SG11201408337PA - Methods of decellularizing bone - Google Patents

Methods of decellularizing bone

Info

Publication number
SG11201408337PA
SG11201408337PA SG11201408337PA SG11201408337PA SG11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA SG 11201408337P A SG11201408337P A SG 11201408337PA
Authority
SG
Singapore
Prior art keywords
international
bone
methods
decellularizing
nesota
Prior art date
Application number
SG11201408337PA
Inventor
Jeffrey Ross
Blaise Porter
Original Assignee
Miromatrix Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miromatrix Medical Inc filed Critical Miromatrix Medical Inc
Publication of SG11201408337PA publication Critical patent/SG11201408337PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4646—Devices for cleaning bone graft

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Mattresses And Other Support Structures For Chairs And Beds (AREA)
  • Seats For Vehicles (AREA)
  • Pens And Brushes (AREA)

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188525 A1 (51) International Patent Classification: C12N 5/071 (2010.01) A61F 2/28 (2006.01) C12N 5/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/045387 12 June 2013 (12.06.2013) English (30) Priority Data: 61/659,046 13 June 2012 (13.06.2012) English US (72) Inventors; and (71) Applicants : ROSS, Jeffrey [US/US]; 470 Liberty Heights Drive, Chaska, Minnesota 55318 (US). PORTER, Blaise [US/US]; 18683 Bearpath Trail, Eden Prairie, Min­ nesota 55347 (US). (74) Agents: MADDEN, Robert et al.; Schwegman, Lundberg & Woessner, P.A., P.O. Box 2938, Minneapolis, Min­ nesota 55402 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: METHODS OF DECELLULARIZING BONE CJ oo 00 i-H en i-H o CJ O £ CANCELLOUS SPACE BEING FLUSHED OUT DRILL & TAP THIS AREA THREAD TO IN FITTING FLUID IN CAN ATTACH ANY TUBE TO APPLY FLUID/SOLVENT PRESSURE FLUID OUT ma 3 (57) Abstract: Methods of decellularizing bone, e.g., human bone, are provided.
SG11201408337PA 2012-06-13 2013-06-12 Methods of decellularizing bone SG11201408337PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261659046P 2012-06-13 2012-06-13
PCT/US2013/045387 WO2013188525A1 (en) 2012-06-13 2013-06-12 Methods of decellularizing bone

Publications (1)

Publication Number Publication Date
SG11201408337PA true SG11201408337PA (en) 2015-01-29

Family

ID=48703894

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201408337PA SG11201408337PA (en) 2012-06-13 2013-06-12 Methods of decellularizing bone

Country Status (13)

Country Link
US (1) US9290738B2 (en)
EP (1) EP2861721A1 (en)
JP (2) JP2015524680A (en)
KR (1) KR20150033644A (en)
CN (1) CN104937094B (en)
AU (1) AU2013274322B2 (en)
BR (1) BR112014031224A2 (en)
CA (1) CA2876648C (en)
HK (1) HK1209159A1 (en)
IN (1) IN2014DN11201A (en)
MX (1) MX359769B (en)
SG (1) SG11201408337PA (en)
WO (1) WO2013188525A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE552007T1 (en) 2005-08-26 2012-04-15 Univ Minnesota DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES
WO2012031162A1 (en) 2010-09-01 2012-03-08 Doris Taylor Methods of recellularizing a tissue or organ for improved transplantability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
EP2970891B1 (en) 2013-03-15 2020-10-21 Miromatrix Medical Inc. Use of perfusion decellularized liver for islet cell recellularization
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
JP6271298B2 (en) * 2014-02-28 2018-01-31 国立大学法人 東京医科歯科大学 Method for producing decellularized tissue
JP6302756B2 (en) * 2014-06-06 2018-03-28 シスメックス株式会社 Cell collection method and processed bone used in the method
EP3095469B1 (en) 2015-05-22 2019-09-11 Ilyas Inci Process for bone tissue decellularization
CN114672451A (en) 2015-09-11 2022-06-28 通用医疗公司 Regeneration of functional pulmonary vascular bed
CN107456603A (en) * 2016-06-03 2017-12-12 香港大学深圳医院 A kind of bone holder material and preparation method for being enriched with magnesium ion
CN106075583B (en) * 2016-07-07 2020-07-14 中国人民解放军第二军医大学 Method for preparing acellular matrix biological material by perfusion-pressure difference method
US11278643B2 (en) 2016-09-06 2022-03-22 Mayo Foundation For Medical Education And Research Use of resected liver serum for whole liver-engineering
CN110227182B (en) * 2019-01-17 2020-12-15 浙江大学医学院附属邵逸夫医院 Preparation method of gradient mineralized bone extracellular matrix material
JP7336242B2 (en) * 2019-04-05 2023-08-31 株式会社三共 slot machine
CN110237303B (en) * 2019-06-27 2021-06-29 浙江大学医学院附属邵逸夫医院 Preparation method of acellular periosteum matrix gel material from natural tissue source
KR20230015192A (en) * 2021-07-22 2023-01-31 한스바이오메드 주식회사 A method for manufacturing acellular dermal matrix

