SG10201902903RA - Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine - Google Patents
Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidineInfo
- Publication number
- SG10201902903RA SG10201902903RA SG10201902903RA SG10201902903RA SG10201902903RA SG 10201902903R A SG10201902903R A SG 10201902903RA SG 10201902903R A SG10201902903R A SG 10201902903RA SG 10201902903R A SG10201902903R A SG 10201902903RA SG 10201902903R A SG10201902903R A SG 10201902903RA
- Authority
- SG
- Singapore
- Prior art keywords
- ylvinyl
- pyrrolidin
- pyrimidine
- synthesis
- salt forms
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11879608P | 2008-12-01 | 2008-12-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201902903RA true SG10201902903RA (en) | 2019-05-30 |
Family
ID=41650077
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201406410UA SG10201406410UA (en) | 2008-12-01 | 2009-11-30 | Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
SG10201902903RA SG10201902903RA (en) | 2008-12-01 | 2009-11-30 | Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201406410UA SG10201406410UA (en) | 2008-12-01 | 2009-11-30 | Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
Country Status (26)
Country | Link |
---|---|
US (1) | US8604191B2 (de) |
EP (2) | EP3279195B1 (de) |
JP (1) | JP5710490B2 (de) |
KR (1) | KR20110098763A (de) |
CN (1) | CN102232070A (de) |
AU (1) | AU2009322624B2 (de) |
BR (1) | BRPI0922759A2 (de) |
CA (2) | CA2742366C (de) |
CL (1) | CL2011001258A1 (de) |
CO (1) | CO6390106A2 (de) |
DK (1) | DK3279195T3 (de) |
EC (1) | ECSP11011167A (de) |
ES (2) | ES2820857T3 (de) |
HK (1) | HK1250572A1 (de) |
HU (1) | HUE050540T2 (de) |
IL (2) | IL266097B (de) |
MX (1) | MX2011005611A (de) |
NZ (3) | NZ703381A (de) |
PE (1) | PE20110589A1 (de) |
PL (1) | PL3279195T3 (de) |
PT (1) | PT3279195T (de) |
RU (2) | RU2533819C2 (de) |
SG (2) | SG10201406410UA (de) |
UA (1) | UA107336C2 (de) |
WO (1) | WO2010065443A1 (de) |
ZA (1) | ZA201103737B (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9145396B2 (en) * | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
WO2011112428A2 (en) * | 2010-03-11 | 2011-09-15 | Targacept, Inc. | Arylvinylazacycloalkane compounds for constipation |
EA035335B1 (ru) | 2014-10-20 | 2020-05-28 | Ойстер Поинт Фарма, Инк. | Способы лечения офтальмологических расстройств с применением варениклина |
JP7090551B2 (ja) | 2016-04-07 | 2022-06-24 | オイスター ポイント ファーマ インコーポレイテッド | 眼状態の治療方法 |
WO2020014217A1 (en) | 2018-07-10 | 2020-01-16 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
EP3820443A1 (de) | 2018-07-10 | 2021-05-19 | Oyster Point Pharma, Inc. | Kombinationen von positiven allosterischen modulatoren und nikotinischen acetylcholinrezeptoragonisten zur behandlung von augenleiden |
TW202206078A (zh) | 2020-04-28 | 2022-02-16 | 美商奧伊斯特普安生物製藥公司 | 局部投與菸鹼乙醯膽鹼受體促效劑用以抑制冠狀病毒感染 |
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US4649041A (en) * | 1983-07-20 | 1987-03-10 | Warner-Lambert Company | Magnesium trisilicate suitable for preparation of medicament adsorbates of antinauseants |
SU1605922A3 (ru) * | 1987-05-01 | 1990-11-07 | Фудзисава Фармасьютикал Ко., Лтд (Фирма) | Способ получени производных пирролидина или их солей |
US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
US5852041A (en) | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
US5493026A (en) | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
US5604231A (en) | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
US5597919A (en) | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
US5585388A (en) | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
ES2097703B1 (es) * | 1995-04-12 | 1997-12-01 | Decox S L | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. |
