SG11201810633WA - New fluorescent dyes and their uses as biomarkers - Google Patents
New fluorescent dyes and their uses as biomarkersInfo
- Publication number
- SG11201810633WA SG11201810633WA SG11201810633WA SG11201810633WA SG11201810633WA SG 11201810633W A SG11201810633W A SG 11201810633WA SG 11201810633W A SG11201810633W A SG 11201810633WA SG 11201810633W A SG11201810633W A SG 11201810633WA SG 11201810633W A SG11201810633W A SG 11201810633WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- ffc
- chesterford
- pct
- essex
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves
- C09B62/02—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring
- C09B62/36—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring to some other heterocyclic ring
- C09B62/365—Specific dyes not provided for in groups C09B62/38 - C09B62/42
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1088—Heterocyclic compounds characterised by ligands containing oxygen as the only heteroatom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Luminescent Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 Ill 11111 0 11101 HOE HI 1 0 0111011001111111101011 MEV OEN Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2018/060482 Al 05 April 2018 (05.04.2018) WIP0 I PCT (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) Applicant: (72) Inventor: ROMANOV, Nikolai; International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 417/04 (2006.01) A61K 49/10 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 491/04 (2006.01) CO9K 11/06 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/EP2017/074880 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 29 September 2017 (29.09.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Priority Data: (84) Designated States (unless otherwise indicated, for every 62/402,635 30 September 2016 (30.09.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ILLUMINA CAMBRIDGE LIMITED UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, [GB/GB]; Chesterford Research Park, Little Chesterford, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Nr. Saffron Walden Essex CB10 1XL (GB). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, c/o Illumina Cambridge MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Limited, Chesterford Research Park, Little Chesterford, Nr. TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Saffron Walden Essex CB10 1XL (GB). KM, ML, MR, NE, SN, TD, TG). Agent: MURGITROYD & COMPANY; Scotland House, Declarations under Rule 4.17: 165-169 Scotland Street, Glasgow Strathclyde G5 8PL _ as to applicant's entitlement to apply for and be granted a (GB). patent (Rule 4.1700) (74) = = = = D O V , CD °, Z n 0 1 —i 0 0 a c. , 0 .., m0 C/ ) n r r l Fluorescen Inte t ns ity ( Ar bitrary Un it) g Z n = H co 2, R ( o DYES AND THEIR USES AS BIOMARKERS / R ) R N g i R3 0 0 N I R2 R 4 (I) labels. The compounds may be (54) = = = = = = 1 © © -.... 1-1 N (57) _ used 250 200 150 100 50 0 -• r • 0 \ \ . . ill 11. \ \\ / 4 1 \ .\\ i / 0 \\ \ \\ / \ . • 6 1 4 \\ \.\\ \ \ \‘• \ \ • \ s \• \\\,'• — ffc-star440sx — — ffc-1-9 -- ffc-I-10 --- ffc-1-6 ---- ffc-1-1 470 520 570 620 670 720 770 Wavelength (nm) \" 171c 1 relates to new fluorescent dyes and their uses as fluorescent in nucleic acid sequencing applications. [Continued on next page] WO 2018/060482 Al 11111111111111011101010111110111010111110110011111111111101011111110110111111 Published: — with international search report (Art. 21(3))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402635P | 2016-09-30 | 2016-09-30 | |
| PCT/EP2017/074880 WO2018060482A1 (en) | 2016-09-30 | 2017-09-29 | New fluorescent dyes and their uses as biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810633WA true SG11201810633WA (en) | 2018-12-28 |
Family
ID=60268333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810633WA SG11201810633WA (en) | 2016-09-30 | 2017-09-29 | New fluorescent dyes and their uses as biomarkers |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10385214B2 (en) |
