SG10201808102WA - Bicyclic heterocycle compounds and their uses in therapy - Google Patents
Bicyclic heterocycle compounds and their uses in therapyInfo
- Publication number
- SG10201808102WA SG10201808102WA SG10201808102WA SG10201808102WA SG10201808102WA SG 10201808102W A SG10201808102W A SG 10201808102WA SG 10201808102W A SG10201808102W A SG 10201808102WA SG 10201808102W A SG10201808102W A SG 10201808102WA SG 10201808102W A SG10201808102W A SG 10201808102WA
- Authority
- SG
- Singapore
- Prior art keywords
- bicyclic heterocycle
- therapy
- compounds
- heterocycle compounds
- cancer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. [Figure No. 1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1322755.8A GB201322755D0 (en) | 2013-12-20 | 2013-12-20 | Bicyclic heterocycle compounds and their uses in therapy |
| GB201406986A GB201406986D0 (en) | 2014-04-17 | 2014-04-17 | Bicyclic heterocycle compounds and their uses in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201808102WA true SG10201808102WA (en) | 2018-10-30 |
Family
ID=52134239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201808102WA SG10201808102WA (en) | 2013-12-20 | 2014-12-19 | Bicyclic heterocycle compounds and their uses in therapy |
| SG11201604795RA SG11201604795RA (en) | 2013-12-20 | 2014-12-19 | Bicyclic heterocycle compounds and their uses in therapy |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201604795RA SG11201604795RA (en) | 2013-12-20 | 2014-12-19 | Bicyclic heterocycle compounds and their uses in therapy |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9783538B2 (en) |
| EP (2) | EP3083616B1 (en) |
| JP (3) | JP6470756B2 (en) |
| KR (1) | KR102408262B1 (en) |
| CN (3) | CN115368356A (en) |
| AU (2) | AU2014369446C1 (en) |
| BR (2) | BR112016014561B1 (en) |
| CA (1) | CA2933939C (en) |
| CY (1) | CY1124436T1 (en) |
| DK (1) | DK3083616T3 (en) |
| ES (1) | ES2883289T3 (en) |
| HR (1) | HRP20211406T1 (en) |
| HU (1) | HUE056297T2 (en) |
| IL (1) | IL246239B (en) |
| LT (1) | LT3083616T (en) |
| MX (1) | MX2016008131A (en) |
| MY (2) | MY193649A (en) |
| NZ (2) | NZ758528A (en) |
| PH (1) | PH12016501139B1 (en) |
| PL (1) | PL3083616T3 (en) |
| PT (1) | PT3083616T (en) |
| RS (1) | RS62301B1 (en) |
| RU (1) | RU2696310C1 (en) |
| SA (1) | SA516371360B1 (en) |
| SG (2) | SG10201808102WA (en) |
| SI (1) | SI3083616T1 (en) |
| TW (1) | TWI649319B (en) |
| WO (1) | WO2015092420A1 (en) |
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| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| JP6470756B2 (en) * | 2013-12-20 | 2019-02-13 | アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | Bicyclic heterocyclic compounds and their use in therapy |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
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| US20220096436A1 (en) | 2019-01-17 | 2022-03-31 | Debiopharm International S.A. | Combination product for the treatment of cancer |
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| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| US20230348352A1 (en) * | 2020-05-04 | 2023-11-02 | Otsuka Pharmaceutical Co., Ltd. | Methods for synthesizing anhydrous lactic acid |
| KR20230005928A (en) * | 2020-05-04 | 2023-01-10 | 오츠카 세이야쿠 가부시키가이샤 | IAP antagonist compounds and intermediates and methods for synthesizing them |
| KR20230020942A (en) * | 2020-06-04 | 2023-02-13 | 베이진 엘티디 | Pyrido[2,3-B][1,4]oxazine or tetrahydropyrido[2,3-B][1,4]oxazepine as an IAP antagonist |
| CA3181715A1 (en) | 2020-08-27 | 2022-03-03 | Otsuka Pharmaceutical Co., Ltd. | Biomarkers for cancer therapy using mdm2 antagonists |
| GB202103080D0 (en) | 2021-03-04 | 2021-04-21 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| TW202322822A (en) | 2021-08-20 | 2023-06-16 | 日商大塚製藥股份有限公司 | Combination drug |
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