SG10202100726XA - Compositions and methods for the depletion of cd117+cells - Google Patents
Compositions and methods for the depletion of cd117+cellsInfo
- Publication number
- SG10202100726XA SG10202100726XA SG10202100726XA SG10202100726XA SG10202100726XA SG 10202100726X A SG10202100726X A SG 10202100726XA SG 10202100726X A SG10202100726X A SG 10202100726XA SG 10202100726X A SG10202100726X A SG 10202100726XA SG 10202100726X A SG10202100726X A SG 10202100726XA
- Authority
- SG
- Singapore
- Prior art keywords
- depletion
- compositions
- cells
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Diabetes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662351725P | 2016-06-17 | 2016-06-17 | |
US201662437729P | 2016-12-22 | 2016-12-22 | |
US201762448782P | 2017-01-20 | 2017-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202100726XA true SG10202100726XA (en) | 2021-02-25 |
Family
ID=60119017
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811290VA SG11201811290VA (en) | 2016-06-17 | 2017-06-19 | Compositions and methods for the depletion of cd117+cells |
SG10202100726XA SG10202100726XA (en) | 2016-06-17 | 2017-06-19 | Compositions and methods for the depletion of cd117+cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811290VA SG11201811290VA (en) | 2016-06-17 | 2017-06-19 | Compositions and methods for the depletion of cd117+cells |
Country Status (13)
Country | Link |
---|---|
US (3) | US10111966B2 (en) |
EP (1) | EP3472178A4 (en) |
JP (2) | JP7062647B2 (en) |
KR (2) | KR20190038537A (en) |
CN (1) | CN109661400A (en) |
AU (4) | AU2017204125B1 (en) |
BR (1) | BR112018076306A2 (en) |
CA (1) | CA3028134A1 (en) |
IL (2) | IL303455A (en) |
MA (1) | MA45408A (en) |
MX (1) | MX2018015684A (en) |
SG (2) | SG11201811290VA (en) |
WO (1) | WO2017219029A2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3028145A1 (en) | 2016-06-17 | 2017-12-21 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cells |
JOP20190155A1 (en) * | 2016-12-21 | 2019-06-23 | Novartis Ag | Antibody drug conjugates for ablating hematopoietic stem cells |
JP7038717B2 (en) * | 2016-12-23 | 2022-03-18 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Amanitin antibody conjugate |
WO2018134787A2 (en) | 2017-01-20 | 2018-07-26 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd137+ cells |
US20200188527A1 (en) * | 2017-03-31 | 2020-06-18 | The Children's Medical Center Corporation | Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation |
AU2018302098A1 (en) | 2017-07-18 | 2020-02-20 | Csl Behring Gene Therapy, Inc. | Compositions and methods for treating beta-hemoglobinopathies |
AU2018329066B2 (en) * | 2017-09-08 | 2022-02-17 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | Amanitin antibody conjugate |
EP3700540A4 (en) | 2017-10-24 | 2021-11-10 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+ cells |
EP3700568A4 (en) | 2017-10-24 | 2021-11-10 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+ cells |
EP3717022A4 (en) * | 2017-11-29 | 2021-11-10 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd5+ cells |
WO2019234694A2 (en) * | 2018-06-07 | 2019-12-12 | Magenta Therapeutics, Inc. | Therapeutic methods using antibody drug conjugates (adcs) |
TW202014209A (en) * | 2018-06-20 | 2020-04-16 | 瑞士商諾華公司 | Antibody drug conjugates for ablating hematopoietic stem cells |
