SG11201804714XA - Electrode integration into organs on chip devices - Google Patents

Electrode integration into organs on chip devices

Info

Publication number
SG11201804714XA
SG11201804714XA SG11201804714XA SG11201804714XA SG11201804714XA SG 11201804714X A SG11201804714X A SG 11201804714XA SG 11201804714X A SG11201804714X A SG 11201804714XA SG 11201804714X A SG11201804714X A SG 11201804714XA SG 11201804714X A SG11201804714X A SG 11201804714XA
Authority
SG
Singapore
Prior art keywords
international
iii
microchannel
rule
opened
Prior art date
Application number
SG11201804714XA
Inventor
Olivier Henry
Der Meer Andries Van
Donald Ingber
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of SG11201804714XA publication Critical patent/SG11201804714XA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/305—Electrodes, e.g. test electrodes; Half-cells optically transparent or photoresponsive electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C3/00—Assembling of devices or systems from individually processed components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 111111111111110 III OE III OE III II III 11111111111111111111 OE HIRE 1111111H (10) International Publication Number WO 2017/106727 Al WIPO I PCT (43) International Publication Date 22 June 2017 (22.06.2017) (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 5/07 (2010.01) G01N 27/40 (2006.01) kind of national protection available): AE, AG, AL, AM, C12M 3/04 (2006.01) GO1N 33/50 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BOIL 3/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: PCT/US2016/067294 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 16 December 2016 (16.12.2016) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, English (25) Filing Language: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English (26) Publication Language: (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/268,454 16 December 2015 (16.12.2015) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/297,659 19 February 2016 (19.02.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: PRESIDENT AND FELLOWS OF HAR- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, VARD COLLEGE [US/US]; 17 Quincy Street, Cam- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, bridge, Massachusetts 02138 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: HENRY, Olivier; 519 Washington Street, Apt. GW, KM, ML, MR, NE, SN, TD, TG). 15, Brookline, Massachusetts 02446 (US). VAN DER MEER, Andries; Renbaanstraat 18, 7523 ZW Enschede Declarations under Rule 4.17: (NL). INGBER, Donald, E.; 162 W. Canton St., Boston, as to applicant's entitlement to apply for and be granted a Massachusetts 02118 (US). patent (Rule 4.170) (74) Agents: RESNICK, David, S. et al.; Nixon Peabody LLP, as to the applicant's entitlement to claim the priority of the 70 W. Madison St., Suite 3500, Chicago, Illinois 60602- earlier application (Rule 4.17 (iii)) 4224 (US). [Continued on next page] (54) Title: ELECTRODE INTEGRATION INTO ORGANS ON CHIP DEVICES 120 c 134 1 130 32 109 I 107 126 128 126 128 121 122 104 101 124 102 133 108 106 127 110 108 W O 20 17 / 1067 27 Al 106 129 FIG. lE (57) : A method of fabricating electrodes includes foiining a first metallic film layer on an upper surface of a first material substrate, and attaching a first polymeric layer to the upper surface of the first material substrate to fon]] a first opened microchannel. The method further includes forming a second metallic film layer on a portion of a lower surface of a second material substrate, and attaching a second polymeric layer to the lower surface of the second material substrate to form a second opened microchannel. The method also includes attaching the first opened microchannel to a bottom side of the membrane and the second opened microchannel to the top side of the membrane. The first metallic film layer and the second metallic film layer each constitute transparent electrodes and are positioned with the membrane therebetween. WO 2017/106727 Al MIDEDIMOMONIIMOID130101101100MOIMMOVOIMIE Published: — before the expiration of the time limit for amending the — with international search report (Art. 21(3)) claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
SG11201804714XA 2015-12-16 2016-12-16 Electrode integration into organs on chip devices SG11201804714XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268454P 2015-12-16 2015-12-16
US201662297659P 2016-02-19 2016-02-19
PCT/US2016/067294 WO2017106727A1 (en) 2015-12-16 2016-12-16 Electrode integration into organs on chip devices

