SG11201811329UA - Spheroids including biologically-relevant materials and related methods - Google Patents
Spheroids including biologically-relevant materials and related methodsInfo
- Publication number
- SG11201811329UA SG11201811329UA SG11201811329UA SG11201811329UA SG11201811329UA SG 11201811329U A SG11201811329U A SG 11201811329UA SG 11201811329U A SG11201811329U A SG 11201811329UA SG 11201811329U A SG11201811329U A SG 11201811329UA SG 11201811329U A SG11201811329U A SG 11201811329UA
- Authority
- SG
- Singapore
- Prior art keywords
- louisville
- kentucky
- suite
- international
- university
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11011110111010101111101 110100111101111110011101110 111111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/005477 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: search Foundation, Inc., 300 East Market Street, Suite 300, A61L 27/52 (2006.01) C08J 3/24 (2006.01) Louisville, Kentucky 40202 (US). A61L 27/54 (2006.01) A61K 35/12 (2015.01) (74) Agent: WRIGHT, Terry L. et al.; c/o Stites & Harbi- A61L 27/56 (2006.01) A61K 35/39 (2015.01) A61L 27/24 (2006.01) C12N 5/0735 (2010.01) son, PLLC, 400 West Market Street, Suite 1800, Louisville, Kentucky 40202 (US). (21) International Application Number: PCT/US2017/039483 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 27 June 2017 (27.06.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/354,929 27 June 2016 (27.06.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/422,694 16 November 2016 (16.11.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: UNIVERSITY OF LOUISVILLE (84) Designated States (unless otherwise indicated, for every RESEARCH FOUNDATION, INC. [US/US]; 300 East kind of regional protection available): ARIPO (BW, GH, Market Street, Suite 300, Louisville, Kentucky 40202-1959 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Inventors: WILLIAMS, Stuart K.; c/o University of TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Louisville Research Foundation, Inc., 300 East Market EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Street, Suite 300, Louisville, Kentucky 40202 (US). GET- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (72) = — TLER, Brian C.; c/o University of Louisville Research TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Foundation, Inc., 300 East Market Street, Suite 300, KM, ML, MR, NE, SN, TD, TG). = Louisville, Kentucky 40202 (US). ZAKHARI, Joseph S.; c/o University of Louisville Research Foundation, Inc., 300 = East Market Street, Suite 300, Louisville, Kentucky 40202 _= = (US). GANDHI, Piyani S.; c/o University of Louisville Re- = Title: SPHEROIDS INCLUDING BIOLOGICALLY-RELEVANT MATERIALS AND RELATED METHODS = (54) = = Spheroid = = = = Pluronic = = Super Hydrophobic .4 \ , S U rf ac e IN IN 7r k r) FIG. ID 0 0 . a ' — c . (57) : A method of making a spheroid is provided that includes the step of providing a suspension having one or more bio- logically-relevant materials dispersed within a biocompatible medium. An amount of a hydrophilic material is deposited on a defined 0 area of a super-hydrophobic surface, and a droplet of the suspension is bioprinted onto the hydrophilic material positioned on the su- ei per-hydrophobic to thereby create the spheroid. [Continued on next page] WO 2018/005477 Al OII Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the earlier application (Rule 4.17(iii)) priority of the Published: — with international search report (Art. 21(3))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662354929P | 2016-06-27 | 2016-06-27 | |
US201662422694P | 2016-11-16 | 2016-11-16 | |
PCT/US2017/039483 WO2018005477A1 (en) | 2016-06-27 | 2017-06-27 | Spheroids including biologically-relevant materials and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201811329UA true SG11201811329UA (en) | 2019-01-30 |
Family
ID=60785530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811329UA SG11201811329UA (en) | 2016-06-27 | 2017-06-27 | Spheroids including biologically-relevant materials and related methods |
Country Status (9)
Country | Link |
---|---|
US (1) | US11419962B2 (en) |
EP (1) | EP3474914A4 (en) |
JP (1) | JP6875670B2 (en) |
KR (1) | KR102446764B1 (en) |
CN (1) | CN109906092A (en) |
AU (1) | AU2017290569B2 (en) |
CA (1) | CA3028736A1 (en) |
SG (1) | SG11201811329UA (en) |