JP2021530546A (en) * | 2018-07-23 | 2021-11-11 | マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. | Use of anti-CD137 antibody drug conjugate (ADC) in allogeneic cell therapy |
JP2021535092A (en) | 2018-08-13 | 2021-12-16 | フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド | Conjoined twins and how to use them |
BR112021008437A2 (en) * | 2018-10-30 | 2021-09-28 | Magenta Therapeutics, Inc. | METHODS FOR ALLOGENIC HEMATOPOIETIC STEM CELL TRANSPLANTATION |
CA3117816A1 (en) * | 2018-11-26 | 2020-06-04 | Forty Seven, Inc. | Humanized antibodies against c-kit |
BR112021012240A2 (en) | 2018-12-23 | 2022-01-18 | Csl Behring Llc | Hematopoietic stem cell gene therapy for wiskott-aldrich syndrome |
CA3134689A1 (en) * | 2019-04-24 | 2020-10-29 | Anthony Boitano | Conditioning methods for gene therapy |
WO2020219778A2 (en) * | 2019-04-24 | 2020-10-29 | Magenta Therapeutics, Inc. | Anti-cd117 antibody-drug conjugates and uses thereof |
EP3959243A4 (en) * | 2019-04-24 | 2023-04-12 | Magenta Therapeutics, Inc. | Anti-cd117 antibodies and uses thereof |
EP3959242A4 (en) * | 2019-04-24 | 2023-09-13 | Magenta Therapeutics, Inc. | Anthracycline antibody-drug conjugates and uses thereof |
WO2020219775A1 (en) * | 2019-04-24 | 2020-10-29 | Magenta Therapeutics, Inc. | Anti-cd117 antibody-drug conjugates and uses thereof |
AU2020336969A1 (en) * | 2019-08-29 | 2022-03-03 | Beam Therapeutics Inc. | Compositions and methods for non-toxic conditioning |
US20230310508A1 (en) * | 2020-10-16 | 2023-10-05 | The Board Of Trustees Of The Leland Stanford Junior University | Hematopoietic stem cell engraftment with a combination of agents |
WO2022099083A1 (en) * | 2020-11-06 | 2022-05-12 | Bluebird Bio, Inc. | Methods |
CN113485489B (en) * | 2021-06-18 | 2022-05-10 | 淮阴工学院 | Method for regulating and controlling outlet temperature of evaporator of ORC system |
WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
WO2024121632A1 (en) | 2022-12-09 | 2024-06-13 | Crispr Therapeutics Ag | Use of anti-cd117 antibody drug conjugate (adc) |
Family Cites Families (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451575A (en) | 1988-02-19 | 1995-09-19 | J. W. Broadbent Nominees Pty., Ltd. | Method of treating liver dysfunction with 24-R scymnol |
US5786457A (en) | 1989-02-23 | 1998-07-28 | Colorado State University Research Foundation | Hormone-nuclease compounds and method for regulating hormone related diseases |
WO1990009799A1 (en) | 1989-02-23 | 1990-09-07 | Colorado State University Research Foundation | GnRH ANALOGS FOR DESTROYING GONADOTROPHS |
US5273738A (en) | 1990-03-03 | 1993-12-28 | Fred Hutchinson Cancer Research Center | Radiation delivery to lymphoid and marrow tissues |
US5367057A (en) | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
DK0578774T3 (en) | 1991-04-05 | 1999-04-26 | Univ Washington | Monoclonal antibodies against stem cell factor receptors |
WO1993015751A1 (en) | 1992-02-14 | 1993-08-19 | Merck & Co., Inc. | CHIMERIC TOXINS BINDING TO THE GnRH RECEPTOR |
EP0703990A4 (en) | 1993-04-30 | 1997-09-24 | Lxr Biotechnology Inc | Methods of identifying potentially therapeutically effective agents and cell strains for use therein |
US6106834A (en) | 1993-06-02 | 2000-08-22 | Research Corporation Technologies, Inc. | Use of anti-CD45 leukocyte antigen antibodies for immunomodulation |
