SG11201706236SA - Methods for enhancing efficacy of therapeutic immune cells - Google Patents
Methods for enhancing efficacy of therapeutic immune cellsInfo
- Publication number
- SG11201706236SA SG11201706236SA SG11201706236SA SG11201706236SA SG11201706236SA SG 11201706236S A SG11201706236S A SG 11201706236SA SG 11201706236S A SG11201706236S A SG 11201706236SA SG 11201706236S A SG11201706236S A SG 11201706236SA SG 11201706236S A SG11201706236S A SG 11201706236SA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- immune cells
- therapeutic immune
- enhancing efficacy
- efficacy
- Prior art date
Links
- 230000002708 enhancing effect Effects 0.000 title 1
- 210000002865 immune cell Anatomy 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464429—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/05—Fusion polypeptide containing a localisation/targetting motif containing a GOLGI retention signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562112765P | 2015-02-06 | 2015-02-06 | |
US201562130970P | 2015-03-10 | 2015-03-10 | |
PCT/SG2016/050063 WO2016126213A1 (en) | 2015-02-06 | 2016-02-05 | Methods for enhancing efficacy of therapeutic immune cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201706236SA true SG11201706236SA (en) | 2017-08-30 |
Family
ID=56564429
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913124RA SG10201913124RA (en) | 2015-02-06 | 2016-02-05 | Methods for enhancing efficacy of therapeutic immune cells |
SG11201706236SA SG11201706236SA (en) | 2015-02-06 | 2016-02-05 | Methods for enhancing efficacy of therapeutic immune cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913124RA SG10201913124RA (en) | 2015-02-06 | 2016-02-05 | Methods for enhancing efficacy of therapeutic immune cells |
Country Status (18)
Country | Link |
---|---|
US (4) | US10765699B2 (en) |
EP (2) | EP3253865B1 (en) |
JP (4) | JP6895380B2 (en) |
KR (1) | KR20170109052A (en) |
CN (4) | CN115029362A (en) |
AU (2) | AU2016216149B2 (en) |
CA (1) | CA2975851A1 (en) |
DK (1) | DK3253865T3 (en) |
ES (1) | ES2926384T3 (en) |
HR (1) | HRP20220890T1 (en) |
HU (1) | HUE059662T2 (en) |
LT (1) | LT3253865T (en) |
PL (1) | PL3253865T3 (en) |
PT (1) | PT3253865T (en) |
RS (1) | RS63574B1 (en) |
SG (2) | SG10201913124RA (en) |
SI (1) | SI3253865T1 (en) |
WO (1) | WO2016126213A1 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2948462A1 (en) | 2014-05-15 | 2015-11-19 | National University Of Singapore | Modified natural killer cells and uses thereof |
WO2016126213A1 (en) * | 2015-02-06 | 2016-08-11 | National University Of Singapore | Methods for enhancing efficacy of therapeutic immune cells |
CN114230670A (en) | 2015-02-27 | 2022-03-25 | 美商生物细胞基因治疗有限公司 | Chimeric Antigen Receptors (CARs) targeting hematologic malignancies, compositions thereof, and methods of use |
SG11201810023QA (en) | 2016-05-27 | 2018-12-28 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof |
CN109689693B (en) * | 2016-11-03 | 2022-06-28 | 深圳华大生命科学研究院 | Method and system for improving gene editing efficiency |
SG10201912387PA (en) | 2016-11-22 | 2020-02-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
EP3585403A4 (en) * | 2017-02-22 | 2020-12-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tim3-binding chimeric antigen receptors |
WO2018169922A2 (en) * | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
CN117363636A (en) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | Polynucleotide encoding chimeric receptor |
BR112019020001A2 (en) | 2017-03-27 | 2020-04-28 | Nat Univ Singapore | stimulating cell lines for ex vivo expansion and activation of natural killer cells |
SG11202000402PA (en) | 2017-08-10 | 2020-02-27 | Nat Univ Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
CA3079076A1 (en) * | 2017-10-18 | 2019-04-25 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Methods and compounds for improved immune cell therapy |
WO2019084273A1 (en) | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | Anti-cd45-based lymphodepletion methods and uses thereof in conjunction with act-based cancer therapies |
JP7372920B2 (en) * | 2017-12-29 | 2023-11-01 | セレクティス | Methods for improving the generation of CAR T cells |
