SG10201803698UA - Novel antiviral agents against hbv infection - Google Patents

Novel antiviral agents against hbv infection

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Publication number
SG10201803698UA
SG10201803698UA SG10201803698UA SG10201803698UA SG10201803698UA SG 10201803698U A SG10201803698U A SG 10201803698UA SG 10201803698U A SG10201803698U A SG 10201803698UA SG 10201803698U A SG10201803698U A SG 10201803698UA SG 10201803698U A SG10201803698U A SG 10201803698UA
Authority
SG
Singapore
Prior art keywords
antiviral agents
agents against
hbv infection
against hbv
novel
Prior art date
Application number
SG10201803698UA
Inventor
Xiaodong Xu
Ju-Tao Guo
Tong Xiao
Yanming Du
Timothy Block
Simon David Peter Baugh
Hong Ye
Original Assignee
Univ Drexel
Baruch S Blumberg Inst
Arbutus Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Drexel, Baruch S Blumberg Inst, Arbutus Biopharma Inc filed Critical Univ Drexel
Publication of SG10201803698UA publication Critical patent/SG10201803698UA/en

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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Abstract

NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION The present invention is directed toward novel compounds and novel methods of use of said compounds of the formula (I), useful as nucleocapsid assembly inhibitors for the treatment of viruses, especially but not exclusively, including pregenomic RNA encapsidation inhibitors of HBV for the treatment of Hepatitis B virus (HBV) infection and related conditions. (Formula (I)) Including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein A, R1, R2, R3, R4, R5, R6, R7, and R8 are defined herein. No Fig.
SG10201803698UA 2012-12-27 2013-12-27 Novel antiviral agents against hbv infection SG10201803698UA (en)

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