US6024957A (en) | 1993-06-02 | 2000-02-15 | Research Corporation Technologies, Inc. | Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same |
ES2174879T3 (en) | 1993-09-08 | 2002-11-16 | Imclone Systems Inc | MONOCLONAL ANTIBODIES RECOGNIZING FLK-2 RECEPTORS AND ISOLATION OF HEMATOPOYETIC PRIMITIVE MOTHER CELL POPULATIONS. |
GB2282812A (en) | 1993-10-15 | 1995-04-19 | Merck & Co Inc | Cytotoxic/receptor ligand conjugates linked via lysine radicals |
GB9323199D0 (en) | 1993-11-10 | 1994-01-05 | Falkenberg J H F | Leukaemia treatment |
DE4343261C2 (en) | 1993-12-17 | 1995-11-02 | Susanne Holzer | Process for the preparation of raw materials for immunoassays and bioassays |
US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
DE19600589C1 (en) | 1996-01-10 | 1997-01-16 | Univ Eberhard Karls | Antibody A3C6E2 |
DE19608769C1 (en) | 1996-03-07 | 1997-04-10 | Univ Eberhard Karls | Monoclonal antibody BV10A4H2 specific for human FLT3/FLK2 receptor |
IL129138A0 (en) | 1996-10-11 | 2000-02-17 | Bristol Myers Squibb Co | Methods and compositions for immunomodulation |
EP0973550B1 (en) | 1997-04-11 | 2002-10-09 | G.D. SEARLE & CO. | Antagonistic anti-avb3 integrin antibodies |
DE19727814C1 (en) | 1997-06-30 | 1998-10-01 | Univ Eberhard Karls | Monoclonal antibody specific for human tyrosine kinase receptor protein |
DE19808453C2 (en) | 1998-02-27 | 2000-12-14 | Gsf Forschungszentrum Umwelt | Expression vector for the conditional regulation of the expression of the large subunit of RNA polymerase II |
US6339062B1 (en) | 1998-11-23 | 2002-01-15 | Inkine Pharmaceutical Company, Inc. | Retroinverso polypeptides that mimic or inhibit thrombospondin activity |
EP1208219A1 (en) | 1999-04-08 | 2002-05-29 | Pavel Sergeev | Synthesis of biologically active compounds in cells |
US6159443A (en) | 1999-04-29 | 2000-12-12 | Vanderbilt University | X-ray guided drug delivery |
AUPQ014699A0 (en) | 1999-05-04 | 1999-05-27 | Access Pharmaceuticals Australia Pty Limited | Amplification of folate-mediated targeting to tumor cells using nanoparticles |
AUPQ014799A0 (en) | 1999-05-04 | 1999-05-27 | Access Pharmaceuticals Australia Pty Limited | Amplification of folate-mediated targeting to tumor cells using polymers |
US7217811B2 (en) | 2000-10-18 | 2007-05-15 | The United States Of America As Represented By The Department Of Health And Human Services | Human gene critical to fertility |
EP2298878A3 (en) | 2000-11-03 | 2011-11-16 | Dana Farber Cancer Institute | Compositions and methods for the diagnosis of cancer |
US20050069538A1 (en) | 2003-09-18 | 2005-03-31 | Gregorio Aversa | Therapeutic binding molecules |
GB0110430D0 (en) | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
GB0122914D0 (en) | 2001-09-22 | 2001-11-14 | Univ Nottingham | Modulation of stat activity |
CN1184890C (en) | 2001-10-09 | 2005-01-19 | 湖南师范大学 | Thuricide engineering bacterium double-effect pesticide containing amatoxin gene |
JP2005536180A (en) | 2001-12-03 | 2005-12-02 | アブジェニックス・インコーポレーテッド | Anti-CD45RB antibodies for use in the treatment of autoimmune diseases and the treatment of transplant rejection |
AR037756A1 (en) | 2001-12-17 | 2004-12-01 | Bayer Corp | ANTIBODY INHIBITING THE ACTIVITY OF THE PRECURSOR CELL FACTOR AND ITS USE FOR THE TREATMENT OF ASTHMA. |
US7183385B2 (en) | 2002-02-20 | 2007-02-27 | Cell Signaling Technology, Inc. | Phospho-specific antibodies to Flt3 and uses thereof |
