SG11201809381XA - Polynucleotides encoding interleukin-12 (il12) and uses thereof - Google Patents
Polynucleotides encoding interleukin-12 (il12) and uses thereofInfo
- Publication number
- SG11201809381XA SG11201809381XA SG11201809381XA SG11201809381XA SG11201809381XA SG 11201809381X A SG11201809381X A SG 11201809381XA SG 11201809381X A SG11201809381X A SG 11201809381XA SG 11201809381X A SG11201809381X A SG 11201809381XA SG 11201809381X A SG11201809381X A SG 11201809381XA
- Authority
- SG
- Singapore
- Prior art keywords
- cambridge
- modernatx
- massachusetts
- square
- international
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 November 2017 (23.11.2017) WIPO I PCT omit VIII two III VIII NEE 111°011mm oimIE (10) International Publication Number WO 2017/201350 Al (51) International Patent Classification: A61K 38/20 (2006.01) Cl 2N 15/67 (2006.01) CO7K 14/54 (2006.01) (21) International Application Number: PCT/US2017/033422 (22) International Filing Date: 18 May 2017 (18.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/338,483 18 May 2016 (18.05.2016) US 62/443,693 07 January 2017 (07.01.2017) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) 1-1 kr) O 1-1 O N _ N O 1-1 N C (71) Applicant: MODERNATX, INC. [US/US]; 200 Technol- with sequence listing part of description (Rule 5.2(a)) ogy Square, Cambridge, Massachusetts 02139 (US). (72) Inventors: FREDERICK, Joshua; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachu- setts 02139 (US). HEWITT, Susannah; c/o MODER- NATX, INC., 200 Technology Square, Cambridge, Mass- achusetts 02139 (US). BAI, Ailin; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachu- setts 02139 (US). HOGE, Stephen; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachusetts 02139 (US). PRESNYAK, Vladimir; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachusetts 02139 (US). MCFADYEN, Iain; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachusetts 02139 (US). BENENATO, Kerry; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachusetts 02139 (US). KUMARASINGHE, Ellalahewage Sathya- jith; c/o MODERNATX, INC., 200 Technology Square, Cambridge, Massachusetts 02139 (US). (74) Agent: MANDRAGOURAS, Amy, E. et al.; Nelson Mullins Riley & Scarborough LLP, One Post Office Square, Boston, Massachusetts 02109-2127 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (54) Title: POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF (57) : The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open read- ing frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence opti- mized polynucleotides.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662338483P | 2016-05-18 | 2016-05-18 | |
US201762443693P | 2017-01-07 | 2017-01-07 | |
PCT/US2017/033422 WO2017201350A1 (en) | 2016-05-18 | 2017-05-18 | Polynucleotides encoding interleukin-12 (il12) and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201809381XA true SG11201809381XA (en) | 2018-12-28 |
Family
ID=58794205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809381XA SG11201809381XA (en) | 2016-05-18 | 2017-05-18 | Polynucleotides encoding interleukin-12 (il12) and uses thereof |
Country Status (22)
Country | Link |
---|---|
US (5) | US10646549B2 (en) |
EP (2) | EP3458083B1 (en) |
JP (2) | JP7246930B2 (en) |
KR (2) | KR102469450B1 (en) |
CN (1) | CN109195621A (en) |
AU (1) | AU2017268397B2 (en) |
CA (1) | CA3024470A1 (en) |
DK (1) | DK3458083T3 (en) |
ES (1) | ES2941411T3 (en) |
FI (1) | FI3458083T3 (en) |
HR (1) | HRP20230050T1 (en) |
HU (1) | HUE061077T2 (en) |
IL (1) | IL262501A (en) |
LT (1) | LT3458083T (en) |
MX (2) | MX2018013509A (en) |
PL (1) | PL3458083T3 (en) |
PT (1) | PT3458083T (en) |
RS (1) | RS63912B1 (en) |
RU (1) | RU2769316C2 (en) |
SG (1) | SG11201809381XA (en) |
SI (1) | SI3458083T1 (en) |
WO (1) | WO2017201350A1 (en) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
JP2016538829A (en) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | Polynucleotide encoding low density lipoprotein receptor |
CN105939767B (en) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | Sound electrophoretic apparatus with alliteration electrophoresis chamber |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
AU2016324310B2 (en) | 2015-09-17 | 2021-04-08 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
PL3718565T3 (en) | 2015-10-22 | 2022-09-19 | Modernatx, Inc. | Respiratory virus vaccines |
