SG11201811554SA - Antisense oligonucleotides for modulating htra1 expression - Google Patents

Antisense oligonucleotides for modulating htra1 expression

Info

Publication number
SG11201811554SA
SG11201811554SA SG11201811554SA SG11201811554SA SG11201811554SA SG 11201811554S A SG11201811554S A SG 11201811554SA SG 11201811554S A SG11201811554S A SG 11201811554SA SG 11201811554S A SG11201811554S A SG 11201811554SA SG 11201811554S A SG11201811554S A SG 11201811554SA
Authority
SG
Singapore
Prior art keywords
roche
fremtidsvej
international
horsholm
copenhagen
Prior art date
Application number
SG11201811554SA
Inventor
Roberto Iacone
Peter Hagedorn
Susanne Kammler
Søren Ottosen
Sindri Traustason
Heidi Hudlebusch
Lykke Pedersen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201811554SA publication Critical patent/SG11201811554SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 IIIIIIIII101111101001H0111010111111111111110111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/002105 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C12N 15/113 (2010.01) A61P 27/02 (2006.01) kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/EP2017/065937 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (22) International Filing Date: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 28 June 2017 (28.06.2017) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Published: (30) Priority Data: — with international search report (Art. 21(3)) 16177508.5 01 July 2016 (01.07.2016) EP — with sequence listing part of description (Rule 5.2(a)) 17170129.5 09 May 2017 (09.05.2017) EP (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). — = Inventors: IACONE, Roberto; c/o F. Hoffmann-La Roche (72) AG, Grenzacherstrasse 124, 4070 Basel (CH). HAGE- = DORN, Peter; c/o Roche Innovation Center Copenhagen _ A/S, Fremtidsvej 3, 2970 Horsholm (DK). KAMMLER, Susanne; c/o Roche Innovation Center Copenhagen A/S, Fremtidsvej 3,2970 Horsholm (DK). OTTOSEN, Soren; c/ = o Roche Innovation Center Copenhagen A/S, Fremtidsvej 3, 2970 Horsholm (DK). TRAUSTASON, Sindri; c/o Roche = _= Innovation Center Copenhagen A/S, Fremtidsvej 3, 2970 Horsholm (DK). HUDLEBUSCH, Heidi; c/o Roche limo- vation Center Copenhagen A/S, Fremtidsvej 3, 2970 flor- sholm (DK). PEDERSEN, Lykke; c/o Roche Innovation Center Copenhagen A/S, Fremtidsvej 3, 2970 Horsholm = = — = (DK). — _ Agent: TURNER, Mark; Grenzacherstrasse 124, 4070 (74) Basel (CH). = Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, — CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = — 1-1 kr) 0 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 N i © © CO\" (54) Title: ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION 1-1 0 (57) : The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading N i to modulation of the expression of HTRA1. Modulation of HTRA expression is beneficial for a range of medical disorders, such as 0 macular degeneration, e.g. age-related macular degeneration.
SG11201811554SA 2016-07-01 2017-06-28 Antisense oligonucleotides for modulating htra1 expression SG11201811554SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16177508 2016-07-01
EP17170129 2017-05-09
PCT/EP2017/065937 WO2018002105A1 (en) 2016-07-01 2017-06-28 Antisense oligonucleotides for modulating htra1 expression

Publications (1)

Publication Number Publication Date
SG11201811554SA true SG11201811554SA (en) 2019-01-30

Family

ID=59295175

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202005885VA SG10202005885VA (en) 2016-07-01 2017-06-28 Antisense oligonucleotides for modulating htra1 expression
SG11201811554SA SG11201811554SA (en) 2016-07-01 2017-06-28 Antisense oligonucleotides for modulating htra1 expression

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202005885VA SG10202005885VA (en) 2016-07-01 2017-06-28 Antisense oligonucleotides for modulating htra1 expression

Country Status (21)

