SG11201503982XA - Substituted reverse pyrimidine bmi-1 inhibitors - Google Patents
Substituted reverse pyrimidine bmi-1 inhibitorsInfo
- Publication number
- SG11201503982XA SG11201503982XA SG11201503982XA SG11201503982XA SG11201503982XA SG 11201503982X A SG11201503982X A SG 11201503982XA SG 11201503982X A SG11201503982X A SG 11201503982XA SG 11201503982X A SG11201503982X A SG 11201503982XA SG 11201503982X A SG11201503982X A SG 11201503982XA
- Authority
- SG
- Singapore
- Prior art keywords
- inhibitors
- bmi
- substituted reverse
- reverse pyrimidine
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728907P | 2012-11-21 | 2012-11-21 | |
| PCT/US2013/071132 WO2014081906A2 (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine bmi-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201503982XA true SG11201503982XA (en) | 2015-06-29 |
Family
ID=50776672
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201503982XA SG11201503982XA (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine bmi-1 inhibitors |
| SG10201600149VA SG10201600149VA (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine bmi-1 inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201600149VA SG10201600149VA (en) | 2012-11-21 | 2013-11-21 | Substituted reverse pyrimidine bmi-1 inhibitors |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US10428050B2 (en) |
| EP (1) | EP2922828B1 (en) |
| JP (3) | JP6412503B2 (en) |
| KR (4) | KR102356487B1 (en) |
| CN (2) | CN104918919A (en) |
| AR (1) | AR093579A1 (en) |
| AU (1) | AU2013348009C1 (en) |
| BR (1) | BR112015011760B1 (en) |
| CA (1) | CA2892045C (en) |
| CL (1) | CL2015001377A1 (en) |
| CR (1) | CR20150294A (en) |
| CU (1) | CU24387B1 (en) |
| DK (1) | DK2922828T3 (en) |
| EA (2) | EA031405B1 (en) |
| EC (1) | ECSP15019948A (en) |
| ES (1) | ES2821529T3 (en) |
| HK (1) | HK1215032A1 (en) |
| IL (2) | IL238871B (en) |
| MA (1) | MA38208B1 (en) |
| MX (2) | MX2015006469A (en) |
| NI (1) | NI201500072A (en) |
| NZ (2) | NZ746607A (en) |
| PE (1) | PE20151413A1 (en) |
| PH (1) | PH12015501130A1 (en) |
| PL (1) | PL2922828T3 (en) |
| PT (1) | PT2922828T (en) |
| SA (1) | SA517381847B1 (en) |
| SG (2) | SG11201503982XA (en) |
| TW (1) | TWI623531B (en) |
| UA (1) | UA118094C2 (en) |
| WO (1) | WO2014081906A2 (en) |
| ZA (1) | ZA201503642B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104918919A (en) * | 2012-11-21 | 2015-09-16 | Ptc医疗公司 | Substituted reverse pyrimidine bmi-1 inhibitors |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015006591A1 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| US10370371B2 (en) * | 2013-08-30 | 2019-08-06 | Ptc Therapeutics, Inc. | Substituted pyrimidine Bmi-1 inhibitors |
| EP3071553A4 (en) | 2013-11-21 | 2017-08-02 | PTC Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| JP7001593B2 (en) | 2015-08-11 | 2022-01-19 | コグノア， インコーポレイテッド | Methods and devices for determining developmental progress using artificial intelligence and user input |
| US10851082B2 (en) | 2015-10-28 | 2020-12-01 | Northwestern University | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) |
| US20190016680A1 (en) * | 2016-01-14 | 2019-01-17 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| WO2018148365A1 (en) | 2017-02-09 | 2018-08-16 | Cognoa, Inc. | Platform and system for digital personalized medicine |
| EP3664803A4 (en) | 2017-08-01 | 2021-05-05 | PTC Therapeutics, Inc. | Dhodh inhibitor for use in treating hematologic cancers |
