SG11201804127SA - Ctla4 binders - Google Patents
Ctla4 bindersInfo
- Publication number
- SG11201804127SA SG11201804127SA SG11201804127SA SG11201804127SA SG11201804127SA SG 11201804127S A SG11201804127S A SG 11201804127SA SG 11201804127S A SG11201804127S A SG 11201804127SA SG 11201804127S A SG11201804127S A SG 11201804127SA SG 11201804127S A SG11201804127S A SG 11201804127SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- technologiepark
- rule
- california
- avenue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau III111111111111111111111111111111111111111111111111111111111H111111111R111111111111111 (10) International Publication Number WO 2017/087588 Al WIPOI PCT (43) International Publication Date 26 May 2017 (26.05.2017) BOUTTON, Carlo [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). (72) Inventors; and (71) Applicants NZ, US only): DOMBRECHT, Bruno [BE/BE]; Technologiepark 21, 9052 Zwijnaaarde (BE). VICTOR, Bjorn [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). (74) Common Representative: MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (51) International Patent Classification: C07K 16/18 (2006.01) 961% 3 9 / 3 95 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2016/062393 (22) International Filing Date: 17 November 2016 (17.11.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/257,001 18 November 2015 (18.11.2015) US (71) Applicant (for all designated States except US): MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US). (72) Inventors; and (71) Applicants NZ, US only): PUNNONEN, Juha [US/US]; 901 S. California Avenue, Palo Alto, California 94304 (US). BEAUMONT, Maribel [FR/US]; 901 S. California Avenue, Palo Alto, California 94304 (US). (72) Inventors; and (71) Applicants US only): BUYSE, Marie-Ange [BE/BE]; Technologiepark 21, 9052 Zwijnaarde (BE). [Continued on next page] (54) Title: CTLA4 BINDERS 500 96 non—biased healthy human subjects 400 • 300 leve l a t 360 secon ds ( RU) • .• ••• •• 200 100 . % ••••.•• :Is • :::t OOOOO ,„,1„, OOOOO 01.?\"9 4.1.••• 4, 1013700112 F023700912 F023700925 W O 20 17 /0875 88 Al FIG.10A (57) : The present invention provides molecules, such as ISVDs and Nanobodies, that bind to CTLA4 or human serum al - bumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided. WO 2017/087588 Al MIONIM011EMIMOIDE11111111111111111111111111111111111111111111111111111 TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art 21(3)) with sequence listing part of description (Rule 5.2(a)) Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562257001P | 2015-11-18 | 2015-11-18 | |
PCT/US2016/062393 WO2017087588A1 (en) | 2015-11-18 | 2016-11-17 | Ctla4 binders |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201804127SA true SG11201804127SA (en) | 2018-06-28 |
Family
ID=57472066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201804127SA SG11201804127SA (en) | 2015-11-18 | 2016-11-17 | Ctla4 binders |
Country Status (30)
Country | Link |
---|---|
US (2) | US10501542B2 (en) |
EP (1) | EP3377527A1 (en) |
JP (1) | JP6768800B2 (en) |
KR (1) | KR102095140B1 (en) |
CN (1) | CN108473565B (en) |
AR (1) | AR106753A1 (en) |
AU (1) | AU2016355569B2 (en) |
BR (1) | BR112018009972B1 (en) |
CA (1) | CA3004900C (en) |
CL (1) | CL2018001326A1 (en) |
CO (1) | CO2018005161A2 (en) |
CR (1) | CR20180279A (en) |
DO (1) | DOP2018000125A (en) |
EA (1) | EA038179B1 (en) |
EC (1) | ECSP18045497A (en) |
GE (1) | GEP20207174B (en) |
HK (1) | HK1254952A1 (en) |
IL (1) | IL259173A (en) |
JO (1) | JO3739B1 (en) |
MA (1) | MA43259A (en) |
MX (1) | MX2018006246A (en) |
MY (1) | MY189590A (en) |
NI (1) | NI201800062A (en) |
PH (1) | PH12018501079A1 (en) |
SG (1) | SG11201804127SA (en) |
SV (1) | SV2018005693A (en) |