Country Link
US (2) US10519450B2 (en)
EP (1) EP3478839A1 (en)
JP (3) JP7060525B2 (en)
KR (1) KR20190025970A (en)
CN (1) CN109415732B (en)
AU (1) AU2017289204A1 (en)
BR (1) BR112018077321A2 (en)
CA (1) CA3026855A1 (en)
CL (1) CL2018003698A1 (en)
CO (1) CO2018013240A2 (en)
CR (1) CR20180606A (en)
IL (1) IL263489A (en)
MA (1) MA45620A (en)
MX (1) MX2018015722A (en)
PE (1) PE20190381A1 (en)
PH (1) PH12018502707A1 (en)
RU (1) RU2019101298A (en)
SG (2) SG10202005885VA (en)
TW (1) TW201803990A (en)
WO (1) WO2018002105A1 (en)
ZA (1) ZA201808291B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201990069A1 (en) 2016-06-21 2019-06-28 ОРИОН ОФТАЛМОЛОДЖИ ЭлЭлСи DERIVATIVES OF HETEROCYCLIC PROLINAMIDE
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives
US10519450B2 (en) 2016-07-01 2019-12-31 Hoffmann-La Roche Inc. Antisense oligonucleotides for modulating HTRA1 expression
MX2020006430A (en) 2017-12-22 2020-09-17 Roche Innovation Ct Copenhagen As Oligonucleotides comprising a phosphorodithioate internucleoside linkage.
WO2019122277A1 (en) 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Novel thiophosphoramidites
TW201934750A (en) 2017-12-22 2019-09-01 丹麥商羅氏創新中心哥本哈根有限公司 GAPMER oligonucleotides comprising a phosphorodithioate internucleoside linkage
US11332733B2 (en) 2018-02-12 2022-05-17 lonis Pharmaceuticals, Inc. Modified compounds and uses thereof
WO2020007772A1 (en) * 2018-07-02 2020-01-09 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides targeting gbp-1
WO2020109344A1 (en) * 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Occular administration device for antisense oligonucleotides
WO2020109343A1 (en) * 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (en) 1997-03-07 2006-03-15 武 今西 Novel bicyclonucleosides and oligonucleotide analogues
DE04020014T1 (en) 1997-09-12 2006-01-26 Exiqon A/S Bi-cyclic - nucleoside, nucleotide and oligonucleotide analogs
AU5290499A (en) 1998-08-03 2000-02-28 Novartis Ag Human htra serine protease
EP1152009B2 (en) 1999-02-12 2017-09-06 Daiichi Sankyo Company, Limited Novel nucleosides and oligonucleotide analogues
NZ514348A (en) 1999-05-04 2004-05-28 Exiqon As L-ribo-LNA analogues
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
EP2141233B1 (en) 2002-11-18 2016-10-19 Roche Innovation Center Copenhagen A/S Antisense design
CA2609180A1 (en) 2005-05-24 2006-11-30 Isis Pharmaceuticals, Inc. Modulation of lmw-ptpase expression
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
KR20130042043A (en) 2006-01-27 2013-04-25 아이시스 파마수티컬즈 인코포레이티드 6-modified bicyclic nucleic acid analogs
WO2007134181A2 (en) 2006-05-11 2007-11-22 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
JP2009544317A (en) 2006-07-26 2009-12-17 イェール ユニバーシティー Diagnosis and treatment of age-related macular degeneration
US20100166743A1 (en) 2006-10-06 2010-07-01 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
WO2008094370A2 (en) * 2006-12-22 2008-08-07 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
US8278425B2 (en) 2007-05-30 2012-10-02 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
ES2386492T3 (en) 2007-06-08 2012-08-21 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
TW200911290A (en) 2007-07-02 2009-03-16 Alcon Res Ltd RNAI-mediated inhibition of HTRA1 for treatment of macular degeneration
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US20100330097A1 (en) 2007-11-01 2010-12-30 Hageman Gregory S Predicting amd with snps within or near c2, factor b, plekha1, htra1, prelp, or loc387715
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
DK2356129T3 (en) 2008-09-24 2013-05-13 Isis Pharmaceuticals Inc Substituted alpha-L bicyclic nucleosides
EP2462153B1 (en) 2009-08-06 2015-07-29 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
WO2011156202A1 (en) 2010-06-08 2011-12-15 Isis Pharmaceuticals, Inc. Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
FR2965278B1 (en) 2010-09-23 2014-10-10 Univ Caen Basse Normandie PROCESS FOR IN VITRO OR EX VIVO PRODUCTION OF CHONDROCYTES AND USES THEREOF
KR20140067092A (en) 2011-09-07 2014-06-03 마리나 바이오테크, 인크. Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
EP2850092B1 (en) 2012-04-09 2017-03-01 Ionis Pharmaceuticals, Inc. Tricyclic nucleic acid analogs
JP2016522674A (en) 2012-05-16 2016-08-04 ラナ セラピューティクス インコーポレイテッド Compositions and methods for regulating gene expression
CN104837996A (en) 2012-11-15 2015-08-12 罗氏创新中心哥本哈根有限公司 Anti APOB antisense conjugate compounds
CA3001362C (en) 2015-10-30 2020-10-13 Genentech, Inc. Anti-htra1 antibodies and methods of use thereof
US10519450B2 (en) 2016-07-01 2019-12-31 Hoffmann-La Roche Inc. Antisense oligonucleotides for modulating HTRA1 expression
WO2018087200A1 (en) 2016-11-11 2018-05-17 Roche Innovation Center Copenhagen A/S Therapeutic oligonucleotides capture and detection
US20190055564A1 (en) 2017-06-01 2019-02-21 F. Hoffmann-La Roche Ag Antisense oligonucleotides for modulating htra1 expression

