SG10201706045RA - Pertuzumab variants and evaluation thereof - Google Patents
Pertuzumab variants and evaluation thereofInfo
- Publication number
- SG10201706045RA SG10201706045RA SG10201706045RA SG10201706045RA SG10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA SG 10201706045R A SG10201706045R A SG 10201706045RA
- Authority
- SG
- Singapore
- Prior art keywords
- evaluation
- pertuzumab variants
- pertuzumab
- variants
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44747—Composition of gel or of carrier mixture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361812603P | 2013-04-16 | 2013-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201706045RA true SG10201706045RA (en) | 2017-08-30 |
Family
ID=50694078
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201706045RA SG10201706045RA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
SG10201911353WA SG10201911353WA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
SG11201508536PA SG11201508536PA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201911353WA SG10201911353WA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
SG11201508536PA SG11201508536PA (en) | 2013-04-16 | 2014-04-15 | Pertuzumab variants and evaluation thereof |
Country Status (25)
Country | Link |
---|---|
US (7) | US9815904B2 (en) |
EP (2) | EP2986643A2 (en) |
JP (2) | JP2016522176A (en) |
KR (2) | KR20150143649A (en) |
CN (1) | CN105121471A (en) |
AR (1) | AR095863A1 (en) |
AU (3) | AU2014254086B2 (en) |
BR (1) | BR112015024926A2 (en) |
CA (2) | CA3071678A1 (en) |
CL (3) | CL2015003049A1 (en) |
CR (1) | CR20150576A (en) |
EA (1) | EA201591643A1 (en) |
HK (1) | HK1211948A1 (en) |
IL (2) | IL241103B (en) |
MA (1) | MA38567A1 (en) |
MX (2) | MX368259B (en) |
MY (1) | MY173295A (en) |
NZ (2) | NZ712012A (en) |
PE (2) | PE20151769A1 (en) |
PH (1) | PH12015502382A1 (en) |
RU (2) | RU2737727C2 (en) |
SG (3) | SG10201706045RA (en) |
TW (1) | TWI554284B (en) |
WO (1) | WO2014172371A2 (en) |
ZA (1) | ZA201506594B (en) |
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BRPI0812682A2 (en) | 2008-06-16 | 2010-06-22 | Genentech Inc | metastatic breast cancer treatment |
KR20160084500A (en) | 2009-10-26 | 2016-07-13 | 에프. 호프만-라 로슈 아게 | Method for the production of a glycosylated immunoglobulin |
BR112015024926A2 (en) | 2013-04-16 | 2017-10-10 | Genentech Inc | compositions, article of manufacture, methods for treating a cancer patient, for evaluating a composition, for evaluating biological activity, for producing a composition and for evaluating the fragmentation of a composition and variant of pertuzumab |
KR102313262B1 (en) * | 2016-12-28 | 2021-10-14 | 제넨테크, 인크. | Treatment of advanced HER2-expressing cancer |
JP6741875B2 (en) | 2017-01-17 | 2020-08-19 | ジェネンテック, インコーポレイテッド | Subcutaneous HER2 antibody preparation |
KR102417583B1 (en) | 2017-03-02 | 2022-07-07 | 제넨테크, 인크. | Adjuvant treatment of her2-positive breast cancer |
KR20190140952A (en) * | 2017-04-24 | 2019-12-20 | 제넨테크, 인크. | ERBB2 / HER2 mutations in transmembrane and proximal membrane domains |
WO2019055631A1 (en) | 2017-09-13 | 2019-03-21 | Mayo Foundation For Medical Education And Research | Identification and monitoring of acid hydrolysis products of immunoglobulin heavy chains |
JP7259778B2 (en) | 2020-01-31 | 2023-04-18 | トヨタ自動車株式会社 | Vehicles and automated driving systems |
CN113189184B (en) * | 2021-04-28 | 2022-09-09 | 浙江大学 | Capillary gel electrophoresis sample buffer solution containing cysteine |
AU2022263700A1 (en) | 2021-04-29 | 2023-11-16 | Hyslink Therapeutics | Preparation method and application of antibody drug conjugate |
KR102511384B1 (en) | 2022-04-14 | 2023-03-16 | 지용환 | The rice swipper that can reduce grain damage |
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BR112015024926A2 (en) | 2013-04-16 | 2017-10-10 | Genentech Inc | compositions, article of manufacture, methods for treating a cancer patient, for evaluating a composition, for evaluating biological activity, for producing a composition and for evaluating the fragmentation of a composition and variant of pertuzumab |
CN105934253A (en) | 2013-12-17 | 2016-09-07 | 豪夫迈·罗氏有限公司 | Methods of treating HER2-positive cancers using pd-1 axis binding antagonists and anti-HER2 antibodies |
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