SG10201508066VA - Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto - Google Patents

Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto

Info

Publication number
SG10201508066VA
SG10201508066VA SG10201508066VA SG10201508066VA SG10201508066VA SG 10201508066V A SG10201508066V A SG 10201508066VA SG 10201508066V A SG10201508066V A SG 10201508066VA SG 10201508066V A SG10201508066V A SG 10201508066VA SG 10201508066V A SG10201508066V A SG 10201508066VA
Authority
SG
Singapore
Prior art keywords
benzazepine
tetrahydro
chloro
methyl
processes
Prior art date
Application number
SG10201508066VA
Inventor
Ulrich Weigl
Frank Porstmann
Christoph Straessler
Lars Ulmer
Ulf Koetz
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of SG10201508066VA publication Critical patent/SG10201508066VA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
SG10201508066VA 2006-04-03 2007-04-02 Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto SG10201508066VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78919106P 2006-04-03 2006-04-03

Publications (1)

Publication Number Publication Date
SG10201508066VA true SG10201508066VA (en) 2015-10-29

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SG10201508066VA SG10201508066VA (en) 2006-04-03 2007-04-02 Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto

Country Status (7)

Country Link
US (4) US8168782B2 (en)
EP (3) EP2001852A2 (en)
JP (2) JP5199997B2 (en)
CN (1) CN101466684B (en)
CA (1) CA2646044A1 (en)
SG (1) SG10201508066VA (en)
WO (1) WO2007120517A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
SI2332921T1 (en) * 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
EP1838677B1 (en) 2004-12-21 2009-09-09 Arena Pharmaceuticals, Inc. Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
EP2322162A1 (en) 2004-12-23 2011-05-18 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
JP5199997B2 (en) * 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド Process for preparing 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and related intermediates
EP2099743B1 (en) 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (en) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. Processes for the preparation of 5-ht2c receptor agonists
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
MX2013002430A (en) 2010-09-01 2013-07-22 Arena Pharm Inc Fast-dissolve dosage forms of 5-ht2c agonists.
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
EP2611449A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
SG188364A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Salts of lorcaserin with optically active acids
RU2674670C1 (en) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Method of correction of body mass
EP2999692A1 (en) 2013-05-20 2016-03-30 LEK Pharmaceuticals d.d. Novel synthetic processes to 8-chloro-3-benzo[d]azepine via friedel-crafts alkylation of olefin
CN103333111A (en) * 2013-06-14 2013-10-02 苏州汇和药业有限公司 Preparation method of lorcaserin hydrochloride
EP3010887A1 (en) 2013-06-21 2016-04-27 LEK Pharmaceuticals d.d. Preparation of chiral 1-methyl-2,3,4,5-1h-benzodiazepines via asymmetric reduction of alpha-substituted styrenes
US9714225B2 (en) * 2013-11-13 2017-07-25 Cadila Healthcare Limited Processes for the preparation of lorcaserin
CN105228986B (en) * 2014-04-21 2017-11-07 杭州普晒医药科技有限公司 A kind of lorcaserin eutectic and preparation method thereof, pharmaceutical composition and purposes
WO2015170346A1 (en) 2014-05-09 2015-11-12 Council Of Scientific & Industrial Research A process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-benzo[d]azepine its enantiomers
CN104016919A (en) * 2014-06-18 2014-09-03 安徽省逸欣铭医药科技有限公司 Lorcaserin hydrochloride analogue, as well as preparation method and application thereof
CN104130188B (en) * 2014-08-05 2016-08-31 南京工业大学 The preparation method of 8-chloro-1-methyl-2,3,4,5-tetrahydrochysene-1H-3-benzazepine
WO2016069875A1 (en) 2014-10-30 2016-05-06 Arena Pharmaceuticals, Inc. Compositions and methods for ceasing tobacco smoking
WO2016151451A1 (en) * 2015-03-24 2016-09-29 Aurobindo Pharma Ltd A process for the preparation of lorcaserin hydrochloride
CN104844512B (en) * 2015-05-15 2017-03-29 东北制药集团股份有限公司 A kind of preparation method of green card color woods hydrochloride semi-hydrate crystal formation
CN104829532A (en) * 2015-05-15 2015-08-12 浙江理工大学 Method for preparing lorcaserin hydrochloride single crystal
EP3210975A1 (en) 2016-02-24 2017-08-30 Enantia, S.L. Cocrystals of lorcaserin
WO2018013886A1 (en) 2016-07-14 2018-01-18 Lanxess Solutions Us Inc. Cast urethanes made from low free monomer prepolymer with polycarbonate backbone
CN111499575B (en) * 2020-05-05 2022-03-25 河北师范大学 Method for preparing lorcaserin
CN112358406A (en) * 2020-10-28 2021-02-12 山东省药学科学院 Preparation method of lorcaserin intermediate
CN112574108B (en) * 2020-12-29 2023-08-11 甘肃兴荣精细化工有限公司 Preparation method of polysubstituted benzo [ b ] azepine compound
CN113387885B (en) * 2021-05-08 2023-01-03 兰州大学 Preparation method of 1-benzazepine compound
CN115784911A (en) * 2022-10-19 2023-03-14 山东省药学科学院 Synthetic method of 1- [2- (4-chlorophenyl) -ethylamino ] -2-propanol

