensed heterocyclic compound as a RET kinase inhibitor
CN109836428A (en) * 2019-02-27 2019-06-04 华东师范大学 Pyrazoles [4,3-d] pyrimidine derivatives and purposes with immunosuppressive activity
EP3996736A4 (en) * 2019-07-10 2023-05-24 Musc Foundation for Research Development Endostatin peptides for the treatment of tumors, fibrosis and acute lung injury
CR20220308A (en) 2019-11-25 2022-08-04 Amgen Inc Heterocyclic compounds as delta-5 desaturase inhibitors and methods of use
TW202337433A (en) * 2022-02-08 2023-10-01 美商德洛斯股份有限公司 Compositions and methods for use in the treatment of cancer and other indications
CN114751910B (en) * 2022-05-17 2023-02-24 重庆文理学院 Compound capable of inducing cell megalophage death and preparation method and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130633A1 (en) * 1981-08-01 1983-02-17 Basf Ag, 6700 Ludwigshafen 7-AMINO-AZOLO (1,5-A) PYRIMIDINE AND FUNGICIDES CONTAINING THEM
WO1992018504A1 (en) * 1991-04-22 1992-10-29 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME
JP3163413B2 (en) * 1994-06-21 2001-05-08 株式会社大塚製薬工場 Painkillers
PT714898E (en) * 1994-06-21 2002-04-29 Otsuka Pharma Co Ltd PYRAZOLONE-1,5-A | PYRIMIDINE DERIVATIVES
WO1998010590A1 (en) * 1996-09-02 1998-03-12 Sony Corporation Device and method for transmitting video signal
EP1545533A1 (en) * 2002-09-04 2005-06-29 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP1534710B1 (en) * 2002-09-04 2007-10-24 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors

Also Published As

Publication number Publication date
JP2007519662A (en) 2007-07-19
ECSP066718A (en) 2006-10-31
CN1909908A (en) 2007-02-07
NO20063758L (en) 2006-10-23
IL176737A0 (en) 2006-10-31
RU2006130003A (en) 2008-04-10
AU2005205915A1 (en) 2005-08-04
CA2552885A1 (en) 2005-08-04
WO2005070431A1 (en) 2005-08-04
AU2005205915B2 (en) 2009-05-21
TW200528103A (en) 2005-09-01
BRPI0507071A (en) 2007-06-19
KR20070009546A (en) 2007-01-18
TNSN06226A1 (en) 2007-12-03
MA28400B1 (en) 2007-01-02
AR049769A1 (en) 2006-09-06
EP1708710A1 (en) 2006-10-11

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