PL3394030T3 (en) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
KR102469450B1 (en) | 2016-05-18 | 2022-11-22 | 모더나티엑스, 인크. | Polynucleotides Encoding Interleukin-12 (IL12) and Uses Thereof |
WO2018089540A1 (en) | 2016-11-08 | 2018-05-17 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
MA50335A (en) * | 2016-12-08 | 2020-08-19 | Modernatx Inc | NUCLEIC ACID VACCINES AGAINST RESPIRATORY VIRUSES |
CA3055653A1 (en) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
HUE060693T2 (en) * | 2017-03-15 | 2023-04-28 | Modernatx Inc | Compound and compositions for intracellular delivery of therapeutic agents |
EP3596042B1 (en) | 2017-03-15 | 2022-01-12 | Modernatx, Inc. | Crystal forms of amino lipids |
MA48047A (en) | 2017-04-05 | 2020-02-12 | Modernatx Inc | REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY |
WO2018213731A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
WO2018232357A1 (en) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Rna formulations |
MA49922A (en) | 2017-08-18 | 2021-06-02 | Modernatx Inc | PROCESSES FOR HPLC ANALYSIS |
JP7408098B2 (en) | 2017-08-18 | 2024-01-05 | モデルナティエックス インコーポレイテッド | RNA polymerase variants |
US11866696B2 (en) | 2017-08-18 | 2024-01-09 | Modernatx, Inc. | Analytical HPLC methods |
AU2018385759B2 (en) | 2017-12-14 | 2021-10-21 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
CA3101969A1 (en) * | 2018-05-31 | 2019-12-05 | Beth Israel Deaconess Medical Center | Rna-aided immunotherapeutics |
CN112399860A (en) | 2018-06-06 | 2021-02-23 | 麻省理工学院 | Circular RNA for translation in eukaryotic cells |
GB2600800B (en) | 2018-09-04 | 2023-08-16 | Univ Texas | Compositions and methods for organ specific delivery of nucleic acids |
CN112996519A (en) | 2018-09-04 | 2021-06-18 | 德克萨斯大学***董事会 | Compositions and methods for organ-specific delivery of nucleic acids |
US20230081530A1 (en) * | 2018-09-14 | 2023-03-16 | Modernatx, Inc. | Methods and compositions for treating cancer using mrna therapeutics |
KR102524247B1 (en) * | 2018-12-21 | 2023-04-21 | 가톨릭대학교 산학협력단 | p40-EBI3 COMPLEX AND USES THEREOF |
WO2020146700A1 (en) * | 2019-01-10 | 2020-07-16 | Massachusetts Institute Of Technology | Lipid nanoparticles |
TW202043256A (en) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | Prostate neoantigens and their uses |
KR20210152480A (en) * | 2019-03-14 | 2021-12-15 | 엔진 인코포레이티드 | Chitosan polyplex-based local expression of IL-12 alone or in combination with type-I IFN inducers for the treatment of mucosal cancer |
CN109932511B (en) * | 2019-03-22 | 2020-02-04 | 南昌大学第二附属医院 | Urine exosome phospholipid marker for liver cancer screening and kit thereof |
WO2020209934A1 (en) * | 2019-04-11 | 2020-10-15 | Massachusetts Institute Of Technology | Novel chimeric antigen receptors and libraries |
CA3139032A1 (en) | 2019-05-22 | 2020-11-26 | Robert Alexander WESSELHOEFT | Circular rna compositions and methods |
JP2022548304A (en) | 2019-09-19 | 2022-11-17 | モデルナティエックス インコーポレイテッド | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
EP3920976B1 (en) | 2019-12-04 | 2023-07-19 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
EP4106730A4 (en) * | 2020-02-19 | 2024-03-27 | Univ Florida | Multilamellar rna nanoparticles and methods of sensitizing tumors to treatment with immune checkpoint inhibitors |
KR20220144831A (en) | 2020-02-21 | 2022-10-27 | 콤바인드 테라퓨틱스, 인코포레이션 | Compositions and methods for organ protective expression and modulation of encoding ribonucleic acids |
WO2021204179A1 (en) | 2020-04-09 | 2021-10-14 | Suzhou Abogen Biosciences Co., Ltd. | Nucleic acid vaccines for coronavirus |
BR112022020203A2 (en) | 2020-04-09 | 2022-11-22 | Suzhou Abogen Biosciences Co Ltd | COMPOSITION OF LIPID NANOPARTICLES |
WO2021233849A1 (en) | 2020-05-17 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Viral vectors and nucleic acids for regulated gene therapy |
CN116710079A (en) | 2020-07-24 | 2023-09-05 | 斯特兰德生物科技公司 | Lipid nanoparticles comprising modified nucleotides |
JP2024503000A (en) | 2021-01-08 | 2024-01-24 | ストランド セラピューティクス インコーポレイテッド | Expression constructs and their use |
US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
CN113509542A (en) * | 2021-04-20 | 2021-10-19 | 嘉晨西海(杭州)生物技术有限公司 | Medicine for expressing interleukin 12 and aiming at tumor based on mRNA and preparation method thereof |
US20230263742A1 (en) * | 2021-05-06 | 2023-08-24 | Stemirna Therapeutics Co., Ltd. | A lipid |