US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
US5726189A (en) | 1996-05-03 | 1998-03-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
ZA9711092B (en) | 1996-12-11 | 1999-07-22 | Smithkline Beecham Corp | Novel compounds. |
US5952339A (en) | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
US6310043B1 (en) | 1998-08-07 | 2001-10-30 | Governors Of The University Of Alberta | Treatment of bacterial infections |
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CA2415468A1 (en) * | 2000-07-11 | 2003-01-10 | Yoshio Ogino | Ester derivatives |
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AR053364A1 (es) * | 2005-04-20 | 2007-05-02 | Smithkline Beecham | Compuesto de 1h-imidazo 84,5-c) piridin -2- ilo, composicion farmaceutica que lo comprende, proceso para prepararla y su uso para preparar un medicamento para tratamiento de cancer o artritis |
US7598255B2 (en) * | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
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WO2008157365A2 (en) * | 2007-06-15 | 2008-12-24 | Targacept, Inc. | Vinylazacycloalkanes for treating neuropathic pain |
TW201024283A (en) * | 2008-12-01 | 2010-07-01 | Targacept Inc | Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine |
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2009
- 2009-11-30 PT PT171793698T patent/PT3279195T/pt unknown
- 2009-11-30 EP EP17179369.8A patent/EP3279195B1/de active Active
- 2009-11-30 DK DK17179369.8T patent/DK3279195T3/da active
- 2009-11-30 CA CA2742366A patent/CA2742366C/en active Active
- 2009-11-30 HU HUE17179369A patent/HUE050540T2/hu unknown
- 2009-11-30 NZ NZ703381A patent/NZ703381A/en unknown
- 2009-11-30 ES ES17179369T patent/ES2820857T3/es active Active
- 2009-11-30 NZ NZ592554A patent/NZ592554A/xx unknown
- 2009-11-30 MX MX2011005611A patent/MX2011005611A/es active IP Right Grant
- 2009-11-30 WO PCT/US2009/066078 patent/WO2010065443A1/en active Application Filing
- 2009-11-30 NZ NZ611965A patent/NZ611965A/en unknown
- 2009-11-30 EP EP09775408.9A patent/EP2364307B1/de active Active
- 2009-11-30 IL IL266097A patent/IL266097B/en unknown
- 2009-11-30 CA CA3090738A patent/CA3090738C/en active Active
- 2009-11-30 PE PE2011001110A patent/PE20110589A1/es active IP Right Grant
- 2009-11-30 PL PL17179369T patent/PL3279195T3/pl unknown
- 2009-11-30 SG SG10201406410UA patent/SG10201406410UA/en unknown
- 2009-11-30 ES ES09775408.9T patent/ES2641762T3/es active Active
- 2009-11-30 AU AU2009322624A patent/AU2009322624B2/en active Active
- 2009-11-30 JP JP2011538710A patent/JP5710490B2/ja active Active
- 2009-11-30 SG SG10201902903RA patent/SG10201902903RA/en unknown
- 2009-11-30 RU RU2011127010/04A patent/RU2533819C2/ru active IP Right Revival
- 2009-11-30 US US13/129,898 patent/US8604191B2/en active Active
- 2009-11-30 KR KR1020117014867A patent/KR20110098763A/ko not_active Application Discontinuation
- 2009-11-30 BR BRPI0922759A patent/BRPI0922759A2/pt not_active IP Right Cessation
- 2009-11-30 CN CN2009801480732A patent/CN102232070A/zh active Pending
- 2009-11-30 UA UAA201108206A patent/UA107336C2/ru unknown
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2011
- 2011-05-09 IL IL212798A patent/IL212798B/en active IP Right Grant
- 2011-05-20 ZA ZA2011/03737A patent/ZA201103737B/en unknown
- 2011-05-30 CL CL2011001258A patent/CL2011001258A1/es unknown
- 2011-06-29 CO CO11081403A patent/CO6390106A2/es not_active Application Discontinuation
- 2011-06-29 EC EC2011011167A patent/ECSP11011167A/es unknown
-
2014
- 2014-09-11 RU RU2014136983A patent/RU2700796C2/ru active
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2018
- 2018-08-02 HK HK18109939.5A patent/HK1250572A1/zh unknown
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