TN (1) | TN2018000169A1 (en) |
TW (1) | TWI754622B (en) |
UA (1) | UA125337C2 (en) |
WO (1) | WO2017087588A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3222634A1 (en) | 2007-06-18 | 2017-09-27 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
US20180009888A9 (en) | 2011-06-23 | 2018-01-11 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
RU2746738C2 (en) | 2014-05-16 | 2021-04-20 | Аблинкс Нв | Improved variable domains of immunoglobulins |
WO2017085172A2 (en) * | 2015-11-18 | 2017-05-26 | Ablynx Nv | Improved serum albumin binders |
KR102317574B1 (en) | 2015-11-18 | 2021-10-26 | 머크 샤프 앤드 돔 코포레이션 | Pd1 and/or lag3 binders |
TWI754622B (en) | 2015-11-18 | 2022-02-11 | 美商默沙東藥廠 | Ctla4 binders |
JP7461741B2 (en) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | Anti-PD-L1 and IL-2 Cytokines |
WO2019096121A1 (en) * | 2017-11-17 | 2019-05-23 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against pd-l1 |
WO2019179388A1 (en) * | 2018-03-19 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-ctla-4 antibody polypeptide |
SG11202101982RA (en) | 2018-09-26 | 2021-03-30 | Ascendis Pharma As | Degradable hyaluronic acid hydrogels |
JP2022514702A (en) | 2018-12-21 | 2022-02-14 | オーエスイー・イミュノセラピューティクス | Bifunctional anti-PD-1 / IL-7 molecule |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
CN110950957B (en) * | 2019-12-13 | 2022-03-08 | 源道隆(苏州)医学科技有限公司 | Polypeptide capable of binding CTLA4 and application thereof |
AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Ose Immunotherapeutics | Bifunctional molecules comprising an IL-7 variant |
CN115626956A (en) * | 2020-01-16 | 2023-01-20 | 三优生物医药(上海)有限公司 | CTLA-4 binding molecules and uses thereof |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
WO2022159575A1 (en) * | 2021-01-20 | 2022-07-28 | Bioentre Llc | Ctla4-binding proteins and methods of treating cancer |
IL307419A (en) | 2021-04-09 | 2023-12-01 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
WO2023163968A1 (en) * | 2022-02-24 | 2023-08-31 | Merck Sharp & Dohme Llc | Stable formulations of a multivalent vhh based cytotoxic t lymphocyte associated antigen 4 (ctla4) binder binding to human ctla4 and methods of use thereof |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1319120C (en) | 1985-04-01 | 1993-06-15 | John Henry Kenten | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
DK1087013T3 (en) | 1992-08-21 | 2009-05-11 | Univ Bruxelles | Immunoglobulins without light chains |
JPH08502168A (en) | 1992-09-29 | 1996-03-12 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Trophic factors with ion channel-inducing activity in neuronal cells |
US6824779B1 (en) | 1993-07-26 | 2004-11-30 | Dana-Farber Cancer Institute, Inc. | Methods for inhibiting the interaction of B7-2 with its natural ligand |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
CN1203178C (en) | 1997-10-27 | 2005-05-25 | 尤尼利弗公司 | Multivalent antigen-binding proteins |
PT1914244E (en) | 1999-04-09 | 2013-07-26 | Kyowa Hakko Kirin Co Ltd | Method of modulating the activity of functional immune molecules |
US20020006403A1 (en) | 1999-12-14 | 2002-01-17 | Xue-Zhong Yu | CD28-specific antibody compositions for use in methods of immunosuppression |
US7795002B2 (en) | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
ES2367891T3 (en) | 2000-09-29 | 2011-11-10 | Schering Corporation | INTERLEUCINA-10 PEGILADA. |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
ATE477275T1 (en) | 2000-12-26 | 2010-08-15 | Inst Nat Sante Rech Med | ANTIBODIES AGAINST CD28 |
WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
WO2004041865A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Stabilized single domain antibodies |