US20030232369A1 (en) | 2002-04-17 | 2003-12-18 | Bushnell David A. | Molecular structure of RNA polymerase II |
DE10219866A1 (en) | 2002-05-03 | 2003-11-20 | Isolde Riede-Kainrath | Treatment and prevention of tumors, using compounds that modulate expression of switch genes or genes for RNA polymerase II, or activity of their products |
WO2004002425A2 (en) * | 2002-06-28 | 2004-01-08 | Bio Transplant, Inc. | Process for promoting graft acceptance by depletion of hematopoietic stem cells |
AU2002953073A0 (en) | 2002-11-21 | 2003-01-16 | Access Pharmaceuticals Australia Pty Limited | Amplification of biotin-mediated targeting |
US7166691B2 (en) | 2002-12-20 | 2007-01-23 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Saposin C and receptors as targets for treatment of benign and malignant disorders |
WO2006002064A2 (en) | 2004-06-14 | 2006-01-05 | Aerovance, Inc. | Antibody inhibiting stem cell factor activity and use for treatment of asthma |
US20060014197A1 (en) | 2004-07-15 | 2006-01-19 | Wisconsin Alumni Research Foundation | In vivo screening methods for identifying inhibitors of RNA polymerases |
CN103251953A (en) | 2004-07-19 | 2013-08-21 | 约翰·霍普金斯大学 | Flt3 inhibitors for immune suppression |
EP1661584A1 (en) | 2004-11-26 | 2006-05-31 | Heinz Dr. Faulstich | Use of conjugates of amatoxins and phallotoxins with macromolecules for cancer and inflammation therapy |
EP1904088A4 (en) | 2005-05-24 | 2010-03-31 | Dana Farber Cancer Inst Inc | Compositions and methods for the treatment of cancer |
US20110014151A1 (en) | 2006-01-11 | 2011-01-20 | Biotech Igg Ab | Macromolecule conjugate |
US20080003224A1 (en) | 2006-01-27 | 2008-01-03 | Cellerant Therapeutics, Inc. | Compositions and methods for treating haematological proliferative disorders |
WO2007121326A2 (en) | 2006-04-12 | 2007-10-25 | Crosslink Genetics Corporation | Compositions and methods for modulating gene expression |
TWI395754B (en) | 2006-04-24 | 2013-05-11 | Amgen Inc | Humanized c-kit antibody |
ES2371085T3 (en) | 2006-05-27 | 2011-12-27 | Faulstich, Heinz, Dr. | USE OF AMATOXIN OR FALOTOXIN CONJUGATES WITH MACROMOLECULES FOR TUMOR THERAPY AND INFLAMMATION. |
EP3255061B1 (en) * | 2006-11-03 | 2021-06-16 | The Board of Trustees of the Leland Stanford Junior University | Selective immunodepletion of endogenous stem cell niche for engraftment |
US20100093008A1 (en) | 2007-03-02 | 2010-04-15 | Cell Signaling Technology, Inc. | Phospho-specific antibodies to flt3 (tyr969) and uses thereof |
BRPI0812970A2 (en) | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugates containing hydrophilic spacers |
US20090053168A1 (en) | 2007-07-17 | 2009-02-26 | Richard Rickles | Treatments of b-cell proliferative disorders |
US9518097B2 (en) | 2007-11-09 | 2016-12-13 | Board Of Trustees Of Michigan State University | Identification and use of genes encoding amatoxin and phallotoxin |
AR071891A1 (en) | 2008-05-30 | 2010-07-21 | Imclone Llc | ANTI-FLT3 HUMAN ANTIBODIES (THIROSINE KINASE 3 RECEPTOR HUMAN FMS TYPE) |
WO2010045218A1 (en) | 2008-10-13 | 2010-04-22 | Board Of Regents, The University Of Texas System | Molecular clock mechanism of hybrid vigor |
US8940705B2 (en) | 2009-01-09 | 2015-01-27 | The Regents Of The University Of California | Method of treating disease and selectively modulating transcriptional regulation by a glucocorticoid receptor by administering aclacinomycin and dexamethasone |