AU2019211411A1 (en) * | 2018-01-25 | 2020-08-20 | Cullinan Mica Corp. | MICA/B antibodies and methods of use |
CN108314739B (en) * | 2018-02-05 | 2020-07-14 | 深圳市默赛尔生物医学科技发展有限公司 | Multi-signal chimeric antigen receptor, expression gene thereof, NK cell modified by multi-signal chimeric antigen receptor and application of NK cell |
EP3758755A1 (en) * | 2018-02-26 | 2021-01-06 | Ablynx N.V. | Improved nucleotide sequences encoding peptide linkers |
CN112055717B (en) * | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling adhesives expressed in immune cells |
EP3784776A4 (en) * | 2018-05-23 | 2022-01-26 | National University of Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
US20200054675A1 (en) * | 2018-06-01 | 2020-02-20 | Washington University | Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy |
CN109207430A (en) * | 2018-09-25 | 2019-01-15 | 华东师范大学 | A kind of Chimeric antigen receptor NK cell and its preparation method and application |
CN109266618B (en) * | 2018-10-18 | 2021-04-23 | 赛元生物科技(杭州)有限公司 | Macrophage capable of targeting tumor cells and preparation method thereof |
KR20200049594A (en) * | 2018-10-24 | 2020-05-08 | 주식회사 툴젠 | Manipulated immune cell |
CN109652379B (en) * | 2018-12-29 | 2022-08-16 | 博生吉医药科技(苏州)有限公司 | CD7 chimeric antigen receptor modified NK-92MI cell and application thereof |
CN113766956B (en) | 2019-03-05 | 2024-05-07 | 恩卡尔塔公司 | CD 19-directed chimeric antigen receptor and use thereof in immunotherapy |
JP7137696B2 (en) | 2019-05-14 | 2022-09-14 | プロヴェンション・バイオ・インコーポレイテッド | Methods and compositions for preventing type 1 diabetes |
GB201914611D0 (en) * | 2019-10-09 | 2019-11-20 | Autolus Ltd | Engineered immune cell |
CN113005088A (en) * | 2019-12-19 | 2021-06-22 | 苏州方德门达新药开发有限公司 | Engineered T cells, their preparation and use |
CN113088495A (en) * | 2020-01-09 | 2021-07-09 | 苏州方德门达新药开发有限公司 | Engineered T cells, their preparation and use |
CN112195155A (en) * | 2020-08-11 | 2021-01-08 | 广东万海细胞生物科技有限公司 | Universal CAR-T cell and preparation method thereof |
CN114525259A (en) * | 2020-11-03 | 2022-05-24 | 南京北恒生物科技有限公司 | Chimeric antigen receptor targeting CD7 and uses thereof |
EP4243839A1 (en) | 2020-11-13 | 2023-09-20 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
AU2021401934A1 (en) * | 2020-12-14 | 2023-06-22 | Allogene Therapeutics, Inc. | Methods and reagents for characterizing car t cells for therapies |
JP2024500847A (en) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | Chimeric antigen receptor systems with compatible receptor specificities |
CN113416701B (en) * | 2021-07-28 | 2023-05-09 | 新疆西部赛澳生物科技有限责任公司 | NK cell culture medium and culture method |
CN116731205B (en) * | 2023-05-19 | 2024-02-27 | 皖南医学院第一附属医院(皖南医学院弋矶山医院) | Immunopotentiating fusion protein for expressing TGF beta RII and TIM3 extracellular region and application thereof |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3785186T2 (en) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | BINDING MOLECULE WITH SINGLE POLYPEPTIDE CHAIN. |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
CA2018248A1 (en) * | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
ATE207080T1 (en) | 1991-11-25 | 2001-11-15 | Enzon Inc | MULTIVALENT ANTIGEN-BINDING PROTEINS |
US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
JP2001516766A (en) | 1997-09-19 | 2001-10-02 | デイナ−ファーバー キャンサー インスティチュート,インコーポレイテッド | Intracellularly expressed antibody-mediated regulation of immune response |
EP1235842A4 (en) | 1999-10-15 | 2003-04-23 | Univ Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
AU2002220265A1 (en) * | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
AU2002361390A1 (en) | 2001-12-14 | 2003-06-30 | Friedrich-Alexander-Universitaet Erlangen-Nuernberg | Anti-cd7 immunotoxin as fusion protein |
CN103467602B (en) | 2003-07-02 | 2018-04-10 | 依奈特制药公司 | For adjusting the composition and method of NK cytoactives |
US20090191213A9 (en) | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
WO2005017163A2 (en) | 2003-08-15 | 2005-02-24 | Imperial College Innovations Limited | Phenotypic knockout of cell-surface proteins |