IL309505A (en) | 2021-09-03 | 2024-02-01 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
CN116829578A (en) * | 2021-10-08 | 2023-09-29 | 苏州艾博生物科技有限公司 | Polynucleotides encoding interleukin-12 (IL-12) and compositions and methods related thereto |
WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
CN116179549A (en) | 2021-12-08 | 2023-05-30 | 南京吉迈生物技术有限公司 | Modification of gene transcription and translation efficiency by 5' UTR sequence variants |
CN114044741B (en) * | 2022-01-13 | 2022-04-15 | 北京悦康科创医药科技股份有限公司 | Cationic lipid compound, composition containing same and application |
WO2023144330A1 (en) | 2022-01-28 | 2023-08-03 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
WO2023196988A1 (en) * | 2022-04-07 | 2023-10-12 | Modernatx, Inc. | Methods of use of mrnas encoding il-12 |
CN116621965A (en) * | 2022-05-06 | 2023-08-22 | 珠海丽凡达生物技术有限公司 | Therapeutic nucleic acid molecules, mixtures, medicaments and their use in the treatment of solid tumors |
CN114994331B (en) * | 2022-05-17 | 2023-02-24 | 无锡科金生物科技有限公司 | Kit for detecting protein expression level and preparation method and application thereof |
WO2023227608A1 (en) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
Family Cites Families (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5082767A (en) | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
US6140496A (en) | 1990-10-09 | 2000-10-31 | Benner; Steven Albert | Precursors for deoxyribonucleotides containing non-standard nucleosides |
US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
US5922685A (en) | 1996-06-05 | 1999-07-13 | Powderject Vaccines, Inc. | IL-12 gene therapy of tumors |
CA2268276A1 (en) | 1996-10-18 | 1998-04-30 | Jeff Nordstrom | Gene expression and delivery systems and uses |
US5994104A (en) | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
JP2001521759A (en) | 1997-11-12 | 2001-11-13 | ザ ブリガム アンド ウィメンズ ホスピタル,インコーポレイテッド | Translational enhancer element of human amyloid precursor protein gene |
EP1987845B1 (en) | 1997-11-20 | 2012-03-21 | Vical Incorporated | Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor. |
US7521178B1 (en) | 1998-04-23 | 2009-04-21 | Takara Bio Inc. | Method for synthesizing DNA |
EP1030680A4 (en) | 1998-09-15 | 2003-05-02 | Genetics Inst | Treatment of kaposi's sarcoma with il-12 |
AU6270499A (en) | 1998-09-29 | 2000-04-17 | Phylos, Inc. | Synthesis of codon randomized nucleic acids |
EP2829609A1 (en) | 1999-08-24 | 2015-01-28 | E. R. Squibb & Sons, L.L.C. | Human CTLA-4 antibodies and their uses |
DE60113805T2 (en) | 2000-01-20 | 2006-07-13 | Universität Zürich Institut für Medizinische Virologie | Intratumoral administration of naked IL-12-encoding nucleic acid molecules |
US7468275B2 (en) | 2000-01-28 | 2008-12-23 | The Scripps Research Institute | Synthetic internal ribosome entry sites and methods of identifying same |
WO2001055369A1 (en) | 2000-01-28 | 2001-08-02 | The Scripps Research Institute | Synthetic internal ribosome entry sites and methods of identifying same |
ES2164011B1 (en) | 2000-02-25 | 2003-05-16 | Inst Cientifico Tecnol Navarra | COMBINED USE OF IP-10 CHEMIOKIN AND INTERLEUCINE-12 IN THE PREPARATION OF COMPOSITIONS FOR THE TREATMENT OF EVIL TUMORS. |
ES2272448T3 (en) | 2000-03-15 | 2007-05-01 | Genexine Co., Ltd. | GENES OF THE IL-12P40 MUNATE SUBUNITY TO IMPROVE THE ACTIVITY OF IL-12 AND USE OF THEMSELVES IN A GENETIC VACCINE COADYUVANT. |
KR20020010206A (en) | 2000-07-27 | 2002-02-04 | 이시우 | DNA vector comprising a single chain IL-12 and B7.1, and Anti-cancer cell vaccine transformed with the above vector |
ES2340532T3 (en) | 2001-06-05 | 2010-06-04 | Curevac Gmbh | MRNA WITH AN INCREASED G / C CONTENT THAT CODIFIES FOR A BACTERIAL ANTIGEN AND USING THE SAME. |
WO2003004685A2 (en) | 2001-07-03 | 2003-01-16 | University Of Utah Research Foundation | Soluble steroidal peptides for nucleic acid delivery |
EP2428571B1 (en) | 2001-09-28 | 2018-07-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
EP1452593B1 (en) | 2001-11-14 | 2009-04-08 | Toyo Boseki Kabushiki Kaisha | Dna synthesis promoters, dna polymerase-associated factors and utilization thereof |
CA2409775C (en) | 2001-12-03 | 2010-07-13 | F. Hoffmann-La Roche Ag | Reversibly modified thermostable enzymes for dna synthesis and amplification in vitro |
