SG11201809959PA - Methods of decreasing trisulfide bonds during recombinant production of polypeptides - Google Patents
Methods of decreasing trisulfide bonds during recombinant production of polypeptidesInfo
- Publication number
- SG11201809959PA SG11201809959PA SG11201809959PA SG11201809959PA SG11201809959PA SG 11201809959P A SG11201809959P A SG 11201809959PA SG 11201809959P A SG11201809959P A SG 11201809959PA SG 11201809959P A SG11201809959P A SG 11201809959PA SG 11201809959P A SG11201809959P A SG 11201809959PA
- Authority
- SG
- Singapore
- Prior art keywords
- media
- international
- cystine
- polypeptides
- cysteine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/196902 A3 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: (72) Inventors: GAWLITZEK, Martin; c/o Genentech, Inc., 1 C12P 21/08 (2006.01) DNA Way, South San Francisco, CA 94080 (US). MARK- ERT, Sven; Penzberger Str. 16, 82404 Sindelsdorf (DE). (21) International Application Number: POPP, Oliver; Floesserstr. 15, 82377 Penzberg (DE). PCT/US2017/031832 SHIRATORI, Masaru, Ken; c/o Genentech, Inc., 1 Dna (22) International Filing Date: Way, South San Francisco, CA 94080 (US). TROBES, 09 May 2017 (09.05.2017) Thomas; Demleitnerstr. 23, 81371 Muenchen (DE). WUU, Jessica; c/o Genentech, Inc., 1 DNA Way, South San Fran- (25) Filing Language: English cisco, CA 94080 (US). (26) Publication Language: English (74) Agent: ONUFRYK, Christina et al.; Morrison & Foerster (30) Priority Data: LLP, 755 Page Mill Road, Palo Alto, CA 94304-1018 (US). 62/334,433 10 May 2016 (10.05.2016) US (81) Designated States (unless otherwise indicated, for every (71) Applicant (for all designated States except AL, AT, BA, kind of national protection available): AE, AG, AL, AM, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR): GENEN- DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, TECH, INC. [US/US]; 1 DNA Way, South San Francisco, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, CA 94080-4990 (US). KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant (for AL, AT, BE, BG, CH, CN, CY, CZ, DE, DK, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. only): F. HOFFMANN-LA ROCHE AG [CH/CH]; Gren- = zacherstrasse 124, 4070 Basel (CH). = = Title: METHODS OF DECREASING TRISULFIDE BONDS DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES (54) FIG. 1 = = = 50 = = _ 40 _ = < —F—Media 1, cysteine + Fe E —II—Media 1, cystine + Fe = E 30 ' —O-Media 2, cysteine + Fe = —0—Media 2, cystine, + Fe = Z 7.—Media 1, cysteine 20 • —0—Media 1, cystine —c—Media 2, cysteine en 10 —#— Media 2, cystine ei © 0 irr • cT 0 12 24 36 48 60 72 t:T 1-1 Time (hours) Ir - - 1-1 N (57) : Provided herein are cell culture media and methods culturing host cells expressing polypeptides to reduce the level of trisulfide bonds in polypeptides produced by the host cells. [Continued on next page] WO 2017/196902 A3 MUNRO DOI 01011MMEM31111111111 1111111101101 1111111110fin (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, F1, FR, GB, GR, HR, HU, 1E, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 22 February 2018 (22.02.2018)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662334433P | 2016-05-10 | 2016-05-10 | |
PCT/US2017/031832 WO2017196902A2 (en) | 2016-05-10 | 2017-05-09 | Methods of decreasing trisulfide bonds during recombinant production of polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201809959PA true SG11201809959PA (en) | 2018-12-28 |
Family
ID=59034843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809959PA SG11201809959PA (en) | 2016-05-10 | 2017-05-09 | Methods of decreasing trisulfide bonds during recombinant production of polypeptides |
Country Status (13)
Country | Link |
---|---|
US (1) | US20190169667A1 (en) |
EP (1) | EP3455364A2 (en) |
JP (4) | JP7181091B2 (en) |
KR (2) | KR20230124093A (en) |
CN (2) | CN114703244A (en) |
AR (1) | AR108436A1 (en) |
AU (1) | AU2017264754A1 (en) |
BR (1) | BR112018073133A2 (en) |
CA (1) | CA3022955A1 (en) |
IL (1) | IL262781A (en) |
MX (1) | MX2018013683A (en) |
SG (1) | SG11201809959PA (en) |
WO (1) | WO2017196902A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200115443A1 (en) * | 2018-10-12 | 2020-04-16 | Trican Biotechnology Co., Ltd | Bi-functional fusion proteins and uses thereof |
