SG11201807982UA - Substituted inhibitors of menin-mll and methods of use - Google Patents
Substituted inhibitors of menin-mll and methods of useInfo
- Publication number
- SG11201807982UA SG11201807982UA SG11201807982UA SG11201807982UA SG11201807982UA SG 11201807982U A SG11201807982U A SG 11201807982UA SG 11201807982U A SG11201807982U A SG 11201807982UA SG 11201807982U A SG11201807982U A SG 11201807982UA SG 11201807982U A SG11201807982U A SG 11201807982UA
- Authority
- SG
- Singapore
- Prior art keywords
- huron
- floor
- international
- ann arbor
- parkway
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 111110111011110110101101011110111110111011 11 International Bureau ... .jd ..... .,,,, (10) International Publication Number (43) International Publication Date WO 2017/161028 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: (US). GREMBECKA, Jolanta; 1600 Huron Parkway, A61K 31/535 (2006.01) 2nd Floor, Ann Arbor, MI 48109 (US). CIERPICKI, To- (21) International Application Number: masz; 1600 Huron Parkway, 2nd Floor, Ann Arbor, MI 48109 (US). KLOSSOWSKI, Szymon; 1600 Huron Park- PCT/US2017/022564 way, 2nd Floor, Ann Arbor, MI 48109 (US). POLLOCK, (22) International Filing Date: Jonathan; 1600 Huron Parkway, 2nd Floor, Ann Arbor, 15 March 2017 (15.03.2017) MI 48109 (US). BORKIN, Dmitry; 1600 Huron Parkway, 2nd Floor, Ann Arbor, MI 48109 (US). (25) Filing Language: English (74) Agents: CHANG, Andrew, L. et al.; Wilson Sonsini (26) Publication Language: English Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA (30) Priority Data: 94304-1050 (US). 62/309,372 16 March 2016 (16.03.2016) US (81) Designated States (unless otherwise indicated, for every 62/334,369 10 May 2016 (10.05.2016) US kind of national protection available): AE, AG, AL, AM, 62/431,389 7 December 2016 (07.12.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 62/446,640 16 January 2017 (16.01.2017) US BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, — (71) Applicants: KURA ONCOLOGY, INC. [US/US]; 11119 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, North Torrey Pines Road, Suite 125, La Jolla, CA 92037 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (US). THE REGENTS OF THE UNIVERSITY OF KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MICHIGAN [US/US]; 1600 Huron Parkway, 2nd Floor, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Ann Arbor, MI 48109 (US). NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (72) Inventors: WU, Tao; 2355 Terraza Guitara, Carlsbad, CA TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 92009 (US). LI, Liansheng; 13569 Arroyo Dale Lane, San ZA, ZM, ZW. Diego, CA 92130 (US). WANG, Yi; 7556 Charmant Drive, Apartment 1732, San Diego, CA 92122 (US). REN, (84) Designated States (unless otherwise indicated, for every Pingda; 5534 Havenridge Way, San Diego, CA 92130 kind of regional protection available): ARIPO (BW, GH, [Continued on next page] Title: SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE (54) FIG. 4 MV4;11 s.c. model 2000 -0-vehicle Control 1500 --Compound B, 50 mg/kg/bid, po -9-Compound B, 100 mg/kg/bid, po E ) -IEI-Compound B, 200 mg/kg/qd, po > 1000 8 -0-Compound B, 200 mg/kg/bid, po E +., c w as 500 1-1 ei 2 © 0 2 4 6 8 10 12 14 16 18 1-1 Treatment period (day) 1-1 1-1 (57) : The present disclosure provides methods of inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion N oncoproteins. The methods are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin. Compositions for use in these methods are also provided. C WO 2017/161028 Al 1#110HOMOIDEIRMEMOMMIDEMIMMOIMEN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Published: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, DE, LT, — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, SE, GA, claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662309372P | 2016-03-16 | 2016-03-16 | |
US201662334369P | 2016-05-10 | 2016-05-10 | |
US201662431389P | 2016-12-07 | 2016-12-07 | |
US201762446640P | 2017-01-16 | 2017-01-16 | |
PCT/US2017/022564 WO2017161028A1 (en) | 2016-03-16 | 2017-03-15 | Substituted inhibitors of menin-mll and methods of use |
Publications (1)
Publication Number | Publication Date |
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SG11201807982UA true SG11201807982UA (en) | 2018-10-30 |
Family
ID=59851028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201807982UA SG11201807982UA (en) | 2016-03-16 | 2017-03-15 | Substituted inhibitors of menin-mll and methods of use |
Country Status (27)
Country | Link |
---|---|
US (2) | US10781218B2 (en) |
EP (2) | EP3429591B1 (en) |
JP (3) | JP6919977B2 (en) |
KR (1) | KR102419531B1 (en) |
CN (2) | CN109152784B (en) |
AU (1) | AU2017232516B2 (en) |
BR (1) | BR112018068703B1 (en) |
CA (1) | CA3015847A1 (en) |
CY (1) | CY1126066T1 (en) |
DK (1) | DK3429591T3 (en) |
ES (1) | ES2947636T3 (en) |
FI (1) | FI3429591T3 (en) |
HK (1) | HK1259232A1 (en) |
HR (1) | HRP20230537T1 (en) |
HU (1) | HUE061989T2 (en) |
IL (1) | IL261606B (en) |
LT (1) | LT3429591T (en) |
MD (1) | MD3429591T2 (en) |
MX (1) | MX2018011105A (en) |
PH (1) | PH12018501952A1 (en) |
PL (1) | PL3429591T3 (en) |
PT (1) | PT3429591T (en) |
RS (1) | RS64261B1 (en) |
SG (1) | SG11201807982UA (en) |
SI (1) | SI3429591T1 (en) |
TW (1) | TWI747889B (en) |
WO (1) | WO2017161028A1 (en) |
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