AU2003228440B2 (en) | 2002-04-01 | 2008-10-02 | Walter Reed Army Institute Of Research | Method of designing synthetic nucleic acid sequences for optimal protein expression in a host cell |
US7595303B1 (en) | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
DE10248141B4 (en) | 2002-10-11 | 2007-04-19 | Universitätsklinikum Hamburg-Eppendorf | Nucleic acids and their use for gene therapy |
DE10260805A1 (en) | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Method and device for optimizing a nucleotide sequence for expression of a protein |
WO2004110371A2 (en) | 2003-05-30 | 2004-12-23 | University Of South Florida | Method for the treatment of malignancies |
CA2533701A1 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
GB0329146D0 (en) | 2003-12-16 | 2004-01-21 | Glaxosmithkline Biolog Sa | Vaccine |
DE102004042546A1 (en) | 2004-09-02 | 2006-03-09 | Curevac Gmbh | Combination therapy for immune stimulation |
EP1640018A1 (en) | 2004-09-24 | 2006-03-29 | Universität Zürich | Combinational therapy for treating cancer |
LT2439273T (en) | 2005-05-09 | 2019-05-10 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
US7550264B2 (en) | 2005-06-10 | 2009-06-23 | Datascope Investment Corporation | Methods and kits for sense RNA synthesis |
US8101385B2 (en) | 2005-06-30 | 2012-01-24 | Archemix Corp. | Materials and methods for the generation of transcripts comprising modified nucleotides |
CA2613442C (en) | 2005-06-30 | 2016-08-23 | Archemix Corp. | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts |
CN105330741B (en) | 2005-07-01 | 2023-01-31 | E.R.施贵宝&圣斯有限责任公司 | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
ES2937245T3 (en) | 2005-08-23 | 2023-03-27 | Univ Pennsylvania | RNA containing modified nucleosides and methods of using the same |
US9012219B2 (en) | 2005-08-23 | 2015-04-21 | The Trustees Of The University Of Pennsylvania | RNA preparations comprising purified modified RNA for reprogramming cells |
WO2007025008A2 (en) | 2005-08-24 | 2007-03-01 | The Scripps Research Institute | Translation enhancer-element dependent vector systems |
DE102005046490A1 (en) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | New nucleic acid molecule comprising promoter, a transcriptable nucleic acid sequence, a first and second nucleic acid sequence for producing modified RNA with transcriptional stability and translational efficiency |
PT1966238E (en) | 2005-12-30 | 2012-07-31 | Merck Patent Gmbh | Interleukin-12p40 variants with improved stability |
EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
CA2633754C (en) | 2006-01-05 | 2013-06-18 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
WO2007084364A2 (en) | 2006-01-13 | 2007-07-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Improved il-12 for expression in mammalian cells |
KR101241477B1 (en) | 2006-01-27 | 2013-03-08 | 엘지이노텍 주식회사 | Nitride semiconductor light-emitting device and manufacturing method thereof |
EP2522749A1 (en) | 2006-03-02 | 2012-11-14 | The Ohio State University | MicroRNA expression profile associated with pancreatic cancer |
US7919079B2 (en) | 2006-03-31 | 2011-04-05 | Biosante Pharmaceuticals, Inc. | Cancer immunotherapy compositions and methods of use |
CA2647282A1 (en) | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
US20080046192A1 (en) | 2006-08-16 | 2008-02-21 | Richard Lathrop | Polypepetide-encoding nucleotide sequences with refined translational kinetics and methods of making same |
EP2115138A2 (en) | 2006-09-19 | 2009-11-11 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
DE102006051516A1 (en) | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Base) modified RNA to increase the expression of a protein |
WO2008054828A2 (en) | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
CN101622348A (en) | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | Gene and the approach regulated as the miR-20 of targets for therapeutic intervention |
CA2673029C (en) | 2006-12-22 | 2017-03-28 | Archemix Corp. | Materials and methods for the generation of transcripts comprising modified nucleotides |
ES2654303T3 (en) | 2007-05-04 | 2018-02-13 | University Health Network | IL-12 immunotherapy against cancer |
WO2008147974A1 (en) | 2007-05-23 | 2008-12-04 | University Of South Florida | Micro-rnas modulating immunity and inflammation |
WO2008154098A2 (en) | 2007-06-07 | 2008-12-18 | Wisconsin Alumni Research Foundation | Reagents and methods for mirna expression analysis and identification of cancer biomarkers |