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2900415A (en) 1954-12-14 1959-08-18 Lakeside Lab Inc Synthesized antispasmodic compounds
CH481110A (en) 1967-02-17 1969-11-15 Geigy Ag J R Process for the preparation of 1,2,4,5-tetrahydro-3-azepines
CH498122A (en) 1968-02-09 1970-10-31 Geigy Ag J R Process for the preparation of a new tetrahydroazepine derivative
CH500194A (en) 1968-02-15 1970-12-15 Ciba Geigy Ag Anorexigenic benzazepins
CA974989A (en) 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4233217A (en) * 1968-03-11 1980-11-11 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H, 3 benzazepines
FR314F (en) 1968-03-22 1970-05-25
FR7736M (en) 1968-09-02 1970-03-09
US3716639A (en) * 1970-03-11 1973-02-13 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepines
US3795683A (en) * 1970-08-19 1974-03-05 Hoffmann La Roche 2,3,4,5-tetrahydro-1h-3-benzazepines
LU65954A1 (en) * 1972-08-25 1974-03-07
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
SE7510988L (en) 1975-10-01 1977-04-02 Draco Ab NEW PHARMACEUTICAL ACTIVE ASSOCIATIONS
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) * 1977-04-01 1978-08-22 Smithkline Corporation 2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones
CA1090797A (en) 1978-06-20 1980-12-02 Kenneth G. Holden Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1h- 3-benzazepine compounds
AU515236B2 (en) 1978-06-26 1981-03-26 Smithkline Corporation Substituted-1-thienyl and furyl-2,3,4,5-tetrahydro-14-3 benzazepine derivatives
ZA792785B (en) 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
IE50355B1 (en) 1979-10-20 1986-04-02 Wyeth John & Brother Ltd Morpholine derivatives
ZA827887B (en) 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
EP0080779B1 (en) 1981-11-27 1986-07-16 Smithkline Beckman Corporation 3-benzazepines as alpha-2 antagonists
FR2518544A1 (en) 1981-12-22 1983-06-24 Lipha 3-Hydroxy-ethyl 1,3,4,5-tetra:hydro 1,3-benzodiazepine-2-thione(s) - and related cpds. are antidepressants, intermediate 2-amino-phenyl-ethyl-amino-ethanol derivs. are also new
FR2525603A1 (en) 1982-04-27 1983-10-28 Adir BENZOAZACYCLOALKYL-SPIRO-IMIDAZOLININES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US4988690A (en) 1982-06-14 1991-01-29 Hoechst-Roussel Pharmaceuticals Inc. 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
DE3418270A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW AMINOTETRAL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US4541954A (en) 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP0204349A3 (en) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Heteroaromatic amine derivatives, medicaments containing them and process for their preparation
GB8610668D0 (en) 1986-05-01 1986-06-04 Pfizer Ltd Anti-arrhythmia agents
US4762845A (en) * 1986-05-21 1988-08-09 Abbott Laboratories 7-(3-Substituted imino-1-pyrrolidinyl)-quinolone-3-carboxylic acids
EP0285287A3 (en) 1987-03-23 1990-08-16 Smithkline Beecham Corporation 3-benzazepine compounds for use in treating gastrointestinal motility disorders
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA882080B (en) 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
US5247080A (en) * 1987-03-27 1993-09-21 Schering Corporation Substituted benzazepines useful as intermediates for producing pharmaceutically active compounds