Publications (1)

Publication Number Publication Date
SG11201804714XA true SG11201804714XA (en) 2018-07-30

Family

ID=59057687

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201804714XA SG11201804714XA (en) 2015-12-16 2016-12-16 Electrode integration into organs on chip devices

Country Status (4)

Country Link
US (1) US20190025240A1 (en)
GB (1) GB2561775A (en)
SG (1) SG11201804714XA (en)
WO (1) WO2017106727A1 (en)

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SG11201907202WA (en) * 2017-02-27 2019-09-27 Harvard College Integrated multi-electrode array and trans-endothelial electrical resistance in organ-on-a-chip microsystems
CN107629958B (en) * 2017-08-08 2020-07-14 浙江理工大学 Microfluidic chip with three-dimensional graphene interface and preparation method thereof
CN107475072B (en) * 2017-08-24 2020-12-11 浙江理工大学 Cell dynamic characteristic monitoring system and method based on three-dimensional graphene interface electrode
US11015161B2 (en) 2017-09-06 2021-05-25 The Charles Stark Draper Laboratory, Inc. Electroporation aided biological material delivery system and method
JP2019190888A (en) * 2018-04-19 2019-10-31 ティーイーアイソリューションズ株式会社 Fluid chip and analyzer
US20210154665A1 (en) * 2018-04-19 2021-05-27 Tei Solutions Inc. Fluid chip and analysis device
CN109096740B (en) * 2018-07-20 2021-09-17 山东一诺威聚氨酯股份有限公司 Antibacterial antistatic TPU (thermoplastic polyurethane) film material and preparation method thereof
CN109852542B (en) * 2018-12-18 2020-09-04 北京化工大学 Micro-fluidic chip for single-cell impedance flow detection and processing method thereof
JP7316063B2 (en) 2019-03-01 2023-07-27 株式会社Ｓｃｒｅｅｎホールディングス inspection device
RU200073U1 (en) * 2020-05-24 2020-10-05 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский университет "Высшая школа экономики" (НИУ ВШЭ) DEVICE FOR MEASURING THE TRANSEPITELIAL ELECTRIC RESISTANCE OF MAMMAL BARRIER CELLS
JP2023123989A (en) * 2022-02-25 2023-09-06 株式会社Ｓｃｒｅｅｎホールディングス Flow passage device

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
WO2007021741A2 (en) * 2005-08-10 2007-02-22 President And Fellows Of Harvard College Methods of using a nanotransfer printing stamp having conductively coated sidewalls
US9084546B2 (en) * 2005-08-31 2015-07-21 The Regents Of The University Of Michigan Co-electrodeposited hydrogel-conducting polymer electrodes for biomedical applications
US20070176629A1 (en) * 2005-11-28 2007-08-02 Electronics And Telecommunications Research Institute Molecular electronic device having organic conducting electrode as protective layer
EP3778858A1 (en) * 2008-07-16 2021-02-17 Children's Medical Center Corporation Device with microchannels and method of use
US20120211373A1 (en) * 2011-02-22 2012-08-23 The Regents Of The University Of Michigan Microfluidic system for measuring cell barrier function
US9952096B2 (en) * 2012-06-05 2018-04-24 President And Fellows Of Harvard College Ultra-thin optical coatings and devices and methods of using ultra-thin optical coatings
US9006845B2 (en) * 2013-01-16 2015-04-14 Infineon Technologies, A.G. MEMS device with polymer layer, system of a MEMS device with a polymer layer, method of making a MEMS device with a polymer layer
US9698204B2 (en) * 2013-12-06 2017-07-04 Sharp Kabushiki Kaisha Light-emitting substrate, photovoltaic cell, display device, lighting device, electronic device, organic light-emitting diode, and method of manufacturing light-emitting substrate

Also Published As

Publication number Publication date
GB2561775A (en) 2018-10-24
US20190025240A1 (en) 2019-01-24
WO2017106727A1 (en) 2017-06-22
GB201811613D0 (en) 2018-08-29

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