DK2170959T3 (en) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | ANTIBODIES AGAINST HUMAN PROGRAMMED DEATH RECEPTOR PD-1 |
US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
TWI359030B (en) | 2007-08-24 | 2012-03-01 | Univ Nat Taiwan | Treatment of cellular proliferative disorders |
PT2201100E (en) | 2007-09-14 | 2016-06-03 | Univ Brussel Vrije | Enhancing the t-cells stimulatory capacity of human antigen presenting cells and their use in vaccination |
US20110086904A1 (en) | 2007-09-17 | 2011-04-14 | The Trustees Of The University Of Pennsylvania | GENERATION OF HYPERSTABLE mRNAs |
EP2591804A3 (en) * | 2007-09-24 | 2014-04-16 | Bar-Ilan University | Polymer nanoparticles coated by magnetic metal oxide and uses thereof |
KR101541935B1 (en) | 2007-09-26 | 2015-08-05 | 인트렉손 코포레이션 | Synthetic 5'UTRs, expression vectors, and methods for increasing transgene expression |
JP2011505143A (en) | 2007-11-30 | 2011-02-24 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | MicroRNA expression profiling and peripheral blood targeting in lung cancer |
EP2610340B1 (en) | 2007-12-11 | 2014-10-01 | The Scripps Research Institute | Compositions and methods related to mRNA translational enhancer elements |
EP2072618A1 (en) | 2007-12-14 | 2009-06-24 | Johannes Gutenberg-Universität Mainz | Use of RNA for reprogramming somatic cells |
JP5749494B2 (en) * | 2008-01-02 | 2015-07-15 | テクミラ ファーマシューティカルズ コーポレイション | Improved compositions and methods for delivery of nucleic acids |
WO2009100430A2 (en) | 2008-02-08 | 2009-08-13 | Asuragen, Inc | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
US20110052502A1 (en) | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA Signatures Associated with Human Chronic Lymphocytic Leukemia (CCL) and Uses Thereof |
AU2009238175C1 (en) * | 2008-04-15 | 2023-11-30 | Arbutus Biopharma Corporation | Novel lipid formulations for nucleic acid delivery |
EP2112235A1 (en) | 2008-04-24 | 2009-10-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Compositions and methods for microRNA expression profiling of nasopharyngeal carcinoma |
WO2009140206A1 (en) | 2008-05-11 | 2009-11-19 | The Gov. Of The U. S. A., As Represented By The Secretary Of The Dept. Of Health And Human Services | Improved expression of il-12 family heterodimers |
PL215513B1 (en) | 2008-06-06 | 2013-12-31 | Univ Warszawski | New borane phosphate analogs of dinucleotides, their application, RNA particle, method of obtaining RNA and method of obtaining peptides or protein |
US8401798B2 (en) | 2008-06-06 | 2013-03-19 | Dna Twopointo, Inc. | Systems and methods for constructing frequency lookup tables for expression systems |
US7561973B1 (en) | 2008-07-31 | 2009-07-14 | Dna Twopointo, Inc. | Methods for determining properties that affect an expression property value of polynucleotides in an expression system |
US8126653B2 (en) | 2008-07-31 | 2012-02-28 | Dna Twopointo, Inc. | Synthetic nucleic acids for expression of encoded proteins |
WO2009149539A1 (en) | 2008-06-10 | 2009-12-17 | Université de Montréal | Enhancing antigen-specific cd8+ t cell response using irf-7 mrna |
WO2010018563A2 (en) | 2008-08-12 | 2010-02-18 | Rosetta Genomics Ltd. | Compositions and methods for the prognosis of lymphoma |
NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
US9074206B2 (en) | 2008-11-13 | 2015-07-07 | Fudan University | Compositions and methods for micro-RNA expression profiling of colorectal cancer |
SI2376535T1 (en) | 2008-12-09 | 2017-07-31 | F. Hoffmann-La Roche Ag | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP2358902A1 (en) | 2008-12-10 | 2011-08-24 | Universität Regensburg | Compositions and methods for micro-rna expression profiling of cancer stem cells |
CA2760446C (en) | 2009-04-30 | 2018-01-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible interleukin-12 |
WO2010129860A2 (en) | 2009-05-08 | 2010-11-11 | The Ohio State University Research Foundation | Microrna expression profiling and targeting in chronic obstructive pulmonary disease (copd) lung tissue and methods of use thereof |
DK2440183T3 (en) | 2009-06-10 | 2018-10-01 | Arbutus Biopharma Corp | Improved lipid formulation |
EP2459231B1 (en) | 2009-07-31 | 2016-06-08 | Ethris Gmbh | Rna with a combination of unmodified and modified nucleotides for protein expression |
EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