| EP (2) | EP3519410B1 (en) |
| JP (2) | JP7002478B2 (en) |
| KR (2) | KR102582172B1 (en) |
| CN (1) | CN109476654B (en) |
| AU (2) | AU2017335223B2 (en) |
| CA (1) | CA3026019C (en) |
| ES (1) | ES2914688T3 (en) |
| IL (2) | IL297749A (en) |
| SG (1) | SG11201810633WA (en) |
| WO (1) | WO2018060482A1 (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
| GB201716931D0 (en) * | 2017-10-16 | 2017-11-29 | Illumina Cambridge Ltd | New fluorescent compounds and their use as biomarkers |
| WO2020010495A1 (en) * | 2018-07-09 | 2020-01-16 | 深圳华大智造极创科技有限公司 | Method for nucleic acid sequencing |
| CA3103900A1 (en) | 2019-03-01 | 2020-09-10 | Illumina Cambridge Limited | Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels |
| WO2020178231A1 (en) | 2019-03-01 | 2020-09-10 | Illumina, Inc. | Multiplexed fluorescent detection of analytes |
| MX2020013416A (en) * | 2019-03-01 | 2021-04-28 | Illumina Cambridge Ltd | Tertiary amine substituted coumarin compounds and their uses as fluorescent labels. |
| NL2023327B1 (en) * | 2019-03-01 | 2020-09-17 | Illumina Inc | Multiplexed fluorescent detection of analytes |
| JP2023510454A (en) | 2019-11-27 | 2023-03-14 | イルミナ ケンブリッジ リミテッド | Pigments and compositions containing cyclooctatetraene |
| JP2023531009A (en) | 2020-06-22 | 2023-07-20 | イルミナ ケンブリッジ リミテッド | Nucleosides and nucleotides with 3' acetal blocking groups |
| US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
| US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
| US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| CN114671842B (en) * | 2020-12-24 | 2024-05-28 | 郑州思昆生物工程有限公司 | Fluorescent compound, preparation method thereof, fluorescent modified nucleotide and kit |
| WO2022243480A1 (en) | 2021-05-20 | 2022-11-24 | Illumina, Inc. | Compositions and methods for sequencing by synthesis |
| US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
| WO2023034079A1 (en) | 2021-09-01 | 2023-03-09 | Illumina Software, Inc. | Amplitude modulation for accelerated base calling |
| WO2023107622A1 (en) | 2021-12-10 | 2023-06-15 | Illumina, Inc. | Parallel sample and index sequencing |
| WO2023175018A1 (en) | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on separate polynucleotides |
| CA3223115A1 (en) | 2022-03-28 | 2023-10-05 | Xiaolin Wu | Labeled avidin and methods for sequencing |
| AU2023246772A1 (en) | 2022-03-29 | 2024-01-18 | Illumina Inc. | Chromenoquinoline dyes and uses in sequencing |
| US20230357845A1 (en) | 2022-03-31 | 2023-11-09 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| CA3222797A1 (en) | 2022-03-31 | 2023-10-05 | Ramesh NEELAKANDAN | Nucleosides and nucleotides with 3' vinyl blocking group |
| US20230383342A1 (en) | 2022-05-31 | 2023-11-30 | Illumina Cambridge Limited | Compositions and methods for nucleic acid sequencing |
| WO2024003087A1 (en) | 2022-06-28 | 2024-01-04 | Illumina, Inc. | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
| WO2024068889A2 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Compositions and methods for reducing photo damage during sequencing |
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| DE2411969A1 (en) | 1974-03-13 | 1975-09-25 | Bayer Ag | DYE LASER |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| AU6846698A (en) | 1997-04-01 | 1998-10-22 | Glaxo Group Limited | Method of nucleic acid amplification |
| US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| CA2339121A1 (en) | 1998-07-30 | 2000-02-10 | Shankar Balasubramanian | Arrayed biomolecules and their use in sequencing |
| GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
| AR021833A1 (en) | 1998-09-30 | 2002-08-07 | Applied Research Systems | METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID |
| US6391937B1 (en) | 1998-11-25 | 2002-05-21 | Motorola, Inc. | Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers |
| US6169185B1 (en) | 1999-02-25 | 2001-01-02 | Day-Glo Color Corp. | Ink jet printing inks |