| EP3564235A1 (en) * | 2018-05-03 | 2019-11-06 | Northwestern University | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (mnk1) and 2 (mnk2) |
| CN113164479A (en) * | 2018-08-17 | 2021-07-23 | Ptc医疗公司 | Methods for treating pancreatic cancer |
| CN109988172B (en) * | 2019-01-10 | 2020-09-29 | 石家庄学院 | Synthesis method of pyrazolo [1,5-A ] pyrimidine heterocyclic compound and derivative |
| EP3911418A1 (en) * | 2019-01-15 | 2021-11-24 | PTC Therapeutics, Inc. | Method for treating an acute myeloid leukemia |
| CA3131249A1 (en) * | 2019-02-28 | 2020-09-03 | Ptc Therapeutics, Inc. | Method for treating a multiple myeloma |
| US20220185795A1 (en) | 2019-03-11 | 2022-06-16 | Ptc Therapeutics, Inc. | Compound form having enhanced bioavailability and formulations thereof |
| WO2020198065A1 (en) | 2019-03-22 | 2020-10-01 | Cognoa, Inc. | Personalized digital therapy methods and devices |
| AU2020248103A1 (en) * | 2019-03-27 | 2021-10-21 | Ptc Therapeutics, Inc. | Combinations useful in a method for treating sarcoma |
| CA3135929A1 (en) * | 2019-04-02 | 2020-10-08 | Hinova Pharmaceuticals Inc. | Aromatic amine compound and use thereof in preparation of ar and brd4 dual inhibitors and regulators |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH593266A5 (en) | 1973-09-20 | 1977-11-30 | Delalande Sa | |
| DE69530989T2 (en) | 1994-08-13 | 2004-05-19 | Yuhan Corp. | NEW PYRIMID DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
| IN188411B (en) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| KR100272471B1 (en) | 1998-11-17 | 2000-11-15 | 김선진 | Novel pyrimidine derivatives and processes for the preparation thereof |
| GB9905075D0 (en) * | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| US6498165B1 (en) | 1999-06-30 | 2002-12-24 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| JP2003511378A (en) | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | Triazine kinase inhibitors |
| EP1224185B1 (en) | 1999-10-27 | 2005-11-30 | Novartis AG | Thiazole and imidazo[4,5-b]pyridine compounds and their pharmaceutical use |
| WO2001060816A1 (en) | 2000-02-17 | 2001-08-23 | Amgen Inc. | Kinase inhibitors |
| EP1274705A1 (en) | 2000-03-29 | 2003-01-15 | Cyclacel Limited | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders |
| AU2001292670A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU9458401A (en) | 2000-09-20 | 2002-04-02 | Ortho Mcneil Pharm Inc | Pyrazine derivatives as modulators of tyrosine kinases |
| US6716851B2 (en) | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
| WO2002047690A1 (en) * | 2000-12-12 | 2002-06-20 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| EP1377573B1 (en) | 2000-12-15 | 2005-07-27 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| JP4309657B2 (en) | 2001-02-20 | 2009-08-05 | アストラゼネカ・アクチエボラーグ | 2-Allylamino-pyrimidine for the treatment of GSK-3-related disorders |
| ES2360205T3 (en) * | 2001-03-02 | 2011-06-01 | Agennix Ag | THREE HYBRID TEST SYSTEM. |
| CA2450555A1 (en) | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
| US6689778B2 (en) | 2001-07-03 | 2004-02-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of Src and Lck protein kinases |
| WO2003011837A1 (en) | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AU2003212634A1 (en) | 2002-03-11 | 2003-09-22 | Zetiq Technologies Ltd. | Compounds useful in the treatment of cancer |
| NZ537156A (en) | 2002-05-23 | 2007-06-29 | Cytopia Pty Ltd | Kinase inhibitors |