US20110082055A1 (en) | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
JP2013512251A (en) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Simultaneous inhibition of PD-L1 / PD-L2 |
PL3338765T3 (en) | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Steroid derivative for the delivery of mrna in human genetic diseases |
WO2011076142A1 (en) | 2009-12-24 | 2011-06-30 | Fudan University | Compositions and methods for microrna expession profiling in plasma of colorectal cancer |
WO2011076143A1 (en) | 2009-12-24 | 2011-06-30 | Fudan University | Compositions and methods for microrna expression profiling of lung cancer |
EP2341145A1 (en) | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
WO2011094683A2 (en) | 2010-01-29 | 2011-08-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of identifying myelodysplastic syndromes |
EP2354246A1 (en) | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
WO2011113030A2 (en) | 2010-03-11 | 2011-09-15 | H.Lee Moffitt Cancer Center & Research Institute | Human cancer micro-rna expression profiles predictive of chemo-response |
WO2011157294A1 (en) | 2010-06-16 | 2011-12-22 | Universita' Degli Studi Di Padova | Compositions for use in treating or preventing cancer, breast cancer, lung cancer, ovarian cancer, metastasis, heart failure, cardiac remodelling, dilated cardiomyopathy, autoimmune diseases, or diseases or disorders related thereto |
US20130230884A1 (en) | 2010-07-16 | 2013-09-05 | John Chaput | Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation |
WO2012038448A1 (en) | 2010-09-21 | 2012-03-29 | Riboxx Gmbh | Method for synthesizing rna using dna template |
WO2012072096A1 (en) | 2010-12-03 | 2012-06-07 | Biontech Ag | Method for cellular rna expression |
KR20120066952A (en) | 2010-12-15 | 2012-06-25 | 주식회사 롤팩 | Antibacterial vacuum film having 7 layers structure and method for manufacturing the same |
EP2651445A2 (en) | 2010-12-16 | 2013-10-23 | SPRNA GmbH | Pharmaceutical composition consisting of rna having alkali metal as counter ion and formulated with dications |
WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
CN103476943A (en) | 2011-03-10 | 2013-12-25 | 普罗维克图斯药品公司 | Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer |
EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
WO2012151212A1 (en) | 2011-05-01 | 2012-11-08 | University Of Rochester | Multifocal hepatocellular carcinoma microrna expression patterns and uses thereof |
EP2706690B1 (en) | 2011-05-02 | 2018-03-21 | LG Electronics Inc. | Method for transmitting/receiving data in wireless access system and base station for same |
WO2012153187A2 (en) | 2011-05-06 | 2012-11-15 | Xentech | Markers for cancer prognosis and therapy and methods of use |
EP4043025A1 (en) | 2011-06-08 | 2022-08-17 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
ES2610245T3 (en) | 2011-07-15 | 2017-04-26 | Leo Pharma A/S | MicroRNA profiling for diagnosis in cutaneous T-cell lymphoma (CTCL) |
US20150080243A1 (en) | 2011-09-01 | 2015-03-19 | Allegro Diagnostics Corp. | Methods and compositions for detecting cancer based on mirna expression profiles |
WO2013039857A1 (en) | 2011-09-12 | 2013-03-21 | modeRNA Therapeutics | Engineered nucleic acids and methods of use thereof |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
WO2013053775A1 (en) | 2011-10-11 | 2013-04-18 | Universität Zürich Prorektorat Mnw | Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy |
WO2013066678A1 (en) | 2011-10-26 | 2013-05-10 | Georgetown University | Microrna expression profiling of thyroid cancer |
KR101981873B1 (en) | 2011-11-28 | 2019-05-23 | 메르크 파텐트 게엠베하 | Anti-pd-l1 antibodies and uses thereof |
KR20220132652A (en) | 2011-12-12 | 2022-09-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same |
EP2623121A1 (en) | 2012-01-31 | 2013-08-07 | Bayer Innovation GmbH | Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen |
WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
CA2868398A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
EP2672197A1 (en) | 2012-06-06 | 2013-12-11 | Hörmann Energietechnik GmbH & Co. KG | Mounting assembly for mounting plate-like bodies to the roof of a building |
EP3884949A1 (en) | 2012-06-08 | 2021-09-29 | Translate Bio, Inc. | Pulmonary delivery of mrna to non-lung target cells |
EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | Nuclease resistant polynucleotides and uses thereof |