CN101412759A (en) | 2003-01-10 | 2009-04-22 | 埃博灵克斯股份有限公司 | Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation |
DK1687338T3 (en) | 2003-11-07 | 2011-02-07 | Ablynx Nv | Camelidae single-domain antibodies VHH targeting epidermal growth factor receptor and uses thereof |
AU2005293752A1 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease |
CA2588892A1 (en) | 2004-12-02 | 2006-06-08 | Dormantis Limited | Anti-il-1r1 single domain antibodies and therapeutic uses |
EP1888640B1 (en) | 2005-05-18 | 2012-03-14 | Ablynx N.V. | Improved nanobodies against tumor necrosis factor-alpha |
PL3415535T3 (en) * | 2005-05-20 | 2021-06-14 | Ablynx N.V. | Improved nanobodies tm for the treatment of aggregation-mediated disorders |
EP1957536A2 (en) | 2005-12-01 | 2008-08-20 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
EP1957537A2 (en) | 2005-12-01 | 2008-08-20 | Domantis Limited | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
FR2894741B1 (en) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | SATELLITE RECEPTION CHAIN |
EP1976991A1 (en) | 2006-01-24 | 2008-10-08 | Domantis Limited | Fusion proteins that contain natural junctions |
WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
JP2010511397A (en) | 2006-12-05 | 2010-04-15 | アブリンクス エン.ヴェー. | Peptides that can bind to serum proteins |
WO2008071447A2 (en) * | 2006-12-15 | 2008-06-19 | Ablynx N.V. | Amino acid sequences that modulate the interaction between cells of the immune system |
MX2009012650A (en) | 2007-05-24 | 2010-02-18 | Ablynx Nv | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders. |
PT2207809E (en) | 2007-09-26 | 2013-10-09 | Amgen Inc | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
WO2009068630A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Immunoglobulin constructs |
US9212226B2 (en) | 2008-05-16 | 2015-12-15 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
EP2315778A2 (en) | 2008-07-18 | 2011-05-04 | Domantis Limited | Compositions monovalent for cd28 binding and methods of use |
US8679496B2 (en) | 2009-07-16 | 2014-03-25 | Glaxo Group Limited | Anti-serum albumin single variable domains |
WO2012175400A1 (en) | 2011-06-23 | 2012-12-27 | Ablynx Nv | Serum albumin binding proteins |
US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
US20180009888A9 (en) | 2011-06-23 | 2018-01-11 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
TW201321405A (en) | 2011-08-17 | 2013-06-01 | Glaxo Group Ltd | Modified proteins and peptides |
WO2013066765A1 (en) | 2011-11-01 | 2013-05-10 | Merck Sharp & Dohme Corp. | Mutation of tup1 in glycoengineered yeast |
CN104781277A (en) * | 2012-09-13 | 2015-07-15 | 诺华股份有限公司 | antigen binding molecule with terminal modification |
WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
AR095374A1 (en) | 2013-03-15 | 2015-10-14 | Amgen Res (Munich) Gmbh | UNION MOLECULES FOR BCMA AND CD3 |
EP3049439B1 (en) * | 2013-09-26 | 2019-12-25 | Ablynx N.V. | Bispecific nanobodies |
RU2746738C2 (en) | 2014-05-16 | 2021-04-20 | Аблинкс Нв | Improved variable domains of immunoglobulins |
BR122018009619B1 (en) | 2014-05-16 | 2024-01-02 | Ablynx N.V | IMPROVED IMMUNOGLOBULIN VARIABLE DOMAINS |
DK3303394T3 (en) | 2015-05-29 | 2020-07-06 | Agenus Inc | ANTI-CTLA-4 ANTIBODIES AND PROCEDURES FOR USE THEREOF |
TWI754622B (en) | 2015-11-18 | 2022-02-11 | 美商默沙東藥廠 | Ctla4 binders |
KR102317574B1 (en) | 2015-11-18 | 2021-10-26 | 머크 샤프 앤드 돔 코포레이션 | Pd1 and/or lag3 binders |
AU2016355568A1 (en) | 2015-11-18 | 2018-06-21 | Merck Sharp & Dohme Llc | PD1/CTLA4 Binders |
SG11201804839WA (en) | 2015-12-14 | 2018-07-30 | Macrogenics Inc | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof |
-
2016
- 2016-11-17 TW TW105137708A patent/TWI754622B/en active
