SG11201704309YA - Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereof - Google Patents
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereofInfo
- Publication number
- SG11201704309YA SG11201704309YA SG11201704309YA SG11201704309YA SG11201704309YA SG 11201704309Y A SG11201704309Y A SG 11201704309YA SG 11201704309Y A SG11201704309Y A SG 11201704309YA SG 11201704309Y A SG11201704309Y A SG 11201704309YA SG 11201704309Y A SG11201704309Y A SG 11201704309YA
- Authority
- SG
- Singapore
- Prior art keywords
- benzoic acid
- oxymorphone
- prodrugs
- making
- methods
- Prior art date
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 2
- 239000005711 Benzoic acid Substances 0.000 title 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 title 1
- 235000010233 benzoic acid Nutrition 0.000 title 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 title 1
- -1 heteroaryl carboxylic acid Chemical class 0.000 title 1
- 229960005118 oxymorphone Drugs 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462086326P | 2014-12-02 | 2014-12-02 | |
PCT/US2015/063351 WO2016089951A1 (en) | 2014-12-02 | 2015-12-02 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201704309YA true SG11201704309YA (en) | 2017-06-29 |
Family
ID=55022688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201704309YA SG11201704309YA (en) | 2014-12-02 | 2015-12-02 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereof |
Country Status (19)
Country | Link |
---|---|
US (4) | US9682076B2 (en) |
EP (1) | EP3226907A1 (en) |
JP (2) | JP6462877B2 (en) |
KR (1) | KR20170094251A (en) |
CN (1) | CN106999487A (en) |
AU (1) | AU2015358606B9 (en) |
BR (1) | BR112017011764A2 (en) |
CA (1) | CA2969221C (en) |
CL (1) | CL2017001417A1 (en) |
CO (1) | CO2017005203A2 (en) |
HK (1) | HK1244209A1 (en) |
IL (1) | IL252472A0 (en) |
MA (1) | MA40937A (en) |
MX (1) | MX2017006935A (en) |
NZ (1) | NZ731586A (en) |
PH (1) | PH12017500859A1 (en) |
RU (1) | RU2683274C2 (en) |
SG (1) | SG11201704309YA (en) |
WO (1) | WO2016089951A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9682076B2 (en) | 2014-12-02 | 2017-06-20 | Kempharm, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof |
RU2657803C1 (en) * | 2017-03-21 | 2018-06-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный университет" | Agent possessing anti-inflammatory and analgesic action |
JP7369687B2 (en) | 2017-07-20 | 2023-10-26 | スーチョウ ランシンダタイ ファーマシューティクス エルティーディー シーオー. | Abuse Deterrent Long Acting Extended Release Opioid Prodrug |
CN111836813A (en) * | 2018-02-23 | 2020-10-27 | 罗德科技公司 | Novel opioid compounds and uses thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
NZ298712A (en) | 1995-01-16 | 1998-12-23 | Commw Scient Ind Res Org | Fatty acid acyl group conjugates as therapeutic compounds |
DE19602963A1 (en) | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | New morphine derivatives |
ATE526950T1 (en) | 1999-10-29 | 2011-10-15 | Euro Celtique Sa | CONTROLLED RELEASE HYDROCODONE FORMULATIONS |
WO2005032474A2 (en) | 2003-09-30 | 2005-04-14 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
CN1514729B (en) | 2001-06-05 | 2012-09-05 | 控制释放***公司 | Sustained-release analgesic compounds |
US6740641B2 (en) | 2001-07-27 | 2004-05-25 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain |
US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
WO2004082620A2 (en) | 2003-03-13 | 2004-09-30 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower the abuse potential and extended duration of action |
AU2007238625A1 (en) | 2006-04-14 | 2007-10-25 | Shire Llc | Compositions and methods for enhancing analgesic potency of covalently bound compounds, attenuating its adverse side effects, and preventing their abuse |
EP2046393B1 (en) * | 2006-05-26 | 2014-02-12 | Signature Therapeutics, Inc. | Controlled release of phenolic opioids |
WO2008055237A2 (en) | 2006-10-31 | 2008-05-08 | Rebit, Inc. | System for automatically recovering a computer memory using shadowed data and file directory structures |
US20120142718A1 (en) | 2007-02-16 | 2012-06-07 | Jenkins Thomas E | N-17-Alkylated Prodrugs of Opioids |
WO2009092073A2 (en) | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid and peptide prodrugs of opioid analgesics with reduced gi side-effects |