WO (1) | WO2018005477A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108715833B (en) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | Preparation method of microsphere loaded with platelet lysate |
KR102489607B1 (en) * | 2018-10-24 | 2023-01-17 | 포항공과대학교 산학협력단 | Method of manufacturing cell spheroid using three-dimensional printing method |
CN109569344B (en) * | 2018-12-17 | 2021-01-08 | 浙江大学 | Method for preparing suspended micro-droplets by using micro-fluidic device |
KR102156310B1 (en) * | 2019-03-06 | 2020-09-15 | 울산과학기술원 | A method for manufacturing cell spheroid using bio-ink |
CN110004111B (en) * | 2019-04-22 | 2021-10-08 | 清华-伯克利深圳学院筹备办公室 | Preparation method of organoid sphere |
KR102201546B1 (en) * | 2020-03-27 | 2021-01-11 | 가톨릭대학교 산학협력단 | Acellular dermal matrix layer for living transplant loaded with cells and method for preparing same |
WO2024015237A1 (en) * | 2022-07-12 | 2024-01-18 | University Of Louisville Research Foundation, Inc. | 3-d bioprinting comprising biologically-relevant materials and related methods |
CN115518193A (en) * | 2022-09-23 | 2022-12-27 | 青岛大学 | Fish skin collagen/SVF photo-crosslinking composite hydrogel and preparation method and application thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US4963489A (en) | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
DK0671923T3 (en) | 1992-10-09 | 2001-08-13 | Advanced Tissue Sciences Inc | Liver reserve cells |
US6284503B1 (en) * | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
JP5583312B2 (en) | 2007-02-20 | 2014-09-03 | 富士フイルム株式会社 | Tissue formation substrate, tissue formation kit, tissue formation method using the same, and three-dimensional tissue formed by the tissue formation method |
KR101207841B1 (en) * | 2010-10-05 | 2012-12-04 | 한국과학기술원 | Method for fabrication of microparticles with superhydrophobic surface structures and coating them on substrates |
JP2013542728A (en) | 2010-10-21 | 2013-11-28 | オルガノボ,インク. | Devices, systems, and methods for creating an organization |
CN102070788B (en) * | 2010-11-17 | 2013-09-11 | 无锡中科光远生物材料有限公司 | Bionic method for preparing hydrogel |
KR101909328B1 (en) * | 2012-07-27 | 2018-10-17 | 가부시키가이샤 지씨 | Tissue regeneration construct, and method for producing tissue regeneration construct |
CN103087086B (en) * | 2013-01-15 | 2015-12-02 | 中国科学院化学研究所 | Organic-inorganic hybrid molecule and preparation method thereof with preparing the application in super-hydrophobic coat |
WO2015027086A1 (en) * | 2013-08-21 | 2015-02-26 | University Of Louisville Research Foundation, Inc. | Methods of making spheroids including biologically-relevant materials |
KR20150029280A (en) * | 2013-09-10 | 2015-03-18 | (주)안트로젠 | Autologous and allogenic adipose tissue-derived mesenchymal stem cells composition for treatment of diabetic wound |
US11903612B2 (en) * | 2013-11-04 | 2024-02-20 | University Of Iowa Research Foundation | Bioprinter and methods of using same |
KR101555239B1 (en) * | 2014-10-21 | 2015-09-25 | 연세대학교 산학협력단 | Method of forming cell spheroids and apparatus of forming cell spheroids |
CN104970003A (en) * | 2015-06-30 | 2015-10-14 | 徐小杨 | Cell droplet rapid vitrification freeze-thawing carrier and method |
-
2017
- 2017-06-27 CN CN201780050308.9A patent/CN109906092A/en active Pending
- 2017-06-27 AU AU2017290569A patent/AU2017290569B2/en active Active
- 2017-06-27 WO PCT/US2017/039483 patent/WO2018005477A1/en unknown
- 2017-06-27 CA CA3028736A patent/CA3028736A1/en active Pending
- 2017-06-27 US US16/312,042 patent/US11419962B2/en active Active
- 2017-06-27 SG SG11201811329UA patent/SG11201811329UA/en unknown
- 2017-06-27 JP JP2018567666A patent/JP6875670B2/en active Active
- 2017-06-27 KR KR1020197002641A patent/KR102446764B1/en active IP Right Grant
- 2017-06-27 EP EP17821071.2A patent/EP3474914A4/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11419962B2 (en) | 2022-08-23 |
AU2017290569B2 (en) | 2022-01-20 |
US20190381213A1 (en) | 2019-12-19 |
KR102446764B1 (en) | 2022-09-22 |
EP3474914A1 (en) | 2019-05-01 |
JP2019520824A (en) | 2019-07-25 |
WO2018005477A1 (en) | 2018-01-04 |
AU2017290569A1 (en) | 2019-01-17 |
CN109906092A (en) | 2019-06-18 |
KR20190022790A (en) | 2019-03-06 |
JP6875670B2 (en) | 2021-05-26 |
EP3474914A4 (en) | 2020-01-15 |
CA3028736A1 (en) | 2018-01-04 |
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