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545221A (en) 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
US3639084A (en) 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
DE2453363B2 (en) 1974-11-11 1976-08-26 Solco Basel AG, Birsfelden (Schweiz) METHOD OF MANUFACTURING HETEROLOGICAL ARTERIAL TRANSPLANTS
JPS5516016A (en) 1978-07-18 1980-02-04 Dai Ichi Kogyo Seiyaku Co Ltd Improved salt-resistant water-absorbing material
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
FR2699408B1 (en) * 1992-12-21 1995-03-24 Bioland Method for treating bone tissue and corresponding implantable biomaterials.
US5976104A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby
US5556379A (en) * 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
JPH10511563A (en) 1994-09-12 1998-11-10 アドバンスド ティシュー サイエンシズ，インコーポレーテッド Three-dimensional human cell culture and its use on a heart valve framework
US5846484A (en) * 1997-03-20 1998-12-08 Osteotech, Inc. Pressure flow system and method for treating a fluid permeable workpiece such as a bone
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US6448076B2 (en) 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6432712B1 (en) 1999-11-22 2002-08-13 Bioscience Consultants, Llc Transplantable recellularized and reendothelialized vascular tissue graft
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US20050249816A1 (en) 1999-12-29 2005-11-10 Wake Forest University Health Services Tissue engineered liver constructs
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
AU2001255741B2 (en) 2000-04-28 2005-08-04 Baylor College Of Medicine Decellularized vascular prostheses
DE10021627B4 (en) 2000-05-04 2009-11-19 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Method for producing a vascularized bioartificial tissue and associated experimental reactor
ATE332964T1 (en) 2000-08-16 2006-08-15 Univ Duke DECELLULARIZED OBJECTS AND TISSUES PRODUCED USING TISSUE TECHNOLOGY
US6749064B1 (en) 2000-08-25 2004-06-15 Sanita L. Alrey Bag with article display aperture and support surface
EP1333870A2 (en) 2000-09-20 2003-08-13 Regeneration Technologies, Inc. Method of preparing and processing transplant tissue
IL139708A0 (en) 2000-11-15 2002-02-10 Amiel Gilad Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
DE10064948C1 (en) 2000-12-20 2002-07-11 Auto Tissue Gmbh Process for decellularizing foreign material for the production of bioprostheses and device for carrying out the process
EP3246396B1 (en) 2001-02-14 2020-01-29 Celularity, Inc. Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
CA2445110A1 (en) 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
GB2375771A (en) 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
EP1317934A1 (en) 2001-11-08 2003-06-11 Artiss GmbH Process for the preparation of an acellularized tissue matrix and the resulting tissue matrix
AU2002340463A1 (en) 2001-11-16 2003-06-10 Children's Medical Center Corporation Augmentation of organ function
DE60239217D1 (en) 2001-11-16 2011-03-31 Childrens Medical Center GENERATION OF WOVEN TECHNOLOGY MANUFACTURED FEMALE REPRODUCTIVE ORGANS
US20030180268A1 (en) 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
JP4149897B2 (en) 2002-11-07 2008-09-17 学校法人 聖マリアンナ医科大学 Method for preparing tracheal graft and tracheal graft
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
MXPA05006210A (en) 2002-12-13 2005-08-19 Cilag Ag Controlled release preparations comprising tramadol and topiramate.
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP2006223101A (en) 2003-05-15 2006-08-31 Univ Waseda Living organism tissue retaining unit and living organism tissue treating apparatus including the same
WO2005118014A2 (en) 2004-06-01 2005-12-15 Medtronic, Inc. Decellurisation processes for making bioprotheses
JP3773943B2 (en) 2004-09-24 2006-05-10 国立大学法人 東京大学 Grasping state determination system and method
DE102005023599A1 (en) 2005-05-18 2006-11-23 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Bioartificial heart tissue graft and process for its preparation
US20100093066A1 (en) 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
ATE552007T1 (en) 2005-08-26 2012-04-15 Univ Minnesota DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES
CN101066477B (en) 2007-05-17 2010-10-06 中国人民解放军第三军医大学 Biological artificial blood vessel capable of in vivo capturing endothelial ancestral cell
WO2009073594A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
JP2009207700A (en) * 2008-03-04 2009-09-17 Cell Remover:Kk Device for decellularization treatment
CA2757457C (en) 2009-03-31 2018-05-29 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues
WO2012031162A1 (en) 2010-09-01 2012-03-08 Doris Taylor Methods of recellularizing a tissue or organ for improved transplantability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone

