SG11201808682XA - Silicone atoms containing ivacaftor analogues - Google Patents
Silicone atoms containing ivacaftor analoguesInfo
- Publication number
- SG11201808682XA SG11201808682XA SG11201808682XA SG11201808682XA SG11201808682XA SG 11201808682X A SG11201808682X A SG 11201808682XA SG 11201808682X A SG11201808682X A SG 11201808682XA SG 11201808682X A SG11201808682X A SG 11201808682XA SG 11201808682X A SG11201808682X A SG 11201808682XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- analogues
- english
- april
- Prior art date
Links
- PURKAOJPTOLRMP-UHFFFAOYSA-N ivacaftor Chemical class C1=C(O)C(C(C)(C)C)=CC(C(C)(C)C)=C1NC(=O)C1=CNC2=CC=CC=C2C1=O PURKAOJPTOLRMP-UHFFFAOYSA-N 0.000 title abstract 3
- 229920001296 polysiloxane Polymers 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000007111 proteostasis Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/16—Anti-Parkinson drugs
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319439P | 2016-04-07 | 2016-04-07 | |
| PCT/US2017/026579 WO2017177124A1 (en) | 2016-04-07 | 2017-04-07 | Silicone atoms containing ivacaftor analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201808682XA true SG11201808682XA (en) | 2018-11-29 |
Family
ID=58549338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201808682XA SG11201808682XA (en) | 2016-04-07 | 2017-04-07 | Silicone atoms containing ivacaftor analogues |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10662207B2 (ko) |
| EP (1) | EP3440057B1 (ko) |
| JP (1) | JP7061076B2 (ko) |
| KR (1) | KR102448404B1 (ko) |
| CN (1) | CN109563047A (ko) |
| AR (1) | AR108203A1 (ko) |
| AU (1) | AU2017248253B2 (ko) |
| BR (1) | BR112018070747B1 (ko) |
| CA (1) | CA3019663A1 (ko) |
| IL (1) | IL262030B (ko) |
| MA (1) | MA43775A (ko) |
| MX (1) | MX2018012331A (ko) |
| NZ (1) | NZ746793A (ko) |
| SA (1) | SA518400164B1 (ko) |
| SG (1) | SG11201808682XA (ko) |
| WO (1) | WO2017177124A1 (ko) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ768373A (en) | 2014-10-06 | 2024-03-22 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| WO2017019589A1 (en) | 2015-07-24 | 2017-02-02 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| AU2016336437B2 (en) | 2015-10-06 | 2020-06-18 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
| EP3440057B1 (en) | 2016-04-07 | 2021-09-22 | Proteostasis Therapeutics, Inc. | Silicone atoms containing ivacaftor analogues |
| CA3028966A1 (en) | 2016-06-21 | 2017-12-28 | Proteostasis Therapeutics, Inc. | Substituted phenyl-isoxazole-carboxamide compounds and use thereof for increasing cftr activity |
| US10570115B2 (en) * | 2016-09-30 | 2020-02-25 | Vertex Pharmaceuticals Incorporated | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| AU2017371200B2 (en) | 2016-12-09 | 2021-05-06 | Vertex Pharmaceuticals Incorporated | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| EP3641763A4 (en) * | 2017-06-21 | 2021-03-24 | The Johns Hopkins University | MUCOVISCIDOSIS TRANSMEMBRANE CONTROL REGULATOR MODULATORS FOR TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC RENAL DISEASES |
| BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| ES2912657T3 (es) | 2017-08-02 | 2022-05-26 | Vertex Pharma | Procesos para preparar compuestos de pirrolidina |
| WO2019071078A1 (en) * | 2017-10-06 | 2019-04-11 | Proteostasis Therapeutics, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY |
| US10654829B2 (en) | 2017-10-19 | 2020-05-19 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
| KR20200097293A (ko) * | 2017-12-08 | 2020-08-18 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| US11066417B2 (en) | 2018-02-15 | 2021-07-20 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators |
| WO2019195739A1 (en) | 2018-04-05 | 2019-10-10 | Alexander Russell Abela | Modulators of cystic fibrosis transmembrane conductance regulator |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| JP2021530465A (ja) | 2018-06-27 | 2021-11-11 | プロテオステイシス セラピューティクス， インコーポレイテッド | プロテアソーム活性増強化合物 |
| CN109663129B (zh) * | 2019-02-27 | 2021-05-11 | 四川大学华西第二医院 | 扩张型心肌病治疗药物及其应用 |
| TW202120517A (zh) | 2019-08-14 | 2021-06-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| TW202115092A (zh) | 2019-08-14 | 2021-04-16 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| US11873300B2 (en) | 2019-08-14 | 2024-01-16 | Vertex Pharmaceuticals Incorporated | Crystalline forms of CFTR modulators |
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-
2017
- 2017-04-07 EP EP17718318.3A patent/EP3440057B1/en active Active
- 2017-04-07 BR BR112018070747-3A patent/BR112018070747B1/pt active IP Right Grant
- 2017-04-07 US US16/091,401 patent/US10662207B2/en active Active
- 2017-04-07 CN CN201780031083.2A patent/CN109563047A/zh active Pending
- 2017-04-07 CA CA3019663A patent/CA3019663A1/en active Pending
- 2017-04-07 MA MA043775A patent/MA43775A/fr unknown
- 2017-04-07 WO PCT/US2017/026579 patent/WO2017177124A1/en active Application Filing
- 2017-04-07 KR KR1020187031895A patent/KR102448404B1/ko active IP Right Grant
- 2017-04-07 NZ NZ746793A patent/NZ746793A/en unknown
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- 2017-04-07 AU AU2017248253A patent/AU2017248253B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US20210061823A1 (en) | 2021-03-04 |
| JP2019513741A (ja) | 2019-05-30 |
| AU2017248253A1 (en) | 2018-10-18 |
| AU2017248253B2 (en) | 2021-07-29 |
| WO2017177124A1 (en) | 2017-10-12 |
| US10662207B2 (en) | 2020-05-26 |
| KR20180132803A (ko) | 2018-12-12 |
| KR102448404B1 (ko) | 2022-09-27 |
| RU2018137683A3 (ko) | 2020-05-18 |
| RU2018137683A (ru) | 2020-05-12 |
| NZ746793A (en) | 2022-10-28 |
| MX2018012331A (es) | 2019-05-23 |
| CN109563047A (zh) | 2019-04-02 |
| IL262030A (en) | 2018-11-29 |
| CA3019663A1 (en) | 2017-10-12 |
| AR108203A1 (es) | 2018-07-25 |
| BR112018070747A2 (pt) | 2019-06-18 |
| US20190153000A1 (en) | 2019-05-23 |
| SA518400164B1 (ar) | 2022-05-08 |
| US20240109922A1 (en) | 2024-04-04 |
| US11248010B2 (en) | 2022-02-15 |
| MA43775A (fr) | 2021-05-05 |
| EP3440057B1 (en) | 2021-09-22 |
| IL262030B (en) | 2021-10-31 |
| JP7061076B2 (ja) | 2022-04-27 |
| EP3440057A1 (en) | 2019-02-13 |
| BR112018070747B1 (pt) | 2024-01-09 |
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