US9233173B2 (en) | 2009-04-08 | 2016-01-12 | Deutsches Krebsforschungszentrum | Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy |
KR20110140124A (en) * | 2009-04-08 | 2011-12-30 | 하인즈 파울스티히 | Amatoxin-armed target-binding moieties for the treatment of cancer |
JP2012528117A (en) * | 2009-05-28 | 2012-11-12 | グラクソ グループ リミテッド | Targeting stem cells |
WO2011026026A1 (en) * | 2009-08-31 | 2011-03-03 | Immunomedics, Inc. | Compositions and methods of use of immunotoxins comprising ranpirnase (rap) show potent cytotoxic activity |
US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
CN102791865B (en) | 2009-12-21 | 2015-07-01 | 凯津公司 | Improved techniques for transfecting protoplasts |
EA027502B1 (en) | 2009-12-23 | 2017-08-31 | Зиниммуне Гмбх | Anti-flt3 antibodies and methods of using the same |
EP2521782B1 (en) | 2010-01-05 | 2019-04-10 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists for the treatment or the prevention of pain disorders |
KR20110085038A (en) | 2010-01-19 | 2011-07-27 | 울산대학교 산학협력단 | Method for selective depletion of cd137 positive cells using anti-cd137-antibody and toxin complex |
CN101861796B (en) | 2010-05-18 | 2012-02-15 | 四川大学 | Method for culturing amanita pantherina by using waste distillage after fermentation of coloured rice |
EP2603231B1 (en) | 2010-07-13 | 2021-12-29 | Rhode Island Board Of Governors For Higher Education | Compositions comprising a pH-sensitive membrane insertion polipeptide. |
SG10201506906VA (en) | 2010-09-09 | 2015-10-29 | Pfizer | 4-1bb binding molecules |
EP2436398B1 (en) | 2010-09-30 | 2013-01-23 | Heidelberg Pharma GmbH | Amatoxin-conjugates with improved linkers |
US20130288373A1 (en) | 2010-12-20 | 2013-10-31 | Kenneth Verstraete | Crystal structure of flt3 ligand-receptor complex |
CN102526034B (en) | 2010-12-24 | 2015-02-25 | 四川大学华西医院 | Establishment of fulminant liver function failure model of rhesus |
US20150018408A1 (en) | 2013-07-10 | 2015-01-15 | The Regents Of The University Of Michigan | Therapeutic antibodies and uses thereof |
WO2012103165A2 (en) | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
EP2497499A1 (en) | 2011-03-10 | 2012-09-12 | Heidelberg Pharma GmbH | Amatoxin-conjugates with improved linkages |
AR086044A1 (en) | 2011-05-12 | 2013-11-13 | Imclone Llc | ANTIBODIES THAT SPECIFICALLY JOIN A C-KIT EXTRACELLULAR DOMAIN AND USES OF THE SAME |
WO2013131927A1 (en) | 2012-03-06 | 2013-09-12 | Novartis Ag | Combining dna-damaging agents and modulators of actin polymerization for the treatment of cancer |
EP2849790B1 (en) | 2012-05-15 | 2019-04-10 | Concortis Biosystems, Corp | Drug-conjugates, conjugation methods, and uses thereof |
WO2013192546A1 (en) | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and mehtods of using the same |
EP2684865A1 (en) | 2012-07-13 | 2014-01-15 | Heidelberg Pharma GmbH | Methods for synthesizing amatoxin building block and amatoxins |
CN102786586A (en) | 2012-07-20 | 2012-11-21 | 包海鹰 | Discovery of peptide toxins in Amanita pallidorosea fermentation mycelium |
EP4063391A1 (en) | 2012-07-25 | 2022-09-28 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
WO2014043403A1 (en) | 2012-09-12 | 2014-03-20 | Agensys, Inc. | Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase |
BR112015006368B1 (en) | 2012-09-24 | 2022-02-08 | Medimmune Limited | PROCESS FOR PRODUCTION OF STABLE EUKARYOTIC CELL LINE |
