SG10201600791TA - Cysteine engineered antibodies and conjugates - Google Patents

Cysteine engineered antibodies and conjugates

Info

Publication number
SG10201600791TA
SG10201600791TA SG10201600791TA SG10201600791TA SG10201600791TA SG 10201600791T A SG10201600791T A SG 10201600791TA SG 10201600791T A SG10201600791T A SG 10201600791TA SG 10201600791T A SG10201600791T A SG 10201600791TA SG 10201600791T A SG10201600791T A SG 10201600791TA
Authority
SG
Singapore
Prior art keywords
conjugates
cysteine engineered
engineered antibodies
antibodies
cysteine
Prior art date
Application number
SG10201600791TA
Inventor
Sunil Bhakta
Jagath R Junutula
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG10201600791TA publication Critical patent/SG10201600791TA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • C—CHEMISTRY; METALLURGY
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    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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