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2017
- 2017-05-09 CN CN202210369636.8A patent/CN114703244A/en active Pending
- 2017-05-09 CA CA3022955A patent/CA3022955A1/en active Pending
- 2017-05-09 KR KR1020237026988A patent/KR20230124093A/en active Application Filing
- 2017-05-09 EP EP17729222.4A patent/EP3455364A2/en active Pending
- 2017-05-09 SG SG11201809959PA patent/SG11201809959PA/en unknown
- 2017-05-09 MX MX2018013683A patent/MX2018013683A/en unknown
- 2017-05-09 CN CN201780028779.XA patent/CN109154014A/en active Pending
- 2017-05-09 WO PCT/US2017/031832 patent/WO2017196902A2/en unknown
- 2017-05-09 AU AU2017264754A patent/AU2017264754A1/en not_active Abandoned
- 2017-05-09 BR BR112018073133A patent/BR112018073133A2/en not_active Application Discontinuation
- 2017-05-09 KR KR1020187035681A patent/KR20190005966A/en not_active Application Discontinuation
- 2017-05-09 JP JP2018559294A patent/JP7181091B2/en active Active
- 2017-05-10 AR ARP170101227A patent/AR108436A1/en unknown
-
2018
- 2018-11-05 IL IL262781A patent/IL262781A/en unknown
- 2018-11-09 US US16/185,369 patent/US20190169667A1/en active Pending
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2021
- 2021-09-03 JP JP2021143722A patent/JP2022000032A/en not_active Withdrawn
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2022
- 2022-11-17 JP JP2022183766A patent/JP2023027081A/en active Pending
-
2023
- 2023-09-11 JP JP2023146941A patent/JP2024001018A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20190005966A (en) | 2019-01-16 |
CN114703244A (en) | 2022-07-05 |
KR20230124093A (en) | 2023-08-24 |
EP3455364A2 (en) | 2019-03-20 |
CA3022955A1 (en) | 2017-11-16 |
JP2022000032A (en) | 2022-01-04 |
AU2017264754A1 (en) | 2018-12-13 |
US20190169667A1 (en) | 2019-06-06 |
JP2024001018A (en) | 2024-01-09 |
JP7181091B2 (en) | 2022-11-30 |
BR112018073133A2 (en) | 2019-04-30 |
WO2017196902A2 (en) | 2017-11-16 |
IL262781A (en) | 2018-12-31 |
JP2019514412A (en) | 2019-06-06 |
CN109154014A (en) | 2019-01-04 |
AR108436A1 (en) | 2018-08-22 |
WO2017196902A3 (en) | 2018-02-22 |
MX2018013683A (en) | 2019-06-17 |
JP2023027081A (en) | 2023-03-01 |
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SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
SG11201900772YA (en) | Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors | |
SG11201809710RA (en) | Genetically engineered cells and methods of making the same | |
SG11201805162VA (en) | Plasmid constructs for heterologous protein expression and methods of use | |
SG11201907846VA (en) | Therapeutic rna | |
SG11201808196UA (en) | Neoantigens and methods of their use | |
SG11201908787WA (en) | Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap | |
SG11201805451TA (en) | Immune effector cell therapies with enhanced efficacy | |
SG11201811048UA (en) | Single-cell transcript sequencing | |
SG11201807538PA (en) | Crispr-cpf1-related methods, compositions and components for cancer immunotherapy | |
SG11201406903SA (en) | Cell culture compositions and methods for polypeptide production | |
SG11201811405QA (en) | Improved differentiation method | |
SG11201809522WA (en) | Method of nucleic acid sequence determination | |
SG11201906213UA (en) | Modulating expression of polypeptides via new gene switch expression systems | |
SG11201804127SA (en) | Ctla4 binders | |
SG11201803169WA (en) | Cellulase variants and polynucleotides encoding same | |
SG11201811232XA (en) | Treatment of amd using aav2 variant with aflibercept | |
SG11201906301UA (en) | Methods of manufacture of nut flours and formulations for oral immunotherapy | |
SG11201901228QA (en) | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide | |
SG11201407417VA (en) | Encoding and reconstruction of residual data based on support information | |
SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof | |
SG11201807114TA (en) | Colony forming medium and use thereof | |
SG11201407866XA (en) | Method for expression of heterologous proteins using a recombinant negative-strand rna virus vector | |
SG11201805052YA (en) | Therapeutic methods using erythrocytes | |
SG11201909087PA (en) | Perfusion medium |