US20140020675A1 (en) | 2012-07-18 | 2014-01-23 | Chandrashekhar Sonwane | Solar receiver |
US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
CN103555734B (en) * | 2012-09-17 | 2015-07-15 | 青岛康立泰药业有限公司 | Coding gene of human interleukin-12, eukaryotic host cell and expression method thereof |
US20150307542A1 (en) | 2012-10-03 | 2015-10-29 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
WO2014071963A1 (en) | 2012-11-09 | 2014-05-15 | Biontech Ag | Method for cellular rna expression |
JP6144355B2 (en) * | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | Chemically modified mRNA |
WO2014089486A1 (en) | 2012-12-07 | 2014-06-12 | Shire Human Genetic Therapies, Inc. | Lipidic nanoparticles for mrna delivering |
CA2897941A1 (en) | 2013-01-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
CN109045289A (en) | 2013-02-22 | 2018-12-21 | 库瑞瓦格股份公司 | Vaccine inoculation and the combination for inhibiting PD-1 approach |
JP6352950B2 (en) | 2013-03-08 | 2018-07-04 | ノバルティス アーゲー | Lipids and lipid compositions for active drug delivery |
EP2964234A4 (en) | 2013-03-09 | 2016-12-07 | Moderna Therapeutics Inc | Heterologous untranslated regions for mrna |
PT2968586T (en) | 2013-03-14 | 2018-11-13 | Ethris Gmbh | Cftr mrna compositions and related methods and uses |
HUE055044T2 (en) | 2013-03-14 | 2021-10-28 | Translate Bio Inc | Methods and compositions for delivering mrna coded antibodies |
WO2014152940A1 (en) | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
ES2708562T3 (en) | 2013-03-14 | 2019-04-10 | Translate Bio Inc | Quantitative evaluation of the efficiency of messenger RNA cover |
EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
KR20150127582A (en) | 2013-03-14 | 2015-11-17 | 샤이어 휴먼 지네틱 테라피즈 인크. | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
ES2680595T3 (en) | 2013-03-14 | 2018-09-10 | Translate Bio, Inc. | Quantitative evaluation for efficacy of messenger RNA to cover |
EP3388834B1 (en) | 2013-03-15 | 2020-04-15 | Translate Bio, Inc. | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
WO2015024667A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Method for increasing expression of rna-encoded proteins |
JP6623353B2 (en) | 2013-09-13 | 2019-12-25 | ベイジーン スウィッツァーランド ゲーエムベーハー | Anti-PD-1 antibodies and their use for therapy and diagnosis |
WO2015050158A1 (en) | 2013-10-01 | 2015-04-09 | 国立大学法人三重大学 | T cell-inducing vaccine containing interepitope sequence promoting antigen presentation |
EP3058082A4 (en) | 2013-10-18 | 2017-04-26 | ModernaTX, Inc. | Compositions and methods for tolerizing cellular systems |
US9629804B2 (en) | 2013-10-22 | 2017-04-25 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger RNA |
WO2015061491A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
ES2806575T3 (en) | 2013-11-01 | 2021-02-18 | Curevac Ag | Modified RNA with decreased immunostimulatory properties |
CA2934028A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
EP3083666A4 (en) * | 2013-12-18 | 2017-09-20 | Intrexon Corporation | Single chain il-12 nucleic acids, polypeptids, and uses thereof |
SG11201603144QA (en) | 2013-12-30 | 2016-07-28 | Curevac Ag | Artificial nucleic acid molecules |
WO2015101415A1 (en) | 2013-12-30 | 2015-07-09 | Curevac Gmbh | Artificial nucleic acid molecules |
CA2946751A1 (en) | 2014-04-23 | 2015-10-29 | Modernatx, Inc. | Nucleic acid vaccines |
SI3766916T1 (en) * | 2014-06-25 | 2023-01-31 | Acuitas Therapeutics Inc. | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
WO2016048903A1 (en) | 2014-09-22 | 2016-03-31 | Intrexon Corporation | Improved therapeutic control of heterodimeric and single chain forms of interleukin-12 |
EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
JP6912384B2 (en) | 2015-04-22 | 2021-08-04 | キュアバック アーゲー | RNA-containing compositions for the treatment of cancer diseases |
CN107847577B (en) | 2015-05-19 | 2021-11-23 | 摩尔福基因有限公司 | Cancer vaccine comprising mRNA encoding M-like protein |
US10682401B2 (en) | 2015-05-19 | 2020-06-16 | Morphogenesis, Inc. | Multi-indication mRNA cancer immunotherapy |
AU2016324310B2 (en) * | 2015-09-17 | 2021-04-08 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
EP3205356A1 (en) | 2016-02-10 | 2017-08-16 | Onkoloski Institut Ljubljana | Plasmid expression vector encoding human interleukin 12 under transcriptional control of p21 promoter and without antibiotic resistance for cancer gene therapy and other uses thereof |