GB201217296D0 (en) | 2012-09-27 | 2012-11-14 | Alta Innovations Ltd | Method of treatment and/or prevention |
SG11201502896XA (en) | 2012-10-16 | 2015-05-28 | Endocyte Inc | Drug delivery conjugates containing unnatural amino acids and methods for using |
CA2896248A1 (en) | 2012-12-27 | 2014-07-03 | Sanofi | Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof |
EP2774624A1 (en) | 2013-03-04 | 2014-09-10 | Heidelberg Pharma GmbH | Amatoxin derivatives |
CN105451773A (en) * | 2013-03-15 | 2016-03-30 | 诺华股份有限公司 | Cell proliferation inhibitors and conjugates thereof |
MX366978B (en) | 2013-03-15 | 2019-08-01 | Novartis Ag | Antibody drug conjugates. |
BR112015032200A2 (en) | 2013-06-24 | 2017-11-21 | Hanwha Chemical Corp | antibody-drug conjugate with improved stability, method of preparation, pharmaceutical composition and use thereof |
FR3008408B1 (en) * | 2013-07-11 | 2018-03-09 | Mc Saf | NOVEL ANTIBODY-MEDICAMENT CONJUGATES AND THEIR USE IN THERAPY |
JP6439690B2 (en) | 2013-07-12 | 2018-12-19 | 石原産業株式会社 | Composition for gene transfer into cells |
US9718888B2 (en) | 2013-07-23 | 2017-08-01 | Ohio State Innovation Foundation | Methods and compositions related to single chain antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72) |
WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
EP3065773A1 (en) * | 2013-11-05 | 2016-09-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human neutralizing anti-kit antibodies and uses thereof |
CN103627757B (en) | 2013-12-02 | 2016-04-13 | 云南大学 | Improve the method for little amanita pantherina mycelium Toxin producing C |
CN105377304B (en) * | 2014-03-10 | 2018-05-15 | 海德堡医药有限责任公司 | Amanita hemolysin derivative |
JP2017509337A (en) | 2014-03-12 | 2017-04-06 | ノバルティス アーゲー | Specific sites for modifying antibodies that make immunoconjugates |
EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
US10487151B2 (en) | 2014-07-23 | 2019-11-26 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (TAG-72) |
US10406179B2 (en) * | 2014-08-26 | 2019-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling |
WO2016036334A1 (en) | 2014-09-03 | 2016-03-10 | Şahi̇n Yücel | Voltametric methods to determine alpha-amanitin and phalloidin |
WO2016061509A1 (en) | 2014-10-17 | 2016-04-21 | The Broad Institute, Inc. | Compositions and methods of treatng muscular dystrophy |
US9938323B2 (en) | 2014-11-06 | 2018-04-10 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase |
CN107207564A (en) | 2014-11-11 | 2017-09-26 | 阿穆尼克斯运营公司 | Target XTEN conjugate compositions and preparation method thereof |
US20160220687A1 (en) | 2015-02-02 | 2016-08-04 | National Guard Health Affairs | Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer |
CN107207582A (en) | 2015-02-16 | 2017-09-26 | 隆萨有限公司 | CL and/or CH1 mutant antibodies for drug conjugate |
SG11201707097RA (en) | 2015-03-04 | 2017-09-28 | Univ Texas | Methods of treating cancer harboring hemizygous loss of tp53 |
EP3268038B1 (en) | 2015-03-09 | 2021-05-05 | Agensys, Inc. | Antibody drug conjugates (adc) that bind to flt3 proteins |
CN107636016B (en) | 2015-03-09 | 2022-02-11 | 海德堡医药有限责任公司 | Amatoxin-antibody conjugates |
WO2016145014A1 (en) | 2015-03-10 | 2016-09-15 | President And Fellows Of Harvard College | Methods for treatment of autism spectrum disorders |
