SG11201401202YA - Antagonists of il17c for the treatment of inflammatory disorders - Google Patents

Antagonists of il17c for the treatment of inflammatory disorders

Info

Publication number
SG11201401202YA
SG11201401202YA SG11201401202YA SG11201401202YA SG11201401202YA SG 11201401202Y A SG11201401202Y A SG 11201401202YA SG 11201401202Y A SG11201401202Y A SG 11201401202YA SG 11201401202Y A SG11201401202Y A SG 11201401202YA SG 11201401202Y A SG11201401202Y A SG 11201401202YA
Authority
SG
Singapore
Prior art keywords
il17c
antagonists
treatment
inflammatory disorders
disorders
Prior art date
Application number
SG11201401202YA
Other languages
English (en)
Inventor
Andreas Bültmann
Robert Mühlbacher
Teresa Garcia
Reginald Christophe Xavier Brys
Luc Nelles
Katja Conrath
Original Assignee
Morphosys Ag
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag, Galapagos Nv filed Critical Morphosys Ag
Publication of SG11201401202YA publication Critical patent/SG11201401202YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201401202YA 2011-10-19 2012-10-19 Antagonists of il17c for the treatment of inflammatory disorders SG11201401202YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161548744P 2011-10-19 2011-10-19
EP11185763 2011-10-19
PCT/EP2012/070736 WO2013057241A1 (en) 2011-10-19 2012-10-19 Antagonists of il17c for the treatment of inflammatory disorders

Publications (1)

Publication Number Publication Date
SG11201401202YA true SG11201401202YA (en) 2014-06-27

Family

ID=48140378

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201401202YA SG11201401202YA (en) 2011-10-19 2012-10-19 Antagonists of il17c for the treatment of inflammatory disorders

Country Status (21)

