SG11201804969PA - Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof - Google Patents
Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereofInfo
- Publication number
- SG11201804969PA SG11201804969PA SG11201804969PA SG11201804969PA SG11201804969PA SG 11201804969P A SG11201804969P A SG 11201804969PA SG 11201804969P A SG11201804969P A SG 11201804969PA SG 11201804969P A SG11201804969P A SG 11201804969PA SG 11201804969P A SG11201804969P A SG 11201804969PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- chimeric
- street
- pct
- human ctla4
- Prior art date
Links
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000043321 human CTLA4 Human genes 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
HingeY 254T T253E 52.98A 33A Humanization Hinge .252Y S254T T256E ;293A E333A K334A (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/106372 Al 22 June 2017 (22.06.2017) WIPO I PCT 111111111111110111010101111101011111011101011011011011111111011111111111110111111 (51) International Patent Classification: A61K 39/00 (2006.01) C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) (21) International Application Number: PCT/US2016/066698 (22) International Filing Date: 14 December 2016 (14.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/267,735 15 December 2015 (15.12.2015) US 62/309,169 16 March 2016 (16.03.2016) US 62/359,036 6 July 2016 (06.07.2016) US (71) Applicant: ONCOIMMUNE, INC. [US/US]; 12111 Parklawn Drive, Suites 107,109, and 111, Rockville, Mary- land 20852 (US). (72) Inventors; and (71) Applicants (for US only): LIU, Yang [US/US]; 502 E Street NE, Washington, District of Columbia 20002 (US). ZHENG, Pan [US/US]; 502 E Street NE, Washington, District of Columbia 20002 (US). DEVENPORT, Martin [GB/US]; 607 Gatestone Street, Gaithersburg, Maryland 20878 (US). — (74) Agents: GALANT, Ron et al.; Polsinelli PC, 161 N. Clark Street, Suite 4200, Chicago, Illinois 60601 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) - (54) Title: CHIMERIC AND HUMANIZED ANTI-HUMAN CTLA4 MONOCLONAL ANTIBODIES AND USES THEREOF W O 20 17 / 10637 2 Al Chimeric Humanized L3D10 L3D10 FIG. 1 (57) : This invention relates to compositions of chimeric and humanized antibodies that bind to the human CTLA4 mo - lecule and their use in cancer immunotherapy and for reduction of autoimmune side effects compared to other immunotherapeutic agents.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562267735P | 2015-12-15 | 2015-12-15 | |
| US201662309169P | 2016-03-16 | 2016-03-16 | |
| US201662359036P | 2016-07-06 | 2016-07-06 | |
| PCT/US2016/066698 WO2017106372A1 (en) | 2015-12-15 | 2016-12-14 | Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201804969PA true SG11201804969PA (en) | 2018-07-30 |
Family
ID=59057509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201804969PA SG11201804969PA (en) | 2015-12-15 | 2016-12-14 | Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10618960B2 (en) |
| EP (1) | EP3389699B1 (en) |
| JP (4) | JP6858779B2 (en) |
| KR (1) | KR20180086219A (en) |
| CN (2) | CN108430499B (en) |
| AU (2) | AU2016370648B2 (en) |
| BR (1) | BR112018012113A2 (en) |
| CA (1) | CA3006984C (en) |
| IL (3) | IL296354B1 (en) |
| MX (1) | MX2018006925A (en) |
| MY (1) | MY186974A (en) |
| SG (1) | SG11201804969PA (en) |
| TW (1) | TWI739781B (en) |
| WO (1) | WO2017106372A1 (en) |
| ZA (1) | ZA201804077B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK3303394T3 (en) | 2015-05-29 | 2020-07-06 | Agenus Inc | ANTI-CTLA-4 ANTIBODIES AND PROCEDURES FOR USE THEREOF |
| CN109715210B (en) * | 2016-09-19 | 2023-05-30 | 昂科医药 | CD80 and CD86 binding protein compositions and uses thereof |
| EA201991383A1 (en) | 2016-12-07 | 2019-12-30 | Эйдженус Инк. | ANTIBODIES AGAINST CTLA-4 AND WAYS OF THEIR APPLICATION |
| WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
| JP2021502100A (en) * | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| US20210047410A1 (en) * | 2018-02-02 | 2021-02-18 | Oncolmmune, Inc. | Methods of selecting and designing safer and more effective anti-ctla-4 antibodies for cancer therapy |