| US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
| US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| WO2002012566A2 (en) | 2000-08-09 | 2002-02-14 | Motorola, Inc. | The use and evaluation of a [2+2] photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
| GB2395953A (en) | 2002-08-23 | 2004-06-09 | Solexa Ltd | Labelled nucleotides |
| SI3002289T1 (en) | 2002-08-23 | 2018-07-31 | Illumina Cambridge Limited | Modified nucleotides for polynucleotide sequencing |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| GB0326073D0 (en) | 2003-11-07 | 2003-12-10 | Solexa Ltd | Improvements in or relating to polynucleotide arrays |
| JP2007525571A (en) | 2004-01-07 | 2007-09-06 | ソレクサ リミテッド | Modified molecular array |
| EP1888743B1 (en) | 2005-05-10 | 2011-08-03 | Illumina Cambridge Limited | Improved polymerases |
| GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
| US8178360B2 (en) | 2006-05-18 | 2012-05-15 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
| EP2758475B1 (en) | 2011-09-23 | 2017-04-26 | Illumina Cambridge Limited | Dyes for labelling molecular ligands |
| DK3623481T3 (en) | 2011-09-23 | 2021-11-15 | Illumina Inc | COMPOSITIONS FOR NUCLEIC ACID SEQUENCE |
| US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
| WO2014135223A1 (en) | 2013-03-08 | 2014-09-12 | Illumina Cambridge Ltd | Rhodamine compounds and their use as fluorescent labels |
| JP6333297B2 (en) | 2013-03-15 | 2018-05-30 | イルミナ ケンブリッジ リミテッド | Modified nucleoside or modified nucleotide |
| US10385214B2 (en) | 2016-09-30 | 2019-08-20 | Illumina Cambridge Limited | Fluorescent dyes and their uses as biomarkers |
-
2017
- 2017-09-28 US US15/719,216 patent/US10385214B2/en active Active
- 2017-09-29 CN CN201780042127.1A patent/CN109476654B/en active Active
- 2017-09-29 IL IL297749A patent/IL297749A/en unknown
- 2017-09-29 JP JP2018566882A patent/JP7002478B2/en active Active
- 2017-09-29 ES ES17794669T patent/ES2914688T3/en active Active
- 2017-09-29 SG SG11201810633WA patent/SG11201810633WA/en unknown
- 2017-09-29 CA CA3026019A patent/CA3026019C/en active Active
- 2017-09-29 KR KR1020227041740A patent/KR102582172B1/en active IP Right Grant
- 2017-09-29 EP EP17794669.6A patent/EP3519410B1/en active Active
- 2017-09-29 WO PCT/EP2017/074880 patent/WO2018060482A1/en unknown
- 2017-09-29 AU AU2017335223A patent/AU2017335223B2/en active Active
- 2017-09-29 IL IL263871A patent/IL263871B2/en unknown
- 2017-09-29 EP EP21195809.5A patent/EP3974425A1/en active Pending
- 2017-09-29 KR KR1020187037385A patent/KR102473054B1/en active IP Right Grant
-
2019
- 2019-08-13 US US16/539,606 patent/US10844225B2/en active Active
-
2020
- 2020-11-17 US US16/950,705 patent/US11370920B2/en active Active
-
2021
- 2021-12-27 JP JP2021212730A patent/JP2022050495A/en not_active Withdrawn
-
2022
- 2022-11-07 AU AU2022268273A patent/AU2022268273A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210071005A1 (en) | 2021-03-11 |
| JP2022050495A (en) | 2022-03-30 |
| AU2017335223A1 (en) | 2018-12-20 |
| KR102582172B1 (en) | 2023-09-22 |
| US20190367738A1 (en) | 2019-12-05 |
| US20180094140A1 (en) | 2018-04-05 |
| ES2914688T3 (en) | 2022-06-15 |
| CN109476654A (en) | 2019-03-15 |
| US10385214B2 (en) | 2019-08-20 |
| CN109476654B (en) | 2022-06-10 |
| WO2018060482A1 (en) | 2018-04-05 |
| AU2017335223B2 (en) | 2022-08-11 |
| NZ748812A (en) | 2020-11-27 |
| JP2019531255A (en) | 2019-10-31 |
| IL263871A (en) | 2019-01-31 |
| IL297749A (en) | 2022-12-01 |
| EP3519410A1 (en) | 2019-08-07 |
| KR102473054B1 (en) | 2022-11-30 |
| JP7002478B2 (en) | 2022-02-10 |
| IL263871B (en) | 2022-12-01 |
| AU2022268273A1 (en) | 2022-12-15 |
| EP3974425A1 (en) | 2022-03-30 |
| KR20190057021A (en) | 2019-05-27 |
| KR20220160714A (en) | 2022-12-06 |
| EP3519410B1 (en) | 2022-03-30 |
| IL263871B2 (en) | 2023-04-01 |
| CA3026019C (en) | 2022-05-17 |
| CA3026019A1 (en) | 2018-04-05 |
| US10844225B2 (en) | 2020-11-24 |
| US11370920B2 (en) | 2022-06-28 |
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