Also Published As

Publication number Publication date
JP7416852B2 (en) 2024-01-17
CR20180606A (en) 2019-02-14
US20200399641A1 (en) 2020-12-24
CN109415732A (en) 2019-03-01
CO2018013240A2 (en) 2018-12-14
JP7060525B2 (en) 2022-04-26
TW201803990A (en) 2018-02-01
JP2019522987A (en) 2019-08-22
EP3478839A1 (en) 2019-05-08
AU2017289204A1 (en) 2019-01-17
CL2018003698A1 (en) 2019-04-05
RU2019101298A (en) 2020-08-03
US10519450B2 (en) 2019-12-31
RU2019101298A3 (en) 2021-01-26
JP2024029178A (en) 2024-03-05
JP2022106785A (en) 2022-07-20
SG10202005885VA (en) 2020-07-29
CN109415732B (en) 2024-01-02
BR112018077321A2 (en) 2019-04-24
ZA201808291B (en) 2019-10-30
PH12018502707A1 (en) 2019-11-11
KR20190025970A (en) 2019-03-12
MX2018015722A (en) 2019-05-27
US20180002701A1 (en) 2018-01-04
PE20190381A1 (en) 2019-03-08
MA45620A (en) 2019-05-08
CA3026855A1 (en) 2018-01-04
WO2018002105A1 (en) 2018-01-04
IL263489A (en) 2019-01-31

Similar Documents

Publication Publication Date Title
SG11201811554SA (en) Antisense oligonucleotides for modulating htra1 expression
SG11201809912UA (en) Hybrid carriers for nucleic acid cargo
SG11201901206SA (en) Trimer stabilizing hiv envelope protein mutations
SG11201811431VA (en) Multispecific antibodies against cd40 and cd137
SG11201807912SA (en) Vaccine against rsv
SG11201811432WA (en) Rna for cancer therapy
SG11201808622SA (en) Chimeric receptors to flt3 and methods of use thereof
SG11201909777YA (en) Modulatory polynucleotides
SG11201906297QA (en) Nucleic acids encoding crispr-associated proteins and uses thereof
SG11201909955XA (en) Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies
SG11201907298WA (en) Methods and compositions for gene transfer across the vasculature
SG11201807573VA (en) Methods for providing single-stranded rna
SG11201908813QA (en) Anti-sirp alpha antibodies
SG11201811338VA (en) A novel botulinum neurotoxin and its derivatives
SG11201805835WA (en) Modified oncolytic virus
SG11201906763RA (en) Pyrrolo [1,2-b] pyridazine derivatives
SG11201804729RA (en) Methods and compositions for treating a serpinc1-associated disorder
SG11201909011PA (en) Niraparib compositions
SG11201808693WA (en) Anti-il-33 antibodies, compositions, methods and uses thereof
SG11201901996UA (en) Formulations of ( r)-2-amino-3-phenylpropyl carbamate
SG11201804704PA (en) Compositions and methods for decreasing tau expression
SG11202000333UA (en) Bicyclic ketone compounds and methods of use thereof
SG11202000312UA (en) Encapsulated polynucleotides and methods of use
SG11201803918VA (en) Production of steviol glycosides in recombinant hosts
SG11201900021PA (en) Methods and compositions for the treatment of cancer