CA2980748A1 (en) | 2015-03-25 | 2016-09-29 | Children's Hospital Medical Center | Use of kit inhibitors to condition subjects for a hematopoietic stem cell (hsc) transplantation |
EP3280720A4 (en) * | 2015-04-06 | 2018-12-05 | President and Fellows of Harvard College | Compositions and methods for non-myeloablative conditioning |
WO2016164745A1 (en) | 2015-04-10 | 2016-10-13 | The Methodist Hospital System | Cd117 ligand-drug conjugates for targeted cancer therapy |
US20180110871A1 (en) | 2015-04-17 | 2018-04-26 | Endocyte, Inc. | Dual disulfide drug conjugates |
CN104862314B (en) | 2015-05-11 | 2017-12-01 | 昆明理工大学 | A kind of and the aptamer of α amanita hemolysin specific bonds and application |
EP3297647A1 (en) | 2015-05-18 | 2018-03-28 | Universidade Do Porto | Use of polymyxin as an antidote for intoxications by amatoxins |
AU2016268038A1 (en) | 2015-05-22 | 2017-12-14 | Memorial Sloan Kettering Cancer Center | Systems and methods for determining optimum patient-specific antibody dose for tumor targeting |
EP3954394A1 (en) | 2015-06-19 | 2022-02-16 | Centurion BioPharma Corporation | Delivery systems for controlled drug release |
US10961308B2 (en) | 2015-06-29 | 2021-03-30 | The General Hospital Corporation | Embigin inhibition for promotion of hematopoietic stem and progenitor cell expansion |
GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
EP3322449A1 (en) | 2015-07-16 | 2018-05-23 | Cellerant Therapeutics, Inc. | Cysteine-substituted immunoglobulins |
AU2016303489B2 (en) | 2015-07-31 | 2023-02-16 | University Of Florida Research Foundation, Inc. | Hematopoietic stem cells in combinatorial therapy with immune checkpoint inhibitors against cancer |
CN105177009B (en) | 2015-08-10 | 2018-05-25 | 昆明理工大学 | A kind of aptamer and application with α-amanita hemolysin specific bond |
SG11201806594QA (en) | 2016-02-04 | 2018-09-27 | Suzhou M Conj Biotech Co Ltd | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof |
CN106153768B (en) | 2016-06-30 | 2019-01-01 | 佛山科学技术学院 | Amanita hemolysin molecular engram material is used for the solid phase extraction method of α-amanitin and β-amanitin |
JOP20190155A1 (en) * | 2016-12-21 | 2019-06-23 | Novartis Ag | Antibody drug conjugates for ablating hematopoietic stem cells |
-
2017
- 2017-06-19 IL IL303455A patent/IL303455A/en unknown
- 2017-06-19 IL IL263744A patent/IL263744B2/en unknown
- 2017-06-19 MX MX2018015684A patent/MX2018015684A/en unknown
- 2017-06-19 KR KR1020197001540A patent/KR20190038537A/en not_active IP Right Cessation
- 2017-06-19 KR KR1020237014621A patent/KR20230066647A/en not_active Application Discontinuation
- 2017-06-19 BR BR112018076306-3A patent/BR112018076306A2/en unknown
- 2017-06-19 CN CN201780050606.8A patent/CN109661400A/en active Pending
- 2017-06-19 US US15/626,910 patent/US10111966B2/en active Active
- 2017-06-19 SG SG11201811290VA patent/SG11201811290VA/en unknown
- 2017-06-19 MA MA045408A patent/MA45408A/en unknown
- 2017-06-19 EP EP17814263.4A patent/EP3472178A4/en active Pending
- 2017-06-19 WO PCT/US2017/038158 patent/WO2017219029A2/en active Application Filing
- 2017-06-19 JP JP2019518186A patent/JP7062647B2/en active Active
- 2017-06-19 AU AU2017204125A patent/AU2017204125B1/en active Active
- 2017-06-19 CA CA3028134A patent/CA3028134A1/en active Pending
- 2017-06-19 SG SG10202100726XA patent/SG10202100726XA/en unknown
-
2018