WO1988007858A1 (en) 1987-04-09 1988-10-20 Smithkline Beckman Corporation Sulfinyl and sulfonyl substituted 3-benzazepines
US4957914A (en) * 1987-05-15 1990-09-18 Syntex (U.S.A.) Inc. 1,9-alkano-bridged-2,3,4,5-tetrahydro-1H-3-benzazepines
JP2502723B2 (en) 1989-01-25 1996-05-29 株式会社日立ビルシステムサービス Elevator Remote monitoring mechanism inspection device
US5422355A (en) * 1989-06-02 1995-06-06 John Wyeth & Brother, Limited Composition for treating depression with (N-heteroaryl)alkylamines
US5178786A (en) * 1989-08-04 1993-01-12 The Lubrizol Corporation Corrosion-inhibiting compositions and functional fluids containing same
ZA914536B (en) 1990-06-15 1992-03-25 Schering Corp 8-lower alkyl-5-cycloalkyl or 5-cycloakenyl substituted benzazepines and pharmaceutical compositions containing them
US5275915A (en) * 1991-06-05 1994-01-04 Dainippon Ink And Chemicals, Inc. Developer for light-sensitive material
AU1927992A (en) 1991-06-21 1993-01-25 Smithkline Beecham Plc Medicaments
EP0558824A1 (en) * 1992-02-04 1993-09-08 Duphar International Research B.V Method for the preparation of vicinal aminoalcohols and optically active O-protected derivatives thereof
US5241065A (en) 1992-02-25 1993-08-31 Schering Corporation 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity
JPH05339263A (en) 1992-06-08 1993-12-21 Wakunaga Pharmaceut Co Ltd Dihydropyridine derivative
JPH06298746A (en) 1993-04-19 1994-10-25 Showa Denko Kk Production of cyclic imido ester
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof
US5387685A (en) * 1993-07-16 1995-02-07 American Cyanamid Co MDR reversal agents
GB9322976D0 (en) 1993-11-08 1994-01-05 Pfizer Ltd Therapeutic agents
DE4419247A1 (en) * 1994-06-01 1995-12-07 Merckle Gmbh New pyrrolizine keto-acid, keto-ester and carboxamide derivs.
DE4419315A1 (en) * 1994-06-01 1995-12-07 Merckle Gmbh New hetero- and oxo-pyrrolizine derivs.
DE4419246A1 (en) * 1994-06-01 1995-12-07 Merckle Gmbh New hetero-aryl substd. pyrrolizine derivs.
DE4427838A1 (en) 1994-08-05 1996-02-08 Thomae Gmbh Dr K Condensed azepine derivatives, pharmaceutical compositions containing them and methods for their preparation
DE4429079A1 (en) 1994-08-17 1996-02-22 Thomae Gmbh Dr K Cyclic urea derivatives, pharmaceutical compositions containing them and processes for their preparation
JPH08134048A (en) 1994-11-08 1996-05-28 Sumitomo Chem Co Ltd Production of oxazolines
GB9508622D0 (en) 1995-04-28 1995-06-14 Pfizer Ltd Therapeutic agants
US5958543A (en) * 1995-07-07 1999-09-28 Stor Media,Inc. Micro-texturing for sputtered, thin film magnetic media disks utilizing titanium sputtered in the presence of hydrogen to form micro-texturing
JPH0930960A (en) 1995-07-18 1997-02-04 Takasago Internatl Corp Therapeutic agent for fungal infectious disease
JPH0987258A (en) 1995-09-28 1997-03-31 Sumitomo Chem Co Ltd Oxazolines, their production and production of asymmetric cyclopropanecarboxylic acids
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
US5892116A (en) 1996-01-03 1999-04-06 Georgetown University Gelators
US5925651A (en) * 1996-04-03 1999-07-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
JP2001501172A (en) 1996-08-15 2001-01-30 スミスクライン・ビーチャム・コーポレイション IL-8 receptor antagonist
WO1998040385A1 (en) 1997-03-07 1998-09-17 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