- 2016-11-17 SG SG11201804127SA patent/SG11201804127SA/en unknown
- 2016-11-17 CN CN201680079309.1A patent/CN108473565B/en active Active
- 2016-11-17 EP EP16805654.7A patent/EP3377527A1/en active Pending
- 2016-11-17 MX MX2018006246A patent/MX2018006246A/en unknown
- 2016-11-17 GE GEAP201614811A patent/GEP20207174B/en unknown
- 2016-11-17 AU AU2016355569A patent/AU2016355569B2/en active Active
- 2016-11-17 CR CR20180279A patent/CR20180279A/en unknown
- 2016-11-17 JO JOP/2016/0243A patent/JO3739B1/en active
- 2016-11-17 JP JP2018525615A patent/JP6768800B2/en active Active
- 2016-11-17 KR KR1020187016799A patent/KR102095140B1/en active IP Right Grant
- 2016-11-17 EA EA201891166A patent/EA038179B1/en unknown
- 2016-11-17 BR BR112018009972-4A patent/BR112018009972B1/en active IP Right Grant
- 2016-11-17 US US15/353,886 patent/US10501542B2/en active Active
- 2016-11-17 UA UAA201806764A patent/UA125337C2/en unknown
- 2016-11-17 TN TNP/2018/000169A patent/TN2018000169A1/en unknown
- 2016-11-17 MA MA043259A patent/MA43259A/en unknown
- 2016-11-17 CA CA3004900A patent/CA3004900C/en active Active
- 2016-11-17 WO PCT/US2016/062393 patent/WO2017087588A1/en active Application Filing
- 2016-11-17 MY MYPI2018000772A patent/MY189590A/en unknown
- 2016-11-18 AR ARP160103542A patent/AR106753A1/en unknown
-
2018
- 2018-05-06 IL IL259173A patent/IL259173A/en unknown
- 2018-05-15 NI NI201800062A patent/NI201800062A/en unknown
- 2018-05-15 SV SV2018005693A patent/SV2018005693A/en unknown
- 2018-05-16 CO CONC2018/0005161A patent/CO2018005161A2/en unknown
- 2018-05-17 CL CL2018001326A patent/CL2018001326A1/en unknown
- 2018-05-18 DO DO2018000125A patent/DOP2018000125A/en unknown
- 2018-05-18 PH PH12018501079A patent/PH12018501079A1/en unknown
- 2018-06-14 EC ECIEPI201845497A patent/ECSP18045497A/en unknown
- 2018-11-02 HK HK18114056.2A patent/HK1254952A1/en unknown
-
2019
- 2019-11-27 US US16/697,575 patent/US11649290B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201804127SA (en) | Ctla4 binders | |
SG11201804178YA (en) | Pd1 and/or lag3 binders | |
SG11201907753TA (en) | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof | |
SG11201909081YA (en) | Anti-ilt4 antibodies and antigen-binding fragments | |
SG11201810883TA (en) | Combination therapy | |
SG11201909955XA (en) | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies | |
SG11201901548SA (en) | Anti-tim-3 antibodies and use thereof | |
SG11201903857UA (en) | Antibodies to pd-1 and uses thereof | |
SG11201910182RA (en) | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof | |
SG11201811003PA (en) | Anti-pd-l1 antibodies and uses thereof | |
SG11201808622SA (en) | Chimeric receptors to flt3 and methods of use thereof | |
SG11201803956UA (en) | Anti-dr5 antibodies and methods of use thereof | |
SG11201804839WA (en) | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof | |
SG11201900480YA (en) | Anti-tim-3 antibodies | |
SG11201808979UA (en) | Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof | |
SG11201907580SA (en) | Combination therapies for treatment of bcma-related cancers and autoimmune disorders | |
SG11201906341XA (en) | Improved serum albumin binders | |
SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
SG11201804510PA (en) | Biparatopic polypeptides antagonizing wnt signaling in tumor cells | |
SG11201806992VA (en) | Antibodies to tigit | |
SG11201804161VA (en) | Compositions comprising bacterial strains | |
SG11201907846VA (en) | Therapeutic rna | |
SG11201804134YA (en) | Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment | |
SG11201910134SA (en) | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof | |
SG11201908326YA (en) | Methods of treating neurodegenerative diseases |