| EP3746479A4 (en) * | 2018-02-02 | 2021-11-24 | OncoC4, Inc. | Mutant anti-ctla-4 antibodies with improved immunotherapeutic effect but attenuated adverse effects |
| WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| EP3802613A4 (en) * | 2018-06-05 | 2022-03-09 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | Dimer and use thereof |
| EP3617230A1 (en) * | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
| JP2022514702A (en) | 2018-12-21 | 2022-02-14 | オーエスイー・イミュノセラピューティクス | Bifunctional anti-PD-1 / IL-7 molecule |
| KR20210121045A (en) * | 2018-12-27 | 2021-10-07 | 기가젠, 인코포레이티드 | Anti-CTLA-4 binding proteins and methods of use thereof |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Ose Immunotherapeutics | Bifunctional molecules comprising an IL-7 variant |
| JP7440724B2 (en) * | 2020-04-13 | 2024-02-29 | ビオシオン インコーポレイテッド | Antibodies that bind to CTLA4 and uses thereof |
| WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
| WO2022117572A2 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | An ltbr agonist in combination therapy against cancer |
| WO2022169269A1 (en) * | 2021-02-03 | 2022-08-11 | 주식회사 유틸렉스 | Anti-ctla-4 antibody and use thereof |
| IL307419A (en) | 2021-04-09 | 2023-12-01 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
| EP4320156A1 (en) | 2021-04-09 | 2024-02-14 | Ose Immunotherapeutics | Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains |
| JP7345889B2 (en) * | 2021-06-17 | 2023-09-19 | 株式会社ニューギン | gaming machine |
| CA3234491A1 (en) * | 2021-10-08 | 2023-04-13 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| AU2022361768A1 (en) * | 2021-10-08 | 2024-05-02 | Kashiv Biosciences, Llc | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
| WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
| WO2024059833A1 (en) | 2022-09-16 | 2024-03-21 | OncoC4, Inc. | Use of anti-ctla-4 antibodies for treating adenoid cystic carcinoma |
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| US20150079100A1 (en) * | 2012-03-23 | 2015-03-19 | Bristol-Myers Squibb Company | Methods of treatments using ctla-4 antibodies |
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2016
- 2016-12-14 CN CN201680073425.2A patent/CN108430499B/en active Active
- 2016-12-14 AU AU2016370648A patent/AU2016370648B2/en active Active
- 2016-12-14 US US16/062,350 patent/US10618960B2/en active Active
- 2016-12-14 MX MX2018006925A patent/MX2018006925A/en unknown
- 2016-12-14 IL IL296354A patent/IL296354B1/en unknown
- 2016-12-14 JP JP2018530560A patent/JP6858779B2/en active Active
- 2016-12-14 WO PCT/US2016/066698 patent/WO2017106372A1/en active Application Filing
- 2016-12-14 IL IL259988A patent/IL259988B2/en unknown
- 2016-12-14 CN CN202210802423.XA patent/CN116063492A/en active Pending
- 2016-12-14 BR BR112018012113A patent/BR112018012113A2/en active Search and Examination
- 2016-12-14 IL IL310404A patent/IL310404A/en unknown
- 2016-12-14 EP EP16876612.9A patent/EP3389699B1/en active Active
- 2016-12-14 CA CA3006984A patent/CA3006984C/en active Active
- 2016-12-14 SG SG11201804969PA patent/SG11201804969PA/en unknown
- 2016-12-14 KR KR1020187017368A patent/KR20180086219A/en unknown
- 2016-12-14 MY MYPI2018000904A patent/MY186974A/en unknown
- 2016-12-15 TW TW105141656A patent/TWI739781B/en active
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2018
- 2018-06-18 ZA ZA2018/04077A patent/ZA201804077B/en unknown
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2020
- 2020-02-27 US US16/803,972 patent/US11629188B2/en active Active
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2021
- 2021-03-23 JP JP2021049294A patent/JP2021100957A/en active Pending
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2022
- 2022-06-15 JP JP2022096901A patent/JP7286845B2/en active Active
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2023
- 2023-03-22 US US18/188,098 patent/US20230391870A1/en active Pending
- 2023-05-19 AU AU2023203169A patent/AU2023203169A1/en active Pending
- 2023-05-24 JP JP2023085801A patent/JP2023106547A/en active Pending
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