SG11201806018YA - Protein cage-stabilized pickering emulsions and the use thereof - Google Patents

Protein cage-stabilized pickering emulsions and the use thereof

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Publication number
SG11201806018YA
SG11201806018YA SG11201806018YA SG11201806018YA SG11201806018YA SG 11201806018Y A SG11201806018Y A SG 11201806018YA SG 11201806018Y A SG11201806018Y A SG 11201806018YA SG 11201806018Y A SG11201806018Y A SG 11201806018YA SG 11201806018Y A SG11201806018Y A SG 11201806018YA
Authority
SG
Singapore
Prior art keywords
protein
international
nanyang
singapore
agent
Prior art date
Application number
SG11201806018YA
Inventor
Sierin Lim
Miridul Sarker
Nikodem Tomczak
Original Assignee
Univ Nanyang Tech
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nanyang Tech, Agency Science Tech & Res filed Critical Univ Nanyang Tech
Publication of SG11201806018YA publication Critical patent/SG11201806018YA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/33—Free of surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 11111 011101110111011011110011011111011 III 11 International Bureau 0.. ..... ..Yi jd (10) International Publication Number ...... ......:;,/ (43) International Publication Date WO 2017/123160 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 8/06 (2006.01) A61K 47/42 (2017.01) kind of national protection available): AE, AG, AL, AM, A61K 9/107 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/SG2017/050020 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 16 January 2017 (16.01.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 10201600290W 14 January 2016 (14.01.2016) SG (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: NANYANG TECHNOLOGICAL UNI- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, VERSITY [SG/SG]; 50 Nanyang Avenue, Singapore TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 639798 (SG). AGENCY FOR SCIENCE, TECHNO- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, LOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, #20-10, Connexis, Singapore 138632 (SG). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: LIM, Sierin; c/o Nanyang Technological Uni- — versity, 50 Nanyang Avenue, Singapore 639798 (SG). GW, KM, ML, MR, NE, SN, TD, TG). — SARKER, Miridul; c/o Nanyang _ Technological Univer- Published: = sity, 50 Nanyang Avenue, Singapore 639798 (SG). TOM- — with international search report (Art. 21(3)) for Science, Technology Way, #20-10, Connexis, — with sequence listing part of description (Rule 5.2(a)) CZAK, Nikodem; c/o Agency = And Research, 1 Fusionopolis Singapore 138632 (SG). = (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; Office, Rochor Road, Singa- . P.O Box 1088, Rochor Post pore 911833 (SG). PICKERING EMULSIONS AND THE USE THEREOF (54) Title: PROTEIN CAGE-STABILIZED 11 = — _ Figure = 1 = nm = 25 = ,.,b., . structure of E2 Protein cage Aqueou Crystallograhic 1-1 *1! with loaded cargo Phase 0 it Hydrophobic Moiecule Schematic diagram of E2 protein Hydrophilic Molecule cage-stabilized Pickering emulsion 1-1 cr) r‘l 1-1 It-- ._, (57) : The present invention relates to a Pickering emulsion comprising an aqueous phase, an oil phase and a nanoparticle, ::::; wherein the nanoparticle is a protein cage. The protein cage is preferably a Bacillus stearothermophilus E2 protein of pyruvate de- e , ' hydrogenase multi-enzyme complex or an E2LC2 protein. Preferably the aqueous or oil phase of the Pickering emulsion com prises 0 an agent, or the protein cage is coupled to or loaded with an agent, wherein the agent is a therapeutic, nutritional, nutraceutical or cosmetic agent. The invention further includes use of the Pickering emulsions disclosed herein in pharmaceutical, cosmetic, or food applications, or as a controlled release delivery system, and use of protein cages as emulsifiers in Pickering emulsions.
SG11201806018YA 2016-01-14 2017-01-16 Protein cage-stabilized pickering emulsions and the use thereof SG11201806018YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201600290W 2016-01-14
PCT/SG2017/050020 WO2017123160A1 (en) 2016-01-14 2017-01-16 Protein cage-stabilized pickering emulsions and the use thereof