ES2718192T3 (en) | 2016-02-25 | 2019-06-28 | Provecs Medical Gmbh | Novel immunostimulatory vector system |
KR102469450B1 (en) | 2016-05-18 | 2022-11-22 | 모더나티엑스, 인크. | Polynucleotides Encoding Interleukin-12 (IL12) and Uses Thereof |
SG10201913631TA (en) | 2016-08-19 | 2020-03-30 | Curevac Ag | Rna for cancer therapy |
CN110267978A (en) | 2016-10-07 | 2019-09-20 | 得克萨斯大学体系董事会 | The T cell of the IL-12 of expression film anchoring for treating cancer |
-
2017
- 2017-05-18 KR KR1020187036222A patent/KR102469450B1/en active IP Right Grant
- 2017-05-18 RU RU2018144292A patent/RU2769316C2/en active
- 2017-05-18 SG SG11201809381XA patent/SG11201809381XA/en unknown
- 2017-05-18 JP JP2018560509A patent/JP7246930B2/en active Active
- 2017-05-18 DK DK17726458.7T patent/DK3458083T3/en active
- 2017-05-18 PL PL17726458.7T patent/PL3458083T3/en unknown
- 2017-05-18 HU HUE17726458A patent/HUE061077T2/en unknown
- 2017-05-18 FI FIEP17726458.7T patent/FI3458083T3/en active
- 2017-05-18 WO PCT/US2017/033422 patent/WO2017201350A1/en unknown
- 2017-05-18 ES ES17726458T patent/ES2941411T3/en active Active
- 2017-05-18 PT PT177264587T patent/PT3458083T/en unknown
- 2017-05-18 CN CN201780030730.8A patent/CN109195621A/en active Pending
- 2017-05-18 KR KR1020227040214A patent/KR20220159479A/en not_active Application Discontinuation
- 2017-05-18 LT LTEPPCT/US2017/033422T patent/LT3458083T/en unknown
- 2017-05-18 EP EP17726458.7A patent/EP3458083B1/en active Active
- 2017-05-18 CA CA3024470A patent/CA3024470A1/en active Pending
- 2017-05-18 RS RS20230055A patent/RS63912B1/en unknown
- 2017-05-18 MX MX2018013509A patent/MX2018013509A/en unknown
- 2017-05-18 SI SI201731299T patent/SI3458083T1/en unknown
- 2017-05-18 AU AU2017268397A patent/AU2017268397B2/en active Active
- 2017-05-18 EP EP22204799.5A patent/EP4186518A1/en active Pending
- 2017-05-18 HR HRP20230050TT patent/HRP20230050T1/en unknown
-
2018
- 2018-10-21 IL IL262501A patent/IL262501A/en unknown
- 2018-11-05 MX MX2022008602A patent/MX2022008602A/en unknown
- 2018-11-15 US US16/192,274 patent/US10646549B2/en active Active
-
2020
- 2020-04-07 US US16/842,300 patent/US11000573B2/en active Active
-
2021
- 2021-05-05 US US17/308,686 patent/US11311602B2/en active Active
-
2022
- 2022-04-15 US US17/721,583 patent/US11571463B2/en active Active
-
2023
- 2023-02-06 US US18/164,796 patent/US20240024422A1/en active Pending
- 2023-03-15 JP JP2023040409A patent/JP2023072056A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201809381XA (en) | Polynucleotides encoding interleukin-12 (il12) and uses thereof | |
SG11201903674YA (en) | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof | |
SG11201909949XA (en) | Targeted immunotolerance | |
SG11201907422RA (en) | Anti-tau antibodies and methods of use thereof | |
SG11201909395TA (en) | Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof | |
SG11201909777YA (en) | Modulatory polynucleotides | |
SG11201810933QA (en) | Anti-c5 antibodies and uses thereof | |
SG11201907889YA (en) | Glycan-interacting compounds and methods of use | |
SG11201810023QA (en) | Anti-tim-3 antibodies and methods of use thereof | |
SG11201807401RA (en) | Therapeutic membrane vesicles | |
SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
SG11201806322QA (en) | Maytansinoid derivatives, conjugates thereof, and methods of use | |
SG11201806496SA (en) | Antigen binding proteins that bind pd-l1 | |
SG11201809374VA (en) | Cd40l-fc fusion polypeptides and methods of use thereof | |
SG11201807279QA (en) | Binding proteins and methods of use thereof | |
SG11201805268XA (en) | T cell receptors specific for the ny-eso-1 tumor antigen-hla-a*02 complex | |
SG11201901020RA (en) | Anti-siglec-7 antibodies for the treatment of cancer | |
SG11201907427YA (en) | Engineered transferrin receptor binding polypeptides | |
SG11201910096RA (en) | Anti-cd3-binding domains and antibodies comprising them, and methods for their generation and use | |
SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
SG11201908051RA (en) | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function | |
SG11201804673WA (en) | Novel anti-claudin antibodies and methods of use | |
SG11201908238SA (en) | Anti-c5 antibodies and uses thereof | |
SG11201809594WA (en) | Nicotine particles and compositions | |
SG11201810987TA (en) | A thermoplastic optical device |