Also Published As

Publication number Publication date
MX2014015270A (en) 2015-08-12
CA2876648C (en) 2020-09-22
JP2015524680A (en) 2015-08-27
AU2013274322A1 (en) 2015-01-29
HK1209159A1 (en) 2016-03-24
JP2019072524A (en) 2019-05-16
CN104937094B (en) 2018-06-01
CA2876648A1 (en) 2013-12-19
IN2014DN11201A (en) 2015-10-02
BR112014031224A2 (en) 2017-06-27
WO2013188525A1 (en) 2013-12-19
US20130337560A1 (en) 2013-12-19
US9290738B2 (en) 2016-03-22
MX359769B (en) 2018-10-10
KR20150033644A (en) 2015-04-01
AU2013274322B2 (en) 2017-03-09
EP2861721A1 (en) 2015-04-22
CN104937094A (en) 2015-09-23

Similar Documents

Publication Publication Date Title
SG11201408337PA (en) Methods of decellularizing bone
SG11201408092UA (en) Endoprosthesis and delivery device for implanting such endoprosthesis
SG11201803897QA (en) Pressure control device, dispenser comprising said pressure control device and method of manufacturing
SG11201804758QA (en) Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab
SG11201806588PA (en) Devices and methods for fluid transfer through a placed peripheral intravenous catheter
SG11201805570WA (en) Systems and methods for long term transdermal administration
SG11201807573VA (en) Methods for providing single-stranded rna
SG11201407455PA (en) Seaweed-based food packaging coating
SG11201900817XA (en) Systems and methods for delivering an intravascular device to the mitral annulus
SG11201407851RA (en) Synthesis of pyrrolo [2, 3 - b] pyridines
SG11201408769QA (en) Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
SG11201805927YA (en) Spiroheptane salicylamides and related compounds as inhibitors of rock
SG11201407200TA (en) Liquid formulation
SG11201809908TA (en) Stabilized glycopeptide antibiotic formulations
SG11201408124PA (en) Differentiation of human embryonic stem cells into pancreatic endocrine cells
SG11201408539UA (en) Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof
SG11201500005SA (en) Pyrimidine pyrazolyl derivatives
SG11201408307VA (en) Needle guard
SG11201408251SA (en) A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota
SG11201407740UA (en) Flush enhancing male luer tip design for syringes and any luer connector
SG11201810177VA (en) Pet-imaging immunomodulators
SG11201408119PA (en) Systems and methods for data center cooling and water desalination
SG11201407294UA (en) Contamination identification system
SG11201909003YA (en) Integrated vascular access device and anchor pad
SG11201907774VA (en) Sulfoximine glycosidase inhibitors