Publications (1)

Publication Number Publication Date
SG11201806018YA true SG11201806018YA (en) 2018-08-30

Family

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SG10201912690PA SG10201912690PA (en) 2016-01-14 2017-01-16 Protein cage-stabilized pickering emulsions and the use thereof
SG11201806018YA SG11201806018YA (en) 2016-01-14 2017-01-16 Protein cage-stabilized pickering emulsions and the use thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201912690PA SG10201912690PA (en) 2016-01-14 2017-01-16 Protein cage-stabilized pickering emulsions and the use thereof

Country Status (6)

Country Link
US (1) US20190008972A1 (en)
EP (1) EP3402457A4 (en)
KR (1) KR20180102158A (en)
IL (1) IL293762A (en)
SG (2) SG10201912690PA (en)
WO (1) WO2017123160A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020007885A1 (en) * 2018-07-02 2020-01-09 Naturex S.A. Emulsion comprising antioxidant particles
CN109679114B (en) * 2018-12-12 2021-06-04 青岛古高生物科技有限公司 Preparation method and application of Pickering emulsion with stable protein nanocages
CN110101084B (en) * 2019-04-04 2023-02-10 华南理工大学 Algae oil nano pickering emulsion and oil powder stabilized by yolk protein peptide particles as well as preparation method and application thereof
CN110218341A (en) * 2019-05-15 2019-09-10 大连工业大学 A kind of preparation method for the Pickering High Internal Phase Emulsion that casein is stable
CN110218340A (en) * 2019-05-15 2019-09-10 大连工业大学 A kind of method that ultrasonic wave added casein solution forms phase cream in height
CN110786517A (en) * 2019-11-12 2020-02-14 上海海洋大学 Euphausia superba protein Pickering emulsion and preparation method thereof
EP4103160A1 (en) * 2020-02-13 2022-12-21 ETH Zurich Nanoparticles encapsulating small molecules
CN111713564B (en) * 2020-04-17 2023-01-24 天津科技大学 Collagen-based artificial edible solid fat and preparation method thereof
CN111631385A (en) * 2020-06-17 2020-09-08 武汉轻工大学 Curcumin-loaded Pickering emulsion and preparation method thereof
CN111760074A (en) * 2020-07-17 2020-10-13 华南农业大学 Preparation method of lignin-chitosan porous scaffold material
CN112617200A (en) * 2020-12-09 2021-04-09 集美大学 Preparation method of fish oil gel
CN113292984B (en) * 2021-06-22 2023-02-03 东营施普瑞石油工程技术有限公司 With CO 2 Pickering emulsion of/double-response surfactant and preparation method thereof
CN114540045B (en) * 2022-01-26 2022-10-28 中国科学院兰州化学物理研究所 Preparation method of plant essential oil O/W type Pickering emulsion
CN115812840A (en) * 2022-12-05 2023-03-21 河北农业大学 Preparation method and application of almond protein stable high internal phase emulsion
CN116426038B (en) * 2023-04-06 2023-10-17 江南大学 Synergistically stable starch-based pickering emulsion and application thereof in medicine and food fields
CN117426465A (en) * 2023-12-20 2024-01-23 中国农业大学 Method for regulating and controlling cage type protein embedding and improving anthocyanin stability by utilizing ultrahigh pressure technology

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6285951B2 (en) * 2012-12-13 2018-02-28 ネステク ソシエテ アノニム Emulsions stabilized by whey protein micelles
US20150335704A1 (en) * 2014-05-23 2015-11-26 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions comprising gels and methods for fabricating thereof
CN104013955B (en) * 2014-06-18 2016-02-24 中国科学院过程工程研究所 A kind of not containing O/w emulsion and uses thereof of surfactant

Also Published As

Publication number Publication date
EP3402457A1 (en) 2018-11-21
US20190008972A1 (en) 2019-01-10
EP3402457A4 (en) 2019-10-09
KR20180102158A (en) 2018-09-14
SG10201912690PA (en) 2020-03-30
IL293762A (en) 2022-08-01
WO2017123160A1 (en) 2017-07-20

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