SG10201912941PA - Combination therapies targeting pd-1, tim-3, and lag-3 - Google Patents
Combination therapies targeting pd-1, tim-3, and lag-3Info
- Publication number
- SG10201912941PA SG10201912941PA SG10201912941PA SG10201912941PA SG10201912941PA SG 10201912941P A SG10201912941P A SG 10201912941PA SG 10201912941P A SG10201912941P A SG 10201912941PA SG 10201912941P A SG10201912941P A SG 10201912941PA SG 10201912941P A SG10201912941P A SG 10201912941PA
- Authority
- SG
- Singapore
- Prior art keywords
- tim
- lag
- combination therapies
- therapies targeting
- targeting
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Memory System Of A Hierarchy Structure (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762481973P | 2017-04-05 | 2017-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201912941PA true SG10201912941PA (en) | 2020-02-27 |
Family
ID=62027945
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912941PA SG10201912941PA (en) | 2017-04-05 | 2018-04-05 | Combination therapies targeting pd-1, tim-3, and lag-3 |
SG11201908919X SG11201908919XA (en) | 2017-04-05 | 2018-04-05 | Combination therapies targeting pd-1, tim-3, and lag-3 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201908919X SG11201908919XA (en) | 2017-04-05 | 2018-04-05 | Combination therapies targeting pd-1, tim-3, and lag-3 |
Country Status (19)
Country | Link |
---|---|
US (2) | US11939380B2 (en) |
EP (3) | EP4116328A1 (en) |
JP (3) | JP2020513009A (en) |
KR (2) | KR20220083863A (en) |
CN (2) | CN110621698B (en) |
AU (2) | AU2018247916A1 (en) |
BR (1) | BR112019020662A2 (en) |
CA (2) | CA3058960C (en) |
CL (2) | CL2019002850A1 (en) |
CO (1) | CO2019012080A2 (en) |
EA (1) | EA201992350A1 (en) |
IL (1) | IL269644A (en) |
MA (1) | MA49042A (en) |
MX (2) | MX2019011961A (en) |
PE (1) | PE20191741A1 (en) |
PH (1) | PH12019502191A1 (en) |
SG (2) | SG10201912941PA (en) |
TW (2) | TWI801376B (en) |
WO (1) | WO2018185232A1 (en) |
Families Citing this family (16)
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MD3443009T2 (en) | 2016-04-12 | 2022-02-28 | Symphogen As | Anti-tim-3 antibodies and compositions |
MY200602A (en) | 2016-07-14 | 2024-01-04 | Bristol Myers Squibb Co | Antibodies against tim3 and uses thereof |
WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
CN117567622A (en) | 2016-10-13 | 2024-02-20 | 正大天晴药业集团股份有限公司 | anti-LAG-3 antibodies and compositions |
PL3606946T3 (en) | 2017-04-03 | 2022-11-28 | F. Hoffmann-La Roche Ag | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
EP4116328A1 (en) | 2017-04-05 | 2023-01-11 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Combination therapies targeting pd-1, tim-3, and lag-3 |
BR112019019821A2 (en) | 2017-04-05 | 2020-04-22 | Hoffmann La Roche | bispecific antibody, polynucleotide, prokaryotic or eukaryotic host cell, methods of producing the bispecific antibody, treating an individual who has cancer or a chronic viral infection and inhibiting tumor cell growth, pharmaceutical composition and use of the bispecific antibody |
US10894833B2 (en) * | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
CN111253485A (en) * | 2018-11-30 | 2020-06-09 | 上海开拓者生物医药有限公司 | Anti-human TIM-3 monoclonal antibody and application thereof |
US20220249659A1 (en) * | 2019-05-13 | 2022-08-11 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer |
CN113214396B (en) * | 2020-07-31 | 2022-04-19 | 北京市神经外科研究所 | Single-chain antibody of anti-TIM 3 and application thereof in preparing medicine for treating tumor |
CN112812179B (en) * | 2021-01-19 | 2022-07-22 | 北京大学 | High-affinity high-specificity anti-CMTM 6 monoclonal antibody and application thereof |
US20230416367A1 (en) * | 2022-06-07 | 2023-12-28 | Incyte Corporation | Combination therapy of anti-pd-1 active agent, anti-tim-3 active agent, and anti-lag-3 active agent for treating cancer |
WO2024041652A1 (en) * | 2022-08-25 | 2024-02-29 | Beigene, Ltd. | Methods of cancer treatment |
WO2024041651A1 (en) * | 2022-08-25 | 2024-02-29 | Beigene, Ltd. | Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies and anti-lag3 antibodies |
WO2024051670A1 (en) * | 2022-09-06 | 2024-03-14 | 正大天晴药业集团股份有限公司 | Pharmaceutical combination of antibody binding to tim-3 and antibody binding to pd-1 |
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MX2018003936A (en) * | 2015-10-02 | 2018-07-06 | Symphogen As | Anti-pd-1 antibodies and compositions. |
MD3443009T2 (en) | 2016-04-12 | 2022-02-28 | Symphogen As | Anti-tim-3 antibodies and compositions |
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MY200602A (en) | 2016-07-14 | 2024-01-04 | Bristol Myers Squibb Co | Antibodies against tim3 and uses thereof |
JOP20190013A1 (en) | 2016-08-25 | 2019-01-31 | Lilly Co Eli | Anti-tim-3 antibodies |
CN117567622A (en) | 2016-10-13 | 2024-02-20 | 正大天晴药业集团股份有限公司 | anti-LAG-3 antibodies and compositions |
EA201991214A1 (en) | 2016-11-18 | 2019-10-31 | ANTIBODIES AGAINST PD-1 AND THEIR COMPOSITION | |
JOP20190133A1 (en) | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | Anti-tim-3 antibodies for combination with anti-pd-1 antibodies |
EP4116328A1 (en) * | 2017-04-05 | 2023-01-11 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Combination therapies targeting pd-1, tim-3, and lag-3 |
JOP20190222A1 (en) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | Anti-pd-l1-anti-tim-3 bispecific antibodies |
-
2018
- 2018-04-05 EP EP22177869.9A patent/EP4116328A1/en active Pending
- 2018-04-05 EP EP18719068.1A patent/EP3606957A1/en active Pending
- 2018-04-05 CA CA3058960A patent/CA3058960C/en active Active
- 2018-04-05 KR KR1020227019731A patent/KR20220083863A/en not_active Application Discontinuation
- 2018-04-05 CA CA3185303A patent/CA3185303A1/en active Pending
- 2018-04-05 PE PE2019001998A patent/PE20191741A1/en unknown
- 2018-04-05 WO PCT/EP2018/058752 patent/WO2018185232A1/en active Application Filing
- 2018-04-05 AU AU2018247916A patent/AU2018247916A1/en active Pending
- 2018-04-05 KR KR1020197030876A patent/KR20190137105A/en not_active Application Discontinuation
- 2018-04-05 EA EA201992350A patent/EA201992350A1/en unknown
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2019
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2021
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