- 2018-01-22 AU AU2018200503A patent/AU2018200503C1/en active Active
- 2018-10-11 US US16/158,164 patent/US20190134217A1/en not_active Abandoned
-
2020
- 2020-02-18 AU AU2020201138A patent/AU2020201138A1/en not_active Abandoned
-
2021
- 2021-02-10 US US17/173,119 patent/US20210162063A1/en active Pending
-
2022
- 2022-04-04 AU AU2022202233A patent/AU2022202233A1/en active Pending
- 2022-04-20 JP JP2022069352A patent/JP2022106807A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3028134A1 (en) | 2017-12-21 |
AU2017204125B1 (en) | 2017-10-26 |
IL263744A (en) | 2019-01-31 |
EP3472178A2 (en) | 2019-04-24 |
IL303455A (en) | 2023-08-01 |
IL263744B2 (en) | 2023-11-01 |
AU2020201138A1 (en) | 2020-03-05 |
AU2018200503A1 (en) | 2018-02-15 |
US20170360954A1 (en) | 2017-12-21 |
WO2017219029A2 (en) | 2017-12-21 |
AU2022202233A1 (en) | 2022-04-21 |
BR112018076306A2 (en) | 2019-03-26 |
AU2018200503B2 (en) | 2020-03-05 |
KR20190038537A (en) | 2019-04-08 |
JP2019522680A (en) | 2019-08-15 |
SG11201811290VA (en) | 2019-01-30 |
JP7062647B2 (en) | 2022-05-06 |
KR20230066647A (en) | 2023-05-16 |
WO2017219029A3 (en) | 2018-01-25 |
EP3472178A4 (en) | 2020-02-19 |
MX2018015684A (en) | 2019-08-29 |
MA45408A (en) | 2019-04-24 |
JP2022106807A (en) | 2022-07-20 |
US20190134217A1 (en) | 2019-05-09 |
US20210162063A1 (en) | 2021-06-03 |
CN109661400A (en) | 2019-04-19 |
AU2018200503C1 (en) | 2020-08-27 |
IL263744B1 (en) | 2023-07-01 |
WO2017219029A8 (en) | 2019-01-17 |
US10111966B2 (en) | 2018-10-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL263744A (en) | Compositions and methods for the depletion of cd117 plus cells | |
IL263743A (en) | Compositions and methods for the depletion of cells | |
SG11202003280SA (en) | Compositions and methods for the depletion of cd117+ cells | |
IL268058A (en) | Compositions and methods for the depletion of cd137plus cells | |
EP3700540A4 (en) | Compositions and methods for the depletion of cd117+ cells | |
HK1258041A1 (en) | Immune cell compositions and methods of use | |
HRP20192145T1 (en) | Carrier-antibody compositions and methods of making and using the same | |
HK1250481A1 (en) | Modified t cells and methods of making and using the same | |
IL255932A (en) | Novel cell epitopes and combination of cell epitopes for use in the immuno-therapy of myeloma and other cancers | |
HK1244841A1 (en) | Methods and compositions for selectively eliminating cells of interest | |
SG11202004116QA (en) | T cell manufacturing compositions and methods | |
HK1256726A1 (en) | Carrier-binding agent compositions and methods of making and using the same | |
IL269334A (en) | Improved t cell compositions and methods | |
SG11202004294XA (en) | Compositions and methods for the depletion of cd5+ cells | |
SG11202004192XA (en) | Compositions and methods for the depletion of cd2+ cells | |
EP3096742A4 (en) | Compositions and methods for modifying the surface of cells and methods of use | |
GB201711206D0 (en) | Compositions and methods of cell attachment | |
PT3113774T (en) | Compositions of grapiprant and methods for using the same | |
HK1254866A1 (en) | Novel cell epitopes and combination of cell epitopes for use in the immuno-therapy of myeloma and other cancers | |
IL251588A0 (en) | Methods and compositions for increasing the potency of antifungal agents | |
GB201518637D0 (en) | Cell co-cultures and methods of making the same |