| BRPI0312288B8 (en) | 2002-06-28 | 2021-05-25 | Nippon Shinyaku Co Ltd | amide derivatives |
| GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7060850B2 (en) * | 2002-07-11 | 2006-06-13 | Fluorous Technologies Incorporated | Fluorous tagging and scavenging reactants and methods of synthesis and use thereof |
| US20040110821A1 (en) * | 2002-08-07 | 2004-06-10 | Konkel Michael J. | GAL3 receptor antagonists for the treatment of affective disorders |
| UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| AU2003301302A1 (en) | 2002-10-15 | 2004-05-04 | Smithkline Beecham Corporation | Pyradazine compounds as gsk-3 inhibitors |
| US7169781B2 (en) | 2003-10-17 | 2007-01-30 | Hoffmann-La Roche Inc. | Imidazole derivatives and their use as pharmaceutical agents |
| CA2545427C (en) | 2004-01-12 | 2012-08-21 | Cytopia Research Pty Ltd | Selective kinase inhibitors |
| WO2005076854A2 (en) | 2004-02-04 | 2005-08-25 | Smithkline Beecham Corporation | Pyrimidinone compounds useful as kinase inhibitors |
| PL2332940T3 (en) * | 2004-03-30 | 2013-03-29 | Vertex Pharma | Azaindoles useful as inhibitors of JAK and other protein kinases |
| JP2006045119A (en) | 2004-08-04 | 2006-02-16 | Toray Ind Inc | Pyrazine derivative and nephritis-treating agent using the same as active ingredient |
| US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| BRPI0607062A2 (en) | 2005-02-28 | 2009-08-04 | Japan Tobacco Inc | aminopyridine compound with syk inhibitory activity, pharmaceutical composition and therapeutic agent comprising the same |
| CA2601257A1 (en) | 2005-03-10 | 2006-09-21 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives for treatment of hyperproliferative disorders |
| ATE456565T1 (en) | 2006-06-22 | 2010-02-15 | Biovitrum Ab Publ | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS |
| WO2008040753A1 (en) * | 2006-10-03 | 2008-04-10 | Neurosearch A/S | Indazolyl derivatives useful as potassium channel modulating agents |
| CN101516873A (en) | 2006-10-03 | 2009-08-26 | 神经研究公司 | Indazolyl derivatives useful as potassium channel modulating agents |
| EP2078018B1 (en) | 2006-10-19 | 2012-03-14 | Signal Pharmaceuticals LLC | Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors |
| EA200900799A1 (en) | 2006-12-22 | 2009-12-30 | Новартис Аг | Heteroarylheteroaryl compounds as inhibitors of CDK, intended for the treatment of cancer, inflammation and the fight against viral infections |
| TW200902010A (en) | 2007-01-26 | 2009-01-16 | Smithkline Beecham Corp | Anthranilamide inhibitors of aurora kinase |
| EP2121633A2 (en) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| TW200846344A (en) | 2007-04-25 | 2008-12-01 | Astrazeneca Ab | Chemical compounds |
| GB0714573D0 (en) | 2007-07-26 | 2007-09-05 | Imp Innovations Ltd | Marker gene |
| EP2203436A1 (en) | 2007-09-17 | 2010-07-07 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| CA2704599C (en) | 2007-11-16 | 2015-05-12 | Incyte Corporation | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
| CA2707989A1 (en) | 2007-12-07 | 2009-06-11 | Novartis Ag | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
| DE102008005493A1 (en) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4- (Pyrrolo [2,3-c] pyridines-3-yl) -pyrimidin-2-yl-amine derivatives |
| GB0801416D0 (en) | 2008-01-25 | 2008-03-05 | Piramed Ltd | Pharmaceutical compounds |
| EP2271631B1 (en) | 2008-04-22 | 2018-07-04 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8680113B2 (en) * | 2008-07-01 | 2014-03-25 | Ptc Therapeutics, Inc. | BMI-1 protein expression modulators |