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
EP1791868B1 (en) | 2004-07-01 | 2011-02-23 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
EP1814567A4 (en) | 2004-10-27 | 2009-05-06 | Medimmune Inc | Use of modulators of epha2 and ephrina1 for the treatment and prevention of infections |
EP3072522B1 (en) | 2005-01-06 | 2019-04-24 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
US20070036773A1 (en) * | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
US7973136B2 (en) | 2005-10-06 | 2011-07-05 | Xencor, Inc. | Optimized anti-CD30 antibodies |
WO2007126782A2 (en) * | 2006-03-28 | 2007-11-08 | Hampton University | Hadron treatment planning with adequate biological weighting |
NZ578943A (en) * | 2007-03-01 | 2012-09-28 | Symphogen As | Recombinant anti-epidermal growth factor receptor antibody compositions |
ES2424745T3 (en) | 2007-09-07 | 2013-10-08 | Agensys, Inc. | Antibodies and related molecules that bind to 24P4C12 proteins |
JP5774312B2 (en) | 2008-01-24 | 2015-09-09 | ノボ・ノルデイスク・エー/エス | Humanized anti-human NKG2A monoclonal antibody |
EP2488867B1 (en) * | 2009-10-14 | 2020-09-30 | Janssen Biotech, Inc. | Methods of affinity maturing antibodies |
US9273283B2 (en) * | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
JP5947311B2 (en) | 2010-12-09 | 2016-07-06 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Use of chimeric antigen receptor modified T cells for the treatment of cancer |
LT2800811T (en) | 2012-05-25 | 2017-09-11 | The Regents Of The University Of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
HUE053556T2 (en) * | 2012-07-13 | 2021-07-28 | Univ Pennsylvania | Toxicity management for anti-tumor activity of cars |
ES2824024T3 (en) * | 2012-10-10 | 2021-05-11 | Sangamo Therapeutics Inc | T cell modifying compounds and uses thereof |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
KR101521224B1 (en) | 2012-12-20 | 2015-05-19 | 한양대학교 산학협력단 | Humanized single chain fragment antibody(scFv) carrier specific for T cell |
WO2014106123A1 (en) * | 2012-12-27 | 2014-07-03 | Aduro Biotech, Inc. | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
CN105101803A (en) * | 2013-02-06 | 2015-11-25 | 人类起源公司 | Modified T lymphocytes having improved specificity |
DK3004337T3 (en) | 2013-05-29 | 2017-11-13 | Cellectis | Method for constructing T cells for immunotherapy using RNA-guided Cas nuclease system |
CA2930215C (en) | 2013-11-21 | 2021-04-27 | Ucl Business Plc | A cell comprising more than one chimeric antigen receptor |
GB201405845D0 (en) * | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
AU2015289644A1 (en) | 2014-07-15 | 2017-02-02 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
JP2017531430A (en) | 2014-10-07 | 2017-10-26 | セレクティスCellectis | Method for modulating the activity of immune cells induced by CAR |
US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
PT3560953T (en) | 2014-12-24 | 2024-03-26 | Autolus Ltd | Cell |
WO2016126213A1 (en) | 2015-02-06 | 2016-08-11 | National University Of Singapore | Methods for enhancing efficacy of therapeutic immune cells |
CN114230670A (en) | 2015-02-27 | 2022-03-25 | 美商生物细胞基因治疗有限公司 | Chimeric Antigen Receptors (CARs) targeting hematologic malignancies, compositions thereof, and methods of use |
WO2016138846A1 (en) * | 2015-03-02 | 2016-09-09 | Shanghai Sidansai Biotechnology Co., Ltd | Reducing immune tolerance induced by pd‐l1 |
EP3310915A4 (en) | 2015-06-19 | 2019-04-10 | Massachusetts Institute of Technology | Tumor immunotherapy |
MA42895A (en) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | MODIFIED CELLS FOR ADOPTIVE CELL THERAPY |
WO2017023803A1 (en) | 2015-07-31 | 2017-02-09 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
EP3359168A4 (en) | 2015-10-06 | 2019-08-07 | Regents of the University of Minnesota | Therapeutic compounds and methods |
US20180371052A1 (en) | 2015-12-22 | 2018-12-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
WO2017213979A1 (en) | 2016-06-06 | 2017-12-14 | St. Jude Children's Research Hospital | Anti-cd7 chimeric antigen receptor and method of use thereof |
CN109562126A (en) | 2016-06-24 | 2019-04-02 | 美商生物细胞基因治疗有限公司 | Chimeric antigen receptor (CAR), composition and its application method |