AUPP020297A0 (en) 1997-11-05 1997-11-27 University Of Melbourne, The A novel receptor, and compounds which bind thereto
JP3603177B2 (en) 1998-03-26 2004-12-22 参天製薬株式会社 New urea derivatives
CA2325741C (en) 1998-03-26 2007-05-08 Santen Pharmaceutical Co., Ltd. Urea derivatives having tnf- .alpha. production inhibitory effects
EP0987235B1 (en) 1998-08-25 2003-03-12 MERCK PATENT GmbH Method for the conversion of arenes or alkenes with iodoalkenes, aryl iodides or arenediazonium salts
DE60006618T2 (en) * 1999-08-06 2004-09-23 F. Hoffmann-La Roche Ag Tetrahydrobenzo (d) azepines and their use as metabotropic glutamate receptor antagonists
EP1074549B1 (en) 1999-08-06 2003-11-19 F. Hoffmann-La Roche Ag Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors
DE10003708A1 (en) * 2000-01-28 2001-08-02 Solvent Innovation Gmbh Novel chiral ionic liquids and methods for their preparation in enantiomerically pure or enantiomerically enriched form
DE60132235T2 (en) 2000-11-14 2009-05-07 Smithkline Beecham P.L.C., Brentford TETRAHYDROBENZAZEPINE DERIVATIVES FOR USE AS DOPAMINE D3 RECEPTOR MODULATORS (ANTIPSYCHOTIC AGENTS)
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
WO2002074746A1 (en) 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Benzazepine derivatives
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
EP1430032A2 (en) 2001-09-24 2004-06-23 Elan Pharmaceuticals, Inc. Substituted amides for the treatment of neurological disorders
EP1513522A2 (en) 2002-01-18 2005-03-16 Sri International Methods of treating conditions associated with an edg receptor
CA2478183C (en) * 2002-03-12 2010-02-16 Merck & Co. Inc. Substituted amides
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
CN1805939B (en) * 2003-06-17 2010-10-13 艾尼纳制药公司 Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
SI2332921T1 (en) * 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
JP2008508348A (en) 2004-08-02 2008-03-21 ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ Compounds for inhibiting copper-containing amine oxidase and uses thereof
JPWO2006043710A1 (en) 2004-10-19 2008-05-22 株式会社リバース・プロテオミクス研究所 Drug discovery target protein and target gene, and screening method
EP1838677B1 (en) * 2004-12-21 2009-09-09 Arena Pharmaceuticals, Inc. Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
EP2322162A1 (en) 2004-12-23 2011-05-18 Arena Pharmaceuticals, Inc. 5HT2C receptor modulator compositions and methods of use
JP5199997B2 (en) * 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド Process for preparing 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and related intermediates
EP2099743B1 (en) * 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists

Also Published As

Publication number Publication date
US8501935B2 (en) 2013-08-06
US8168782B2 (en) 2012-05-01
US20090143576A1 (en) 2009-06-04
CN101466684A (en) 2009-06-24
EP2471779A1 (en) 2012-07-04
EP2518053A1 (en) 2012-10-31
US8802845B2 (en) 2014-08-12
JP2013053164A (en) 2013-03-21
US20150038701A1 (en) 2015-02-05
JP5833535B2 (en) 2015-12-16
JP5199997B2 (en) 2013-05-15
CN101466684B (en) 2012-06-20
WO2007120517A2 (en) 2007-10-25
US20130178619A1 (en) 2013-07-11
EP2001852A2 (en) 2008-12-17
US20120283431A1 (en) 2012-11-08
JP2009532470A (en) 2009-09-10
WO2007120517A3 (en) 2008-06-19
CA2646044A1 (en) 2007-10-25

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