| US8518952B2 (en) | 2008-08-06 | 2013-08-27 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors |
| EP2331527A1 (en) * | 2008-09-02 | 2011-06-15 | NeuroSearch A/S | Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators |
| TW201028399A (en) * | 2008-11-27 | 2010-08-01 | Shionogi & Co | Pyrimidine derivative and pyridine derivative both having pi3k inhibitory activity |
| JPWO2010092962A1 (en) | 2009-02-12 | 2012-08-16 | アステラス製薬株式会社 | Heterocyclic derivatives |
| NZ595372A (en) | 2009-03-27 | 2013-11-29 | Vetdc Inc | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
| CN102459265A (en) | 2009-05-27 | 2012-05-16 | 雅培制药有限公司 | Pyrimidine inhibitors of kinase activity |
| US20110039873A1 (en) | 2009-06-08 | 2011-02-17 | Gaeta Federico C A | SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY |
| RS57869B1 (en) * | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitors of influenza viruses replication |
| EP2451802A1 (en) | 2009-07-07 | 2012-05-16 | Pathway Therapeutics, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
| CN102471345A (en) | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | Pyrrolopyrazine inhibitors of kinases |
| US8435980B2 (en) | 2009-07-15 | 2013-05-07 | Abbvie Inc. | Pyrrolopyridine inhibitors of kinases |
| JP2011136925A (en) * | 2009-12-28 | 2011-07-14 | Dainippon Sumitomo Pharma Co Ltd | Nitrogen-containing bicyclic compound |
| SG182480A1 (en) | 2010-01-12 | 2012-08-30 | Ab Science | Thiazole and oxazole kinase inhibitors |
| UY33213A (en) | 2010-02-18 | 2011-09-30 | Almirall Sa | PIRAZOL DERIVATIVES AS JAK INHIBITORS |
| ES2365960B1 (en) * | 2010-03-31 | 2012-06-04 | Palobiofarma, S.L | NEW ANTAGONISTS OF ADENOSINE RECEPTORS. |
| WO2012022725A2 (en) * | 2010-08-19 | 2012-02-23 | F. Hoffmann-La Roche Ag | Conversion of somatic cells to induced reprogrammed neural stem cells (irnscs) |
| SG188438A1 (en) | 2010-09-13 | 2013-05-31 | Novartis Ag | Triazine-oxadiazoles |
| US20140088056A1 (en) * | 2010-09-28 | 2014-03-27 | President And Fellows Of Harvard College | Cardiac glycosides are potent inhibitors of interferon-beta gene expression |
| MX2013006467A (en) | 2010-12-09 | 2013-10-01 | Amgen Inc | Bicyclic compounds as pim inhibitors. |
| KR101671341B1 (en) | 2011-02-25 | 2016-11-01 | 주식회사유한양행 | Diaminopyrimidine derivatives and processes for the preparation thereof |
| WO2013004332A1 (en) * | 2011-07-07 | 2013-01-10 | Merck Patent Gmbh | Substituted azaheterocycles for the treatment of cancer |
| US9695228B2 (en) | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| UY35148A (en) | 2012-11-21 | 2014-05-30 | Amgen Inc | HETERODIMERIC IMMUNOGLOBULINS |
| CN104918919A (en) | 2012-11-21 | 2015-09-16 | Ptc医疗公司 | Substituted reverse pyrimidine bmi-1 inhibitors |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
-
2013
- 2013-11-21 CN CN201380070973.6A patent/CN104918919A/en active Pending
- 2013-11-21 PT PT138573266T patent/PT2922828T/en unknown
- 2013-11-21 CN CN202010080540.0A patent/CN111423417B/en active Active
- 2013-11-21 MA MA38208A patent/MA38208B1/en unknown
- 2013-11-21 JP JP2015544124A patent/JP6412503B2/en active Active
- 2013-11-21 EA EA201590992A patent/EA031405B1/en unknown
- 2013-11-21 ES ES13857326T patent/ES2821529T3/en active Active
- 2013-11-21 DK DK13857326.6T patent/DK2922828T3/en active
- 2013-11-21 CA CA2892045A patent/CA2892045C/en active Active