Country Link
US (2) US20140243506A1 (es)
EP (2) EP3360897A1 (es)
JP (1) JP2014530836A (es)
CN (1) CN103974976A (es)
AU (1) AU2012324895B2 (es)
CA (1) CA2852145C (es)
CY (1) CY1120219T1 (es)
DK (1) DK2768859T3 (es)
ES (1) ES2669984T3 (es)
HR (1) HRP20180776T1 (es)
HU (1) HUE037087T2 (es)
LT (1) LT2768859T (es)
ME (1) ME03073B (es)
MX (1) MX360710B (es)
PL (1) PL2768859T3 (es)
PT (1) PT2768859T (es)
RS (1) RS57209B1 (es)
SG (1) SG11201401202YA (es)
SI (1) SI2768859T1 (es)
TR (1) TR201807056T4 (es)
WO (1) WO2013057241A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102089444A (zh) 2008-05-14 2011-06-08 德玛泰克国际公司 利用核酸分析方法来诊断黑素瘤和太阳能雀斑
US20120201821A1 (en) * 2010-10-25 2012-08-09 Gonzalez Jr Lino Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma
JP6944747B2 (ja) * 2014-12-15 2021-10-06 モルフォシス・アーゲー Il−17cに対する抗体
WO2017060289A1 (en) * 2015-10-05 2017-04-13 Morphosys Ag Antagonists of il-17c for the treatment and/or prevention of atopic dermatitis
SI3416983T1 (sl) * 2016-02-19 2021-08-31 Morphosys Ag Protitelesa za IL-17C
US10975152B2 (en) * 2016-05-03 2021-04-13 The Scripps Research Institute TrkB agonist antibodies and methods for treating an ocular degenerative disorder characterized by degeneration of retinal ganglion cells (RGCs)
EP3688031A1 (en) 2017-09-25 2020-08-05 MorphoSys AG Treatment of atopic dermatitis
EP3752645A4 (en) 2018-02-14 2022-04-13 Dermtech, Inc. NEW GENE CLASSIFIERS AND THEIR USES IN NON-MELANOMA SKIN CANCERS
GB201803563D0 (en) 2018-03-06 2018-04-18 Galapagos Nv Antibodies and pharmaceutical compositions thereof for the treatment of autoimmune skin diseases
KR20210031640A (ko) 2018-05-09 2021-03-22 덤테크, 인크. 신규한 유전자 분류자 및 자가면역 질환에서의 이의 용도
CA3134936A1 (en) 2019-03-26 2020-10-01 Dermtech, Inc. Novel gene classifiers and uses thereof in skin cancers
KR20210087891A (ko) * 2019-12-30 2021-07-13 경상국립대학교병원 박테리아 감염증 예방 또는 치료용 약학 조성물
CN112795637A (zh) * 2021-01-08 2021-05-14 孙洪臣 靶向il-17c的抑制剂在治疗炎症相关慢性肾脏疾病中的用途
WO2022204375A1 (en) * 2021-03-25 2022-09-29 The Regents Of The University Of Michigan Compositions and methods for detecting, preventing, and treating disturbed microbiota-immune homeostasis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725609C (en) 1995-08-18 2002-01-03 Morphosys Ag Protein/(poly)peptide libraries
NZ508878A (en) 1998-05-15 2003-08-29 Genentech Inc IL-17B and IL-17Cactive variants of IL-17 which stimulates epithelial, endothelial and fibroblastic cells
ATE417925T1 (de) 1999-07-20 2009-01-15 Morphosys Ag Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
PT1240325E (pt) * 1999-12-23 2010-01-07 Genentech Inc Polipéptidos homólogos de il-17 e il-17r e suas utilizações terapêuticas
US20040197306A1 (en) 2000-05-24 2004-10-07 Gorman Daniel M. Mammalian receptor proteins; related reagents and methods
AU2002357060A1 (en) 2001-12-03 2003-06-17 Abgenix, Inc. Antibody categorization based on binding characteristics
EA200700823A1 (ru) * 2004-10-18 2008-02-28 Займодженетикс, Инк., Сша Растворимый zcytor21, анти-zcytor21 антитела и связывающие партнёры и способы применения при воспалении
US20070129302A1 (en) * 2005-10-18 2007-06-07 Zeren Gao Il-17c antagonists and methods of using the same
EP2064237A2 (en) * 2006-10-18 2009-06-03 ZymoGenetics, Inc. Il-17c antagonists and methods of using the same
KR101615215B1 (ko) * 2007-12-07 2016-04-25 지모제넥틱스, 인코포레이티드 항-사람 il-21 단클론성 항체
WO2009132821A1 (en) * 2008-04-28 2009-11-05 Giuliani International Limited Interleukin (il-21) binding proteins and methods of making and using same
CN102648002A (zh) * 2009-10-10 2012-08-22 斯坦福大学托管董事会 Il-17家族细胞因子组合物及用途
US20120201821A1 (en) * 2010-10-25 2012-08-09 Gonzalez Jr Lino Treatment of Gastrointestinal Inflammation and Psoriasis and Asthma
WO2013016220A1 (en) * 2011-07-22 2013-01-31 Amgen Inc. Il-17 receptor a is required for il-17c biology

Also Published As

Publication number Publication date
DK2768859T3 (en) 2018-06-06
MX360710B (es) 2018-11-14
US20140243506A1 (en) 2014-08-28
CA2852145A1 (en) 2013-04-25
ME03073B (me) 2019-01-20
CY1120219T1 (el) 2018-12-12
EP2768859B1 (en) 2018-02-21
NZ623289A (en) 2015-12-24
MX2014004662A (es) 2015-06-02
LT2768859T (lt) 2018-06-11
EP2768859A1 (en) 2014-08-27
HRP20180776T1 (hr) 2018-08-10
SI2768859T1 (en) 2018-06-29
TR201807056T4 (tr) 2018-06-21
AU2012324895B2 (en) 2017-03-16
EP3360897A1 (en) 2018-08-15
RS57209B1 (sr) 2018-07-31
US10815297B2 (en) 2020-10-27
WO2013057241A1 (en) 2013-04-25
ES2669984T3 (es) 2018-05-29
HUE037087T2 (hu) 2018-08-28
CA2852145C (en) 2021-01-12
US20190062422A1 (en) 2019-02-28
CN103974976A (zh) 2014-08-06
PT2768859T (pt) 2018-05-23
PL2768859T3 (pl) 2018-07-31
JP2014530836A (ja) 2014-11-20
AU2012324895A1 (en) 2014-04-17

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