JP2013523599A (en) | 2009-04-02 | 2013-06-17 | シャイア エルエルシー | Novel opioid dicarboxylic acid linked amino acid and peptide prodrugs and uses thereof |
US8871780B2 (en) | 2009-07-02 | 2014-10-28 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof |
UA102916C2 (en) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Composition based on conjugates of hydrocodone with benzoic acid, benzoic acid or heteroaryl carboxylic acid derivatives, prodrugs and method for treatment of abuses |
WO2011009012A1 (en) | 2009-07-15 | 2011-01-20 | Columbia University | METHODS OF SUPPRESSING APPETITE BY THE ADMINISTRATION OF ANTAGONISTS OF THE SEROTONIN HTR1a or HTR2b RECEPTORS OR INHIBITORS OF TPH2 |
US8623888B2 (en) | 2009-07-15 | 2014-01-07 | Mallinckrodt Llc | 3-oxy-hydromorphone derivatives |
TR201809739T4 (en) * | 2009-07-16 | 2018-07-23 | Mallinckrodt Llc | (+) - morphinans as toll-like receptor 9 antagonists and their therapeutic use. |
JP2013503862A (en) | 2009-09-08 | 2013-02-04 | シグネーチャー セラピューティクス,インク. | Composition comprising an enzyme-cleavable ketone-modified opioid prodrug and an optional inhibitor thereof |
EP2593095B1 (en) * | 2010-07-16 | 2019-03-27 | Mallinckrodt LLC | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
US8685916B2 (en) | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
KR101589846B1 (en) * | 2011-10-26 | 2016-01-28 | 켐팜 인코포레이티드 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
US9682076B2 (en) | 2014-12-02 | 2017-06-20 | Kempharm, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof |
-
2015
- 2015-12-02 US US14/956,642 patent/US9682076B2/en active Active
- 2015-12-02 RU RU2017123161A patent/RU2683274C2/en not_active IP Right Cessation
- 2015-12-02 EP EP15816302.2A patent/EP3226907A1/en not_active Withdrawn
- 2015-12-02 KR KR1020177017415A patent/KR20170094251A/en active IP Right Grant
- 2015-12-02 BR BR112017011764-9A patent/BR112017011764A2/en not_active Application Discontinuation
- 2015-12-02 AU AU2015358606A patent/AU2015358606B9/en not_active Ceased
- 2015-12-02 MX MX2017006935A patent/MX2017006935A/en unknown
- 2015-12-02 CN CN201580064812.5A patent/CN106999487A/en active Pending
- 2015-12-02 WO PCT/US2015/063351 patent/WO2016089951A1/en active Application Filing
- 2015-12-02 CA CA2969221A patent/CA2969221C/en active Active
- 2015-12-02 MA MA040937A patent/MA40937A/en unknown
- 2015-12-02 NZ NZ731586A patent/NZ731586A/en not_active IP Right Cessation
- 2015-12-02 JP JP2017529821A patent/JP6462877B2/en not_active Expired - Fee Related
- 2015-12-02 SG SG11201704309YA patent/SG11201704309YA/en unknown
-
2017
- 2017-05-08 US US15/589,158 patent/US10071091B2/en active Active
- 2017-05-09 PH PH12017500859A patent/PH12017500859A1/en unknown
- 2017-05-23 IL IL252472A patent/IL252472A0/en unknown
- 2017-05-25 CO CONC2017/0005203A patent/CO2017005203A2/en unknown
- 2017-06-02 CL CL2017001417A patent/CL2017001417A1/en unknown
-
2018
- 2018-03-16 HK HK18103710.3A patent/HK1244209A1/en unknown
- 2018-08-03 US US16/054,578 patent/US10463660B2/en active Active
- 2018-12-27 JP JP2018244453A patent/JP2019077695A/en not_active Withdrawn
-
2019
- 2019-09-17 US US16/573,313 patent/US10758528B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2017123161A3 (en) | 2019-01-09 |
IL252472A0 (en) | 2017-07-31 |
CO2017005203A2 (en) | 2017-08-31 |
PH12017500859A1 (en) | 2017-11-06 |
AU2015358606B9 (en) | 2019-05-02 |
NZ731586A (en) | 2018-06-29 |
US10071091B2 (en) | 2018-09-11 |
US9682076B2 (en) | 2017-06-20 |
US10463660B2 (en) | 2019-11-05 |
US20180338968A1 (en) | 2018-11-29 |
MA40937A (en) | 2017-10-11 |
MX2017006935A (en) | 2017-08-10 |
US10758528B2 (en) | 2020-09-01 |
RU2683274C2 (en) | 2019-03-27 |
US20170312270A1 (en) | 2017-11-02 |
WO2016089951A1 (en) | 2016-06-09 |
JP2017538696A (en) | 2017-12-28 |
CA2969221C (en) | 2021-01-12 |
KR20170094251A (en) | 2017-08-17 |
CA2969221A1 (en) | 2016-06-09 |
RU2017123161A (en) | 2019-01-09 |
US20200030316A1 (en) | 2020-01-30 |
AU2015358606A1 (en) | 2017-05-25 |
CN106999487A (en) | 2017-08-01 |
HK1244209A1 (en) | 2018-08-03 |
EP3226907A1 (en) | 2017-10-11 |
BR112017011764A2 (en) | 2018-07-10 |
CL2017001417A1 (en) | 2018-02-09 |
JP2019077695A (en) | 2019-05-23 |
JP6462877B2 (en) | 2019-01-30 |
US20160151352A1 (en) | 2016-06-02 |
AU2015358606B2 (en) | 2019-04-18 |
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