- 2013-11-21 US US14/443,911 patent/US10428050B2/en active Active
- 2013-11-21 UA UAA201505533A patent/UA118094C2/en unknown
- 2013-11-21 PE PE2015000665A patent/PE20151413A1/en unknown
- 2013-11-21 SG SG11201503982XA patent/SG11201503982XA/en unknown
- 2013-11-21 NZ NZ74660713A patent/NZ746607A/en unknown
- 2013-11-21 EA EA201890142A patent/EA035349B1/en not_active IP Right Cessation
- 2013-11-21 CU CU2015000053A patent/CU24387B1/en unknown
- 2013-11-21 EP EP13857326.6A patent/EP2922828B1/en active Active
- 2013-11-21 AR ARP130104300A patent/AR093579A1/en active IP Right Grant
- 2013-11-21 NZ NZ70890913A patent/NZ708909A/en unknown
- 2013-11-21 BR BR112015011760-0A patent/BR112015011760B1/en active IP Right Grant
- 2013-11-21 AU AU2013348009A patent/AU2013348009C1/en active Active
- 2013-11-21 MX MX2015006469A patent/MX2015006469A/en unknown
- 2013-11-21 KR KR1020217020963A patent/KR102356487B1/en active IP Right Grant
- 2013-11-21 SG SG10201600149VA patent/SG10201600149VA/en unknown
- 2013-11-21 KR KR1020227035587A patent/KR20220143164A/en not_active IP Right Cessation
- 2013-11-21 TW TW102142555A patent/TWI623531B/en active
- 2013-11-21 KR KR1020227002513A patent/KR102455889B1/en active IP Right Grant
- 2013-11-21 KR KR1020157016184A patent/KR102275676B1/en active IP Right Grant
- 2013-11-21 PL PL13857326T patent/PL2922828T3/en unknown
- 2013-11-21 WO PCT/US2013/071132 patent/WO2014081906A2/en active Application Filing
-
2015
- 2015-05-18 IL IL238871A patent/IL238871B/en active IP Right Grant
- 2015-05-20 CL CL2015001377A patent/CL2015001377A1/en unknown
- 2015-05-21 EC ECIEPI201519948A patent/ECSP15019948A/en unknown
- 2015-05-21 SA SA517381847A patent/SA517381847B1/en unknown
- 2015-05-21 NI NI201500072A patent/NI201500072A/en unknown
- 2015-05-21 PH PH12015501130A patent/PH12015501130A1/en unknown
- 2015-05-21 MX MX2021009892A patent/MX2021009892A/en unknown
- 2015-05-22 ZA ZA2015/03642A patent/ZA201503642B/en unknown
- 2015-06-05 CR CR20150294A patent/CR20150294A/en unknown
-
2016
- 2016-03-16 HK HK16103069.2A patent/HK1215032A1/en unknown
-
2018
- 2018-09-28 JP JP2018183173A patent/JP6617186B2/en active Active
-
2019
- 2019-03-10 IL IL265253A patent/IL265253A/en unknown
- 2019-09-26 US US16/583,442 patent/US11180483B2/en active Active
- 2019-11-11 JP JP2019203706A patent/JP6918898B2/en active Active
-
2021
- 2021-11-10 US US17/523,480 patent/US20220064150A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL265253A (en) | Substituted reverse pyrimidine bmi-1 inhibitors | |
| HK1244004A1 (en) | Lactam kinase inhibitors | |
| HK1226057A1 (en) | Substituted pyrimidine bmi-1 inhibitors | |
| HK1210775A1 (en) | Imidazotriazinecarbonitriles useful as kinase inhibitors | |
| ZA201504200B (en) | Beta-lactamase inhibitors | |
| HK1208442A1 (en) | Substituted pyrrolopyrimidinylamino-benzothiazolones as mknk kinase inhibitors mknk | |
| RS63503B1 (en) | Rho kinase inhibitors | |
| SI2855480T1 (en) | Pteridines as fgfr inhibitors | |
| GB201211310D0 (en) | CSF-1R kinase inhibitors | |
| SG11201500973WA (en) | Amino-quinolines as kinase inhibitors | |
| HK1205106A1 (en) | Substituted pyrimidine compounds and their use as syk inhibitors syk | |
| EP2903970A4 (en) | Substituted pyrimidinyl kinase inhibitors | |
| HK1209422A1 (en) | Fbxo3 inhibitors fbxo3 | |
| EP2913325A4 (en) | Substituted pyrimidine compound and uses thereof | |
| EP2922823A4 (en) | Pyrimidine pde10 inhibitors |