CA2937157A1 (en) | 2016-07-25 | 2018-01-25 | Ucl Business Plc | Protein-based t-cell receptor knockdown |
WO2018027036A1 (en) | 2016-08-03 | 2018-02-08 | Dipersio John F | Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors |
SG10201912387PA (en) | 2016-11-22 | 2020-02-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
GB201622044D0 (en) | 2016-12-22 | 2017-02-08 | Ucl Business Plc | T cell-targeted T cells |
AU2018208614A1 (en) | 2017-01-10 | 2019-07-11 | The General Hospital Corporation | Modified T cells and methods of their use |
SG11202000402PA (en) | 2017-08-10 | 2020-02-27 | Nat Univ Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
JP2022512994A (en) | 2018-11-14 | 2022-02-07 | メディシックス セラピューティクス ピーティーイー リミテッド | Two gene vectors that generate CAR-T cells and their use |
-
2016
- 2016-02-05 WO PCT/SG2016/050063 patent/WO2016126213A1/en active Application Filing
- 2016-02-05 KR KR1020177024662A patent/KR20170109052A/en not_active Application Discontinuation
- 2016-02-05 SG SG10201913124RA patent/SG10201913124RA/en unknown
- 2016-02-05 CN CN202210667502.4A patent/CN115029362A/en active Pending
- 2016-02-05 US US15/548,577 patent/US10765699B2/en active Active
- 2016-02-05 SI SI201631593T patent/SI3253865T1/en unknown
- 2016-02-05 EP EP16746922.0A patent/EP3253865B1/en active Active
- 2016-02-05 JP JP2017541243A patent/JP6895380B2/en active Active
- 2016-02-05 HU HUE16746922A patent/HUE059662T2/en unknown
- 2016-02-05 AU AU2016216149A patent/AU2016216149B2/en active Active
- 2016-02-05 PT PT167469220T patent/PT3253865T/en unknown
- 2016-02-05 RS RS20220680A patent/RS63574B1/en unknown
- 2016-02-05 ES ES16746922T patent/ES2926384T3/en active Active
- 2016-02-05 PL PL16746922.0T patent/PL3253865T3/en unknown
- 2016-02-05 SG SG11201706236SA patent/SG11201706236SA/en unknown
- 2016-02-05 EP EP22180254.9A patent/EP4134430A1/en active Pending
- 2016-02-05 CN CN202111064400.5A patent/CN113713091A/en active Pending
- 2016-02-05 CA CA2975851A patent/CA2975851A1/en active Pending
- 2016-02-05 CN CN201680018962.7A patent/CN107709548B/en active Active
- 2016-02-05 LT LTEPPCT/SG2016/050063T patent/LT3253865T/en unknown
- 2016-02-05 DK DK16746922.0T patent/DK3253865T3/en active
- 2016-02-05 HR HRP20220890TT patent/HRP20220890T1/en unknown
- 2016-02-05 CN CN202210661143.1A patent/CN114891816A/en active Pending
-
2020
- 2020-07-30 US US16/943,400 patent/US20210046112A1/en active Pending
-
2021
- 2021-06-07 JP JP2021095192A patent/JP7320560B2/en active Active
-
2022
- 2022-06-29 AU AU2022204601A patent/AU2022204601A1/en active Pending
- 2022-07-12 US US17/862,797 patent/US20220370501A1/en active Pending
- 2022-07-12 US US17/862,721 patent/US11679132B2/en active Active
-
2023
- 2023-07-24 JP JP2023119583A patent/JP2023153141A/en active Pending
- 2023-07-24 JP JP2023119584A patent/JP2023153142A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10201913124RA (en) | Methods for enhancing efficacy of therapeutic immune cells | |
HK1245829A1 (en) | Methods for controlled elimination of therapeutic cells | |
IL283258A (en) | Treatment of hypoparathyroidism | |
IL258931A (en) | Therapeutic compounds and methods | |
HK1258062A1 (en) | Methods of administering elagolix | |
PT3132034T (en) | Therapeutic | |
HK1252695A1 (en) | Improved methods and compounds for eliminating immune responses to therapeutic agents | |
GB201512365D0 (en) | Novel therapy | |
IL285882A (en) | Therapeutic uses of l-4-chlorokynurenine | |
HK1258994A1 (en) | Methods for treatment of diseases | |
GB201410216D0 (en) | Therapeutic | |
GB201522223D0 (en) | Therapeutic T cells | |
GB201510637D0 (en) | Therapeutic | |
GB201505382D0 (en) | Novel therapy | |
GB201512139D0 (en) | Methods of treatment | |
GB201516068D0 (en) | Novel therapy | |
GB201407837D0 (en) | Methods of cancer therapy | |
GB201518805D0 (en) | Therapy | |
GB201506944D0 (en) | Therapeutic treatment | |
HUP1500253A2 (en) | Therapeutic energy disc | |
GB201418508D0 (en) | Therapeutic | |
GB201413719D0 (en) | Therapeutic | |
GB201410832D0 (en) | Therapeutic | |
GB201410334D0 (en) | Therapeutic | |
GB201406674D0 (en) | Therapeutic |